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Dr. Michael Koren sits down with a clinical trial participant named Walt to talk about lipoprotein(a), also called Lp(a). At a community health event, Walt discovered he had hight levels of Lp(a), which puts him at an increased risk of heart attack and stroke. Walt asks what Lp(a) is, how it causes damage, and how the investigational clinical trial medications work. The duo then move through how Walt has felt through the clinical trial process and the enrollment demographics in a clinical trial.

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Dr. Michael Koren joins Kevin Geddings to discuss a new concept in cholesterol treatment: gene editing. Dr. Koren talks about a new study, just opening in the United States, that is the first of its class. This study explores gene editing to tackle familial hypercholesterolemia (high cholesterol caused by genetics) through a once-in-a-lifetime, single-shot treatment.

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Rheumatologist Dr. Manish Jain joins Cardiologist Dr. Michael Koren to break down what gout is, why it can be one of the most painful forms of arthritis, and why it can affect far more than the big toe. Dr. Jain explains gout's metabolic underpinnings, the role uric acid plays in the disease, and how systemic complications can affect the kidneys and beyond. The doctoral duo then discusses what uric acid levels mean, why some uric acid results may be misleading, and how important it is to control these levels for a gout patient. The duo finishes by reviewing standard treatments for gout, the importance of "not killing the patient to treat gout," and new treatments on the horizon in gout clinical trials.

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Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com

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Music: Storyblocks - Corporate Inspired

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