On Evidence, Breakthroughs, and the Future of Medicine | Feat. Dr. Eric Topol

In this episode of The Well-Being Manifesto Podcast, hosts Dr. Moain Abu Dabrh and Dr. David Freeman welcome one of the world's most influential physician-scientists, Dr. Eric Topol—cardiologist, geneticist, digital medicine pioneer, and founder of the Scripps Research Translational Institute.

Dr. Topol, author of Deep Medicine, The Creative Destruction of Medicine, and his latest book Super Agers, joins the conversation to explore the future of evidence-based medicine, longevity science, and how emerging breakthroughs in artificial intelligence, genomics, immunology, and lifestyle medicine are reshaping healthcare.

This wide-ranging discussion dives into the critical difference between lifespan and healthspan, why genetics matter less than most people think, and how lifestyle-plus factors—nutrition, exercise, sleep, gut health, social connection, and environmental exposures—play a central role in preventing age-related disease. Dr. Topol explains why the immune system may be the single most important driver of healthy aging and how inflammation ("inflammaging") underlies cancer, cardiovascular disease, and neurodegenerative conditions like Alzheimer's.

You'll also hear Dr. Topol's clear-eyed perspective on:

• How AI in medicine can enable personalized prevention and early disease detection

• Why multimodal AI is essential for predicting risk years before symptoms appear

• The promise and limits of GLP-1 medications beyond weight loss

• New insights into vaccines, including shingles vaccines and dementia risk reduction

• The growing role of the gut microbiome, brain–immune connection, and metabolic health

• Misinformation, medical hype, and rebuilding trust in science and healthcare

• Why prevention—not just treatment—is the future of modern medicine

This episode is essential listening for anyone interested in longevity, preventive medicine, digital health, AI in healthcare, Alzheimer's prevention, lifestyle medicine, healthspan optimization, genomics, and evidence-based wellness.

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