In the final section, Preston travels to Africa to explore Kitum Cave, the suspected origin point of these viruses. He dons a protective suit to enter the cave, searching for clues about the natural reservoir of Ebola. The book concludes with Preston visiting the abandoned Reston facility, reflecting on the ongoing threat of emerging viruses and predicting that Ebola will inevitably return.

Themes

• Threat of emerging infectious diseases

• Contrast between nature's power and human vulnerability

• Heroism and dedication of medical professionals

• Tension between scientific pursuit and public safety

• Global interconnectedness and disease spread

• Ethical dilemmas in disease control and research

• Human impact on ecosystems and consequences

Setting

The events described in The Hot Zone primarily take place in the late 1980s and early 1990s, a time when emerging infectious diseases were becoming a growing concern for public health officials. The book spans multiple geographical areas, with a focus on Central Africa and the United States.

Much of the narrative unfolds in the dense rainforests of Central Africa, particularly around Mount Elgon and Kitum Cave in Kenya. These remote locations serve as the backdrop for the origins and early outbreaks of deadly viruses like Ebola and Marburg. The book vividly depicts the harsh and unforgiving environment of the African wilderness, where these lethal pathogens lurk.

The story then shifts dramatically to the suburbs of Washington, D.C., specifically to Reston, Virginia. Here, in a primate quarantine facility less than 15 miles from the nation's capital, a relative of the Ebola virus is discovered. This juxtaposition of the exotic dangers of the African rainforest with the seemingly safe confines of suburban America creates a chilling sense of how close these deadly viruses can come to populated areas.

Key Figures

• Nancy Jaax: A veterinary pathologist and U.S. Army officer. She works at the United States Army Medical Research Institute of Infectious Diseases (USAMRIID) studying Ebola and other deadly viruses. Nancy is dedicated to her work and family, navigating the challenges of a high-risk career while raising children. She plays a key role in the Reston incident, working to contain the potential outbreak.

• Jerry Jaax: Nancy's husband and fellow Army officer. He supports Nancy in her work and helps coordinate the military response to the Reston incident. Jerry is level-headed and pragmatic, providing a steady presence during tense situations.

• Peter Jahrling: A virologist at USAMRIID who identifies the Reston virus. He accidentally exposes himself to the virus, leading to a tense period of uncertainty about his health. Jahrling's expertise and quick thinking are crucial in understanding and containing the outbreak.

• Gene Johnson: A civilian virus hunter who has extensive experience with Ebola outbreaks in Africa. He serves as a consultant during the Reston incident, providing valuable insights into the nature of filoviruses. Johnson's knowledge and caution help guide the team's approach to the outbreak.

• Charles Monet: A French expatriate in Kenya who becomes infected with the Marburg virus after visiting Kitum Cave. His gruesome deterioration and death in a Nairobi hospital provide a chilling introduction to the horrors of filovirus infections.

• Dan Dalgard: The veterinarian responsible for the monkey facility in Reston, Virginia. He first notices the strange deaths among the monkeys and alerts authorities, initiating the response to the outbreak.

• Thomas Geisbert: A young researcher at USAMRIID who first observes the Ebola-like virus under an electron microscope. His discovery is crucial in identifying the nature of the Reston virus.

• Colonel C.J. Peters: The chief of the disease assessment division at USAMRIID. He oversees the military's response to the Reston incident and coordinates with civilian authorities.

Quick facts

• The book was based on Preston's 1992 New Yorker article titled “Crisis in the Hot Zone".

• Horror writer Stephen King called the first chapter “one of the most horrifying things I've read in my whole life".

• The book was listed as one of around 100 books that shaped a century of science by American Scientist magazine.

• It sparked increased public interest and concern about emerging viruses and biodefense.

• The book's depiction of Ebola's effects has been criticized by some scientists as exaggerated.

• A film adaptation was planned in the 1990s with Robert Redford and Jodie Foster, but it fell through.

• The competing film Outbreak (1995) was hastily produced in response to Fox's planned adaptation of The Hot Zone.

• The book was eventually adapted into a television series for National Geographic in 2019.

• Preston visited the actual Kitum Cave in Africa while researching for the book.

• The Reston virus outbreak described in the book occurred just 15 miles from Washington D.C.

About the Author

Richard Preston is a renowned American writer and journalist, best known for his gripping non-fiction works on infectious diseases and bioterrorism. Born in 1954 in Cambridge, Massachusetts, Preston's educational journey took him from Wellesley High School to Pomona College, culminating in a Ph.D. in English from Princeton University in 1983.

Preston's breakout book, The Hot Zone (1994), catapulted him to literary stardom. This “non-fiction thriller” about ebolaviruses stemmed from his firsthand experiences in Africa and collaborations with U.S. Army researchers. His ability to blend meticulous research with compelling storytelling has become his trademark, earning him a loyal readership and critical acclaim.

Throughout his career, Preston has tackled a diverse range of subjects, from the eradication of smallpox in The Demon in the Freezer to the world of recreational tree climbing in The Wild Trees. His work has not only entertained but also informed and influenced. Notably, his novel The Cobra Event (1998) about a bioterror attack on New York City prompted then-President Bill Clinton to initiate a review of bio-terror threats to the United States.

A regular contributor to The New Yorker since 1985, Preston has received numerous accolades, including the Centers for Disease Control's Champion of Prevention Award - the only non-doctor to receive this honor. He resides in Hopewell, New Jersey, with his family, continuing to produce works that bridge the gap between scientific knowledge and public understanding.