Cremieux went from arguing against the death penalty as a teenager to becoming one of the most influential voices dissecting science online. Now with 250k+ followers on X, he’s known for exposing p-hacking, outcome switching, and selection effects that skew research.

In this conversation with Niklas, here’s what they actually talk about: why effect sizes in journals rarely match FDA data, how gene therapy’s real bottleneck is delivery not targets, and why siRNA is the most underrated modality in biotech right now.

What you’ll hear in this episode:

* The heuristics he uses to spot bad research at a glance

* Why published effect sizes are often 2–3x inflated compared to FDA data

* Selection effects that quietly shape everything from education outcomes to clinical trials

* The real bottleneck in gene therapy (delivery, not targets) and why germline bans hold back obvious wins

* How pragmatic trials and IRB reform could finally fix a broken system

* Why measles might come back and the case for vaccine mandates for kids

* The truth about longevity research: most “breakthroughs” just stop early deaths, not extend the right tail

* China’s clinical trial engine vs the slow US system

* The modality he thinks is most underpriced today: siRNA

For builders in science who care more about getting it right than playing along.

More about GUEST’S work:

* Cremieux’s X

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* Explore the Archive: The Infinita City Times

* Visit Infinita City

* Join the Builders’ Hub on Telegram

* Follow Infinita City on X

Two years ago, policymakers floated a global AI pause, some even suggested bombing data centers to stop progress. Today, the U.S. is pulling back from the brink.

Adam Thierer, author of Permissionless Innovation and Evasive Entrepreneurs, joins Niklas to unpack:

* How the “war on computation” began and the moment the tide turned

* Why sectors “born free” explode with innovation, while “born in captivity” stay stuck

* The explosion of 1,000+ AI-related bills across U.S. states and the risk of a regulatory maze

* The strange alliance between the far left and far right to slow progress

* Why AI could be the ultimate technology of freedom or a tool for repression

* Why compared to 2 years ago there are reasons to be more optimistic now.

If you’re building in AI, biotech, or any frontier space, this is your field guide to defending the right to build.

More about Adam’s work:

* Adam’s X

* Medium

* Amazon Books

Explore Infinita City:

* Explore the Archive: The Infinita City Times

* Visit Infinita City

* Join the Builders’ Hub on Telegram

* Follow Infinita City on X

In this episode, Michael Levin, Director of the Allen Discovery Center at Tufts, breaks down how his lab is rethinking regeneration, cancer, and aging, not through genetics, but through bioelectricity as the software of life.

From pioneering living robots made from frog skin cells to repairing birth defects and regenerating limbs, Levin’s work shows how tissues act as intelligent agents and how future medicine will be about communicating goals to cells, not micromanaging their chemistry.

We cover:

* Why Levin believes the “anatomical compiler” is the endgame: designing an organ or organism on a computer and compiling it into bioelectric instructions for cells.

* How cancer emerges as a breakdown of collective memory and why reconnecting cells electrically can normalize tumors without killing them.

* Proof-of-concept experiments that restore normal brains in tadpoles with birth defect mutations, regenerate frog legs, and even grow functioning eyes in new locations.

* The creation of Anthrobots, synthetic multicellular organisms built from adult human cells that can repair neural damage.

* Why development and regeneration show that genomes don’t dictate fixed outcomes bioelectric memories do.

* The philosophical implications: recognizing agency and intelligence at every level of biology.

If you’re building in biotech, longevity, or frontier medicine, this is a field guide to rewriting the software of life and a preview of the systems that could make aging, cancer, and trauma solvable problems.

More about Michael Levin’s work:

* Dr. Michael Levin's X

* Dr. Michael Levin Website

Explore Infinita City:

* Explore the Archive: The Infinita City Times

* Visit Infinita City

* Join the Builders’ Hub on Telegram

* Follow Infinita City on X