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The Science Of

The Science Of

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Where science curiosity meets the amazing scientists of UCSD!

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Episodios
  • Season 2 Episode 3 | The Science of the Brain’s Treasure Map | Dr. Jacopo Annese, Founder of The Brain Observatory and Human Brain Library

    Season 2 Episode 3 | The Science of the Brain’s Treasure Map | Dr. Jacopo Annese, Founder of The Brain Observatory and Human Brain Library
    Jun 17 2025
    The Science of Podcast episode features Dr. Jacopo Annese, a neuroscientist who is the CEO and Founder of The Brain Observatory, discussing his work on human brain mapping and preservation. Dr. Annese explains his journey from studying zoology to neuroscience, emphasizing the importance of preserving brain tissue for scientific discovery. He describes the process of brain mapping, which involves slicing and digitizing brain samples, and highlights the variability in brain structures. Dr. Annese also discusses the potential of AI in analyzing brain data and the importance of building a global brain bank for personalized medicine. The episode concludes with Dr. Annese advising aspiring scientists to be resilient and independent.Introduction to the Science of Podcast SeriesSpeaker 1 introduces the podcast, emphasizing curiosity and the exploration of various scientific topics.The podcast is hosted by students from the Jackie Robinson Family YMCA and the Elementary Institute of Science.Partnerships include the UCSD Moores Cancer Center and the extended UCSD campus.Funding for the program is provided by SchoolCast, a cloudcast media program.Introduction to the Episode and GuestsSpeaker 2 welcomes listeners to the Science of Podcast series, focusing on human brain mapping and brain tissue preservation.Kelsey Lewis introduces herself and the co-hosts: Danielle-Elizabeth, Josue, and Max.The co-hosts express excitement about learning new things in each episode.Kelsey introduces the guest, Dr. Annese, and asks him to introduce himself.Dr. Jacopo's Background and JourneyDr. Annese shares his background, mentioning his friendship with Charles and their shared passion for education.He describes his journey from studying biology and zoology to mapping the human brain.Dr. Annese recounts his experience at a conference in Moscow where he saw a neuron for the first time, sparking his interest in neuroscience.He discusses his educational path, including his time at UC Davis and Dartmouth, and his transition to studying human brains.Dr. Jacopo's Work in Documentary ProjectsDr. Annese explains how he began to bring neuroscience to the screen due to media requests at UCSD.He shares his experience of telling his own story rather than letting others do it.Dr. Annese discusses the potential of scientists telling their own stories and the importance of communication in science.Rapid Fire Questions with Dr. AnneseDr. Annese answers questions about his inspirations, the most valuable thing he learned, his favorite animal, and his favorite place to study.He shares his appreciation for San Diego and his dream of having his own lab.Dr. Annese discusses his favorite place to study, mentioning London and Dartmouth.He talks about his favorite place in San Diego and his appreciation for the space it offers.Dr. Annese's Innovative Approach to Brain MappingDr. Annese explains his time-honored technique of brain mapping and preservation.He describes the process of slicing and preserving the brainDr. Annese discusses the importance of preserving the morphology of the brain and the challenges of working with human brains.He shares his experience of developing a relationship with brain donors and the emotional aspect of his work.Challenges and Breakthroughs in Brain MappingDr. Annese talks about the challenges of mapping the human brain due to its variability.He explains the importance of understanding the structural map of the brain and its connections.Dr. Annese discusses the potential of using AI to analyze brain data and make predictions.He shares his experience of building his own microscope and the importance of solving problems in research.Future of Brain Mapping and Personalized MedicineDr. Annese discusses the potential of using brain mapping to make predictions and improve clinical care.He explains the importance of having a large dataset of brains to understand disease progression.Dr. Annese shares his vision of creating a world brain bank and the challenges of running a nonprofit lab.He talks about the potential of using brain mapping to help patients and make accurate diagnoses.Final Thoughts and Advice for Aspiring ScientistsDr. Annese advises aspiring scientists to be resilient, rebellious, and confident in their own path.He emphasizes the importance of mentorship but also the need to think independently.Dr. Annese encourages students to explore and dissect brains to gain a deeper understanding of neuroscience.He shares his contact information and invites listeners to visit the Brain Observatory and learn more about his work.The Science Of is a student-produced podcast. The team members are Kelsey Lewis, Evan Sosa, Max Arola, August Ou, Danielle-Elizabeth Mensah-Baah, Zahraa Munaim, and Josue Castillo. The episode was engineered / mixed / mastered by Christelle Auzas from Cloudcast Media. About Cloudcast MediaAs the national leader in local podcasting, Cloudcast Media proudly produces "The Science Of" throught its SchoolCAST ...
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    57 m
  • Season 2 Episode 2 | The Science Of Cancer Immunology | Dr. Asona Lui, assistant professor Radiation Oncology, Moores Cancer Center clinic

    Season 2 Episode 2 | The Science Of Cancer Immunology | Dr. Asona Lui, assistant professor Radiation Oncology, Moores Cancer Center clinic
    May 20 2025
    The Science of Podcast episode features Dr. Asona Lui, an assistant professor in radiation oncology at UCSD Moores Cancer Center, discussing breast cancer and immunology. Dr. Lui specializes in triple-negative breast cancer, which lacks hormone receptors and HER2, making it resistant to standard treatments. She develops mouse models to study the disease and its response to immunotherapy and radiation. Dr. Lui emphasizes the importance of understanding cancer-immune system interactions and the potential of AI and robotic surgery in future healthcare. She advises young scientists to embrace diverse interests and seize opportunities, even if they seem unrelated to their main field.Outline Introduction to the Science of Podcast SeriesSpeaker 1 introduces the podcast, emphasizing curiosity and the pursuit of knowledge in various scientific fields.The podcast is hosted by students from the Jackie Robinson Family YMCA and the Elementary Institute of Science, in partnership with UCSD Moores Cancer Center.Funding for the program is provided by Cloudcast Media.Speaker 2 welcomes listeners to the series, highlighting the focus on different scientific topics in each episode.Introduction to the Episode's Guests and Co-HostsSpeaker 2 introduces the episode's topic: radiation oncology, with a focus on breast cancer and immunology.Dr. Asona Lui is introduced as the guest, specializing in treating breast cancer and triple-negative breast cancer.Co-hosts Kelsey, Zahraa, Danielle-Elizabeth Mensah-Baah, Max, August, and Jose Castillo introduce themselves as students from various schools.Dr. Asona Lui's Background and JourneyDr. Lui shares her background, including her BA in African Studies and her interest in understanding her cultural roots.She discusses her family's background and how it influenced her academic and career choices.Dr. Lui explains her transition from African Studies to cancer research, highlighting the importance of understanding cultural influences on health.She mentions her involvement in acting and performing arts, which she believes has contributed to her success in science.Balancing Science and the ArtsOne of the co-hosts asks Dr. Lui about balancing her interest in the arts with her scientific career.Dr. Lui shares her experience of participating in the arts during medical school and how it helped her mental health.She emphasizes the importance of finding time for hobbies and incorporating them into daily life.Dr. Lui discusses her involvement in singing with the La Jolla Symphony and how it feeds her soul.Dr. Lui's Research and DiscoveriesDr. Lui explains the basics of cancer and immunology, emphasizing the role of the immune system in recognizing and fighting cancer.She describes her research on triple-negative breast cancer and the challenges of treating it without specific targeted therapies.Dr. Lui shares a significant discovery in her research: the role of interferon in cancer cells, which was unexpected and changed their understanding of cancer immunology.She discusses the development of mouse models for triple-negative breast cancer to better understand and treat the disease.Challenges and Future Directions in Cancer ResearchDr. Lui talks about the challenges of treating triple-negative breast cancer and the importance of developing better mouse models.She explains the role of immunotherapy and radiation in treating cancer and the need for more effective treatments.Dr. Lui shares her vision for the future of cancer research, including the use of MRI scans to monitor cancer treatment more effectively.She discusses the potential role of AI and robots in healthcare, particularly in matching patients to clinical trials and performing surgeries remotely.Audience Questions and Dr. Lui's AdviceThe co-hosts ask Dr. Lui about her current research and how it could be applied to cancer treatment.Dr. Lui explains the process of creating mouse models for triple-negative breast cancer and the importance of having a fully functioning immune system in the mice.She shares her advice for young people interested in science and healthcare, emphasizing the importance of following their passions and taking opportunities.Dr. Lui provides her email address for listeners who want to reach out and discuss science and cancer research further.Conclusion and Closing RemarksThe co-hosts thank Dr. Lui for her time and insights, expressing their appreciation for the episode.Dr. Lui reiterates her commitment to helping patients and advancing cancer research.The episode concludes with a reminder of the podcast's mission to explore various scientific topics and inspire curiosity.The co-hosts sign off, encouraging listeners to stay tuned for future episodes of the Science of Podcast series.The Science Of is a student-produced podcast. The team members are Kelsey Lewis, Evan Sosa, Max Arola, August Ou, Danielle-Elizabeth Mensah-Baah, Zahraa Munaim, and Josue Castillo.
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    1 h y 2 m
  • Season 2 Episode 1 | The Science Of Translating Discovery | Dr. Sofia Cardenas-Alcoser, postdoc fellow Gutkind Lab UCSD Moores Cancer Center

    Season 2 Episode 1 | The Science Of Translating Discovery | Dr. Sofia Cardenas-Alcoser, postdoc fellow Gutkind Lab UCSD Moores Cancer Center
    Apr 22 2025
    Welcome to "The Science Of" Podcast, where students from the Jackie Robinson Family YMCA sit down with top scientists, doctors, and other leaders in the world of science from the globally renowned UCSD and the UCSD Moores Cancer Center in La Jolla, CA.The "Science of" podcast episode features Dr. Sofia Cardenas-Alcoser from UCSD's Moores Cancer Center discussing her journey from chemistry to biomedical research, focusing on cell signaling and cancer. She explains the complexities of G protein-coupled receptors (GPCRs) and their role in cancer. Dr. Cardenas-Alcoser highlights a significant discovery linking G protein alpha subunits to immune system infiltration in tumors, potentially leading to new cancer treatments. She emphasizes the importance of mentorship and resilience in research and shares her passion for video games and Twitch streaming. The episode also includes a Q&A segment with young listeners.Enjoy this episode and get your PODucation on!! Introduction to the Science of PodcastDahlia Sandoval introduces the podcast, emphasizing curiosity and the exploration of various scientific topics.The podcast is hosted by students from the Jackie Robinson Family YMCA and the Elementary Institute of Science.Partnerships include the UCSD Moores Cancer Center and the UCSD campus.Funding for the program is provided by Cloudcast Media.Welcome and Episode OverviewDahlia Sandoval welcomes listeners and introduces the episode's focus on cell signaling and circuitry, particularly in relation to cancer cells.August is introduced as the co-host, along with August, Kelsey, and Josue.August introduces Dr. Sofia Cardenas-Alcoser, the guest speaker for the episode.Dr. Sophia Cardenas-Alcoser’s BackgroundDr. Cardenas-Alcoser shares her journey from studying chemistry in Ecuador to pursuing biomedical research in Argentina.She discusses her acceptance into a master's program at the University of La Plata and her subsequent PhD at the University of Buenos Aires.Dr. Cardenas-Alcoser talks about her transition to the UCSD Moores Cancer Center and the challenges she faced as a first-generation researcher.Personal Insights and Game SegmentDr. Cardenas-Alcoser shares her experiences of overcoming language barriers and personal challenges in her research journey.A fun game segment involves questions about her first science experiment, favorite music, and preferences for pets and food.Dr. Cardenas-Alcoser reveals her love for video games and her Twitch channel, where she streams games and discusses science.Exploring Cell Signaling and Cancer ResearchDr. Cardenas-Alcoser explains the concept of cell signaling using the analogy of a cell as an industry with different components.She describes the role of receptors and ligands in cell signaling and the importance of understanding these pathways.The discussion includes the significance of G protein-coupled receptors (GPCRs) and their role in cancer research.Discoveries and Implications in Cancer ResearchDr. Cardenas-Alcoser highlights a significant discovery about the role of G protein alpha subunits in cancer.She explains how the activation of specific G protein pathways can affect the immune system's response to tumors.The potential for using this discovery to develop new cancer treatments is discussed.Challenges and Progress in Cancer ResearchDr. Cardenas-Alcoser talks about the challenges of translating basic research into clinical applications.She shares a story about a dormant project that was revived due to new funding and its potential impact on treating fibrodysplasia.The discussion includes the importance of animal testing and the potential for using the same drug to treat certain cancers.Audience Questions and MentorshipAudience questions cover the importance of mentorship in research and how to seek it.Dr. Cardenas-Alcoser emphasizes the role of mentors in guiding researchers through failures and teaching them how to think critically.She advises young researchers to be persistent and to seek opportunities in labs that align with their interests.Managing Disappointment and Future of Cancer ResearchDr. Cardenas-Alcoser discusses how to manage disappointment in the lab and the importance of learning from failures.She shares her vision for the future of cancer research, predicting that cancer will become more manageable and less deadly.The discussion includes the need for patience and continued interest in finding new treatments.Final Thoughts and Contact InformationDr. Cardenas-Alcoser encourages young researchers to pursue their curiosity and not to be discouraged by a lack of background in research.She provides her contact information for those interested in reaching out to her for mentorship or further discussion.The episode concludes with thanks to the collaborators and listeners, and a teaser for the next episode's topic.Be sure to subscribe to and share "The Science Of" with all of your friends. We appreciate your support."The Science Of" podcast series is ...
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    46 m
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