HOST
Melody Hartzler
| | Book Appointment

AROUND THE TABLE
Kara Siedman
| ResBiotic

In this episode of the Tables Talk Podcast, Dr. Melody Hartzler sits down with Kara Siedman, RD, CDCES, Director of Partnerships at ResBiotic, to examine how microbiome-driven physiology intersects with hormonal transitions during perimenopause and menopause.

As estrogen and progesterone fluctuate and decline, women experience predictable shifts in metabolic regulation, immune signaling, and inflammatory burden. Increasing evidence suggests these changes are tightly linked to alterations in gut microbial diversity, intestinal barrier integrity, and microbial metabolite production. This conversation explores the gut–hormone axis through a mechanistic lens, highlighting how microbiome dysfunction may amplify symptoms such as blood sugar instability, weight gain, estrogen dominance, gastrointestinal distress, and genitourinary changes.

Kara draws on clinical experience and emerging research to clarify why many hormonally driven symptoms occur in the absence of overt disease on conventional testing. The episode emphasizes perimenopause as a critical intervention window—one in which targeted dietary, lifestyle, and microbiome-supportive strategies may meaningfully influence long-term cardiometabolic and immune health.

• Hormonal decline during perimenopause is closely linked to reduced microbiome diversity and resilience
• Estrogen loss impacts intestinal barrier function, inflammation, and metabolic regulation
• The estrobolome plays a central role in estrogen metabolism and symptom expression
• Microbiome-targeted interventions may reduce cardiometabolic risk during menopause
• Diet, fiber diversity, and precision biotics are foundational tools for supporting this transition

• Estrogen and progesterone fluctuations in perimenopause
• Bidirectional signaling between endocrine function and the microbiome
• Declining microbial diversity and reduced short-chain fatty acid production

• Metabolic endotoxemia and LPS-driven inflammation
• Microbiome contributions to blood sugar dysregulation and weight gain
• Links between dysbiosis, immune activation, and chronic disease risk

• Beta-glucuronidase activity and estrogen deconjugation
• Microbial reactivation of estrogen and clinical implications
• Estrogen dominance, elimination pathways, and gut health

• Estrogen-dependent Lactobacillus depletion
• Increased risk of UTIs and yeast infections
• Gut–vaginal microbiome crosstalk and clinical considerations

• Mediterranean-style dietary patterns and...

HOST
Melody Hartzler
| | Book Appointment

AROUND THE TABLE
Mariane Rizkallah
| | DrMariane.com

Acne isn’t just a surface-level issue—it’s a signal from the body that something deeper is out of balance. In this episode we are joined by fellow pharmacist Dr. Mariane Rizkallah to explore how functional medicine offers lasting solutions for acne and chronic inflammation. Dr. Mariane shares her personal journey of overcoming persistent hormonal acne, her transition from traditional pharmacy to integrative healing, and the foundational steps to support whole-body wellness.

What We Cover in This Episode:

• Why acne is more than just a skin issue
• Dr. Mariane personal healing journey from acne, gut issues, and antidepressant side effects
• The importance of gut health and the mind-body connection in skin healing
• Testing vs. guessing: when functional lab testing can make all the difference
• The dangers of DIY supplementing (like DIM and Vitex) without hormone testing
• How to safely support the liver and detoxification pathways
• Why sleep, stress, and emotional health matter for clearer skin
• The Clear Skin Blueprint: Dr. Mariane step-by-step program for healing from within
• Bonus: A sneak peek at her Product Acne Guide and recipe book

Get 50% off The Clear Skin Blueprint Program with code MELODY at checkout

HOST
Melody Hartzler
| | Book Appointment

AROUND THE TABLE
Lindsey Dalton
| | Book Appointment

AROUND THE TABLE
Megan Morrison
| Book Appointment

• Define what the circadian rhythm is
• Dive deep into sunlight and why it’s so crucial for our health and wellbeing
• Introduce the topic of malillumination.
• Explain why it’s so important to have sun exposure first thing in the morning
• Share other ways besides light to regulate the circadian rhythm
• Detail what other health conditions have been linked to circadian rhythm disruption

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