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What if one of the most powerful tools for slowing biological aging has been hiding in plain sight for decades?

This week on The Daily Apple, Dr. Brad Younggren joins us to unpack therapeutic plasma exchange (TPE) and why it could be a game-changer for longevity. Dr. Younggren is an emergency medicine physician, U.S. Army combat veteran, and now CEO and co-founder of Circulate Health
. Under his leadership, Circulate has completed more than a thousand treatments across 24 clinics and published data showing an average 2.6-year slowdown in biological aging.

“Therapeutic plasma exchange isn’t just for rare hospital cases anymore. We’re learning it can lower inflammation, clear out harmful proteins, and even reduce microplastics — all things tied to how fast we age.” — Dr. Brad Younggren

We talk about:

• What TPE actually is (and how it differs from a blood donation).
• Results from the Circulate Trial and why they matter.
• How plasma exchange impacts inflammation, senescent cells, and lipids.
• Early research on microplastics and cognitive decline.
• Why partnerships with clinics may be the fastest path to making longevity care more accessible.

Dr. Younggren also shares his own journey from combat medicine to pioneering new frontiers in healthspan, and where he sees longevity breakthroughs heading in the next decade.

🎙️ Listen now to learn how medicine, technology, and patient care are converging to help us live healthier, longer lives.

Takeaways

1. Therapeutic plasma exchange (TPE) uses established hospital technology in new ways to target aging and inflammation.
2. Clinical data from the Circulate Trial showed an average 2.6-year slowdown in biological aging after six treatments.
3. TPE may help reduce markers of inflammation, senescent cells, and even microplastics in the body.
4. Circulate Health partners with existing clinics instead of building its own, making the treatment more accessible.
5. Longevity medicine is moving fast — but staying grounded in rigorous science and real patient data is essential.

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Exercise is not just about looking good. It is medicine.

Dr. Mary Pardee is back with us to talk about why movement is one of the most powerful and most overlooked prescriptions we have. We get into muscle as “money in the bank” for aging, how to think about strength training if you hate weights, and why consistency beats motivation every single time.

Speaking about resilience and muscle, Dr. Pardee put it this way:
“Yeah, it’s like a retirement account, right? Where you have something to fall back on if times get tough.”

We also cover sarcopenia, brain health, mitochondria, and the kind of “dose” of exercise that really changes your future. This one is packed with practical stuff you can use today.

Find Dr. Mary here:
Instagram: @dr.marypardee

Website: modrnmed.com

🎙️ Full episode out now on The Daily Apple.

Key Takeaways

1. Exercise is one of the most underutilized prescriptions in healthcare.
2. Consistency matters more than motivation: treat workouts like brushing your teeth.
3. Muscle is “currency for aging” and protects against sarcopenia, osteoporosis, and poor outcomes later in life.
4. Exercise supports brain health by boosting BDNF and lowering dementia risk.
5. The right “dose” of strength and cardio is measurable and trackable, just like any other prescription.
6. Building muscle gives you resilience: “Yeah, it’s like a retirement account, right? Where you have something to fall back on if times get tough.” — Dr. Mary Pardee

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From NHL enforcer to mental health advocate: Daniel Carcillo’s story is as raw as it is redemptive. After a career defined by fights, concussions, and two Stanley Cups, Daniel found himself battling depression, dementia-like symptoms, and suicidal thoughts. His turning point came through an unexpected path: psychedelics.

“This medicine didn’t just ease my symptoms. It gave me back my brain, my purpose, and my relationships.”

In this conversation, Daniel shares how psilocybin and intentional healing practices helped him regain his health, rebuild his relationships, and create Experience Onward, a groundbreaking program offering safe, regulated access to psychedelic therapy. He opens up about the hard truths of hockey culture, the cost of repeated brain trauma, and the hope that comes from rewiring both the brain and the spirit.

Follow Daniel’s work on Instagram @DanielCarcillo13 and learn more at ExperienceOnward.com

Episode Takeaways

• What it meant to be an NHL “enforcer” — and the personal cost Daniel paid with over 1,200 penalty minutes and multiple concussions.
• The hidden toll of repeated brain trauma and why so many concussions go undiagnosed.
• Daniel’s turning point: losing a close friend, becoming a father, and facing his own brain health crisis.
• Why Daniel says one psilocybin experience gave him more healing in four hours than years of therapy and costly treatments combined.
• The science behind psychedelics: neuroplasticity, trauma processing, and why FDA trials are taking it seriously.
• Why safe, regulated access matters — and how Experience Onward is pioneering a new model of care.
• Daniel’s personal mission: helping others move beyond survival into true healing.

Prime Health Associates