Have you or a loved one experienced ongoing abdominal pain, fatigue, or digestive issues like diarrhea or loss of appetite? You may be living with one of the lifelong conditions known as Inflammatory Bowel Disease (IBD), which includes Crohn’s disease and ulcerative colitis. In this episode of Hope in the Pipeline, Dr. Paul Wylie, Medical Director of Preferred Research Partners in Little Rock, Arkansas, welcomes Dr. Natasa Jensen to discuss what causes IBD, its symptoms, treatment options, and the importance of early diagnosis and clinical research. You’ll also meet Erik Guzman, a bilingual research coordinator, who shares his inspiring story and efforts to make clinical trials more accessible to the Spanish-speaking community. He discusses barriers to participation, the need for diversity in medical research, and how Preferred Research Partners is building trust and partnerships across Arkansas to create healthier, more informed communities.

For this episode of Hope in the Pipeline, Dr. Wylie is joined by one of our Clinical Research Coordinators, Jessica Watson. They talk about gastroparesis clinical trials, and Jessica explains what a research trial looks like. Interested in learning more? Visit our website for more information about clinical research trials: www.preferredresearchpartners.com

Welcome to the third part of our Hope in the Pipeline series on hypersomnolence disorders. In this episode, we dive deep into:

🔹 Medications used to treat narcolepsy – from older stimulants to newer, longer-lasting options

🔹 The role of antidepressants and sodium oxybate in managing symptoms like cataplexy

🔹 Key differences between narcolepsy and idiopathic hypersomnia (IH)

🔹 Current treatment options for IH and why diagnosis can be so challenging

🔹 Exciting ongoing clinical research at Preferred Research Partners, including a new potential therapy targeting narcolepsy and IH

Welcome back to Hope in the Pipeline! In this episode, we continue our deep dive into narcolepsy, exploring: ✅ What causes cataplexy (sudden loss of muscle tone) ✅ How dream sleep paralysis can leak into wakefulness ✅ Vivid sleep-related hallucinations and automatic behaviors ✅ The detailed diagnostic process for narcolepsy, including sleep studies and genetic testing ✅ How narcolepsy impacts daily life, work, and education ✅ Important ADA protections and reasonable accommodations for people with narcolepsy Narcolepsy is often misunderstood, but with the right knowledge, treatment, and support, people living with it can thrive. If you found this helpful, please like, share, and subscribe for more conversations on sleep health and neurological conditions. 📌 Stay tuned for Part 3 of our hypersomnolence series!

Have you ever felt overwhelmingly sleepy even after a full night’s rest? Narcolepsy and idiopathic hypersomnia are two central disorders of hypersomnolence that affect millions worldwide — often undiagnosed.

In this episode of Hope in the Pipeline, we explore:

🧠 What narcolepsy and idiopathic hypersomnia are

🧠 Key symptoms and differences between the two

🧠 Causes, diagnosis, and treatment options

🧠 The role of the immune system in narcolepsy

🧠 How current clinical trials and research are bringing hope for better therapies

Narcolepsy is a lifelong neurological disorder caused by the loss of hypocretin (orexin), leading to uncontrollable sleepiness, cataplexy, and fragmented nighttime sleep. Idiopathic hypersomnia, on the other hand, can leave people excessively sleepy even after 10+ hours of rest. If you or someone you know struggles with unexplained sleepiness, this video will help you understand these conditions and where research is headed. 👉 Don’t forget to like, share, and subscribe to Hope in the Pipeline for more episodes on rare and underrecognized conditions.

Did you know that the number of blood pressure medications you take could be a sign of untreated obstructive sleep apnea?

There is a strong connection between obstructive sleep apnea (OSA) and hypertension, including the serious health risks of untreated OSA—from stroke and dementia to heart failure and even death. In this episode, Dr. Paul Wylie discusses a new clinical trial testing a promising medication designed to treat BOTH sleep apnea and high blood pressure.

✅ Learn the warning signs

✅ Understand the science

✅ Hear how you can make a difference through clinical research

#sleepapnea #hypertension #sleepmedicine #sleepstudy #obstructivesleepapnea

Did you know that 12% of women experience chronic or episodic migraines, and for many, they’re tied to hormonal cycles? In this episode of Hope in the Pipeline, Dr. Paul Wylie dives into the causes, symptoms, and treatments of menstrual migraines.

🧠In this episode, you’ll learn:

What causes menstrual migraines (hint: estrogen & hormone changes)

How they differ from common migraines

Why they often respond poorly to current medications What symptoms to look for, and how to track them

Why clinical trials matter—and how YOU can get involved

💊 About the Clinical Trial:

Open to individuals 18 years and older 18-week study, with the option for a 1-year extension

Medication is taken just 7 days a month to help prevent migraines

Compensation provided, plus free medication during the extension period if it helps

🧪 This trial is testing a promising FDA-approved treatment for menstrual migraines