Episode 38 of the Performance Around the Clock features another guest from the XVIII Congress of the European Biological Rhythms Society in Lubeck, Germany. We are joined by Professor Andrew Miller, a Professor at the University of Edinburgh and the Chair of the Systems Biology Center for Engineering Biology. Professor Miller is a seminal figure in plant biology whose early work served as the inspiration for host Dr. Satchin Panda to enter the field of plant circadian rhythms.In this episode, we explore Professor Miller’s scientific journey, beginning with his fascination with interacting genetic systems and his move to New York to study plant-microbe symbiosis. The conversation highlights his groundbreaking development of rhythmic bioluminescence using the luciferase protein to visualize the plant clock in real-time. This innovation allowed researchers to identify the genes building the plant clock without killing the specimens, a technique that revolutionized the field.We dive into the critical role the circadian clock plays in agriculture, from measuring day length to trigger flowering to helping crops like barley adapt to the unique growing seasons of Scotland. Professor Miller also explains the fascinating connection between the clock and metabolic timing, detailing how plants use their internal timer to manage starch degradation overnight to avoid starvation before dawn.The discussion moves toward the future of the field, including the creation of "digital twins" through mathematical modeling to predict how specific genomes will perform in various climates. We also touch upon Professor Miller's work with the UK government's ACRE committee, advising on the policy and safety of genetically edited crops to meet the challenges of climate change and food security. Please join us for this wide-ranging and inspiring conversation. If you enjoy this episode, please like, comment, or subscribe. Thanks for watching.Guest:Dr. Andrew MillerUniversity of EdinburghProfessor of Systems BiologyChair of the Systems Biology Center for Engineering BiologyPaper highlight:Circadian clock mutants in Arabidopsis identified by luciferase imaginghttps://pubmed.ncbi.nlm.nih.gov/7855595/Host:Dr. Satchin PandaX (Twitter): @SatchinPandahttps://x.com/SatchinPandaInstagram: @satchin.pandahttps://www.instagram.com/satchin.panda/Links:Donations: https://panda.salk.edu/giving/Research: https://www.salk.edu/scientist/satchidananda-panda/More science: ⁠https://mycircadianclock.org/⁠

Episode 37 of the Performance Around the Clock comes from the XVIII Congress of the European Biological Rhythms Society in Lubeck, Germany. We welcome Professor Anna Krook, a Professor of Integrative Physiology at the Department of Physiology and Pharmacology and chair of the Strategic Research Programme in Diabetes at Karolinska Institutet. Professor Krook is an internationally recognized leader in metabolism, skeletal muscle and insulin biology.

In this episode, we discuss Professor Krook’s research journey, which began with her Ph.D. work on insulin and the insulin receptor gene, identifying rare mutations that cause severe inherited insulin resistance. She then focused on the dysregulation of insulin action seen in Type 2 diabetes, noting that muscle is the main site where insulin action goes wrong. The conversation dives into the fascinating role of the circadian clock in regulating insulin, glucose, and muscle. Dr. Krook explains that while healthy muscle mitochondria show a functional rhythm that peaks in the afternoon, this crucial rhythm is absent in muscle cells from people with Type 2 diabetes. We cover her landmark study showing that for type 2 diabetic men doing high-intensity interval training, exercise in the afternoon led to lower blood glucose control and a beneficial "legacy effect" the next day. In contrast, morning exercise resulted in higher blood glucose levels for that entire day and the next. This negative effect may be linked to higher inflammatory markers and stress markers circulating in the plasma after morning exercise. Please join us for an insightful conversation between Dr. Satchin Panda and Dr. Krook on optimizing exercise timing for metabolic health. If you enjoy this episode, please like, comment or follow. Thanks for listening.

Guest:

Dr. Anna Krook

Karolinska Institutet

Professor of Integrative Physiology

Chair of the Strategic Research Programme in Diabetes

Profile:

https://ki.se/en/people/anna-krook

Integrative Physiology group:

⁠https://ki.se/en/fyfa/integrative-physiology⁠

Paper highlight:

Afternoon exercise is more efficacious than morning exercise at improving blood glucose levels in individuals with type 2 diabetes: a randomised crossover trial

⁠https://pubmed.ncbi.nlm.nih.gov/30426166/⁠

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: ⁠https://mycircadianclock.org/

Episode 37 of the Performance Around the Clock comes from the XVIII Congress of the European Biological Rhythms Society in Lubeck, Germany. We welcome Professor Anna Krook, a Professor of Integrative Physiology at the Department of Physiology and Pharmacology and chair of the Strategic Research Programme in Diabetes at Karolinska Institutet. Professor Krook is an internationally recognized leader in metabolism, skeletal muscle and insulin biology.

In this episode, we discuss Professor Krook’s research journey, which began with her Ph.D. work on insulin and the insulin receptor gene, identifying rare mutations that cause severe inherited insulin resistance. She then focused on the dysregulation of insulin action seen in Type 2 diabetes, noting that muscle is the main site where insulin action goes wrong. The conversation dives into the fascinating role of the circadian clock in regulating insulin, glucose, and muscle. Dr. Krook explains that while healthy muscle mitochondria show a functional rhythm that peaks in the afternoon, this crucial rhythm is absent in muscle cells from people with Type 2 diabetes. We cover her landmark study showing that for type 2 diabetic men doing high-intensity interval training, exercise in the afternoon led to lower blood glucose control and a beneficial "legacy effect" the next day. In contrast, morning exercise resulted in higher blood glucose levels for that entire day and the next. This negative effect may be linked to higher inflammatory markers and stress markers circulating in the plasma after morning exercise. Please join us for an insightful conversation between Dr. Satchin Panda and Dr. Krook on optimizing exercise timing for metabolic health. If you enjoy this episode, please like, comment or follow. Thanks for listening.

Guest:

Dr. Anna Krook

Karolinska Institutet

Professor of Integrative Physiology

Chair of the Strategic Research Programme in Diabetes

Profile:

https://ki.se/en/people/anna-krook

Integrative Physiology group:

https://ki.se/en/fyfa/integrative-physiology

Paper highlight:

Afternoon exercise is more efficacious than morning exercise at improving blood glucose levels in individuals with type 2 diabetes: a randomised crossover trial

https://pubmed.ncbi.nlm.nih.gov/30426166/

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/