Proteins are crucial for life. They're made of amino acids that “fold” into millions of different shapes. And depending on their structure, they do radically different things in our cells. For a long time, predicting those shapes for research was considered a grand biological challenge.

But in 2020, Google’s AI lab DeepMind released Alphafold, a tool that was able to accurately predict many of the structures necessary for understanding biological mechanisms in a matter of minutes. In 2024, the Alphafold team was awarded a Nobel Prize in chemistry for the advance.

Five years later after its release, Host Ira Flatow checks in on the state of that tech and how it’s being used in health research with John Jumper, one of the lead scientists responsible for developing Alphafold.

Guest: John Jumper, scientist at Google Deepmind and co-recipient of the 2024 Nobel Prize in chemistry.

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If you’ve heard the hammering of a woodpecker in the woods, you might have wondered how the birds can be so forceful. What does it take to whack your head against a tree repeatedly, hard enough to drill a hole? A team of researchers wondered that too and set out to investigate, by putting tiny muscle monitors on eight downy woodpeckers and recording them with high-speed video as they pecked away in the lab.

Integrative organismal biologist Nick Antonson, co-author of a report on the work, joins Host Flora Lichtmen to peck away at the mystery.

Plus, you can take two ant eggs with the exact same genes, and one can grow up to be a queen, the other a worker. Neuroscientist and evolutionary biologist Daniel Kronauer joins Flora to share recent research into how an ant becomes a queen.

Guests: Dr. Nick Antonson is an NSF postdoctoral research fellow in the department of ecology, evolution, and organismal biology at Brown University.
Dr. Daniel Kronauer is the Stanley S. and Sydney R. Shuman Professor in the Laboratory of Social Evolution and Behavior at The Rockefeller University in New York.

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Our memories make us who we are—just ask Barbra Streisand. But despite the lyrics in many popular songs, memories aren’t frozen in time. When we call them up, the details shift and change. And neuroscience research shows that we might be able to take that a step further—to manipulate our memories and even implant false ones.

Neuroscientist Steve Ramirez joins Host Ira Flatow to explain how memory manipulation could revolutionize the way we treat brain disorders. They also discuss Ramirez’s book, How to Change a Memory: One Neuroscientist's Quest to Alter the Past, and how the sudden death of his friend and scientific collaborator made him rethink the role of memory.

Guest: Dr. Steve Ramirez is an associate professor of psychology and brain sciences at Boston University and the author of How to Change a Memory.

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Bearded vultures build giant, elaborate nests that are passed down from generation to generation. And according to a new study, some of these scavengers have collected bits and bobs of human history over the course of centuries. Scientists picked apart 12 vulture nests preserved in Spain and discovered a museum collection’s worth of objects, including a woven sandal that could be more than 700 years old.

Host Flora Lichtman talks with study author Ana Belen Marín-Arroyo, an archaeologist who studies ancient humans, about how the nests are giving us a glimpse into vulture culture as well as the lives of the people they lived beside.

Guest: Dr. Ana Belen Marín-Arroyo is an archaeologist and professor of prehistory at the University of Cantabria in Spain.

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The band Phish has toured for over 40 years. One of the draws of their legendary live shows—which can go on for 8 hours—is finding moments of “flow,” when the band members lock into an improvised jam, finding new musical ideas in real time.

Phish fans live for these transcendent moments, but so do the musicians—to the point that Mike Gordon, the band’s bass player, is funding scientific research to better understand flow state.

Host Flora Lichtman sits down with Mike and his research collaborator, neuroscientist Greg Appelbaum, to unpack their research so far and how it’s helping to inform other neuroscience.

Guests:
Mike Gordon is bassist and co-founder of the rock band Phish.
Dr. Greg Appelbaum is a professor in the department of psychiatry at the University of California, San Diego.

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Around 25 years ago, Ardem Patapoutian set out to investigate the fundamental biology behind our sense of touch. Through a long process of gene elimination, he identified a class of sensors in the cell membrane that turn physical pressure into an electrical signal. He changed the game in the field of sensation and perception, and in 2021 shared the Nobel Prize in Physiology or Medicine for his work.

He joins Host Flora Lichtman to talk about his research, the odd jobs he worked along the way, and how he found a sense of belonging in science.

Guest: Dr. Ardem Patapoutian is a professor and the Presidential Endowed Chair in Neurobiology at the Scripps Research Institute in La Jolla, California.

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Over the last five years, billions of people have received at least one dose of a COVID-19 mRNA vaccine. New research has found an unanticipated result of these vaccines: Cancer treatments are more effective for some vaccinated patients, and many live longer than their unvaccinated counterparts. This news comes at a time where the federal government is slashing funding for mRNA research.

Host Ira Flatow speaks to lead study author Adam Grippin and vaccine expert Eric Topol.

Guests: Dr. Adam Grippin is a radiation oncologist at the MC Anderson Cancer Center in Houston, Texas.
Dr. Eric Topol is a cardiologist and genomics professor at the Scripps Research Institute in La Jolla, California.

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One of the biggest debates in the dinosaur world is what was happening right before they went extinct. Were they already declining, or would they have thrived if not for the asteroid? Two recent studies shed some light on this question: one that analyzes a trove of fossils from New Mexico and suggests there was more diversity in the Americas than previously thought, and another that reanalyzes a long-debated juvenile T. rex fossil and finds it’s likely a separate, smaller species.

Host Ira Flatow is joined by authors on those separate studies, paleontologists Steve Brusatte and Lindsay Zanno.

Guests: Dr. Lindsay Zanno is division head of paleontology at the North Carolina Museum of Natural Sciences in Raleigh, NC.
Dr. Steve Brusatte is a paleontologist at the University of Edinburgh in Scotland.

Transcripts for each episode are available within 1-3 days at sciencefriday.com.

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