Despite major advances in our understanding of the biology of mental health disorders, there’s no blood test or brain scan that will confirm if you have depression, anxiety, PTSD, or any other psychiatric illness.

And yet, the American Psychiatric Association recently announced that it will be including biomarkers for mental conditions in the next edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM), which guides diagnosis and treatment of mental illness. So how close are we to pinpointing the biological markers of mental illness, and what does that mean for diagnosis? It’s complicated.

Host Flora Lichtman untangles some of this science with psychiatry researcher John Krystal.

Guest: Dr. John Krystal is a professor of psychiatry, neuroscience, and psychology at the Yale School of Medicine.

Transcripts for each episode are available within 1-3 days at sciencefriday.com.

Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

There’s a long-held idea that autism is more prevalent in boys than girls—the CDC says it’s three times as common. But a growing body of research suggests the reality is more complicated. In a new study, researchers tracked autism diagnoses in millions of Swedish people born from 1985 to 2022. They found that the prevalence of autism is actually pretty even across the sexes, but people with “female” stamped on their birth certificate are often diagnosed later in life.

Host Flora Lichtman speaks with epidemiologist Caroline Fyfe about what this study teaches us about the prevalence of autism. Then, psychology researcher Rachel Moseley, an autistic woman herself, shares how late and missed diagnoses can affect autistic people.

Guests:
Dr. Caroline Fyfe is an epidemiologist at the University of Edinburgh who studied sex differences in autism diagnoses.
Dr. Rachel Moseley is a researcher in psychology at Bournemouth University in the UK, studying the experiences of autistic adults.

Transcripts for each episode are available within 1-3 days at sciencefriday.com.

Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

The gap between vaccine science and vaccine policy has been widening under Health Secretary Robert F. Kennedy Jr. Now, the American Medical Association and the Vaccine Integrity Project, based at the University of Minnesota, have announced that they are partnering to create their own vaccine review process, effectively creating a parallel system to the CDC’s.

Host Ira Flatow talks with Michael Osterholm, executive director of the Vaccine Integrity Project, about the role of this new review panel.

Guest: Dr. Michael Osterholm is the director of the Center for Infectious Disease Research and Policy and executive director of the Vaccine Integrity Project at the University of Minnesota.

Transcripts for each episode are available within 1-3 days at sciencefriday.com.

Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.