New York, 1993. Alice Culvert is a caring wife, a doting new mother, a loyal friend, and a soulful artist - a fashion designer who wears a baby carrier and haute couture with equal aplomb. In their loft in Manhattan's gritty Meatpacking District, Alice and her husband, Oliver, are raising their infant daughter, Doe, delighting in the wonders of early parenthood. Their life together feels so vital and full of promise, which makes Alice's sudden cancer diagnosis especially staggering.
One Saturday night in Las Vegas, 12-year-old Newell Ewing goes out with a friend and doesn't come home. In the aftermath of his disappearance, his mother, Lorraine, makes daily pilgrimages to her son's room and tortures herself with memories. Equally distraught, the boy's father, Lincoln, finds himself wanting to comfort his wife even as he yearns for solace, a loving touch, any kind of intimacy.