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Dr. Michael Koren sits down with Dr. Murali Ramaswamy to explore the concept of Research as a Care Option. They compare this with the misconception of research as a treatment option to reveal how clinical trials provide structured environments that often lead to better health outcomes regardless of the specific intervention. They debunk the idea that clinical trials provide treatment, due to the randomized nature of trials, but discuss the numerous health benefits seen by patients who enter a clinical trial - even those who get a placebo!

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Dr. Michael Koren joins Kevin Geddings to discuss how tariffs could significantly impact pharmaceutical prices. They talk about how barriers to import may affect both prescription and especially over-the-counter medication prices. They move onto the difficulty of starting new drug manufacturing in the US and how clinical trials may provide relief for some patients.

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On this episode, recorded in front of a live audience, Cardiologist Dr. Michael Koren is joined by pulmonologist Dr. Mitchell Rothstein to discuss Chronic Obstructive Pulmonary Disease (COPD). COPD is obstruction of the lungs, making it hard to breathe and represents a significant health challenge . It affects millions of Americans and is a leading cause of mortality, yet receives disproportionately low research funding compared to conditions with fewer annual deaths. The doctors explore this chronic lung condition from its biological mechanisms to the latest treatment approaches, highlighting the critical need for increased awareness and research investment.

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Dr. Michael Koren Join Kevin Geddings to reflect on the evolution of medical research ethics from the troubling practices at Willowbrook Hospital in the 1970s to today's patient-centered approach. He connects this progression to John Lennon and Yoko Ono's final major concert, which raised awareness about conditions at the hospital while highlighting how far ethics in clinical trials have advanced.

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Dr. Michael Koren shares insights from his presentation at the American College of Cardiology meeting in Chicago about a groundbreaking oral PCSK9 inhibitor that could lower cholesterol by 80% when combined with a statin. The development represents a significant advancement in treatment options for the 20% of patients who don't respond adequately to statins alone or experience statin intolerance. They also chat about Chicago and the importance of things in moderation.

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Psychiatrist Dr. Rachna Saralka joins Cardiologist Dr. Michael Koren to explore the emerging field of artificial intelligence in psychology. They discuss the promise and shortfalls of using AI in this field, and the need for hard data and validated results through clinical trials. They get into empathy, the placebo effect, and potential use of AI to train psychologists and other doctors just like chess bots can help teach people to play chess.

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On this Monday Morning Minute, Dr. Michael Koren draws parallels between the NCAA Final Four basketball tournament and the clinical research process. He explains that in medicine, researchers start with literally 10,000 potential molecules, which get whittled down to only three or four medications to be tested in big, phase III clinical trials. This ensures that only the most promising medical technologies get approved, just like the most promising teams get to the National Championships.

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Judith Abbey, DNP, shares her journey from medical student in Ghana to healthcare entrepreneur in Florida, where she founded On the Go Drip, a mobile IV therapy service delivering treatments directly to patients' homes. Dr. Michael Koren asks her about her history and business, and the two of them dive into some of the controversy surrounding supplement treatments.

Helpful Links:

On The Go Drip

Research Methods class at University of North Florida

The Book Clinical Decision Analysis

Be a part of advancing science by participating in clinical research.

Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com

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