WHO IS SHALIN SHAH?

Founder, CEO, and visionary behind Marius Pharmaceuticals, the company that brought Kyzatrex to market—the first FDA-approved oral testosterone replacement therapy. With a background in private equity and investing, he moved into biotech to solve a long-standing problem in hormone health: making testosterone therapy more accessible, more practical, and aligned with modern lifestyles—while supporting education, stigma reduction, and better men’s health outcomes.

In this two-part roundtable, the Biohacking Brothers sit down with Shalin Shah to break down why testosterone is a foundational longevity hormone, how Kyzatrex became the first FDA-approved oral testosterone, and what makes oral pulsatile dosing different from traditional injections.

They cover cardiovascular and cognitive implications, stigma and access, fertility concerns, SHBG and free testosterone, estrogen myths, safety markers like hematocrit, and why patient education and proper lab interpretation matter—especially in a world where testosterone levels are declining across younger men.

WHO IS SHALIN SHAH?

Founder, CEO, and visionary behind Marius Pharmaceuticals, the company that brought Kyzatrex to market—the first FDA-approved oral testosterone replacement therapy. With a background in private equity and investing, he moved into biotech to solve a long-standing problem in hormone health: making testosterone therapy more accessible, more practical, and aligned with modern lifestyles—while supporting education, stigma reduction, and better men’s health outcomes.

In this two-part roundtable, the Biohacking Brothers sit down with Shalin Shah to break down why testosterone is a foundational longevity hormone, how Kyzatrex became the first FDA-approved oral testosterone, and what makes oral pulsatile dosing different from traditional injections.

They cover cardiovascular and cognitive implications, stigma and access, fertility concerns, SHBG and free testosterone, estrogen myths, safety markers like hematocrit, and why patient education and proper lab interpretation matter—especially in a world where testosterone levels are declining across younger men.

WHO IS SANDRA KAUFAN, MD?

Dr. Sandra Kaufman is a physician and longevity scientist known for translating complex cellular aging science into practical, personalized health optimization strategies. Trained as an anesthesiologist with over two decades of clinical experience, she also has a background in cell biology—giving her a rare blend of real-world medicine and deep bench-science thinking.

She’s the author of The Kaufman Protocol: Why We Age and How to Stop It, where she introduces a structured longevity framework designed to move beyond generic “take these supplements” advice. Her work focuses on how and why cells decline over time, and how to intervene with evidence-based therapies—organized into what she calls the “Seven Tenets of Aging.” A key feature of her approach is a scoring/rating system that evaluates therapies by the strength of evidence (from theory and lab data to animal models and human outcomes), helping clinicians and patients build a longevity plan that’s more algorithmic and less guesswork.

WHO IS SANDRA KAUFAN, MD?

Dr. Sandra Kaufman is a physician and longevity scientist known for translating complex cellular aging science into practical, personalized health optimization strategies. Trained as an anesthesiologist with over two decades of clinical experience, she also has a background in cell biology—giving her a rare blend of real-world medicine and deep bench-science thinking.

She’s the author of The Kaufman Protocol: Why We Age and How to Stop It, where she introduces a structured longevity framework designed to move beyond generic “take these supplements” advice. Her work focuses on how and why cells decline over time, and how to intervene with evidence-based therapies—organized into what she calls the “Seven Tenets of Aging.” A key feature of her approach is a scoring/rating system that evaluates therapies by the strength of evidence (from theory and lab data to animal models and human outcomes), helping clinicians and patients build a longevity plan that’s more algorithmic and less guesswork.

WHO IS SANDRA KAUFANN, MD?

Dr. Sandra Kaufman is a physician and longevity scientist known for translating complex cellular aging science into practical, personalized health optimization strategies. Trained as an anesthesiologist with over two decades of clinical experience, she also has a background in cell biology—giving her a rare blend of real-world medicine and deep bench-science thinking.

She’s the author of "The Kaufman Protocol: Why We Age and How to Stop It", where she introduces a structured longevity framework designed to move beyond generic “take these supplements” advice. Her work focuses on how and why cells decline over time, and how to intervene with evidence-based therapies—organized into what she calls the “Seven Tenets of Aging.” A key feature of her approach is a scoring/rating system that evaluates therapies by the strength of evidence (from theory and lab data to animal models and human outcomes), helping clinicians and patients build a longevity plan that’s more algorithmic and less guesswork.

WHO IS TYLER LEBARON MSc, PhD

Founder and executive director of the Molecular Hydrogen Institute (MHI), and one of the world’s leading authorities on molecular hydrogen science. With a background in biochemistry, physiology, and mitochondrial biology, Tyler has dedicated his career to researching how hydrogen impacts oxidative stress, inflammation, cellular signaling, and longevity. His work includes collaborations with top Japanese research labs, contributions to over 3,000 peer-reviewed publications in the field, and leadership in advancing hydrogen therapy as a credible, evidence-based tool for health optimization.

Today, Tyler is recognized internationally as a key figure in molecular medicine, educating clinicians, scientists, and biohackers on how hydrogen can improve cellular resilience, recovery, and long-term human performance.

This time will be exploring how molecular hydrogen impacts deeper longevity pathways—stem cell resilience, inflammation balance, mitochondrial repair, and gene expression. Tyler explains why hydrogen supports recovery without blocking gains, how it activates NRF2 and other longevity pathways, and how dosing really works across tablets, bottles, and inhalation. You’ll also hear where hydrogen research is heading globally, including medical device approvals in Asia and major clinical trials. This final episode reveals why hydrogen is poised to become a cornerstone of personalized longevity medicine.

WHO IS TYLER LEBARON MSc, PhD

Founder and executive director of the Molecular Hydrogen Institute (MHI), and one of the world’s leading authorities on molecular hydrogen science. With a background in biochemistry, physiology, and mitochondrial biology, Tyler has dedicated his career to researching how hydrogen impacts oxidative stress, inflammation, cellular signaling, and longevity. His work includes collaborations with top Japanese research labs, contributions to over 3,000 peer-reviewed publications in the field, and leadership in advancing hydrogen therapy as a credible, evidence-based tool for health optimization.

Today, Tyler is recognized internationally as a key figure in molecular medicine, educating clinicians, scientists, and biohackers on how hydrogen can improve cellular resilience, recovery, and long-term human performance.

Tyler explains the sleep-deprivation study where hydrogen matched caffeine’s performance boost—without overstimulation. You’ll learn why hydrogen doesn’t overload the system, how it protects NAD+, the truth about hydrogen bottles vs tablets, and why selective antioxidant activity matters for recovery, stress resilience, and aging. This episode clarifies hydrogen’s real role inside the mitochondria and why it enhances—rather than blunts—your body’s adaptive responses.

WHO IS TYLER LEBARON MSc, PhD

Founder and executive director of the Molecular Hydrogen Institute (MHI), and one of the world’s leading authorities on molecular hydrogen science. With a background in biochemistry, physiology, and mitochondrial biology, Tyler has dedicated his career to researching how hydrogen impacts oxidative stress, inflammation, cellular signaling, and longevity. His work includes collaborations with top Japanese research labs, contributions to over 3,000 peer-reviewed publications in the field, and leadership in advancing hydrogen therapy as a credible, evidence-based tool for health optimization.

Today, Tyler is recognized internationally as a key figure in molecular medicine, educating clinicians, scientists, and biohackers on how hydrogen can improve cellular resilience, recovery, and long-term human performance.

In this episode we will be exploring how molecular hydrogen boosts cellular resilience, optimizes mitochondrial function, and enhances energy, recovery, and longevity.