As we close out 2025, hosts Dr. Moain Abu Dabrh and Dr. David Freeman pause to reflect on a year of conversations that shaped The Wellbeing Manifesto Podcast—not through quick answers or trending hacks, but through better questions, deeper listening, and honest dialogue.

This year, we sat with clinicians, scientists, journalists, humanists, and leaders who challenged easy narratives and resisted shortcuts. Together, we explored the real forces shaping health, wellbeing, care, culture, technology, trust, movement, meaning, and community—at the personal, societal, and global levels.

What stood out most wasn't consensus—it was integrity. Conversations that honored complexity. Reflections that acknowledged trade-offs. And a shared understanding that health and wellbeing are never just individual choices or just systems—but always both.

In a world optimized for speed and noise, choosing to slow down, think carefully, and listen deeply matters. We are profoundly grateful to our guests for their generosity and intellectual humility—and to our listeners for trusting us with your time and attention.

As we move into the year ahead, our commitment remains clear:
Less hype. More truth. Better living.
Fewer slogans. Deeper conversations. Science, humanity, and lived experience—held in equal measure.

Thank you for being part of this unfolding dialogue. One thoughtful conversation at a time.

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In this episode of The Well-Being Manifesto Podcast, hosts Dr. Moain Abu Dabrh and Dr. David Freeman welcome one of the world's most influential physician-scientists, Dr. Eric Topol—cardiologist, geneticist, digital medicine pioneer, and founder of the Scripps Research Translational Institute.

Dr. Topol, author of Deep Medicine, The Creative Destruction of Medicine, and his latest book Super Agers, joins the conversation to explore the future of evidence-based medicine, longevity science, and how emerging breakthroughs in artificial intelligence, genomics, immunology, and lifestyle medicine are reshaping healthcare.

This wide-ranging discussion dives into the critical difference between lifespan and healthspan, why genetics matter less than most people think, and how lifestyle-plus factors—nutrition, exercise, sleep, gut health, social connection, and environmental exposures—play a central role in preventing age-related disease. Dr. Topol explains why the immune system may be the single most important driver of healthy aging and how inflammation ("inflammaging") underlies cancer, cardiovascular disease, and neurodegenerative conditions like Alzheimer's.

You'll also hear Dr. Topol's clear-eyed perspective on:

• How AI in medicine can enable personalized prevention and early disease detection

• Why multimodal AI is essential for predicting risk years before symptoms appear

• The promise and limits of GLP-1 medications beyond weight loss

• New insights into vaccines, including shingles vaccines and dementia risk reduction

• The growing role of the gut microbiome, brain–immune connection, and metabolic health

• Misinformation, medical hype, and rebuilding trust in science and healthcare

• Why prevention—not just treatment—is the future of modern medicine

This episode is essential listening for anyone interested in longevity, preventive medicine, digital health, AI in healthcare, Alzheimer's prevention, lifestyle medicine, healthspan optimization, genomics, and evidence-based wellness.

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Subscribe for more conversations translating science and experience into realistic, sustainable ways of living—with less hype, more truth, and better health.

In this episode of The Well-Being Manifesto, hosts Dr. Moain Abu Dabrh and Dr. David Freeman sit down with renowned cardiovascular and clinical exercise physiologist Dr. Barry Franklin to explore how movement truly becomes medicine.

Dr. Franklin, a pioneer in cardiovascular disease prevention and past president of the American College of Sports Medicine, breaks down the most dangerous exercise myths, reveals the smallest effective dose of physical activity, and explains how even 1-minute bouts of movement can improve longevity and reduce the risk of heart disease. If you're overwhelmed by fitness trends, confused by VO2 max, METs, and heart rate zones, or worried about starting an exercise plan safely, this episode provides clarity rooted in decades of clinical research.

Learn why:
• 7,000–8,000 steps per day may be more effective than 10,000
• Stair climbing can reduce mortality by up to 30%
• Walking speed predicts longevity and heart health
• High-intensity exercise can be risky for sedentary individuals
• Even a 5% weight loss significantly improves health outcomes
• METs, VO2 max, and aerobic capacity matter for your aging process
• The safest approach to movement is gradual, consistent, and individualized

This conversation is essential listening for anyone interested in healthy aging, longevity, heart disease prevention, functional fitness, exercise safety, metabolic health, and sustainable lifestyle change. Whether you're a medical professional, fitness coach, or simply someone trying to build healthier habits, Dr. Franklin's insights will change how you think about exercise and aging forever.

Subscribe to The Well-Being Manifesto for more expert conversations on health, resilience, optimized performance, and living longer — better.