The Science Of

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  • Where science curiosity meets the amazing scientists of UCSD!

    Welcome to "The Science Of"!!!
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Episodios
  • Season 2 Episode 1 | The Science Of Translating Discovery | Dr. Sofia Cardenas-Alcoser, postdoc fellow Gutkind Lab UCSD Moores Cancer Center

    Season 2 Episode 1 | The Science Of Translating Discovery | Dr. Sofia Cardenas-Alcoser, postdoc fellow Gutkind Lab UCSD Moores Cancer Center
    Apr 22 2025
    Welcome to "The Science Of" Podcast, where students from the Jackie Robinson Family YMCA sit down with top scientists, doctors, and other leaders in the world of science from the globally renowned UCSD and the UCSD Moores Cancer Center in La Jolla, CA.The "Science of" podcast episode features Dr. Sofia Cardenas-Alcoser from UCSD's Moores Cancer Center discussing her journey from chemistry to biomedical research, focusing on cell signaling and cancer. She explains the complexities of G protein-coupled receptors (GPCRs) and their role in cancer. Dr. Cardenas-Alcoser highlights a significant discovery linking G protein alpha subunits to immune system infiltration in tumors, potentially leading to new cancer treatments. She emphasizes the importance of mentorship and resilience in research and shares her passion for video games and Twitch streaming. The episode also includes a Q&A segment with young listeners.Enjoy this episode and get your PODucation on!! Introduction to the Science of PodcastDahlia Sandoval introduces the podcast, emphasizing curiosity and the exploration of various scientific topics.The podcast is hosted by students from the Jackie Robinson Family YMCA and the Elementary Institute of Science.Partnerships include the UCSD Moores Cancer Center and the UCSD campus.Funding for the program is provided by Cloudcast Media.Welcome and Episode OverviewDahlia Sandoval welcomes listeners and introduces the episode's focus on cell signaling and circuitry, particularly in relation to cancer cells.August is introduced as the co-host, along with August, Kelsey, and Josue.August introduces Dr. Sofia Cardenas-Alcoser, the guest speaker for the episode.Dr. Sophia Cardenas-Alcoser’s BackgroundDr. Cardenas-Alcoser shares her journey from studying chemistry in Ecuador to pursuing biomedical research in Argentina.She discusses her acceptance into a master's program at the University of La Plata and her subsequent PhD at the University of Buenos Aires.Dr. Cardenas-Alcoser talks about her transition to the UCSD Moores Cancer Center and the challenges she faced as a first-generation researcher.Personal Insights and Game SegmentDr. Cardenas-Alcoser shares her experiences of overcoming language barriers and personal challenges in her research journey.A fun game segment involves questions about her first science experiment, favorite music, and preferences for pets and food.Dr. Cardenas-Alcoser reveals her love for video games and her Twitch channel, where she streams games and discusses science.Exploring Cell Signaling and Cancer ResearchDr. Cardenas-Alcoser explains the concept of cell signaling using the analogy of a cell as an industry with different components.She describes the role of receptors and ligands in cell signaling and the importance of understanding these pathways.The discussion includes the significance of G protein-coupled receptors (GPCRs) and their role in cancer research.Discoveries and Implications in Cancer ResearchDr. Cardenas-Alcoser highlights a significant discovery about the role of G protein alpha subunits in cancer.She explains how the activation of specific G protein pathways can affect the immune system's response to tumors.The potential for using this discovery to develop new cancer treatments is discussed.Challenges and Progress in Cancer ResearchDr. Cardenas-Alcoser talks about the challenges of translating basic research into clinical applications.She shares a story about a dormant project that was revived due to new funding and its potential impact on treating fibrodysplasia.The discussion includes the importance of animal testing and the potential for using the same drug to treat certain cancers.Audience Questions and MentorshipAudience questions cover the importance of mentorship in research and how to seek it.Dr. Cardenas-Alcoser emphasizes the role of mentors in guiding researchers through failures and teaching them how to think critically.She advises young researchers to be persistent and to seek opportunities in labs that align with their interests.Managing Disappointment and Future of Cancer ResearchDr. Cardenas-Alcoser discusses how to manage disappointment in the lab and the importance of learning from failures.She shares her vision for the future of cancer research, predicting that cancer will become more manageable and less deadly.The discussion includes the need for patience and continued interest in finding new treatments.Final Thoughts and Contact InformationDr. Cardenas-Alcoser encourages young researchers to pursue their curiosity and not to be discouraged by a lack of background in research.She provides her contact information for those interested in reaching out to her for mentorship or further discussion.The episode concludes with thanks to the collaborators and listeners, and a teaser for the next episode's topic.Be sure to subscribe to and share "The Science Of" with all of your friends. We appreciate your support."The Science Of" podcast series is ...
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    46 m
  • Episode 20 | The Science Of Microbes | Dr. David J. Gonzalez, Associate Professor Skaggs School of Pharmacy / Department of Pharmacology

    Episode 20 | The Science Of Microbes | Dr. David J. Gonzalez, Associate Professor Skaggs School of Pharmacy / Department of Pharmacology
    Dec 30 2024
    Welcome to "The Science Of" Podcast, where students from the Jackie Robinson Family YMCA sit down with top scientists, doctors, and other leaders in the world of science from the globally renowned UCSD and the UCSD Moores Cancer Center in La Jolla, CA.In this episode, Riley James, Haydee Arancibia-Hardwick, and Margaux Stack-Babich from the UCSD Moores Cancer Center sit down to discuss THE SCIENCE OF MICROBES with Dr. David Gonzalez, an Associate Professor in Pharmacology at the Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, School of Medicine, as the Founder and Director for the Collaborative Center of Multiplexing Proteomics. Dr. Gonzalez was on this episode joined by his sons, David Jr. and Isaiah, and a lab researcher, Yesenia, an alumna of UC-Riverside. They discuss the importance of microbes, their roles in human health, and the impact of antibiotics on gut microbiomes. They highlight the potential of proteomics in understanding protein interactions and the need for alternative therapeutics. The conversation also touches on the personal and professional journeys of the participants, emphasizing the importance of education and perseverance in scientific careers.Enjoy this episode and get your PODucation on!! "Rapid Fire" Warm-Up Round and Personal IntroductionsThe guests participate in a rapid-fire warm-up round, answering questions about their first science experiments and favorite musicians.Dr. Gonzalez shares his first science experiment involving making plastic in a chemistry class, which sparked his interest in science.Isaiah, David Jr. and Yesenia share their first experiences with science projects The guests discuss their favorite musicians, with from Tame Impala to Kendrick LamarMicrobes and Their ImportanceDr. Gonzalez explains the role of microbes as the gatekeepers of the world, contributing to oxygen production and metabolism in the gut.The conversation touches on the balance between good and bad microbes, with Dr. Gonzalez emphasizing that microbes can be both beneficial and harmful depending on context.The guests discuss the importance of the gut microbiome and its impact on human health, including the role of stool samples in microbiome research.Dr. Gonzalez highlights the advancements in microbiome research at UCSD and the importance of understanding the microbiome for future medical treatments.Applications of Microbiome ResearchThe guests discuss the potential of the gut microbiome in treating diseases and the role of probiotics and antibiotics in maintaining gut health.Dr. Gonzalez mentions the impact of antibiotics on the gut microbiome and the rise of antibiotic-resistant pathogens.The conversation shifts to the role of the microbiome in cancer treatment and the potential of immunotherapies.Dr. Gonzalez shares insights on the use of checkpoint inhibitors and the microbiome's influence on treatment efficacy.Antibacterial and Antimicrobial IndustryThe guests address the challenges of antibacterial and antimicrobial products, emphasizing the need for awareness of antibiotic resistance.Dr. Gonzalez discusses the overuse of antibiotics and the importance of finding alternative therapeutic approaches, such as vaccines.The conversation highlights the role of proteomics in understanding the proteome and its applications in medical research.Dr. Gonzalez explains the power of proteomics in providing a comprehensive view of protein interactions and its potential in developing new drugs.Impact of COVID-19 on Scientific CareersThe guests share their personal experiences and the impact of COVID-19 on their scientific careers and educational paths.Isaiah discusses the challenges of gaining clinical experience during the pandemic and the importance of community outreach and education.David Jr. shares how COVID-19 led him to pursue a PhD in structural biology, focusing on emerging viruses.The guests emphasize the importance of resilience and adaptability in navigating career challenges during the pandemic.Future of Microbiome Research and Personal ReflectionsThe guests discuss their hopes for the future of microbiome research, including the development of alternative therapeutics and the continued advancements in proteomics.Dr. Gonzalez envisions a future where real-time health monitoring is possible through stool analysis.The guests reflect on the importance of education and mentorship in fostering scientific careers and the impact of their work on future generations.The conversation concludes with the guests sharing their admiration for each other and their commitment to continuing their scientific pursuits.Be sure to subscribe to and share "The Science Of" with all of your friends. We appreciate your support."The Science Of" podcast series is brought to you by the UCSD Moores Cancer Center, SchoolCAST, a division of Cloudcast Media, and the Jackie Robinson Family YMCA. Please learn more about both of our sponsors by visiting:...
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    53 m
  • Episode 19 | The Science Of Stem Cells | Dr. Shiri Gur-Cohen, Assistant Professor of Medicine, Division of Regenerative Medicine, UCSD

    Episode 19 | The Science Of Stem Cells | Dr. Shiri Gur-Cohen, Assistant Professor of Medicine, Division of Regenerative Medicine, UCSD
    Dec 12 2024
    Welcome to "The Science Of" Podcast, where students from the Jackie Robinson Family YMCA sit down with top scientists, doctors, and other leaders in the world of science from the globally renowned UCSD and the UCSD Moores Cancer Center in La Jolla, CA.In this episode, Riley James, Haydee Arancibia-Hardwick, and Margaux Stack-Babich sit down to discuss THE SCIENCE OF STEM CELLS with Dr. Shiri Gur-Cohen, a stem cell biologist whose innovative work on lymphatic vascular niche for hair follicle stem cells opened the door to fundamental research areas to advance therapeutics for enhancing tissue regeneration. Dr. Gur-Cohen is currently an Assistant Professor of Medicine in the Division of Regenerative Medicine at the University of California San Diego. Dr. Gur-Cohen’s work with Dr. Elaine Fuchs at The Rockefeller University in New York helped unearth the lymphatic capillary network as a novel stem cell niche component, and her multidisciplinary strategy has advanced our knowledge of how stem cells synchronize and coordinate tissue regeneration. Dr. Gur-Cohen earned her Ph.D. in the Department of Immunology in Dr. Tsvees Lapidot’s lab at the Weizmann Institute of Science, Israel, and completed her B.A. in molecular biochemistry and M.Sc. in medical sciences at the Technion-Israel Institute of Technology. In this episode, you'll hear Dr. Gur-Cohen discuss her research on stem cells and their role in tissue regeneration. Dr. Gur-Cohen explains the difference between embryonic and adult stem cells, emphasizing the potential of adult stem cells to rejuvenate and regenerate tissues. She highlights the importance of understanding the balance between self-renewal and differentiation in stem cells. Dr. Gur-Cohen also addresses the ethical considerations and challenges in stem cell therapies, advocating for careful consultation with physicians. She envisions future advancements in cancer treatment and regenerative medicine, aiming to target cancer-initiating stem cells and rejuvenate old stem cells.Enjoy this episode and get your PODucation on!! EPISODE SUMMARY"Rapid Fire" Warm-Up Questions with Dr. Shiri Gur-CohenDr. Gur-Cohen shares her first science experiment involving collecting animals under rocks and observing their behavior in different light conditions.Dr. Gur-Cohen discusses her favorite musician, Taylor Swift, and her preference for dogs over cats, despite owning a cat due to lifestyle constraints in New York.Dr. Gur-Cohen expresses her desire to visit Antarctica for its extreme conditions and shares her favorite hiking experience in Patagonia.Dr. Gur-Cohen mentions her favorite place to eat in San Diego, highlighting the fresh seafood available in the area.Career Path and Passion for Stem Cell ResearchDr. Gur-Cohen recounts how her career in stem cell research was influenced by mentors who encouraged her to explore her true interests.Dr. Gur-Cohen explains her initial goal to cure cancer, which evolved into a fascination with stem cell biology during her PhD and postdoc years.Dr. Gur-Cohen discusses the importance of understanding how stem cells work in regenerating tissues and the impact of aging on this process.Dr. Gur-Cohen emphasizes the need to understand the balance between self-renewal and differentiation in stem cells to maintain tissue health.Types of Stem Cells and Their ApplicationsDr. Gur-Cohen explains the difference between embryonic and adult stem cells, noting that adult stem cells are already specialized and can only generate specific tissues.Dr. Gur-Cohen discusses her choice to study adult stem cells due to their visual and measurable properties, which are more applicable to human health.Dr. Gur-Cohen highlights the potential of adult stem cells to be taught to have a broader range of differentiation, similar to the regenerative abilities of amphibians like salamanders.Dr. Gur-Cohen elaborates on the importance of understanding the signals and cues that guide stem cells to change their fate during development.Challenges and Future of Stem Cell ResearchDr. Gur-Cohen discusses the challenges of stem cell transplantation, emphasizing the need to understand which stem cells are being used and their life cycle.Dr. Gur-Cohen advises caution when considering stem cell therapies, recommending consultation with physicians and thorough research on the safety and efficacy of treatments.Dr. Gur-Cohen shares her excitement about the potential of CRISPR technology to correct genetic diseases and the importance of understanding the signals that drive regeneration.Dr. Gur-Cohen expresses hope for the future of stem cell research, particularly in cancer treatment and regenerative medicine, and the potential to rejuvenate old stem cells.Audience Questions and Final ThoughtsDr. Gur-Cohen responds to an audience question about the challenges of running her own lab, mentioning funding and the importance of having a supportive environment.Dr. Gur-Cohen shares her experience of starting her lab with ...
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    42 m
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