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The Science Of

The Science Of

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Where science curiosity meets the amazing scientists of UCSD!

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Episodios
  • Season 2 Episode 6 | The Science of T-Cells and Cancer| Dr. Miguel Reina-Campos, Postdoctoral Researcher UCSD, Tissue Immune Networks
    Nov 10 2025
    "The Science Of" podcast episode features Dr. Miguel Reina Campos discussing his journey from Spain to the U.S., focusing on T cells and cancer. Dr. Campos explains the role of tissue-resident memory T cells in fighting diseases, emphasizing their importance in solid tumors. He highlights the impact of hormones like testosterone on immune cell function and the potential of spatial transcriptomics in cancer diagnosis and treatment. Dr. Campos also discusses the challenges of studying immune cells in tissues and the future of cancer treatment, including personalized immunotherapies and mRNA vaccination. He advises aspiring scientists to stay resilient. Introduction to the Science of Podcast SeriesThe students introduce the podcast, emphasizing curiosity and the exploration of various scientific topics.The podcast is hosted by students from the Jackie Robinson Family YMCA and the Elementary Institute of Science.Partnerships include the UCSD Moores Cancer Center and Cloudcast MediaThe program is provided by SchoolCAST, a podcast and curriculum program from Cloudcast Media.The students welcome listeners and introduce the episode's focus on T cells and cancer.Co-hosts Sasha, Max, and the gues, Dr. Miguel Reina Campos, are introduced.Dr. Miguel Reina Campos' Background and JourneyDr. Reina Campos shares his background, starting from his birth in Barcelona, Spain, and his education in molecular biology and biochemistry.He discusses his decision to study in Germany during the 2008 economic crisis and his subsequent move to the U.S. for a master's degree at Scripps Research Institute.His interest in cancer biology and the biology of cancer cells is highlighted.Dr. Reina Campos explains the complexity of tumors and the role of non-tumor cells in tumor growth.He discusses the importance of the immune system in fighting cancer and the impact of immunotherapy.Rapid Fire Questions and Personal InterestsDr. Reina Campos answers rapid-fire questions about his career and personal interests.He shares his initial career interests, including a desire to be a lifeguard and a professional basketball player.His favorite surf spot in San Diego is revealed to be Horseshoe.Dr. Reina Campos discusses the most fascinating discoveries of his career, including the plasticity of tumor cells and the diversity of immune cells in different tissues.He mentions his hobby of paragliding and describes a typical day in his lab, which is chaotic and filled with various tasks.Tissue Resident Memory T Cells and Their Role in DiseaseDr. Reina Campos explains the concept of tissue resident memory T cells and their importance in fighting diseases.He describes how these T cells live in tissues and protect against infections and tumors.The challenges of enhancing anti-tumor responses driven by T cells are discussed.The role of memory in the immune system and its impact on disease protection is explained.The influence of hormones like testosterone on the immune system, especially in the context of cancer, is explored.Gender Differences in Immune Responses and Cancer SusceptibilityDr. Reina Campos discusses the differences in T cell function between genders and its impact on disease susceptibility.He explains the role of the thymus in T cell education and how testosterone affects it.The challenges of studying immune cells within tissues and the use of spatial transcriptomics are highlighted.The potential for using spatial transcriptomics to develop new treatments for patients is discussed.The importance of early diagnosis and prevention in cancer treatment is emphasized.Future Directions in Cancer Treatment and Emerging RisksDr. Reina Campos speculates on the future of cancer treatment and the potential for eradicating certain cancers.He discusses the role of diagnostics in preventing disease and the impact of diet on immune cell function.The potential impact of microplastics on immune responses and disease is mentioned.The use of personalized immunotherapies and the potential of mRNA vaccination in cancer treatment are explored.The high cost and limited accessibility of cellular therapies are noted.Advice for Aspiring Scientists and Contact InformationDr. Reina Campos advises aspiring scientists to stay resilient and persevere in their careers.He provides contact information for those interested in learning more about his work.The episode concludes with the hosts thanking the audience and promoting future episodes of the Science of Podcast series."The Science Of" is a student-produced podcast. The team members are Kelsey Lewis, Evan Sosa, Max Arola, August Ou, Danielle-Elizabeth Mensah-Baah, Zahraa Munaim, Josue Castillo, Sasha Goldschmied, and Noor Munaim. The students who appeared on this episode and/or produced the episode are Danielle-Elizabeth Mensah-Baah, Zahraa Munaim, Max Arola, Sasha Goldschmied. The episode was engineered / mixed / mastered by Christelle Auzas from Cloudcast Media. About Cloudcast MediaAs the national leader in local ...
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    36 m
  • Season 2 Episode 5 | The Science of Cellular Communication | Dr. Anshuman Bhanja, Postdoctoral Scholar UCSD, Immune Cell Signaling
    Oct 27 2025
    "The Science Of" podcast episode explores biotechnology and immune cell communication with Dr. Anshuman Bhanja from UCSD. Dr. Bhanja discusses his journey from India to the U.S., his switch from engineering to biology, and his research on B cells and T cells. He explains how immune cells communicate using the actin cytoskeleton and the role of N-WASP. Dr. Bhanja also touches on the challenges of cancer immunotherapy, the potential of AI in molecular biology, and his vision for creating chimeric antigen receptor B cells to combat cancer metastasis. The episode emphasizes curiosity, innovation, and the importance of boldness in scientific research.Introduction to "The Science Of" Podcast SeriesIntroduction of the podcast, emphasizing curiosity and the exploration of various scientific topics.The podcast is hosted by students from the Jackie Robinson Family YMCA and the Elementary Institute of Science.Partnerships include the UCSD Moores Cancer Center and Cloudcast MediaThe program is provided by SchoolCAST, a podcast and curriculum program from Cloudcast Media.Welcome to The Science Of" Cellular Communication EpisodeListeners are welcomed to "The Science Of" Podcast series, focusing on biotechnology and immune cell communication.The episode is hosted by Max, Sasha, and Zahraa, with a special guest, Dr. Anshuman Bhanja.Sasha, Max, and Zahraa introduce themselves as high school students.The episode aims to explore the molecular choreography inside our bodies and the potential for life-saving research.Introduction of Dr. Anshuman BhanjaDr. Bhanja shares his background, starting in India, moving to the US in 2016, and pursuing a PhD in cell biology and molecular genetics.He discusses his switch from engineering to biology due to a middle school biology teacher and his interest in cars.Dr. Bhanja explains the challenges of research in India compared to the US, including funding and reagent availability.Dr. Bhanja's Journey and Research FocusDr. Bhanja shares his journey from hating biology in middle school to falling in love with it in high school.He discusses the differences in research support between India and the US.Dr. Bhanja talks about his favorite midnight snack, Oreos, and his dream of visiting Hawaii.He mentions his biggest inspiration, Dr. Shinya Yamanaka, and his favorite hobby, surfing.Exploring Cellular CommunicationDr. Bhanja explains cellular communication, emphasizing how cells talk to each other to form tissues and organs.He shares his fascination with immunology, particularly how cells work together to protect the body.Dr. Bhanja discusses the role of B cells in producing antibodies and their communication with T cells.He explains the actin cytoskeleton's role in cellular communication and its impact on immune cell function.Understanding Cancer and Immune Cell CommunicationDr. Bhanja discusses how cancer cells evade the immune system by hijacking communication pathways.He explains the selection process that makes tumors stronger and more resistant to treatment.Dr. Bhanja talks about the role of N-WASP in immune cell function and its critical focus in his research.He shares his interest in studying B cells due to their role in immune function and his mentor's expertise in immunology.Impact of Research on PatientsDr. Bhanja discusses the translational research on car-T cells and their potential impact on cancer treatment.He explains the challenges of translating developmental research into clinical applications.Dr. Bhanja shares his thoughts on the future of AI in molecular biology research and its potential to predict protein structures.He elaborates on the process of creating protein crystals for structural analysis.Future of Immune Cell Communication ResearchDr. Bhanja discusses the potential of understanding immune cell communication to unlock new therapies and technologies.He shares his vision of creating chimeric antigen receptor B cells to target cancer cells more effectively.Dr. Bhanja emphasizes the importance of curiosity and boldness in scientific research.He provides his email for listeners interested in learning more about his work.Conclusion and Final ThoughtsDr. Bhanja shares his message to young listeners, encouraging them to be bold and brave in pursuing their scientific interests.He provides his email for further inquiries about his research.The episode concludes with thanks from the hosts and a reminder of the podcast's collaboration with various institutions.The podcast aims to satisfy scientific curiosities and explore fascinating topics in the world of science."The Science Of" is a student-produced podcast. The team members are Kelsey Lewis, Evan Sosa, Max Arola, August Ou, Danielle-Elizabeth Mensah-Baah, Zahraa Munaim, Josue Castillo, Sasha Goldschmied, and Noor Munaim. The students who appeared on this episode and/or produced the episode are Zahraa Munaim, Max Arola, Sasha Goldschmied.The episode was engineered /mixed/mastered by Christelle Auzas from Cloudcast Media....
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    31 m
  • Season 2 Episode 4 | The Science of Substance Use and the Body | Dr. Alexander Wallace, Postdoctoral Scholar UCSD Department of Psychiatry
    Oct 13 2025
    The "Science of" podcast episode, hosted by students from the Jackie Robinson Family YMCA and the Elementary Institute of Science, features Dr. Alexander Wallace, a postdoctoral fellow at UCSD's psychiatry department. Dr. Wallace discusses the impact of substance use on neurodevelopment and aerobic fitness in young adults. He highlights the complexities of substance use, including the misconceptions about users and the effects of substances like cannabis, alcohol, and nicotine on the developing brain. Dr. Wallace also touches on the role of aerobic fitness in brain health and the ABCD study, which aims to understand the factors influencing substance use. The episode concludes with Dr. Wallace sharing his journey and advice for aspiring scientists.OutlineIntroduction to the Science of Podcast SeriesSpeaker 1 introduces the podcast, emphasizing curiosity and the pursuit of knowledge in various scientific topics.The podcast is hosted by students from the Jackie Robinson Family YMCA and the Elementary Institute of Science, in partnership with UCSD Moores Cancer Research Center.Funding for the program is provided by Schoolcast, a cloudcast media program.Speaker 2 welcomes listeners to the series, highlighting the episode's focus on the effects of certain drugs on neurodevelopment and aerobic fitness.Introduction of Co-Hosts and GuestSpeaker 2 introduces Sasha, the co-host, and mentions the special guest, Dr. Alexander Wallace.Speaker 3 and Speaker 4 introduce themselves as junior students at High Tech High and East Village, respectively.Dr. Wallace is introduced as a postdoctoral fellow in the psychiatry department at UCSD, with a background in clinical psychology and substance use research.Dr. Wallace's Journey and Research InterestsDr. Wallace shares his journey from obtaining a PhD in Clinical Psychology at the University of Wisconsin, Milwaukee, to his current position at UCSD.He mentions his mentor, a world-class leader in adolescent substance use and neurodevelopment.Dr. Wallace discusses his interest in STEM, influenced by his parents who were teachers, and his chance encounter with research during his undergraduate studies.He explains his focus on ADHD and substance use, which led to his current research at UCSD.Rapid Fire Questions and Personal InsightsDr. Wallace answers rapid-fire questions about his first science experiment, favorite scientist, music for concentration, travel destination, favorite place to eat in San Diego, and biggest inspiration.He shares that his biggest inspiration is his mentor because of her kindness and support.Dr. Wallace discusses the importance of education and open communication about substance use to reduce stigma and misconceptions.Myths About Substance Use and Brain DevelopmentDr. Wallace addresses common myths about cannabis, alcohol, and nicotine, emphasizing that substance use does not make someone inherently bad.He explains the complex nature of substance use and the various factors influencing it, such as biology, peers, and family history.Dr. Wallace highlights the importance of educating young adults about the risks and impacts of substance use on the developing brain.Impact of Substances on Brain DevelopmentDr. Wallace explains how substances like alcohol, cannabis, and nicotine affect the developing brain, particularly the frontal regions responsible for executive functions.He discusses the neuroplasticity of the adolescent brain and how substance use can lead to underdevelopment of these regions.Dr. Wallace emphasizes the need for more research to understand the specific effects of different substances on the brain.Neural Processes of Addiction and Gender DifferencesDr. Wallace explains the neural processes of addiction, focusing on the role of dopamine and the cycle of substance use.He discusses the differences in how alcohol affects young women versus young men, noting that women may be more vulnerable to the effects of alcohol.Dr. Wallace highlights the need for more research on substance use in women to better understand and address these differences.Role of Aerobic Fitness in Brain HealthDr. Wallace discusses the role of aerobic fitness in brain health and mental function, particularly as an intervention for substance use.He explains how exercise can help upregulate dopamine receptors and mitigate the harm from substance use.Dr. Wallace mentions his work on the Adolescent Brain Cognitive Development (ABCD) study, which aims to understand the factors influencing substance use and brain development.Newest Discoveries and COVID-19 ImpactDr. Wallace shares his most recent discovery, a study on the impact of cannabis use on depression and brain volume in adolescents.He discusses the findings of the ABCD study, which showed that adolescent substance use decreased during the COVID-19 pandemic.Dr. Wallace highlights the importance of understanding the factors influencing substance use and the need for continued research.Future Directions and Final ThoughtsDr...
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    40 m
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