Episodios

  • Season 2 Episode 6 | The Science of T-Cells and Cancer| Dr. Miguel Reina-Campos, Postdoctoral Researcher UCSD, Tissue Immune Networks

    Season 2 Episode 6 | The Science of T-Cells and Cancer| Dr. Miguel Reina-Campos, Postdoctoral Researcher UCSD, Tissue Immune Networks
    Nov 10 2025
    "The Science Of" podcast episode features Dr. Miguel Reina Campos discussing his journey from Spain to the U.S., focusing on T cells and cancer. Dr. Campos explains the role of tissue-resident memory T cells in fighting diseases, emphasizing their importance in solid tumors. He highlights the impact of hormones like testosterone on immune cell function and the potential of spatial transcriptomics in cancer diagnosis and treatment. Dr. Campos also discusses the challenges of studying immune cells in tissues and the future of cancer treatment, including personalized immunotherapies and mRNA vaccination. He advises aspiring scientists to stay resilient. Introduction to the Science of Podcast SeriesThe students introduce the podcast, emphasizing curiosity and the exploration of various scientific topics.The podcast is hosted by students from the Jackie Robinson Family YMCA and the Elementary Institute of Science.Partnerships include the UCSD Moores Cancer Center and Cloudcast MediaThe program is provided by SchoolCAST, a podcast and curriculum program from Cloudcast Media.The students welcome listeners and introduce the episode's focus on T cells and cancer.Co-hosts Sasha, Max, and the gues, Dr. Miguel Reina Campos, are introduced.Dr. Miguel Reina Campos' Background and JourneyDr. Reina Campos shares his background, starting from his birth in Barcelona, Spain, and his education in molecular biology and biochemistry.He discusses his decision to study in Germany during the 2008 economic crisis and his subsequent move to the U.S. for a master's degree at Scripps Research Institute.His interest in cancer biology and the biology of cancer cells is highlighted.Dr. Reina Campos explains the complexity of tumors and the role of non-tumor cells in tumor growth.He discusses the importance of the immune system in fighting cancer and the impact of immunotherapy.Rapid Fire Questions and Personal InterestsDr. Reina Campos answers rapid-fire questions about his career and personal interests.He shares his initial career interests, including a desire to be a lifeguard and a professional basketball player.His favorite surf spot in San Diego is revealed to be Horseshoe.Dr. Reina Campos discusses the most fascinating discoveries of his career, including the plasticity of tumor cells and the diversity of immune cells in different tissues.He mentions his hobby of paragliding and describes a typical day in his lab, which is chaotic and filled with various tasks.Tissue Resident Memory T Cells and Their Role in DiseaseDr. Reina Campos explains the concept of tissue resident memory T cells and their importance in fighting diseases.He describes how these T cells live in tissues and protect against infections and tumors.The challenges of enhancing anti-tumor responses driven by T cells are discussed.The role of memory in the immune system and its impact on disease protection is explained.The influence of hormones like testosterone on the immune system, especially in the context of cancer, is explored.Gender Differences in Immune Responses and Cancer SusceptibilityDr. Reina Campos discusses the differences in T cell function between genders and its impact on disease susceptibility.He explains the role of the thymus in T cell education and how testosterone affects it.The challenges of studying immune cells within tissues and the use of spatial transcriptomics are highlighted.The potential for using spatial transcriptomics to develop new treatments for patients is discussed.The importance of early diagnosis and prevention in cancer treatment is emphasized.Future Directions in Cancer Treatment and Emerging RisksDr. Reina Campos speculates on the future of cancer treatment and the potential for eradicating certain cancers.He discusses the role of diagnostics in preventing disease and the impact of diet on immune cell function.The potential impact of microplastics on immune responses and disease is mentioned.The use of personalized immunotherapies and the potential of mRNA vaccination in cancer treatment are explored.The high cost and limited accessibility of cellular therapies are noted.Advice for Aspiring Scientists and Contact InformationDr. Reina Campos advises aspiring scientists to stay resilient and persevere in their careers.He provides contact information for those interested in learning more about his work.The episode concludes with the hosts thanking the audience and promoting future episodes of the Science of Podcast series."The Science Of" is a student-produced podcast. The team members are Kelsey Lewis, Evan Sosa, Max Arola, August Ou, Danielle-Elizabeth Mensah-Baah, Zahraa Munaim, Josue Castillo, Sasha Goldschmied, and Noor Munaim. The students who appeared on this episode and/or produced the episode are Danielle-Elizabeth Mensah-Baah, Zahraa Munaim, Max Arola, Sasha Goldschmied. The episode was engineered / mixed / mastered by Christelle Auzas from Cloudcast Media. About Cloudcast MediaAs the national leader in local ...
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    36 m
  • Season 2 Episode 5 | The Science of Cellular Communication | Dr. Anshuman Bhanja, Postdoctoral Scholar UCSD, Immune Cell Signaling

    Season 2 Episode 5 | The Science of Cellular Communication | Dr. Anshuman Bhanja, Postdoctoral Scholar UCSD, Immune Cell Signaling
    Oct 27 2025
    "The Science Of" podcast episode explores biotechnology and immune cell communication with Dr. Anshuman Bhanja from UCSD. Dr. Bhanja discusses his journey from India to the U.S., his switch from engineering to biology, and his research on B cells and T cells. He explains how immune cells communicate using the actin cytoskeleton and the role of N-WASP. Dr. Bhanja also touches on the challenges of cancer immunotherapy, the potential of AI in molecular biology, and his vision for creating chimeric antigen receptor B cells to combat cancer metastasis. The episode emphasizes curiosity, innovation, and the importance of boldness in scientific research.Introduction to "The Science Of" Podcast SeriesIntroduction of the podcast, emphasizing curiosity and the exploration of various scientific topics.The podcast is hosted by students from the Jackie Robinson Family YMCA and the Elementary Institute of Science.Partnerships include the UCSD Moores Cancer Center and Cloudcast MediaThe program is provided by SchoolCAST, a podcast and curriculum program from Cloudcast Media.Welcome to The Science Of" Cellular Communication EpisodeListeners are welcomed to "The Science Of" Podcast series, focusing on biotechnology and immune cell communication.The episode is hosted by Max, Sasha, and Zahraa, with a special guest, Dr. Anshuman Bhanja.Sasha, Max, and Zahraa introduce themselves as high school students.The episode aims to explore the molecular choreography inside our bodies and the potential for life-saving research.Introduction of Dr. Anshuman BhanjaDr. Bhanja shares his background, starting in India, moving to the US in 2016, and pursuing a PhD in cell biology and molecular genetics.He discusses his switch from engineering to biology due to a middle school biology teacher and his interest in cars.Dr. Bhanja explains the challenges of research in India compared to the US, including funding and reagent availability.Dr. Bhanja's Journey and Research FocusDr. Bhanja shares his journey from hating biology in middle school to falling in love with it in high school.He discusses the differences in research support between India and the US.Dr. Bhanja talks about his favorite midnight snack, Oreos, and his dream of visiting Hawaii.He mentions his biggest inspiration, Dr. Shinya Yamanaka, and his favorite hobby, surfing.Exploring Cellular CommunicationDr. Bhanja explains cellular communication, emphasizing how cells talk to each other to form tissues and organs.He shares his fascination with immunology, particularly how cells work together to protect the body.Dr. Bhanja discusses the role of B cells in producing antibodies and their communication with T cells.He explains the actin cytoskeleton's role in cellular communication and its impact on immune cell function.Understanding Cancer and Immune Cell CommunicationDr. Bhanja discusses how cancer cells evade the immune system by hijacking communication pathways.He explains the selection process that makes tumors stronger and more resistant to treatment.Dr. Bhanja talks about the role of N-WASP in immune cell function and its critical focus in his research.He shares his interest in studying B cells due to their role in immune function and his mentor's expertise in immunology.Impact of Research on PatientsDr. Bhanja discusses the translational research on car-T cells and their potential impact on cancer treatment.He explains the challenges of translating developmental research into clinical applications.Dr. Bhanja shares his thoughts on the future of AI in molecular biology research and its potential to predict protein structures.He elaborates on the process of creating protein crystals for structural analysis.Future of Immune Cell Communication ResearchDr. Bhanja discusses the potential of understanding immune cell communication to unlock new therapies and technologies.He shares his vision of creating chimeric antigen receptor B cells to target cancer cells more effectively.Dr. Bhanja emphasizes the importance of curiosity and boldness in scientific research.He provides his email for listeners interested in learning more about his work.Conclusion and Final ThoughtsDr. Bhanja shares his message to young listeners, encouraging them to be bold and brave in pursuing their scientific interests.He provides his email for further inquiries about his research.The episode concludes with thanks from the hosts and a reminder of the podcast's collaboration with various institutions.The podcast aims to satisfy scientific curiosities and explore fascinating topics in the world of science."The Science Of" is a student-produced podcast. The team members are Kelsey Lewis, Evan Sosa, Max Arola, August Ou, Danielle-Elizabeth Mensah-Baah, Zahraa Munaim, Josue Castillo, Sasha Goldschmied, and Noor Munaim. The students who appeared on this episode and/or produced the episode are Zahraa Munaim, Max Arola, Sasha Goldschmied.The episode was engineered /mixed/mastered by Christelle Auzas from Cloudcast Media....
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    31 m
  • Season 2 Episode 4 | The Science of Substance Use and the Body | Dr. Alexander Wallace, Postdoctoral Scholar UCSD Department of Psychiatry

    Season 2 Episode 4 | The Science of Substance Use and the Body | Dr. Alexander Wallace, Postdoctoral Scholar UCSD Department of Psychiatry
    Oct 13 2025
    The "Science of" podcast episode, hosted by students from the Jackie Robinson Family YMCA and the Elementary Institute of Science, features Dr. Alexander Wallace, a postdoctoral fellow at UCSD's psychiatry department. Dr. Wallace discusses the impact of substance use on neurodevelopment and aerobic fitness in young adults. He highlights the complexities of substance use, including the misconceptions about users and the effects of substances like cannabis, alcohol, and nicotine on the developing brain. Dr. Wallace also touches on the role of aerobic fitness in brain health and the ABCD study, which aims to understand the factors influencing substance use. The episode concludes with Dr. Wallace sharing his journey and advice for aspiring scientists.OutlineIntroduction to the Science of Podcast SeriesSpeaker 1 introduces the podcast, emphasizing curiosity and the pursuit of knowledge in various scientific topics.The podcast is hosted by students from the Jackie Robinson Family YMCA and the Elementary Institute of Science, in partnership with UCSD Moores Cancer Research Center.Funding for the program is provided by Schoolcast, a cloudcast media program.Speaker 2 welcomes listeners to the series, highlighting the episode's focus on the effects of certain drugs on neurodevelopment and aerobic fitness.Introduction of Co-Hosts and GuestSpeaker 2 introduces Sasha, the co-host, and mentions the special guest, Dr. Alexander Wallace.Speaker 3 and Speaker 4 introduce themselves as junior students at High Tech High and East Village, respectively.Dr. Wallace is introduced as a postdoctoral fellow in the psychiatry department at UCSD, with a background in clinical psychology and substance use research.Dr. Wallace's Journey and Research InterestsDr. Wallace shares his journey from obtaining a PhD in Clinical Psychology at the University of Wisconsin, Milwaukee, to his current position at UCSD.He mentions his mentor, a world-class leader in adolescent substance use and neurodevelopment.Dr. Wallace discusses his interest in STEM, influenced by his parents who were teachers, and his chance encounter with research during his undergraduate studies.He explains his focus on ADHD and substance use, which led to his current research at UCSD.Rapid Fire Questions and Personal InsightsDr. Wallace answers rapid-fire questions about his first science experiment, favorite scientist, music for concentration, travel destination, favorite place to eat in San Diego, and biggest inspiration.He shares that his biggest inspiration is his mentor because of her kindness and support.Dr. Wallace discusses the importance of education and open communication about substance use to reduce stigma and misconceptions.Myths About Substance Use and Brain DevelopmentDr. Wallace addresses common myths about cannabis, alcohol, and nicotine, emphasizing that substance use does not make someone inherently bad.He explains the complex nature of substance use and the various factors influencing it, such as biology, peers, and family history.Dr. Wallace highlights the importance of educating young adults about the risks and impacts of substance use on the developing brain.Impact of Substances on Brain DevelopmentDr. Wallace explains how substances like alcohol, cannabis, and nicotine affect the developing brain, particularly the frontal regions responsible for executive functions.He discusses the neuroplasticity of the adolescent brain and how substance use can lead to underdevelopment of these regions.Dr. Wallace emphasizes the need for more research to understand the specific effects of different substances on the brain.Neural Processes of Addiction and Gender DifferencesDr. Wallace explains the neural processes of addiction, focusing on the role of dopamine and the cycle of substance use.He discusses the differences in how alcohol affects young women versus young men, noting that women may be more vulnerable to the effects of alcohol.Dr. Wallace highlights the need for more research on substance use in women to better understand and address these differences.Role of Aerobic Fitness in Brain HealthDr. Wallace discusses the role of aerobic fitness in brain health and mental function, particularly as an intervention for substance use.He explains how exercise can help upregulate dopamine receptors and mitigate the harm from substance use.Dr. Wallace mentions his work on the Adolescent Brain Cognitive Development (ABCD) study, which aims to understand the factors influencing substance use and brain development.Newest Discoveries and COVID-19 ImpactDr. Wallace shares his most recent discovery, a study on the impact of cannabis use on depression and brain volume in adolescents.He discusses the findings of the ABCD study, which showed that adolescent substance use decreased during the COVID-19 pandemic.Dr. Wallace highlights the importance of understanding the factors influencing substance use and the need for continued research.Future Directions and Final ThoughtsDr...
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    40 m
  • Season 2 Episode 3 | The Science of the Brain’s Treasure Map | Dr. Jacopo Annese, Founder of The Brain Observatory and Human Brain Library

    Season 2 Episode 3 | The Science of the Brain’s Treasure Map | Dr. Jacopo Annese, Founder of The Brain Observatory and Human Brain Library
    Jun 17 2025
    The Science of Podcast episode features Dr. Jacopo Annese, a neuroscientist who is the CEO and Founder of The Brain Observatory, discussing his work on human brain mapping and preservation. Dr. Annese explains his journey from studying zoology to neuroscience, emphasizing the importance of preserving brain tissue for scientific discovery. He describes the process of brain mapping, which involves slicing and digitizing brain samples, and highlights the variability in brain structures. Dr. Annese also discusses the potential of AI in analyzing brain data and the importance of building a global brain bank for personalized medicine. The episode concludes with Dr. Annese advising aspiring scientists to be resilient and independent.Introduction to the Science of Podcast SeriesSpeaker 1 introduces the podcast, emphasizing curiosity and the exploration of various scientific topics.The podcast is hosted by students from the Jackie Robinson Family YMCA and the Elementary Institute of Science.Partnerships include the UCSD Moores Cancer Center and the extended UCSD campus.Funding for the program is provided by SchoolCast, a cloudcast media program.Introduction to the Episode and GuestsSpeaker 2 welcomes listeners to the Science of Podcast series, focusing on human brain mapping and brain tissue preservation.Kelsey Lewis introduces herself and the co-hosts: Danielle-Elizabeth, Josue, and Max.The co-hosts express excitement about learning new things in each episode.Kelsey introduces the guest, Dr. Annese, and asks him to introduce himself.Dr. Jacopo's Background and JourneyDr. Annese shares his background, mentioning his friendship with Charles and their shared passion for education.He describes his journey from studying biology and zoology to mapping the human brain.Dr. Annese recounts his experience at a conference in Moscow where he saw a neuron for the first time, sparking his interest in neuroscience.He discusses his educational path, including his time at UC Davis and Dartmouth, and his transition to studying human brains.Dr. Jacopo's Work in Documentary ProjectsDr. Annese explains how he began to bring neuroscience to the screen due to media requests at UCSD.He shares his experience of telling his own story rather than letting others do it.Dr. Annese discusses the potential of scientists telling their own stories and the importance of communication in science.Rapid Fire Questions with Dr. AnneseDr. Annese answers questions about his inspirations, the most valuable thing he learned, his favorite animal, and his favorite place to study.He shares his appreciation for San Diego and his dream of having his own lab.Dr. Annese discusses his favorite place to study, mentioning London and Dartmouth.He talks about his favorite place in San Diego and his appreciation for the space it offers.Dr. Annese's Innovative Approach to Brain MappingDr. Annese explains his time-honored technique of brain mapping and preservation.He describes the process of slicing and preserving the brainDr. Annese discusses the importance of preserving the morphology of the brain and the challenges of working with human brains.He shares his experience of developing a relationship with brain donors and the emotional aspect of his work.Challenges and Breakthroughs in Brain MappingDr. Annese talks about the challenges of mapping the human brain due to its variability.He explains the importance of understanding the structural map of the brain and its connections.Dr. Annese discusses the potential of using AI to analyze brain data and make predictions.He shares his experience of building his own microscope and the importance of solving problems in research.Future of Brain Mapping and Personalized MedicineDr. Annese discusses the potential of using brain mapping to make predictions and improve clinical care.He explains the importance of having a large dataset of brains to understand disease progression.Dr. Annese shares his vision of creating a world brain bank and the challenges of running a nonprofit lab.He talks about the potential of using brain mapping to help patients and make accurate diagnoses.Final Thoughts and Advice for Aspiring ScientistsDr. Annese advises aspiring scientists to be resilient, rebellious, and confident in their own path.He emphasizes the importance of mentorship but also the need to think independently.Dr. Annese encourages students to explore and dissect brains to gain a deeper understanding of neuroscience.He shares his contact information and invites listeners to visit the Brain Observatory and learn more about his work.The Science Of is a student-produced podcast. The team members are Kelsey Lewis, Evan Sosa, Max Arola, August Ou, Danielle-Elizabeth Mensah-Baah, Zahraa Munaim, and Josue Castillo. The episode was engineered / mixed / mastered by Christelle Auzas from Cloudcast Media. About Cloudcast MediaAs the national leader in local podcasting, Cloudcast Media proudly produces "The Science Of" throught its SchoolCAST ...
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    57 m
  • Season 2 Episode 2 | The Science Of Cancer Immunology | Dr. Asona Lui, assistant professor Radiation Oncology, Moores Cancer Center clinic

    Season 2 Episode 2 | The Science Of Cancer Immunology | Dr. Asona Lui, assistant professor Radiation Oncology, Moores Cancer Center clinic
    May 20 2025
    The Science of Podcast episode features Dr. Asona Lui, an assistant professor in radiation oncology at UCSD Moores Cancer Center, discussing breast cancer and immunology. Dr. Lui specializes in triple-negative breast cancer, which lacks hormone receptors and HER2, making it resistant to standard treatments. She develops mouse models to study the disease and its response to immunotherapy and radiation. Dr. Lui emphasizes the importance of understanding cancer-immune system interactions and the potential of AI and robotic surgery in future healthcare. She advises young scientists to embrace diverse interests and seize opportunities, even if they seem unrelated to their main field.Outline Introduction to the Science of Podcast SeriesSpeaker 1 introduces the podcast, emphasizing curiosity and the pursuit of knowledge in various scientific fields.The podcast is hosted by students from the Jackie Robinson Family YMCA and the Elementary Institute of Science, in partnership with UCSD Moores Cancer Center.Funding for the program is provided by Cloudcast Media.Speaker 2 welcomes listeners to the series, highlighting the focus on different scientific topics in each episode.Introduction to the Episode's Guests and Co-HostsSpeaker 2 introduces the episode's topic: radiation oncology, with a focus on breast cancer and immunology.Dr. Asona Lui is introduced as the guest, specializing in treating breast cancer and triple-negative breast cancer.Co-hosts Kelsey, Zahraa, Danielle-Elizabeth Mensah-Baah, Max, August, and Jose Castillo introduce themselves as students from various schools.Dr. Asona Lui's Background and JourneyDr. Lui shares her background, including her BA in African Studies and her interest in understanding her cultural roots.She discusses her family's background and how it influenced her academic and career choices.Dr. Lui explains her transition from African Studies to cancer research, highlighting the importance of understanding cultural influences on health.She mentions her involvement in acting and performing arts, which she believes has contributed to her success in science.Balancing Science and the ArtsOne of the co-hosts asks Dr. Lui about balancing her interest in the arts with her scientific career.Dr. Lui shares her experience of participating in the arts during medical school and how it helped her mental health.She emphasizes the importance of finding time for hobbies and incorporating them into daily life.Dr. Lui discusses her involvement in singing with the La Jolla Symphony and how it feeds her soul.Dr. Lui's Research and DiscoveriesDr. Lui explains the basics of cancer and immunology, emphasizing the role of the immune system in recognizing and fighting cancer.She describes her research on triple-negative breast cancer and the challenges of treating it without specific targeted therapies.Dr. Lui shares a significant discovery in her research: the role of interferon in cancer cells, which was unexpected and changed their understanding of cancer immunology.She discusses the development of mouse models for triple-negative breast cancer to better understand and treat the disease.Challenges and Future Directions in Cancer ResearchDr. Lui talks about the challenges of treating triple-negative breast cancer and the importance of developing better mouse models.She explains the role of immunotherapy and radiation in treating cancer and the need for more effective treatments.Dr. Lui shares her vision for the future of cancer research, including the use of MRI scans to monitor cancer treatment more effectively.She discusses the potential role of AI and robots in healthcare, particularly in matching patients to clinical trials and performing surgeries remotely.Audience Questions and Dr. Lui's AdviceThe co-hosts ask Dr. Lui about her current research and how it could be applied to cancer treatment.Dr. Lui explains the process of creating mouse models for triple-negative breast cancer and the importance of having a fully functioning immune system in the mice.She shares her advice for young people interested in science and healthcare, emphasizing the importance of following their passions and taking opportunities.Dr. Lui provides her email address for listeners who want to reach out and discuss science and cancer research further.Conclusion and Closing RemarksThe co-hosts thank Dr. Lui for her time and insights, expressing their appreciation for the episode.Dr. Lui reiterates her commitment to helping patients and advancing cancer research.The episode concludes with a reminder of the podcast's mission to explore various scientific topics and inspire curiosity.The co-hosts sign off, encouraging listeners to stay tuned for future episodes of the Science of Podcast series.The Science Of is a student-produced podcast. The team members are Kelsey Lewis, Evan Sosa, Max Arola, August Ou, Danielle-Elizabeth Mensah-Baah, Zahraa Munaim, and Josue Castillo.
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    1 h y 2 m
  • Season 2 Episode 1 | The Science Of Translating Discovery | Dr. Sofia Cardenas-Alcoser, postdoc fellow Gutkind Lab UCSD Moores Cancer Center

    Season 2 Episode 1 | The Science Of Translating Discovery | Dr. Sofia Cardenas-Alcoser, postdoc fellow Gutkind Lab UCSD Moores Cancer Center
    Apr 22 2025
    Welcome to "The Science Of" Podcast, where students from the Jackie Robinson Family YMCA sit down with top scientists, doctors, and other leaders in the world of science from the globally renowned UCSD and the UCSD Moores Cancer Center in La Jolla, CA.The "Science of" podcast episode features Dr. Sofia Cardenas-Alcoser from UCSD's Moores Cancer Center discussing her journey from chemistry to biomedical research, focusing on cell signaling and cancer. She explains the complexities of G protein-coupled receptors (GPCRs) and their role in cancer. Dr. Cardenas-Alcoser highlights a significant discovery linking G protein alpha subunits to immune system infiltration in tumors, potentially leading to new cancer treatments. She emphasizes the importance of mentorship and resilience in research and shares her passion for video games and Twitch streaming. The episode also includes a Q&A segment with young listeners.Enjoy this episode and get your PODucation on!! Introduction to the Science of PodcastDahlia Sandoval introduces the podcast, emphasizing curiosity and the exploration of various scientific topics.The podcast is hosted by students from the Jackie Robinson Family YMCA and the Elementary Institute of Science.Partnerships include the UCSD Moores Cancer Center and the UCSD campus.Funding for the program is provided by Cloudcast Media.Welcome and Episode OverviewDahlia Sandoval welcomes listeners and introduces the episode's focus on cell signaling and circuitry, particularly in relation to cancer cells.August is introduced as the co-host, along with August, Kelsey, and Josue.August introduces Dr. Sofia Cardenas-Alcoser, the guest speaker for the episode.Dr. Sophia Cardenas-Alcoser’s BackgroundDr. Cardenas-Alcoser shares her journey from studying chemistry in Ecuador to pursuing biomedical research in Argentina.She discusses her acceptance into a master's program at the University of La Plata and her subsequent PhD at the University of Buenos Aires.Dr. Cardenas-Alcoser talks about her transition to the UCSD Moores Cancer Center and the challenges she faced as a first-generation researcher.Personal Insights and Game SegmentDr. Cardenas-Alcoser shares her experiences of overcoming language barriers and personal challenges in her research journey.A fun game segment involves questions about her first science experiment, favorite music, and preferences for pets and food.Dr. Cardenas-Alcoser reveals her love for video games and her Twitch channel, where she streams games and discusses science.Exploring Cell Signaling and Cancer ResearchDr. Cardenas-Alcoser explains the concept of cell signaling using the analogy of a cell as an industry with different components.She describes the role of receptors and ligands in cell signaling and the importance of understanding these pathways.The discussion includes the significance of G protein-coupled receptors (GPCRs) and their role in cancer research.Discoveries and Implications in Cancer ResearchDr. Cardenas-Alcoser highlights a significant discovery about the role of G protein alpha subunits in cancer.She explains how the activation of specific G protein pathways can affect the immune system's response to tumors.The potential for using this discovery to develop new cancer treatments is discussed.Challenges and Progress in Cancer ResearchDr. Cardenas-Alcoser talks about the challenges of translating basic research into clinical applications.She shares a story about a dormant project that was revived due to new funding and its potential impact on treating fibrodysplasia.The discussion includes the importance of animal testing and the potential for using the same drug to treat certain cancers.Audience Questions and MentorshipAudience questions cover the importance of mentorship in research and how to seek it.Dr. Cardenas-Alcoser emphasizes the role of mentors in guiding researchers through failures and teaching them how to think critically.She advises young researchers to be persistent and to seek opportunities in labs that align with their interests.Managing Disappointment and Future of Cancer ResearchDr. Cardenas-Alcoser discusses how to manage disappointment in the lab and the importance of learning from failures.She shares her vision for the future of cancer research, predicting that cancer will become more manageable and less deadly.The discussion includes the need for patience and continued interest in finding new treatments.Final Thoughts and Contact InformationDr. Cardenas-Alcoser encourages young researchers to pursue their curiosity and not to be discouraged by a lack of background in research.She provides her contact information for those interested in reaching out to her for mentorship or further discussion.The episode concludes with thanks to the collaborators and listeners, and a teaser for the next episode's topic.Be sure to subscribe to and share "The Science Of" with all of your friends. We appreciate your support."The Science Of" podcast series is ...
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    46 m
  • Episode 20 | The Science Of Microbes | Dr. David J. Gonzalez, Associate Professor Skaggs School of Pharmacy / Department of Pharmacology

    Episode 20 | The Science Of Microbes | Dr. David J. Gonzalez, Associate Professor Skaggs School of Pharmacy / Department of Pharmacology
    Dec 30 2024
    Welcome to "The Science Of" Podcast, where students from the Jackie Robinson Family YMCA sit down with top scientists, doctors, and other leaders in the world of science from the globally renowned UCSD and the UCSD Moores Cancer Center in La Jolla, CA.In this episode, Riley James, Haydee Arancibia-Hardwick, and Margaux Stack-Babich from the UCSD Moores Cancer Center sit down to discuss THE SCIENCE OF MICROBES with Dr. David Gonzalez, an Associate Professor in Pharmacology at the Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, School of Medicine, as the Founder and Director for the Collaborative Center of Multiplexing Proteomics. Dr. Gonzalez was on this episode joined by his sons, David Jr. and Isaiah, and a lab researcher, Yesenia, an alumna of UC-Riverside. They discuss the importance of microbes, their roles in human health, and the impact of antibiotics on gut microbiomes. They highlight the potential of proteomics in understanding protein interactions and the need for alternative therapeutics. The conversation also touches on the personal and professional journeys of the participants, emphasizing the importance of education and perseverance in scientific careers.Enjoy this episode and get your PODucation on!! "Rapid Fire" Warm-Up Round and Personal IntroductionsThe guests participate in a rapid-fire warm-up round, answering questions about their first science experiments and favorite musicians.Dr. Gonzalez shares his first science experiment involving making plastic in a chemistry class, which sparked his interest in science.Isaiah, David Jr. and Yesenia share their first experiences with science projects The guests discuss their favorite musicians, with from Tame Impala to Kendrick LamarMicrobes and Their ImportanceDr. Gonzalez explains the role of microbes as the gatekeepers of the world, contributing to oxygen production and metabolism in the gut.The conversation touches on the balance between good and bad microbes, with Dr. Gonzalez emphasizing that microbes can be both beneficial and harmful depending on context.The guests discuss the importance of the gut microbiome and its impact on human health, including the role of stool samples in microbiome research.Dr. Gonzalez highlights the advancements in microbiome research at UCSD and the importance of understanding the microbiome for future medical treatments.Applications of Microbiome ResearchThe guests discuss the potential of the gut microbiome in treating diseases and the role of probiotics and antibiotics in maintaining gut health.Dr. Gonzalez mentions the impact of antibiotics on the gut microbiome and the rise of antibiotic-resistant pathogens.The conversation shifts to the role of the microbiome in cancer treatment and the potential of immunotherapies.Dr. Gonzalez shares insights on the use of checkpoint inhibitors and the microbiome's influence on treatment efficacy.Antibacterial and Antimicrobial IndustryThe guests address the challenges of antibacterial and antimicrobial products, emphasizing the need for awareness of antibiotic resistance.Dr. Gonzalez discusses the overuse of antibiotics and the importance of finding alternative therapeutic approaches, such as vaccines.The conversation highlights the role of proteomics in understanding the proteome and its applications in medical research.Dr. Gonzalez explains the power of proteomics in providing a comprehensive view of protein interactions and its potential in developing new drugs.Impact of COVID-19 on Scientific CareersThe guests share their personal experiences and the impact of COVID-19 on their scientific careers and educational paths.Isaiah discusses the challenges of gaining clinical experience during the pandemic and the importance of community outreach and education.David Jr. shares how COVID-19 led him to pursue a PhD in structural biology, focusing on emerging viruses.The guests emphasize the importance of resilience and adaptability in navigating career challenges during the pandemic.Future of Microbiome Research and Personal ReflectionsThe guests discuss their hopes for the future of microbiome research, including the development of alternative therapeutics and the continued advancements in proteomics.Dr. Gonzalez envisions a future where real-time health monitoring is possible through stool analysis.The guests reflect on the importance of education and mentorship in fostering scientific careers and the impact of their work on future generations.The conversation concludes with the guests sharing their admiration for each other and their commitment to continuing their scientific pursuits.Be sure to subscribe to and share "The Science Of" with all of your friends. We appreciate your support."The Science Of" podcast series is brought to you by the UCSD Moores Cancer Center, SchoolCAST, a division of Cloudcast Media, and the Jackie Robinson Family YMCA. Please learn more about both of our sponsors by visiting:...
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    53 m
  • Episode 19 | The Science Of Stem Cells | Dr. Shiri Gur-Cohen, Assistant Professor of Medicine, Division of Regenerative Medicine, UCSD

    Episode 19 | The Science Of Stem Cells | Dr. Shiri Gur-Cohen, Assistant Professor of Medicine, Division of Regenerative Medicine, UCSD
    Dec 12 2024
    Welcome to "The Science Of" Podcast, where students from the Jackie Robinson Family YMCA sit down with top scientists, doctors, and other leaders in the world of science from the globally renowned UCSD and the UCSD Moores Cancer Center in La Jolla, CA.In this episode, Riley James, Haydee Arancibia-Hardwick, and Margaux Stack-Babich sit down to discuss THE SCIENCE OF STEM CELLS with Dr. Shiri Gur-Cohen, a stem cell biologist whose innovative work on lymphatic vascular niche for hair follicle stem cells opened the door to fundamental research areas to advance therapeutics for enhancing tissue regeneration. Dr. Gur-Cohen is currently an Assistant Professor of Medicine in the Division of Regenerative Medicine at the University of California San Diego. Dr. Gur-Cohen’s work with Dr. Elaine Fuchs at The Rockefeller University in New York helped unearth the lymphatic capillary network as a novel stem cell niche component, and her multidisciplinary strategy has advanced our knowledge of how stem cells synchronize and coordinate tissue regeneration. Dr. Gur-Cohen earned her Ph.D. in the Department of Immunology in Dr. Tsvees Lapidot’s lab at the Weizmann Institute of Science, Israel, and completed her B.A. in molecular biochemistry and M.Sc. in medical sciences at the Technion-Israel Institute of Technology. In this episode, you'll hear Dr. Gur-Cohen discuss her research on stem cells and their role in tissue regeneration. Dr. Gur-Cohen explains the difference between embryonic and adult stem cells, emphasizing the potential of adult stem cells to rejuvenate and regenerate tissues. She highlights the importance of understanding the balance between self-renewal and differentiation in stem cells. Dr. Gur-Cohen also addresses the ethical considerations and challenges in stem cell therapies, advocating for careful consultation with physicians. She envisions future advancements in cancer treatment and regenerative medicine, aiming to target cancer-initiating stem cells and rejuvenate old stem cells.Enjoy this episode and get your PODucation on!! EPISODE SUMMARY"Rapid Fire" Warm-Up Questions with Dr. Shiri Gur-CohenDr. Gur-Cohen shares her first science experiment involving collecting animals under rocks and observing their behavior in different light conditions.Dr. Gur-Cohen discusses her favorite musician, Taylor Swift, and her preference for dogs over cats, despite owning a cat due to lifestyle constraints in New York.Dr. Gur-Cohen expresses her desire to visit Antarctica for its extreme conditions and shares her favorite hiking experience in Patagonia.Dr. Gur-Cohen mentions her favorite place to eat in San Diego, highlighting the fresh seafood available in the area.Career Path and Passion for Stem Cell ResearchDr. Gur-Cohen recounts how her career in stem cell research was influenced by mentors who encouraged her to explore her true interests.Dr. Gur-Cohen explains her initial goal to cure cancer, which evolved into a fascination with stem cell biology during her PhD and postdoc years.Dr. Gur-Cohen discusses the importance of understanding how stem cells work in regenerating tissues and the impact of aging on this process.Dr. Gur-Cohen emphasizes the need to understand the balance between self-renewal and differentiation in stem cells to maintain tissue health.Types of Stem Cells and Their ApplicationsDr. Gur-Cohen explains the difference between embryonic and adult stem cells, noting that adult stem cells are already specialized and can only generate specific tissues.Dr. Gur-Cohen discusses her choice to study adult stem cells due to their visual and measurable properties, which are more applicable to human health.Dr. Gur-Cohen highlights the potential of adult stem cells to be taught to have a broader range of differentiation, similar to the regenerative abilities of amphibians like salamanders.Dr. Gur-Cohen elaborates on the importance of understanding the signals and cues that guide stem cells to change their fate during development.Challenges and Future of Stem Cell ResearchDr. Gur-Cohen discusses the challenges of stem cell transplantation, emphasizing the need to understand which stem cells are being used and their life cycle.Dr. Gur-Cohen advises caution when considering stem cell therapies, recommending consultation with physicians and thorough research on the safety and efficacy of treatments.Dr. Gur-Cohen shares her excitement about the potential of CRISPR technology to correct genetic diseases and the importance of understanding the signals that drive regeneration.Dr. Gur-Cohen expresses hope for the future of stem cell research, particularly in cancer treatment and regenerative medicine, and the potential to rejuvenate old stem cells.Audience Questions and Final ThoughtsDr. Gur-Cohen responds to an audience question about the challenges of running her own lab, mentioning funding and the importance of having a supportive environment.Dr. Gur-Cohen shares her experience of starting her lab with ...
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