Inspired by a true story, Mamas' Drama takes place from 1929 to 2004. It shares four generations' experiences as they move through the "mama's baby, daddy's maybe" condition (when the identity of the father is questionable). This story begins in Harriman, Tennessee, when Josephine Stewart is an innocent eight-year-old. Josephine cherishes her daddy, Thomas Sr. Her mama, Millie, reveals to her that Thomas is not her biological father, as she was born from Millie's extramarital affair with the mayor of the small town.