Midlife isn’t a crisis—it’s a calling. In this episode, New York Times bestselling author and Modern Elder Academy founder Chip Conley sits down with host Alexia Brue to reframe aging as a powerful phase of reinvention. Drawing from his work with Airbnb and MEA, Chip explores how emotional resilience, community, and “life literacy” can become the true metrics of a long, meaningful life. With wit and wisdom, he challenges conventional career arcs and invites listeners to consider what a purposeful second (or third) act could look like.

Beth McGroarty of the Global Wellness Institute also joins the conversation to share data on the demographic shifts driving this reframing of midlife. She unpacks how aging boomers are rejecting traditional retirement, how longevity is reshaping work itself, and why we need bold new models for connection, housing, and purpose in later life.

Inside this Episode:

• Why wisdom—not youth—may be the most undervalued longevity asset
• Emotional, cognitive, and social well-being as pillars of healthspan
• New rites of passage: why we need a midlife curriculum
• The Modern Elder Academy and the future of multi-generational living
• Beth McGroarty: Rise of “Don’t-Call-It-Senior-Living” concepts like Mather, the wellness industry’s opportunity to support older workers, and the economic imperative to reimagine purpose after 60
• Why longevity solutions must go beyond biology to meaning, contribution, and community

Resources Mentioned:

• Modern Elder Academy
• Global Wellness Institute
• Mather Institute

Hosted by: Alexia Brue, co-founder of Well+Good; founder of a new healthspan training studio, The Practice; member of the Global Wellness Institute Board of Advisors

To learn more about the Global Wellness Institute please visit us at global wellness institute.org, connect with us on Instagram and subscribe to our YouTube channel.

Produced by: Emily Roberts and Ali Alquiza of Over Lunch

Music provided by: Myndstream

Thank you to our sponsor, Fountain Life, for supporting the GWI Podcast. Head to FountainLife.com to learn more.

Subscribe, rate, & review wherever you listen to podcasts!

What if your skincare routine could go beyond aesthetics and actually slow aging at the cellular level?

In this episode of The Wellness Roundtable: Longevity, Alexia Brue sits down with Carolina Oliveira, MD / co-founder and CEO of OneSkin, a biotech company on a mission to transform skin from a cosmetic afterthought to a longevity biomarker.

Dr. Oliveira shares how her team of scientists developed OS-01, the first topical peptide shown to reduce the burden of senescent cells in skin. We explore the clinical validation behind the product, why “skinspan” matters for your healthspan, and how your skin’s biological age may be a bellwether for systemic inflammation and immune health.

This is not your average skincare chat—it’s a science-backed conversation about the future of personalized longevity, from barrier function to bioinformatics.

This episode also features insights from Beth McGroarty, VP of Research & Forecasting at the Global Wellness Institute.

Inside This Episode:

• Why skin is more than cosmetic: it’s a modifiable aging organ
• The role of senescent cells in driving systemic inflammation
• How OneSkin developed and validated its OS-01 peptide
• The surprising link between topical products and internal biomarkers
• What most longevity enthusiasts overlook about skin health
• How OneSkin is earning credibility with leaders like David Sinclair and Peter Diamandis
• Daily protocols: How Dr. Oliveira approaches her own longevity stack

Resources & Mentioned:

• OneSkin’s OS-01 peptide
• Mentions: David Sinclair, Peter Diamandis, Bryan Johnson
  
  

Hosted by: Alexia Brue, co-founder of Well+Good; founder of a new healthspan training studio, The Practice; member of the Global Wellness Institute Board of Advisors
To learn more about the Global Wellness Institute please visit us at global wellness institute.org, connect with us on Instagram and subscribe to our YouTube channel.

Produced by: Emily Roberts and Ali Alquiza of Over Lunch
Music provided by: Myndstream

Thank you to our sponsor, Fountain Life, for supporting the GWI Podcast. Head to FountainLife.com to learn more.

Subscribe, rate, & review wherever you listen to podcasts!

Short Summary:
Women may live longer—but they spend more of those years in poor health. In this essential conversation, Piraye Beim, MD & founder of Celmatix, reveals why ovarian aging is the hidden accelerant of female biological decline—and why extending ovarian healthspan could be the next major breakthrough in longevity science. From inflammaging to AMH biomarkers, Dr. Beim brings cutting-edge reproductive science into the center of the longevity discourse.

This episode also features insights from Beth McGroarty, VP of Research & Forecasting at the Global Wellness Institute.

Inside this episode:

• The “gonadal gap”: why menopause accelerates aging for women
• Why ovarian function is a key regulator of brain, bone, and metabolic health
• How tracking AMH levels could transform preventive care for women in their 30s and 40s
• The underfunding of female longevity research—and how that’s starting to change
• ARPA-H and other public-private partnerships funding therapeutic innovations
• The potential to delay menopause and extend healthspan through new medical approaches

Resources Mentioned:

• Celmatix
  
  
• ARPA-H research on ovarian aging
  
  
• Global Wellness Institute

Hosted by: Alexia Brue, co-founder of Well+Good; founder of a new healthspan training studio, The Practice; member of the Global Wellness Institute Board of Advisors

To learn more about the Global Wellness Institute please visit us at global wellness institute.org, connect with us on Instagram and subscribe to our YouTube channel.

Produced by: Emily Roberts and Ali Alquiza of Over Lunch

Music provided by: Myndstream

Thank you to our sponsor, Fountain Life, for supporting the GWI Podcast. Head to FountainLife.com to learn more.

Subscribe, rate, & review wherever you listen to podcasts!

Short Summary: What does a true longevity care model look like in practice—not just in theory? Alexia sits down with Robin Berzin, MD and founder and CEO of Parsley Health, the nation’s largest functional medicine and longevity clinic. A longtime force in personalized medicine, Dr. Berzin offers a rare window into how Parsley is merging diagnostics, clinical care, and innovation to shift the healthcare paradigm—from reactive to radically proactive.

In this conversation, Dr. Berzin unpacks the most important—and overlooked—biomarkers for healthspan, the cultural moment that catapulted longevity into the mainstream, and why many people are chasing biohacks while ignoring the root causes of the diseases they already have.

Inside this episode:

• The six biomarker domains that matter most—and why conventional labs fall short
• Why strength training and sauna are at the top of her own longevity list
• The truth about peptides, GLP-1s, and whether rapamycin is ready for prime time
• How Parsley is using AI to scale personalization—without losing the human touch
• What women really need to know about hormone therapy, inflammation, and hidden thyroid issues
• Why she believes estrogen may be “the new longevity drug”

Whether you're a clinician, a consumer, or somewhere in between, this conversation offers a grounded, data-informed look at what it really takes to extend not just lifespan, but healthspan.

Resources Mentioned:

• Parsley Health
• Dr. Robin Berzin’s Newsletter
• Supplement tracking app: SuppCo
• Robin on Instagram: @robinberzinmd
  
  

Hosted by: Alexia Brue, co-founder of Well+Good; founder of a new healthspan training studio, The Practice; member of the Global Wellness Institute Board of Advisors

To learn more about the Global Wellness Institute please visit us at global wellness institute.org, connect with us on Instagram and subscribe to our YouTube channel.

Produced by: Emily Roberts and Ali Alquiza of Over Lunch

Music provided by: Myndstream

Thank you to our sponsor, Fountain Life, for supporting the GWI Podcast. Head to FountainLife.com to learn more.

Subscribe, rate, & review wherever you listen to podcasts!

Short Summary:
Abby Levy, co-founder of Primetime Partners and a leading longevity investor, joins Alexia Brue to break down the massive opportunity—and responsibility—facing business leaders in the age of longevity. From redefining retirement to redesigning financial services and wellness products for older consumers, Abby shares a venture capitalist’s view on where this market is headed, and how brands must evolve to meet the needs of a longer-lived population.

This episode also features insights from David Stewart, founder of the innovative high-growth media platforms of Ageist and SuperAge, and a passionate champion of the modern 50+ lifestyle.

Inside this episode:

• Why the “longevity economy” is one of the biggest demographic shifts of our time
• Healthspan, wealthspan, and workspan: the new pillars of aging well
• How retirement is being reframed as a 30+ year life phase
• Investment trends in telemedicine, caregiving tech, and financial wellness
• Bridging the gap between wellness culture and precision health solutions

Resources Mentioned:

• Primetime Partners
• Ageist and Super Age
• Global Wellness Institute – Longevity Economy Reports

Hosted by: Alexia Brue, co-founder of Well+Good; founder of a new healthspan training studio, The Practice; member of the Global Wellness Institute Board of Advisors

To learn more about the Global Wellness Institute please visit us at global wellness institute.org, connect with us on Instagram and subscribe to our YouTube channel.

Produced by: Emily Roberts and Ali Alquiza of Over Lunch

Music provided by: Myndstream

Thank you to our sponsor, Fountain Life, for supporting the GWI Podcast. Head to FountainLife.com to learn more.

Subscribe, rate, & review wherever you listen to podcasts!

Short Summary:
Regenerative medicine is no longer science fiction. In this deep-dive episode, Adeel Khan, MD a leader in cell therapy innovation, joins Alexia Brue to explore the science behind stem cells, gene editing, and tissue engineering. From MSCs and exosomes to the ethics of access and experimentation, Dr. Khan unpacks both the promise and the hype around the most futuristic corner of the longevity movement.

This episode also features insights from Beth McGroarty, VP of Research & Forecasting at the Global Wellness Institute, who shares her thoughts on regenerative medicine, and whether the wellness industry is ready for this level of science and the potential culture/knowledge gap that’s happening.

Inside this episode:

• What regenerative medicine means—and how it differs from functional medicine
• Why stem cells from your own body may not be the best bet after age 40
• The future of gene editing: CRISPR, prime editing, and cellular repair
• Autologous vs. allogeneic therapies: what's scalable, what's safe
• Equity concerns: how longevity tech could widen the health gap
• Global regulatory hurdles—and the need for new frameworks for safety and efficacy

Resources Mentioned:

• Dr. Adeel Khan’s Eterna Medicinal Practice
• Global Wellness Institute

Hosted by: Alexia Brue, co-founder of Well+Good; founder of a new healthspan training studio, The Practice; member of the Global Wellness Institute Board of Advisors

To learn more about the Global Wellness Institute please visit us at globalwellnessinstitute.org, connect with us on Instagram and subscribe to our YouTube channel.

Produced by: Emily Roberts and Ali Alquiza of Over Lunch

Music provided by: Myndstream

Thank you to our sponsor, Fountain Life, for supporting the GWI Podcast. Head to FountainLife.com to learn more.

Subscribe, rate, & review wherever you listen to podcasts!

Short Summary:
Professor and longevity expert Andrea Maier, MD, PhD, joins Alexia Brue to explore how aging is no longer a fixed destiny, but increasingly a modifiable risk factor. As co-founder of Singapore-based Chi Longevity Clinics, Dr. Maier shares how her team is translating epigenetic science, precision medicine, and behavioral coaching into scalable interventions for healthspan. From biological aging clocks to the future of annual checkups, this episode offers a pragmatic look at how medicine is slowly shifting from sick care to proactive longevity care.

Inside this episode:

• Chronological age vs. biological age—and how to measure the difference
• What precision geroscience looks like in practice: biomarkers, diagnostics, personalized protocols
• How Chi Longevity Clinics are operationalizing evidence-based aging interventions
• Cognitive health and dual-task testing as a window into biological resilience
• How insurance, medical training, and incentives must evolve to support prevention
• Future vision: What your annual “healthspan check-in” could look like by 2030

Resources Mentioned:

• Chi Longevity
• Global Wellness Institute
  
  

Hosted by: Alexia Brue, co-founder of Well+Good; founder of a new healthspan training studio, The Practice; member of the Global Wellness Institute Board of Advisors

To learn more about the Global Wellness Institute please visit us at global wellness institute.org, connect with us on Instagram and subscribe to our YouTube channel.

Produced by: Emily Roberts and Ali Alquiza of Over Lunch

Music provided by: Myndstream

Thank you to our sponsor, Fountain Life, for supporting the GWI Podcast. Head to FountainLife.com to learn more.

Subscribe, rate, & review wherever you listen to podcasts!

Six Senses Wellness pioneer Anna Bjurstam joins Alexia Brue for a wide-ranging conversation on the evolving relationship between wellness and longevity—and why these two frameworks must converge for both to remain meaningful. Drawing on decades of experience across hospitality, spa, and integrative health, Anna shares a global lens on everything from Blue Zones and wearables to the spiritual dimensions of aging well. She also addresses the growing risk of “longevity washing,” and how practitioners can maintain integrity in a rapidly commercializing sector.

This episode also features GWI's Beth McGroarty, who highlights the explosive growth of longevity clinics and destination resorts worldwide, and offers a critical look at the biohacking industry’s rush to rebrand itself as “longevity.”

Expanded Talking Points:

• Wellness vs. longevity: What’s the difference—and why does it matter?
• How the spa and hospitality industries are adopting diagnostics, neurotech, and longevity labs
• Why purpose, joy, and spiritual health must sit alongside biomarkers and senolytics
• Anna’s wearable strategy: seasonally intentional tech use + embodied self-awareness
• Beth McGroarty: Global boom in longevity clinics, how legacy wellness brands are expanding into medicalized models, and the red flags of longevity-branded recovery therapies
• The need for regulatory clarity around treatments like IV drips, cryo, and hyperbaric chambers

Resources:

• Global Wellness Institute (GWI)
• Anna Bjurstam Bio & Projects
• Mentioned book: Lifespan by David Sinclair

Hosted by: Alexia Brue, co-founder of Well+Good; founder of a new healthspan training studio, The Practice; member of the Global Wellness Institute Board of Advisors

To learn more about the GWI please visit us at global wellness institute.org, connect with us on Instagram and subscribe to our YouTube channel.

Produced by: Emily Roberts and Ali Alquiza of Over Lunch

Music provided by: Myndstream

Thank you to our sponsor, Fountain Life, for supporting the GWI Podcast. Head to FountainLife.com to learn more.

Subscribe, rate, & review wherever you listen to podcasts!