We’re tackling your questions about midlife hormone support. We’ll debunk common myths, unpack the research, and break down the basics of hormone support. We’ll also discuss some of the systemic benefits that may come with taking hormones, as well as important considerations for people with a history of health conditions, like cancer or stroke. Joining Dr. Elizabeth Poynor for this discussion is Atria Health Institute’s Chief Content Officer Siobhan O’Connor.

Links to resources mentioned in this episode:

(00:25:29) - Decoding Happiness in Midlife with Dr. Laurie Santos

(00:27:27) - Decoding Brain Fog with Dr. Caroline Gurvich

(00:48:00) - Decoding Partnership in Midlife with Dr. Richard Shapiro

Vaginal estrogen use in breast cancer survivors: a systematic review and meta-analysis of recurrence and mortality risks

Oral micronized progesterone for perimenopausal night sweats and hot flushes a Phase III Canada-wide randomized placebo-controlled 4 month trial

Systematic review and meta-analysis of the effects of menopause hormone therapy on risk of Alzheimer’s disease and dementia

Menopausal Hormone Therapy and Risk of Endometrial Cancer

Allopregnanolone and Reproductive Psychiatry: An Overview

Adverse Changes in Body Composition During the Menopausal Transition and Relation to Cardiovascular Risk: A Contemporary Review

The role of lifestyle medicine in menopausal health: a review of non-pharmacologic interventions

Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise

ADHD and Sex Hormones in Females: A Systematic Review

The range and variation in serum estradiol concentration in perimenopausal and postmenopausal women treated with transdermal estradiol in a real-world setting: a cross-sectional study

The use of HRT containing transdermal estradiol in women with a personal history of venous or arterial thromboembolism: A consecutive series of 115 cases

Recurrent Uncomplicated Urinary Tract Infections in Women: AUA/CUA/SUFU Guideline (2025)

Note: In this show, we use “women” as shorthand for people with XX chromosomes. We understand sex and gender are more complex, and acknowledge the experiences we describe reach beyond that word.

See omnystudio.com/listener for privacy information.

Leading preventive neurologist Dr. David Dodick joins the show to unpack what alcohol is really doing inside the body. We dive into how it affects the brain, why it’s linked to an increased cancer risk, how it influences the immune system, and what makes alcohol especially impactful for women navigating perimenopause and menopause.

If you’ve ever wondered what alcohol use might mean for your long-term health, this conversation is for you.

Special thanks to Antonia Lyons

Links to resources mentioned in this episode:

Office of the Surgeon General: Alcohol and Cancer Risk

Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission

Women's alcohol use in mid-life: Identifying associations between menopause symptoms, drinking behavior, and mental health

Note: In this show, we use “women” as shorthand for people with XX chromosomes. We understand sex and gender are more complex, and acknowledge the experiences we describe reach beyond that word.

See omnystudio.com/listener for privacy information.

We’ve talked a lot on this show about health issues midlife women face. But what about the other people who often have a front-row seat to these changes, and can play a key supporting role? This week, a conversation about supporting a partner who’s going through menopause—with none other than Elizabeth’s own partner: Dr. Richard Shapiro (who also happens to be a pioneering breast cancer and melanoma researcher and surgeon). They talk about the ways they’ve navigated midlife changes in their relationship, common misconceptions about taking hormones, and impacts menopause can have on relationships, as well as give advice for how both partners and clinicians can better support women experiencing menopause.

Links to resources mentioned in this episode:

(00:01:38) Dr. Elizabeth Poynor on Rich Roll’s podcast

Menopausal Hormone Therapy and the Risk of Breast Cancer in Women with a Pathogenic Variant in BRCA1 or BRCA2

The Menopause Society

8 facts about divorce in the United States

Note: In this show, we use “women” as shorthand for people with XX chromosomes. We understand sex and gender are more complex, and acknowledge the experiences we describe reach beyond that word.

See omnystudio.com/listener for privacy information.

What if psychedelics could transform the way we treat trauma, chronic pain, and insomnia? This week, neuroscientist and psychedelic researcher Grace Blest-Hopley joins the show to break down the research on psychedelics and female biology. She discusses how psychedelics work in the brain, and the ways that psychedelic-assisted therapies might be beneficial for women in midlife.

Links to resources mentioned in this episode:

Hystelica’s resources on psychedelic retreats

The Heroic Hearts Project

Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics

Exploring the Therapeutic Effects of Psychedelics Administered to Military Veterans in Naturalistic Retreat Settings

The acute effects of classic psychedelics on memory in humans

Psilocybin with psychological support for treatment-resistant depression: six-month follow-up

Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression

Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial

Johns Hopkins study on psychedelics and Alzheimer’s

Note: In this show, we use “women” as shorthand for people with XX chromosomes. We understand sex and gender are more complex, and acknowledge the experiences we describe reach beyond that word.

See omnystudio.com/listener for privacy information.

What if we reframed the way we approach exercise? On today’s show, Dr. Elizabeth Poynor is joined by Robert Brace - founder of Brace Life Studios. He’s also Elizabeth’s trainer. They discuss how he tailors his workouts to women in midlife, the benefits of exercising in a group and how movement and exercise connect to our mental and spiritual well-being. Robert also gives advice about how to approach training at different hormonal cycle phases, and ways to get started, even when it feels tough.

Links to resources mentioned in this episode:

Robert Brace’s Studio

Martial arts increase oxytocin production

Systematic review: pain, cognition, and cardioprotection—unpacking oxytocin’s contributions in a sport context

Bidirectional Association between Physical Activity and Dopamine Across Adulthood—A Systematic Review

Embodied mood regulation: the impact of body posture on mood recovery, negative thoughts, and mood-congruent recall

Bone mineral density loss in relation to the final menstrual period in a multiethnic cohort: results from the Study of Women's Health Across the Nation (SWAN)

American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise

Menstrual cycle tracker apps – Natural Cycles, Flo and Apple Health

Exercise platforms/apps – Nike Training, TheBraceLife.com

Note: In this show, we use “women” as shorthand for people with XX chromosomes. We understand sex and gender are more complex, and acknowledge the experiences we describe reach beyond that word.

See omnystudio.com/listener for privacy information.

Midlife can be a period of immense change and, sometimes, challenging emotions. But it’s also an opportunity to cultivate deeper, more lasting happiness. In today’s episode, Dr. Laurie Santos — renowned psychologist, happiness expert, and host of The Happiness Lab — shares insights on how midlife women can thrive. She breaks down the components of happiness, explains why we’re often mistaken about what makes us happy, and provides practical tools and habits to boost wellbeing, manage negative emotions, and navigate burnout.

Links to resources mentioned in this episode:

World Happiness Report

University of Michigan’s Healthy Minds Study

Is happiness U-shaped everywhere? Age and subjective well-being in 145 countries

A Global Flourishing Study Finds That Young Adults, Well, Aren’t

Signature Strengths Test

RAIN: Recognize, Allow, Investigate, Nurture

The Happiness Lab with Dr. Laurie Santos

Note: In this show, we use “women” as shorthand for people with XX chromosomes. We understand sex and gender are more complex, and acknowledge the experiences we describe reach beyond that word.

See omnystudio.com/listener for privacy information.

GLP-1s are everywhere. But are they the only medical weight loss intervention worth considering? On today’s episode, Dr. George Fielding - a pioneer of laparoscopic adjustable band surgery and a patient of the procedure himself - offers an insider’s look at the world of weight loss surgeries. How do these surgeries work? Who are they really for? And how should we think about them alongside the surge of GLP-1 medications? We also dig into the stigmas people face when trying to lose weight with medical support, and the biggest misconceptions around obesity.

Links to resources mentioned in this episode:

Genomics reveals eleven obesity endotypes with distinct biological and phenotypic signatures

Obesity Drugs May Drop to as Little as $149 a Month

The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors

Associations of Hysterectomy, Oophorectomy, and Hormone Replacement Therapy With the Risk of Type 2 Diabetes Mellitus in Postmenopausal Women

Note: In this show, we use “women” as shorthand for people with XX chromosomes. We understand sex and gender are more complex, and acknowledge the experiences we describe reach beyond that word.

See omnystudio.com/listener for privacy information.

Almost two-thirds of people diagnosed with Alzheimer’s are women. Shifting hormones make us especially vulnerable. But what if there were ways to lower your risk? Preventive neurologist Dr. Richard Isaacson believes nearly half of dementia cases can be avoided. He shares how to know if you’re at risk for Alzheimer’s and what steps to take for better long-term brain health.

Links to resources mentioned in this episode:

Individualized clinical management of patients at risk for Alzheimer’s dementia

Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function

A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial

Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission

Clinical Application of APOE in Alzheimer's Prevention: A Precision Medicine Approach

Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition

Association of Reproductive History With Brain MRI Biomarkers of Dementia Risk in Midlife

Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial

evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomatic Alzheimer's disease

Sex-Driven Differences in the Effectiveness of Individualized Clinical Management of Alzheimer's Disease Risk

Sex-driven modifiers of Alzheimer risk: A multimodality brain imaging study

The Institute for Neurodegenerative Diseases (IND)

Retain Your Brain

Note: In this show, we use “women” as shorthand for people with XX chromosomes. We understand sex and gender are more complex, and acknowledge the experiences we describe reach beyond that word.

See omnystudio.com/listener for privacy information.