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Dementia Researcher

Dementia Researcher

De: Dementia Researcher
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A biweekly podcast for early career researchers, bringing together fantastic guests to discuss their research, careers + much more. Dedicated to sharing the science, encouraging collaborations, attracting more people to the field, and supporting those already here to succeed. Brought to you by https://www.dementiaresearcher.nihr.ac.uk at University College London, in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia - everything you need, all in one place. supporting early career researchers across the world Register today to recieve weekly bulletins, with news, funding opportunities, jobs, and events.All rights reserved Ciencia
Episodios
  • Rainwater Prize Winners: Advancing Tau Research

    Rainwater Prize Winners: Advancing Tau Research
    Mar 7 2026
    In this episode, Professor Louise Serpell is joined by 2026 Rainwater Prize winners Professor Dennis Dickson, Professor Melissa Murray and Dr Marc Busche. They talk about their work and the science that led to them earning this much deserved award, reflecting on decades of research into tau and its role in neurodegenerative disease. The conversation explores how tau functions in the healthy brain, how it becomes harmful in conditions such as Alzheimer’s disease and progressive supranuclear palsy, and why certain brain regions are especially vulnerable. The discussion covers different forms of tau, including soluble species that may disrupt how neurons fire before visible tangles appear. Brain banking, imaging and fluid biomarkers are highlighted as key tools for understanding disease differences and improving diagnosis. The importance of rare MAPT mutations and what they can teach us about future treatments is also explored. Alongside the science, there are thoughtful reflections on mentorship, risk taking and the value of asking ambitious questions in dementia research. 10 Key Takeaways 🔹Tau is essential but context dependent. It is vital for normal brain function, yet changes in its chemistry, structure or location can drive neurodegeneration. 🔹Tangles are not the whole story. Soluble tau species can disrupt neuronal firing, even in single cells, before visible aggregates appear. 🔹Selective vulnerability defines tauopathies. Disorders such as PSP consistently affect specific brain regions and cell types, including glia, and we still do not fully understand why. 🔹One biomarker does not fit all. Tau PET and fluid markers behave differently across Alzheimer’s disease and primary tauopathies, reflecting structural differences in tau. 🔹Progress depends on bold science. High risk experiments, strong mentorship and access to the right tools are essential for moving the field forward. Find out more about the Rainwater Foundation: https://rainwatercharitablefoundation.org/ -- A transcript of this show, links and show notes and profile on all our guests are available on our website at https://www.dementiaresearcher.nihr.ac.uk -- Follow us on social media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://www.twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://www.bsky.app/profile/dementiare…archer.bsky.social -- Download and Register with our Community App: https://www.onelink.to/dementiaresearcher Chapters 00:00 Introduction to the Conversation 00:08 Introduction to the Rainwater Prize and Its Significance 04:30 Understanding Tau: The Central Protein in Neurodegeneration 09:03 The Role of Tau in Neurodegenerative Diseases 13:52 Exploring the Pathology of Tau and Its Variants 18:16 The Impact of Brain Banking on Neurodegenerative Research 23:24 Progressive Supranuclear Palsy: Symptoms and Pathology 28:13 Heterogeneity in Neurodegenerative Diseases 33:53 Therapeutics Targeting Tau Species 40:36 Mentorship and Leadership in Research
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    49 m
  • Life As A Researcher With ADHD

    Life As A Researcher With ADHD
    Feb 21 2026
    In this episode of the Dementia Research Podcast, host Dr Gemma Lace is joined by guests, Dr Eric Hill from Loughborough University, Kalliopi Mavromati from University of Glasgow, Natalie Wickett from Simon Fraser University and Dr Kate Harris from Newcastle University. Together they discuss the intersection of ADHD and research, exploring personal experiences, misconceptions, and coping strategies. The conversation highlights the unique challenges faced by researchers with ADHD, the importance of understanding and empathy in academic settings, and the various ways individuals navigate their symptoms. The discussion also touches on the role of medication and the need for tailored approaches to support neurodiverse individuals in academia. -- A transcript of this show, links and show notes and profile on all our guests are available on our website at https://www.dementiaresearcher.nihr.ac.uk -- Follow us on social media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://www.twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://www.bsky.app/profile/dementiare…archer.bsky.social -- Download and Register with our Community App: https://www.onelink.to/dementiaresearcher -- Chapters 00:00 Introduction to ADHD in Research 02:56 Understanding ADHD: Definitions and Misconceptions 06:55 Personal Experiences of ADHD 10:37 Hyperfocus: The Double-Edged Sword 14:22 Gender Differences in ADHD Presentation 21:46 ADHD in Academia: Challenges and Realizations 25:35 The Positive Aspects of ADHD 29:11 Coping Mechanisms and Strategies 34:10 Medication: The Good, The Bad, and The Necessary 48:14 Final Thoughts and Key Takeaways
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    56 m
  • Detecting UTIs Early in Dementia

    Detecting UTIs Early in Dementia
    Feb 7 2026
    In this episode of the Dementia Researcher podcast, host Adam Smith chats with with Professor Paul Freemont and researcher Tom Adam from the UK Dementia Research Institute at Imperial College London to discuss the critical issue of urinary tract infections (UTIs) in individuals living with dementia. The conversation highlights the complexities of diagnosing UTIs in people living with dementia, where communication barriers and atypical presentations often lead to misdiagnosis and unnecessary hospitalisations. The guests emphasise the urgent need for improved detection methods, as UTIs can exacerbate cognitive decline and lead to severe health complications. They talk about their work to develop and introduce an innovative novel point-of-care diagnostic device designed specifically for dementia patients, which aims to facilitate early detection of UTIs in a home and care home setting, thereby reducing the reliance on traditional symptom reporting and hospital visits. Key takeaways: 🔹UTIs are a major cause of hospital admission and sudden decline in people living with dementia. 🔹Diagnosing UTIs is harder in dementia because symptoms are often not recognised or communicated. 🔹Current testing methods can be slow and sometimes lead to overuse of antibiotics. 🔹New home based rapid testing technology aims to detect infections earlier and closer to where care happens. 🔹Earlier detection could reduce hospital stays and improve quality of life. 🔹Future monitoring of urine biomarkers could help predict infections before symptoms appear. -- A transcript of this show, links and show notes and profile on all our guests are available on our website at https://www.dementiaresearcher.nihr.ac.uk -- Follow us on social media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://www.twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher https://www.bsky.app/profile/dementiare…archer.bsky.social -- Download and Register with our Community App: https://www.onelink.to/dementiaresearcher Chapters 00:00 Introduction to UTIs in Dementia 04:15 The Seriousness of UTIs in Dementia 18:31 Innovative Approaches to UTI Detection 22:00 Engineering a Diagnostic Device for Home Use 27:04 Innovative UTI Detection Technology 29:41 The Vision for Home Testing 31:40 Personal Motivations Behind the Research 34:40 Understanding the Urinary Microbiome 37:53 Designing the UTI Detection Device 44:20 Testing in Clinical Environments 50:57 Barriers to Market Entry 54:03 Community Awareness and Support 58:46 Outro
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    59 m
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