Welcome to episode 36 of the Performance Around the Clock podcast. In this episode, Dr. Panda hosts Professor Geoff Wahl who is a renowned cancer scientist who conducted foundational research at the Salk Institute for 46 years. His long history in cancer research has focused on understanding the fundamental cellular and genetic mechanisms driving cancer, with an emphasis on the role of stem cells and the p53 tumor suppressor gene in breast and pancreatic cancers. Dr. Wahl also served as the president of the American Association of Cancer Research (AACR), utilizing the position to raise public awareness of the terrible toll of cancer and increase grassroots funding for research. Here, Professor Wahl highlights the crucial role of "foundational research" in combating cancer - explaining that cancer is a group of diseases, not a single one, where cells lose the ability to regulate division, with the most lethal factor being metastatic spread to distant organs. While research in breast cancer has led to effective targeted therapies for primary tumors, like Herceptin for HER2-positive cancers, there is a critical need for more research funding and a greater focus on understanding and treating metastatic cancers and intratumoral heterogeneity, which are major causes of mortality. Highlighting the value of funding foundational research, Dr. Tony Hunter’s work at the Salk Institute on tyrosine kinases has ultimately led to life-saving drugs like Gleevec, contributing to the 33% drop in the U.S. cancer death rate since 1991. We hope you enjoy this episode. If you want to support this channel, please like, comment, follow or donate. Thank you for listening.

Guest:

Dr. Geoff Wahl

Professor Emeritus Salk Institute

Profile:

https://www.salk.edu/scientist/geoffrey-wahl/

Cancer statistics, 2023

https://pubmed.ncbi.nlm.nih.gov/36633525/

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Welcome to episode 35 of the Performance Around the Clock podcast. We’re joined by Dr. Hemal Patel, a distinguished Professor and Vice-Chair for Research in the Department of Anesthesiology at the University of California, San Diego (UCSD) and a VA Research Career Scientist. Holding a Ph.D. in Pharmacology and Toxicology, Dr. Patel's extensive research career has focused on caveolin and mitochondrial biology. In this episode, he discusses the critical role of cell membranes and mitochondria in cellular energy and disease, highlighting how his lab developed a non-invasive blood-based assay for mitochondrial function. This innovative assay, developed through the NASA Twin Study, can assess overall energetic health and disease states without invasive biopsies. Dr. Patel also shares his work on the therapeutic potential of the protein caveolin in conditions like heart disease and neurodegeneration (ALS, Alzheimer's, Parkinson's), and how his recent research has expanded to explore the mind-body connection through the transformative work of Dr. Joe Dispenza. We also talk about how his longtime interest in philosophy and religion has influenced his life and career. Please join us for an wonderful conversion between Dr. Panda and Dr. Patel. If you like this episode, please like, comment or follow. Thanks for listening.

Guest:

Dr. Hemal Patel

Professor and Vice-Chair Department of Anesthesiology, UC San Diego School of Medicine

VA Research Career Scientist

Profile:https://clre.ucsd.edu/faculty/hemal-patel/

Instagram:@hemalpatelphd

https://www.instagram.com/@hemalpatelphd

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Welcome to episode 34 of the Performance Around the Clock. In this episode, host Dr. Satchin Panda, welcomes his esteemed colleague, Dr. Pamela Maher from the Salk Institute for Biological Studies. Dr. Maher is a rare scientist who has taken drug discovery from basic science findings in cells all the way to compounds being tested in human clinical trials. In this episode, they discuss her journey through research on cell membranes and signaling, leading to her pivotal work on cell death pathways like oxytosis and ferroptosis. The conversation also covers the development of potential therapeutics for aging and Alzheimer's disease, including compounds like J147 and CMS-121, and the exploration of cannabinoids for neuroprotection. If you like this episode, please like, comment or follow. Thank you for listening.

Guest:

Dr. Pamela Maher

Research Professor at the Salk Institute

Cellular Neurobiology Laboratory

Profile:

https://www.salk.edu/scientist/pamela-maher/

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Welcome to the Performance Around the Clock podcast. In this episode, Dr. Satchin Panda welcomes one of his scientific heroes, Dr. Susan Golden. Dr. Golden is a pillar in the circadian and cyanobacteria science community and the former director for the Center for Circadian Biology at UC San Diego. She shares her journey from studying gene regulation in cyanobacteria to understanding the circadian clock through this unique organism. Learn how these ancient blue-green algae were instrumental in the oxygenation of Earth's atmosphere and how tools developed to study cyanobacteria led to groundbreaking discoveries. Beyond her research, Dr. Golden also made significant contributions to circadian rhythm education, teaching countless undergraduate students over the years. If you like this episode, please like, comment or subscribe. Thank you for listening.

Guest:

Dr. Susan Golden

Director, Center for Circadian Biology

Chancellor's Associates Chair (III) in Molecular Biology

Distinguished Professor

X (Twitter): @susanksgolden

https://x.com/susanksgolden

Profile:

UCSD:

https://biology.ucsd.edu/research/faculty/sgolden

Wikipedia:

https://en.wikipedia.org/wiki/Susan_Golden

Paper:

Circadian orchestration of gene expression in cyanobacteria

https://pubmed.ncbi.nlm.nih.gov/7601351/

Thanks to 理philosophia onlineについて for the photo of Dr. Takao Kondo

https://www.philosophia.sci.nagoya-u.ac.jp/snapshots/44.html

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

In our last episode from the 2024 Gerontology Society of America (GSA) Annual Scientific Meeting in Seattle, we are honored to host Dr. John Newman and Dr. Brianna Stubbs, both experts in ketone metabolism and aging. Dr. Newman is a geriatrician and researcher at the Buck Institute for Research on Aging and in the Division of Geriatrics at UCSF. His research focuses on how ketone bodies, small molecules that our bodies make for energy during fasting or exercise, also work as molecular signals to control inflammation and gene expression. Dr. Brianna Stubbs is an expert in exogenous ketone metabolism and the Director of Translational Science at the Buck Institute for Research on Aging. She's a former competitive rower and two-time world champion, and she completed her PhD in metabolic physiology at the University of Oxford, where she studied the metabolic effects of ketone esters. Learn all about their work translating ketone research into the field. If you like this episode or podcast, please like, comment or follow. Thank you for listening.

Guests:

Dr. John Newman

Division of Geriatrics at UCSF

Assistant Professor Buck Institute for Research on Aging

X (Twitter): @geriscidoc

https://x.com/geriscidoc

Profile:

Division of Geriatrics at UCSF

https://profiles.ucsf.edu/john.newman

https://medicine.ucsf.edu/people/john-newman

Buck Institute for Research on Aging

https://www.buckinstitute.org/lab/newman-lab/

Dr. Brianna Stubbs

Director of Translational Science at Buck Institute for Research on Aging

X (Twitter): @briannastubbs

https://x.com/briannastubbs

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/
More science: https://mycircadianclock.org/

Coming from the 2024 Gerontology Society of America (GSA) Annual Scientific Meeting in Seattle, we are excited to welcome Dr. Nathan LaBrasseur for the 31st episode of the Performance Around the Clock podcast. Dr. LaBrasseur is the director of the Robert and Arlene Kogod Center on Aging at the Mayo Clinic and an expert on senescence and aging. He's an author of the book "Mayo Clinic on Healthy Aging: An Easy and Comprehensive Guide to Keeping Your Body Young, Your Mind Sharp and Your Spirit Fulfilled" an updated guide on healthy aging. In this episode, learn about the latest in aging and senescence particularly therapeutics for senescent cells - senotherapeutics. Senotherapeutics can be broken down into senolytics which selectively kill senescent cells and senomorphics which suppress senescence-associated secretory phenotype (SASP) to reduce the negative effects of senescence. Thank you for watching. If you like this episode, please like, comment or subscribe.

Guest:

Dr. Nathan LaBrasseur

Director of the Robert and Arlene Kogod Center on Aging @MayoClinic

X (Twitter): @NKLeBRASSEUR

https://x.com/nklebrasseur

Profile:

https://www.mayo.edu/research/faculty/lebrasseur-nathan-k-ph-d-m-s/bio-00055041

Mayo Clinic on Healthy Aging: An Easy and Comprehensive Guide to Keeping Your Body Young, Your Mind Sharp and Your Spirit Fulfilled

https://www.amazon.com/Mayo-Clinic-Healthy-Aging-Comprehensive/dp/B0BQYKS8ND

Host:

Dr. Satchin PandaX (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

We continue our series from the 2024 Gerontology Society of America (GSA) Annual Scientific Meeting in Seattle. Episode 30 of the Performance Around the Clock Podcast, features Dr. Courtney Peterson, a leading researcher in the field of intermittent fasting and time-restricted eating (TRE). Dr. Peterson is an Associate Professor at the University of Alabama at Birmingham where she was notably the first to test early time-restricted eating (eTRE) in humans. Dr. Peterson is the principal investigator of numerous clinical trials on TRE, including the largest randomized controlled trial of intermittent fasting in individuals with type 2 diabetes. Her research combines chronobiology, nutrition, and metabolism and aims to develop dietary interventions to combat cardiometabolic diseases. Learn all about her research in this episode. If you like this episode, please like, comment or subscribe. Thank you for listening.

Guest:

Dr. Courtney Peterson

Associate Professor University of Alabama Birmingham

X (Twitter): @CourtneyP_PhD

Profile:

https://scholars.uab.edu/3393-courtney-peterson

Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes

https://pubmed.ncbi.nlm.nih.gov/29754952/

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Episode 29 of the Performance Around the Clock Podcast is our second episode from the 2024 Gerontology Society of America (GSA) Annual Scientific Meeting in Seattle. We are privileged to host Dr. Steven Austad who is a leading expert in aging biology. Dr. Austad is a Distinguished Professor and Chair of Biology at the University of Alabama at Birmingham, Director of UAB's Nathan Shock Center of Excellence in the Basic Biology of Aging and Senior Scientific Director of the American Federation for Aging Research (AFAR). His varied career from large cat training, longevity field work with opposums, calculating the age of greenland sharks, to work with numerous other species gives Dr. Austad a unique view on longevity and aging. He developed the Longevity Quotient (LQ) which is simplified measure that enables normalized comparisons of various species' longevity. Learn all about his work on longevity and aging in this episode. If you like this episode, please like or follow/subscribe. Thank you for listening.

In addition to authoring over 200 scientific articles and more than 150 newspaper columns on science. Dr. Austad has been a recipient of numerous awards such as:

Fifth Nathan A. Shock Award

Robert W. Kleemeier award

Purdue University Outstanding Alumnus Award

Irving S. Wright Award of Distinction

Fondation IPSEN Longevity Prize

Caroline P. and Charles W. Ireland Prize for Scholarly Distinction.

He is also a fellow of the Gerontological Society of America (GSA) and the American Association for the Advancement of Science (AAAS). In 2021, he was appointed Protective Life Endowed Chair of Health Aging Research at the University of Alabama at Birmingham.

Guest:

Dr. Steven Austad's

X (formerly Twitter): @StevenAustad

https://x.com/StevenAustad

UAB Faculty Page

https://www.uab.edu/cas/biology/people/faculty/steven-n-austad

Books:

“Why We Age”

https://www.amazon.com/Why-We-Age-Science-Discovering/dp/0471148032/

"Methuselah's Zoo."

https://www.amazon.com/Methuselahs-Zoo-Nature-Living-Healthier/dp/B0CL5D1SY7/

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations:https://panda.salk.edu/giving/

Research:https://www.salk.edu/scientist/satchidananda-panda/

More science:https://mycircadianclock.org/