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Publisher's Summary

It begins in Toronto, in the years after the smart drug revolution. Any high school student with a chemjet and internet connection can download recipes and print drugs, or invent them. A seventeen-year-old street girl finds God through a new brain-altering drug called Numinous, used as a sacrament by a new Church that preys on the underclass. But she is arrested and put into detention, and without the drug, commits suicide.

Lyda Rose, another patient in that detention facility, has a dark secret: She was one of the original scientists who developed the drug. With the help of an ex-government agent and an imaginary, drug-induced doctor, Lyda sets out to find the other three survivors of the five who made the Numinous in a quest to set things right.

A mind-bending and violent chase across Canada and the US, Daryl Gregory's Afterparty is a marvelous mix of William Gibson’s Neuromancer, Philip K. Dick’s Ubik, and perhaps a bit of Peter Watts’s Starfish: A last chance to save civilization, or die trying.

©2014 Daryl Gregory (P)2014 Audible, Inc.

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  • Ryan
  • Somerville, MA, United States
  • 07-19-14

Smart, witty altered-consciousness thriller

Afterparty was a pleasant discovery for me, comparable to recent Neal Stephenson or William Gibson, but less geeked-out than the former and a little snarkier than the latter.

The initial setting is a near-future Toronto. A former neuroscientist named Lyda is in a mental hospital, in the wake of a series of breakdowns. It’s about a decade after her biotech startup discovered, while trying to cure schizophrenia, a drug that enables users to experience God. Well, in a manner of speaking. More specifically, Lyda and her colleagues overdosed on the drug and each now experiences a very convincing hallucination of a heavenly spirit companion. In Lyda's case, it's a moralizing winged angel named Doctor Gloria. In more controlled doses, the drug, nicknamed Numinous, makes people feel that they're in the presence of the divine.

It’s not the only mind-altering custom drug in this future. There's now a whole subculture of print-it-at-home drug manufacture, to say nothing of what more serious organizations do with the tech. Some products have amusingly harmless effects, but some alter consciousness in disturbing ways, such as one that removes one character’s natural empathy and turns him into a temporary sociopath.

When a peculiarly troubled teenage patient shows up in the clinic, it dawns on Lyda that Numinous, which her and her colleagues swore to keep secret, is now on the street, being distributed by a strange new “church”. So, Lyda must check herself out of the hospital, evade monitoring systems, get across the border, and track down her former colleagues in the US. Her only allies are a sweetly unaware young man who thinks his consciousness resides in the aquarium toy hanging from his neck, and a crafty American ex-intelligence officer whose own mind has been scrambled by too much "focus" drug over her career. And a cat. And, of course, the amusingly huffy Doctor G, who remains invisible to everyone but Lyda.

This is definitely a smart book, asking meaningful philosophical questions about the nature of being and the implications of messing with our brains/minds. Or of messing with other people's. It's also a witty one, with cleverly written scenes, oddball characters, and a lot of snarky quips from Lyda. For example, when a drug dealer sells a seemingly effective gay-for-a-day "product" to some straight dudebros at a college frat party, she retorts, "product? Don't you mean placebo?" (Well, it made me laugh.)

The story, once it gets going, is interesting. There's also a backstory that emerges, concerning the tragic events that took place at Little Sprout (the startup) ten years ago, what became of Lyda's wife and fellow scientist, who took too much Numinous, how Lyda ended up in the mental hospital, and what happened to her daughter, who she had to give up for adoption. While Gregory doesn’t posit a drastically altered future, I also enjoyed the creative, incidental little ideas that he drops in here and there, such as a plausible successor to smart phones. Like the plot of a good thriller, all the pieces come together in the end, but with some room for taking the characters and setup further, should he choose to.

If there are a few believability issues and the ending is a little predictable, it’s a thriller with a brain and an eye on an approaching bend in the road ahead. And the core questions -- if there is a better us inside ourselves, should we try to access it by tampering with ourselves? Or should we not? Is “divine experience” more about the divine, or the experience? -- are ones that Gregory keeps hovering in our peripheral vision throughout the book, but admirably never tries to answer for us.

10 of 10 people found this review helpful

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God is a drug in this near-future thriller

This is the second book I've read by Daryl Gregory. He seems to like writing speculative fiction set in a near future, rather than settling into a series or a theme. "Raising Stony Mayhall" was one of the best zombie novels I've ever read. Afterparty, his latest, is also set a couple of decades from now, in a world where 3D printers have advanced to manufacturing pharmaceuticals, so anyone can "print" their own custom controlled substances.

Lyda Rose, the protagonist, was a neuroscientist who helped create Numinous. It was supposed to be a treatment for schizophrenia; instead, it helps its users find God. Or gods. Or some god.

The effect is spiritual if not supernatural: Numinous rewires the brain and provides you with your very own guardian angel (in Lyda's case, a judgmental winged psychologist named "Dr. Gloria"). The subjects are absolutely convinced they are receiving messages from the Divine, even if they know intellectually about Numinous. Lyda's conversations with her guardian angel, who she knows is a product of her drug-induced imagination, are believable because deep down, Lyda believes in her.

How Lyda came to be hooked on her own creation, and why she has to escape from a prison-hospital and track down the other former members of her little start-up company that was going to get rich, is a mystery that unfolds in a well-paced thriller with plenty of reveals and twists. There is an Afghan grandmother who is the most powerful drug lord in Seattle, a psychopathic hit man who calls himself "The Vincent" and raises bonsai buffalo herds in his apartment, a millionaire whose adopted daughter is a little prodigy assisted by her "deck" of "IFs" (Imaginary Friends), and of course, Dr. Gloria.

This wasn't quite a grand-slam of a book, but it was interesting and well-paced and original, with believable characters. Definitely recommended.

4 of 4 people found this review helpful

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  • Russell
  • Keswick, ON, Canada
  • 07-31-17

An Answer to the Mystery of Existence

Actually the most rewarding answer I got was to the question "Why is this book called Afterparty?"; ... and that came near the end of the book.

It was a tough start, I almost gave up near the beginning. This was probably a matter of getting used to the writers style and ideas. The main idea of a drug unlocking access to a personal god was just too intriguing for me to give up. Part of the problem was not understanding that the main character Lyda Rose was interacting with a personal god and being confused at the start of the book.

Once the story took off for me there was a lot of hair raising action, interesting characters and a major twist near the end to satisfy my baser instincts. And, while all this is going on we have this highly original idea of a drug called Numinous that unlocks our biological propensity towards explaining life through religion and a deity. Lyda, the scientist still keeps a skeptical distance from her personal god as she talks to it and alternatively craves and rejects its attentions. Others on her team who developed and ingested the potent drug accept their gods without question.

This drug was deemed too dangerous for the general public and got discontinued. The story revolves around Lyda discovering that it has surreptitiously reappeared many years later. She is worried about the harmful effects on the world and she tries to track down where it is coming from. The people who were on her development team are the prime suspects

As for the answer to the mystery of existence - if it was that easy, we would have figured it out after thousands of years trying to explain everything with all sorts of religions. We would all be in agreement at this stage of our collective history.

You will just have to be satisfied with the answer to the question of why is this book called Afterparty in this highly innovative, entertaining adventure.

3 of 3 people found this review helpful

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  • Jon
  • Atwater, CA, United States
  • 05-11-14

Clever, Novel, Entertaining

What made the experience of listening to Afterparty the most enjoyable?

This was a very interesting story populated with very interesting people. I was impressed by the individuals who emerged from this author's mind. He's either possessed or a genius.

What was one of the most memorable moments of Afterparty?

Conversations with Dr. Gloria were always memorable. We'd all be improved if there was a helpful and insightful inner voice-- but would we listen to it?

Which scene was your favorite?

In this not-too-distant world, miniature cattle have been created through genetic engineering and one character keeps them in his living room. This is just a tiny part of the the story, but the reference to these mini-cattle is so casual, with none of the moral qualms that seem to plague our society. The description of this "Home on the Range" was a great scene.

If you were to make a film of this book, what would the tag line be?

The opposite of the Twilight series.

Any additional comments?

The narrator was spectacular. She delivered a myriad of distinctive voices and had brought the characters to life. It was a marvelous performance.

3 of 3 people found this review helpful

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Sophisticated and pharmacologically accurate

Afterparty is a smart, sophisticated tale set in the near future (2030's or so) and offers a compelling perspective on evolving drug use. The premise is the re-emergence of a never commercialized treatment for schizophrenia that has as a unique side effect: a powerful spiritual / mental / emotional sense of connection with God. The story of how a failed biotech drug treatment is re-invented as a semi-religious movement is told by a smart, neuroscientist originally involved with the drug's discovery, but whose subsequent life has been a substance abuse / PTSD nightmare following their business implosion after a murder. Along with a paranoid / neurotic fellow mental hospital inmate who happens to be an ex-national security agent, the heroine delves into the source and reasons for her drug's revival.

The sci-fi elements are fairly benign for a near future tale. Scientifically and pharmacologically, the author is accurate and insightful in crafting an engaging and compelling tale, while at the same time maintaining scientific integrity. Beyond the biological neuroscience aspects, there's also exploration of what constitutes free will at the level of neurons.

The narration is superb, capturing the mood and tone of the tale. There's a solid range of both male and female voices with particular attention to individual peccadilloes.

6 of 7 people found this review helpful

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  • Katherine
  • St. Johns, FL, United States
  • 05-27-14

Joint review

Originally posted at Fantasy Literature as a joint review (me and Marion).

Marion: Daryl Gregory’s pharma-tech novel Afterparty is good entertainment with many wonderful moments. At times it is wildly inventive — filled with images like an apartment full of tiny genetically-engineered bison roaming the “range” of wall to wall grass, or an angel named Dr. Gloria who wears a business suit, white coat, glasses, carries a clipboard and has wings.

Kat and I read this book about the same time. We both gave it four stars but we may have liked different things, so we’re going to discuss the book together. Kat’s comments are in red.

Here’s a brief synopsis of the story.
In the near future, a neuroscientist with a deity in her head checks herself out of an institution and goes searching for the people who are distributing the street drug called Numinous (or sometimes, Logos). Lyda Rose is intimately familiar with the drug because she helped invent it, as a treatment for schizophrenia… and, because of an overdose of the drug at a disastrous “afterparty,” she is intimately familiar with its effects. Specifically, it puts a god in your head. Dr. Gloria is Lyda’s personal god.

Kat, you’re a neuroscientist, and this book is packed with neuroscience. What did you think about it? Was it realistic?

Kat: Yes, I thought it was frighteningly realistic. Scientists have been working for decades trying to tweak drugs that will be more effective treatments for schizophrenia. Gregory gets this just right as he talks about the neuroscience behind drug design. Also, a really hot topic in neuroscience these days is “consciousness” or “self-awareness.” What is consciousness? Which brain areas are involved? What happens when you change activity in those areas? What kind of psychoses or other perceptual experiences may develop when you mess with these areas? Schizophrenia involves change in brain activity and some of the symptoms, such as auditory hallucinations and delusions (which are often religious in nature) involve self-perception. These are fascinating things to speculate about.

Marion: There is a really chilling plausibility and immediacy to that part of the book, particularly when Lyda opines that “any high school student with a chemjet printer and an internet connection could download recipes and print small-batch drugs.”

When we talked about this by email, you and I both used the words “William Gibson-like,” and so have other reviewers. I liked that aspect of the book — the zany, almost-underworld characters like the Millionaires’ Club, the guy raising miniature bison in his apartment.

Kat: Or how about the paranoid guy who thinks he keeps his “self” in a small container around his neck? He made me laugh so many times (and he was particularly well done in the audio version I listened to). Yeah, many of these characters could have walked right out of a Gibson novel, yet they were all unique. But, as we discussed, this is almost over the top. Nearly every character is some sort of bizarre and it comes off as trying just a little too hard. I wish Gregory had saved a couple of those ideas for future books. But still, I loved them.

I was also reminded of Neal Stephenson’s Reamde which is a similar type of weird paranoid adventure. Fans of Gibson and Stephenson will love Afterparty.

Marion: I agree, although I did have some trouble with the “when” of the story. I think there is even a specific year given at one point, but it didn’t stick, and I struggled with just now “near future” we were. On the other hand, I thought the border-crossing scene was spine-tinglingly intense, and there were amazing descriptions. One of my other favorite scenes is the party in New York, when Lyda takes what I’m going to call “the color drug.” That was vivid and hilarious. Dr. Gloria’s reaction to that drug actually had me laughing out loud.

Kat: Those were some of my favorite scenes, too. One of the best lines in the book comes from that Color Bomb scene: “’How are you doing?’ he asked chartreusely.”

Marion: I loved that line!

Kat: It was all very clever. And yes, all throughout the book there were vivid descriptions and apt similes and metaphors. I admired Gregory’s style and look forward to reading more of his work.

As for the timing, it didn’t bother me that I didn’t know exactly. Based on the science, I could tell it was very near future, like within the next 10 years. These are things that could happen very soon. (I don’t think they will, just that they could.)

By the way, because of the science, I could really relate to Lyda. I also studied neuropharmacology in grad school and had a fantasy of finding the perfect treatment (or cure) for schizophrenia. Lyda has a family history of schizophrenia and knows it’s in her genes. She’s desperate for a treatment, as anybody with her knowledge and background would be. I totally understood her. And I was intrigued by the fact that as readers, we don’t know if her current problems (alcohol and drug addictions, invisible angel) are caused by her genetics, the drug she was exposed to, or the immense amount of stress she’s encountered (which can trigger psychoses in people with genetic predispositions).

Marion: I have to say that I had a little bit more trouble with the main character than you did. I think Gregory did himself a disservice by creating Lyda the way he did. Late in the book, one character says that the deity in your head is supposed to make you a better person, and throughout the book various characters express different ideas about whether the effect is a delusion (“your” god) or big-G God. That’s part of the point of the story. Still, I felt with Lyda there were times when Gloria was too literally “the better angel of her nature.” My favorite character was Ollie and probably my second favorite was Sasha, although she is closely tied with Dr. Gloria for sheer awesomeness.

Kat: Dr. Gloria was my favorite character — she was like the classic sarcastic sidekick, but because she was quiet, refined, and sophisticated, she never became annoying (as many sarcastic sidekicks do). As for Ollie, I was intrigued by her special mental powers that came from taking a drug called Clarity. It was just reasonable enough to be almost believable and I enjoyed thinking about that. I’m particularly interested in neuropharmacology, so I found a lot to think about in Afterparty.

Marion: I just wished I could take Clarity myself. By the way, what did you think of the whole God thing?

Kat: Ah, you ask me that because you know I’m a Christian. This is another area that cognitive neuroscientists are interested in these days — what is the nature of religious experiences? How do people experience God? If there’s a place in the brain where neural activity makes people feel spiritual, does that mean that God is an illusion? (Hint: No, because I can stimulate your brain and make you think of your grandmother and you wouldn’t say she’s not real.) Can drugs make us believe in God? If so, does that mean God doesn’t exist?

These are fascinating things to think about. I’ve answered them for myself (based on my own research in the scriptures, history and other areas, not based on “feeling” or “intuition” that I know is so easily altered) but Daryl Gregory leaves these crucial questions unanswered and the ending is ambiguous. Is Lyda’s angel/god real? Nobody else sees Dr. Gloria, but occasionally she can physically alter Lyda’s circumstances. Lyda “knows” Dr. Gloria is just an affect of the drug, but she’s not surprised when miracles happen. I appreciated the ambiguity that Gregory left us with. I thought it was well done.

Marion: I thought he had some powerful points about the nature of faith, but also in the power of fellowship; that the movement associated with Numinous is not top-down and hierarchal, but genuinely grassroots. That was an interesting choice.

I would say we’re pretty much in agreement that Gregory pulled off an entertaining, original story here.

Kat: Yes, and let me say something about the audio version. It’s 11 hours long, was produced by Audible Studios, and read by Tavia Gilbert. Gilbert was so convincing in all the different roles that I completely forgot I was listening to a performance. I think that’s high praise. Readers, this is a great audio choice!

8 of 10 people found this review helpful

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  • Dave
  • Whittier, CA
  • 05-22-14

Chemically Induced Redemption

Imagine going to church, taking communion, and as soon as you swallowed the wafer and wine, seeing God right beside you. Or, if not God, an aspect of God – one that you could converse with, argue with, beg, weep with, and scream at. Now, imagine all that if you were an atheist.

Regardless of what you believe or do not believe, as a science fiction fan you have to wonder: short of this miraculous wafer falling from the sky like manna, where is this drug coming from?

In the not too-distant future, anyone with a 3D printer and passable google-fu can print up DIY drugs. When a new drug called Logos starts seeping into the market, giving people a chemically fused Damascus experience, drug lords start acting like music executives, trying to halt the competition however they can. The thing is Logos, also known as Numinous, actually seems to transform sinners into saints, converting them into evangelicals of Logos: people who would lay down their lives for friends and enemies alike – especially if the outcome furthers the gospel of Logos.

Years ago, Lyda Rose was roofied with an overdose of Numinous – the very drug she helped create. It played a part in the death of her wife, stole the child she was pregnant with, led to frequent stays at various mental institutions, and blessed/cursed her with a constant guardian angel she can’t kick. When Lyda discovers Numinous has leaked out on the street, she and the angel living inside her head check out of their current mental institution, and hit the road to find out who’s been manufacturing Logos.

The road trip Lyda and her friends embark stretches across not only Canada and the United States but also maps free will, redemption, the nature of God, and examines the similarities of religion and substance abuse more explicitly than any other book I can think of (and there are a pretty fair amount of SF/F books that have made that comparison). I appreciate that it seems to treat its characters fairly - a lot of the evangelical-esque characters aren't monsters. They're striving for some kind of redemption - even if it happens to be a chemically induced one.

Also: it’s funny as hell, which is kind of surprising for what seems like such a dark book on the cover. But fans of Raising Stony Mayhall will want to check this one out too.

A large part of that is Tavia Gilbert’s narration - it's a perfect match for Gregory’s prose. Her work here as Lyda, Dr. Gloria, Ollie, and the rest of the gance comes off as intelligent, sharp, witty, and someone you'd want to roadtrip with.

Afterparty is a novel with a dark, chewy center that reminds me quite a bit of William Gibson's later novels, but with a style that cranks up the entertainment factor and laughs making this story way more fun than you'd expect it to be with such heady subject matter.

(Originally posted at The AudioBookaneers)

5 of 6 people found this review helpful

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Great story, held my interest throughout!

Would you listen to Afterparty again? Why?

I listened to it twice in a row! The details that I missed in the beginning because I didn't know what was happening were still interesting enough to hear again. Also, I listened on an international flight and spaced out during some of it. It was good enough to hear again!

Who was your favorite character and why?

Hard to talk about without spoilers. So... SPOILER ALERT!

Dr. Gloria was my favorite character. Is she real or imaginary? Is she God, an Angel, or a figment of the imagination?

Any additional comments?

I really, really enjoyed this book. It was a great thought-experiment to wonder if the hallucinations COULD be, in fact, a doorway to divine as many human traditions have long-believed, or just human construct.The only thing I would have changed about the book is hard to discuss without spoilers. I'll just say this. The author overlooked some interesting psychological "coming to terms" in the end when the main character finds out something she believed for so long about people she cared deeply about was untrue. I would have liked to have had that resolved, in at least a few sentences. Otherwise, AWESOME read!

1 of 1 people found this review helpful

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In the near future, several friends have gathered to celebrate the sale of their company, but their lives are turned upside down by a tragedy.

This book is primarily focused on the events in the life of a woman who attended the party. Her sanity is questionable due to an overdose of a designer drug and her friends also have issues with reality. She is a highly intelligent woman who is motivated by a 10 year old promise. The woman is also gay which proves to be an important plot element. There is action, several scenes of brutality and a lot of discussions about religion (another important element in the plot). Additionally, the F-word is frequently mentioned but is not an important element (unless I missed something).

Am I glad I listened? The topic is unique and the narrator lively, but I did get tired of listening to an emotional roller-coaster. There is a great twist at the end which I enjoyed. A solid four star.

1 of 1 people found this review helpful

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  • Robert
  • East Perth, Australia
  • 05-08-14

great listen

Enjoyed it from start to finish. Loved the narrator... she owned the characters. Can't wait to listen to more from this writer and hopefully this narrator.

3 of 4 people found this review helpful

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  • emmoff
  • 11-17-16

Incredible complex novel

Could not stop listening to this book. My favourite Daryl Gregory book so far. Set in the near future where drugs can induce a belief in god. A thriller/mystery set against a backdrop of grief. Poignant, vicious, hilarious and thoughtful. The plotting is perfect. Highly recommended. Narration super.

1 of 1 people found this review helpful