On this second episode about drug discovery, we discuss small molecule drug libraries and the challenges behind rational design! Don't know what that means? Tune in to find out!

References:

https://www.frontiersin.org/articles/10.3389/fcell.2019.00107/full

https://next.cancer.gov/discoveryresources/resources_ndl.htm

https://www.molbiolcell.org/doi/10.1091/mbc.E22-08-0377

https://www.fda.gov/news-events/press-announcements/fda-approves-first-gene-therapy-treatment-certain-patients-duchenne-muscular-dystrophy

https://www.goodrx.com/health-topic/gene-therapy/crispr-therapeutics-vertex-exa-cel

https://www.broadinstitute.org/what-broad/areas-focus/project-spotlight/crispr-timeline

Hey everyone! Today's episode is about getting into the nitty gritty of drug discovery. We often benefit from the research and development that goes into the creation of drugs we use to treat illnesses without really understanding what goes into that process. In this first part, we will discuss how you conceptually begin the process.

References:

https://www.nature.com/articles/nrd2399

https://www.fda.gov/vaccines-blood-biologics/zolgensma

https://cancerci.biomedcentral.com/articles/10.1186/s12935-019-0806-1

https://www.ncbi.nlm.nih.gov/books/NBK519062/

https://www.sciencedirect.com/science/article/pii/B9780128191828000338

https://www.sciencedirect.com/science/article/pii/0006291X89926788?via%3Dihub

https://www.nature.com/articles/362841a0

https://www.sciencedirect.com/science/article/pii/S0305737220300554

Sorry for the COVID-related break in episodes everyone! In our return, we complete our series on influenza by discussing past epidemics and pandemics to understand how influenza has repeatedly led to large scale medical events. Then we will finish by discussing the current and future state of influenza vaccines!

References:

• https://www.nejm.org/doi/full/10.1056/nejmp058281
• https://www.nature.com/articles/nature08157
• https://pubmed.ncbi.nlm.nih.gov/16208372/
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578040/
• https://www.who.int/news-room/spotlight/history-of-vaccination/history-of-influenza-vaccination
• https://www.scripps.edu/news-and-events/press-room/2020/20200623-wilson-universalflu.html
• https://www.cdc.gov/flu/season/faq-flu-season-2022-2023.htm
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159335/
• https://www.nature.com/articles/nrmicro.2017.118
• https://www.sciencedirect.com/science/article/abs/pii/0042682278901538
• https://www.cdc.gov/flu/prevent/flushot.htm
• https://www.science.org/content/article/innovative-universal-flu-vaccine-shows-promises-it-first-clinical-test
• https://www.science.org/doi/10.1126/science.aaz5143
• https://www.nih.gov/news-events/nih-research-matters/using-mrna-technology-universal-flu-vaccine