This week marks the 7th month we have put out the Top 10 Sleep Threats Power Rankings, but it's the first time we have devoted an entire episode to the list. this week, we have a special guest assessor, Dr. Jade Wu. In this episode we will:

• Find out what Jade thinks are the top threats to your sleep
• Focus on mental health as a sleep detractor
• Learn more about the concept of FOMO or "fear of missing out" and how research is indicating it is a real threat to the sleep of many

Produced by: Maeve Winter

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• Twitter: @drchriswinter
• IG: @drchriwinter
• Threads: @drchriswinter
• Bluesky: @drchriswinter
• The Sleep Solution and The Rested Child

Thanks for listening and sleep well!

Fear not, the Sleep Unplugged podcast is once again here to solve your holiday shopping dilemmas with some of my favorite sleep product companies. In this episode, we will explore a host of sleep-themed gift ideas and product recommendations. In this episode, we will feature the following products:

• SideSleeperZ slip-proof sleep mask
• Authenticity50 bedding
• Bee Ulmo honey
• BlueAir air purification systems (MiniRestful)
• Dagsmejan sleepwear
• Hästens mattresses and sleep products
• Honeydew Sleep pillows
• Loftie alarm clocks
• Moonbrew drink mix
• Natrol Sleep & Restore supplements
• Ozlo sleep earbuds
• Path water
• QuietOn noise cancelling sleep earbuds
• Sleeping Dove comforters
• Sleep Protein
• Truvaga vagal nerve stimulator
• WeLove Creations earplugs
• Zden

Produced by: Maeve Winter

More

• Twitter: @drchriswinter
• IG: @drchriwinter
• Threads: @drchriswinter
• Bluesky: @drchriswinter
• The Sleep Solution and The Rested Child

Thanks for listening and sleep well!

The orexin receptor agonists are coming. After years of managing narcolepsy with stimulants, sodium oxybate, and wake-promoting agents, we soon will have medications that target the root cause of the disorder: the loss of orexin signaling. These new drugs—developed by Takeda, Alkermes, and Centessa—aren’t just incremental improvements. They represent a genuine shift in how we understand and treat hypersomnolence disorders. In this episode, we will:

• Define what orexin is and why losing it destabilizes wakefulness, REM boundaries, muscle tone, and cognition
• Learn how orexin agonists work—not as stimulants, but as replacement therapy for a missing neurotransmitter
• Find out why OX2R is the key receptor, and how selective agonists restore stable wakefulness, reduce cataplexy, and normalize attention
• Review the available clinical data from the new wave of programs: oveporexton (Takeda), alixorexton (Alkermes), and ORX750 (Centessa)
• See what makes these drugs different from modafinil, amphetamines, solriamfetol, and oxybate therapies
• Learn why Phase 1, Phase 2, and Phase 3 trials matter—with quick insights on how these drugs reached such strong results
• Consider safety and side effects, including what Hy’s Law means and why regulators watch liver signals so closely
• Look ahead to what these medications may mean for NT1, NT2, IH, and other hypersomnolence disorders in the coming years
• Speculate why this class represents one of the most exciting moments in modern sleep medicine

Produced by: Maeve Winter

More

• Twitter: @drchriswinter
• IG: @drchriwinter
• Threads: @drchriswinter
• Bluesky: @drchriswinter
• The Sleep Solution and The Rested Child

Thanks for listening and sleep well!