Do you struggle to focus on simple tasks?

Do you feel mentally “slowed down” during the day?

Today, Jay welcomes back his dear friend and trailblazer in functional medicine, Dr. Mark Hyman. Mark Hyman, MD is the co-founder and Chief Medical Officer of Function Health, the fastest growing health company in the U.S. In this extremely vulnerable conversation, Mark recounts his near-death experience after a severe spinal infection left him unable to walk and fighting for his life. Despite decades of living and teaching optimal health, he suddenly found himself dependent on others for even the simplest tasks. Over the course of five determined months, Mark applied the very principles he has championed for years: nutritional excellence, disciplined daily movement, and an unshakable mindset. Not only did he make a full recovery, but came back stronger than ever at the age of 65, proving that the body’s innate healing capacity can be reignited at any stage of life.

The conversation explores the critical role mindset plays in recovery and underscores the often-overlooked connection between diet, lifestyle, and overall well-being. Mark explains how chronic illness is frequently driven by hidden inflammation, fueled by ultra-processed foods, sugar, and environmental toxins. He breaks down the science behind his 10-Day Detox, a simple yet powerful reset proven to dramatically reduce symptoms such as fatigue, pain, and digestive distress. The discussion also delves into the growing prevalence of autoimmune conditions, the hidden epidemic of nutrient deficiencies, and why personalized health data is essential for identifying risks before they become life-threatening.

In this interview, you'll learn:

How to Rebuild Your Health After a Major Setback

How to Use Mindset as Your Greatest Healing Tool

How to Reduce Inflammation Through Diet

How to Spot the Early Signs of Autoimmune Disease

How to Use Food as Medicine Every Day

How to Take Small Daily Steps Toward Lifelong Wellness

Healing isn’t instant, but each intentional choice, a nourishing meal, a mindful moment, a restful night, builds momentum toward changes far greater than expected.

With Love and Gratitude,

Jay Shetty

Join over 750,000 people to receive my most transformative wisdom directly in your inbox every single week with my free newsletter. Subscribe here.

What We Discuss:

00:00 Intro

01:33 Overcoming a Life-Threatening Health Crisis

05:39 What is the Key to Healing?

08:15 Breaking Free from Chronic Pain

09:52 The Powerful Tool That Can Reprogram Your Body

15:03 How Inflammation Silently Damages Your Health

18:51 The Hidden Dangers of Sugar Addiction

23:59 Transforming Health Through Functional Medicine

30:34 Why Autoimmune Diseases Are on the Rise

37:04 Signs Your Immune System Needs Help

40:51 Do You Have an Undiagnosed Autoimmune Condition?

42:41 A Simple 10-Day Reset for Your Body

48:06 The Secret to Healing: Treat the Root Cause

52:44 How AI Is Revolutionizing Healthcare

56:32 The Truth About the Chronic Disease Epidemic

57:55 Understanding How Your Body Really Works

59:02 Expanding Access to Quality Healthcare

01:00:56 The Case for Regulating Ultra-Processed Foods

Episode Resources:

Mark Hyman | Website

Mark Hyman | Instagram

Mark Hyman | Facebook

Mark Hyman | YouTube

Mark Hyman | X

Mark Hyman | Pinterest

Mark Hyman | Books

Function Health

See omnystudio.com/listener for privacy information.

Today, Jay reflects on the lessons about love he wishes he had known in his twenties. He examines how movies, media, and cultural narratives have long shaped unrealistic expectations about romance, often equating love with grand gestures, nonstop excitement, and fairy tale endings. Jay challenges these ideas, by showing that true love is not constant fireworks, but a balance of peace, stability, and passion. He explains how the thrill is often mistaken for attraction, and how the calm that comes from trust and consistency is actually the real foundation of a healthy relationship, even if often mistaken for boredom.

Jay also explores the critical role of self-awareness and boundaries in fostering meaningful relationships. He discusses how love without boundaries can cause you to lose yourself, and how repeating familiar emotional patterns from the past can keep you stuck in cycles that feel comfortable but are ultimately harmful. Through relatable examples, Jay highlights the importance of defining emotional non-negotiables, paying attention to how a partner handles boredom and conflict, and understanding the influence of attachment styles. Jay emphasizes that successful relationships are not about finding someone perfect, but about choosing a partner who is willing to heal, grow, and face challenges together.

In this episode, you'll learn:

How to Set Boundaries Without Pushing Love Away

How to Handle Conflict Without Ruining a Relationship

How to Recognize the Difference Between Lust and Love

How to Break Unhealthy Relationship Patterns

How to Choose Patience and Healing in Relationships

Finding real love isn’t an end goal, it’s an ongoing journey you take with intention, compassion, and patience. It’s something you build over time through quiet moments, healthy boundaries, and a commitment to grow, both on your own and together.

With Love and Gratitude,

Jay Shetty

Join over 750,000 people to receive my most transformative wisdom directly in your inbox every single week with my free newsletter. Subscribe here.

What We Discuss:

00:00 Intro

01:13 Everything You Need to Know About Love

04:12 #1: Chemistry Does Not Equal Compatibility

09:19 #2: Love Without Boundaries is Self Abandonment

12:25 #3: How They Handle Boredom Tells You Everything

14:25 #4: Conflict Doesn't Ruin Relationships, Avoidance Does

16:44 #5: The Thrill is Temporary, Steady Love is Lasting

20:57 #6: How Does Your Partner's Attachment Style Affect You?

23:01 #7: What Feels Familiar Isn’t Always What’s Right

See omnystudio.com/listener for privacy information.

Have you ever failed at something you really wanted?

What did that experience teach you about yourself?

Today, Jay chats with late-night legend Jimmy Kimmel for an unforgettable live conversation at the Greek Theatre in Los Angeles. Jimmy opens the episode playfully roasting Jay, showing off his signature, sharp wit right out of the gate. The laughs quickly give way to a candid, wide-ranging conversation about Jimmy’s life, marked by gutsy decisions, constant reinvention, and moments of surprising vulnerability.

Jimmy reflects on the emotional cost of self-expression, his early struggles with being misunderstood, and how persistence (and a healthy dose of delusion) helped him find his place in the world. Jimmy shares how anxiety has shaped his life, from growing up without much money to now being someone people rely on for support, advice, and even financial help. From outrageous pranks and career missteps to a touching tribute to his prank-loving Aunt Chippy, Jimmy constantly balances humor with disarming honesty. Jimmy also opens up about the challenges of becoming more emotionally available, how therapy has helped him grow, and how being a father, and now a grandfather, has reshaped his priorities and softened his edges.

In this interview, you'll learn:

How to Stay True to Yourself

How to Use Humor as a Tool for Healing

How to Keep a Lifelong Passion Alive

How to Stay Grounded When Success Finds You

How to Cope With Anxiety Through Creative Outlets

How Helping Others is the Key to Healing Yourself

It’s not about being perfect, it’s about being honest, showing up, and continuing to try. Whether through meaningful conversations, creative expression, or simply sharing space with others, healing and connection are always within reach.

With Love and Gratitude,

Jay Shetty

Join over 750,000 people to receive my most transformative wisdom directly in your inbox every single week with my free newsletter. Subscribe here.

What We Discuss:

00:00 Intro

04:44 Why is Putting Yourself Out There So Hard?

08:00 Discovering What Truly Drives You

09:19 The Origins of Jimmy’s Legendary Pranks

11:56 When the Pranks Never Stop

17:02 Failed Firings and Conversations That Went Sideways

18:30 Staying True to Your Creative Voice

21:42 Becoming a Grandfather for the First Time

25:55 Living With Anxiety: How It Shapes Family Life

27:29 Jimmy’s Take on Managing Anxiety

29:56 What It’s Like to Face Financial Pressure

31:17 How Jimmy Met the Love of His Life

32:31 Is Finding Love in LA Really That Hard?

33:17 The Secret to a Strong and Lasting Marriage

38:19 Why Talking About Your Feelings Is So Tough

39:16 What To Do When You’re Feeling Low

43:05 Jimmy on Final Five

Episode Resources:

Jimmy Kimmel | Instagram

Jimmy Kimmel | Facebook

Jimmy Kimmel | YouTube

Jimmy Kimmel | X

Jimmy Kimmel | TikTok

See omnystudio.com/listener for privacy information.