A gripping journey of discovery, The Catalyst moves from the early experiments that first hinted at RNA's spectacular powers, to Cech's own paradigm-shifting finding that it can catalyze cellular reactions, to the cutting-edge biotechnologies poised to reshape our health.

The knowledge of death is so terrifying that we live most of our lives in denial of it. One of the most difficult moments of childhood must be when each of us first realizes that not only we but all our loved ones will die—and there is nothing we can do about it. Or at least, there hasn’t been. Today, we are living through a revolution in biology. Giant strides are being made in understanding why we age—and why some species live longer than others. Could we eventually cheat disease and death and live for a very long time, possibly many times our current lifespan?

Epigenetics is the science of living DNA, charting the chemical pathways that spur DNA into action by turning genes on and off. While the Human Genome Project of the early 2000s was hailed as the key to understanding human heredity and disease, that historic effort was just the beginning. It has taken epigenetics to fill in the picture, explaining how the fixed code of our genome is implemented in countless living processes.

Beginning with opium, the “joy plant,” which has been used for 10,000 years, Thomas Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.

For Blood and Money tells the little-known story of how an upstart biotechnology company created a one-in-a-million cancer drug and how the core team—denied their share of the profits—went and did it again. In this epic saga of money and science, veteran financial journalist Nathan Vardi explains how the invention of two of the biggest cancer drugs in history became (for their backers) two of the greatest Wall Street bets of all time.

It used to be that ravaging another country’s economy required blockading its ports and laying siege to its cities. Now all it takes is a statement posted online by the U.S. government. In Chokepoints, Edward Fishman, a former top State Department sanctions official, takes us deep into the back rooms of power to reveal the untold history of the last two decades of U.S. foreign policy, in which America renounced the gospel of globalization and waged a new kind of economic war.

In Waves in an Impossible Sea, physicist Matt Strassler tells a startling tale of elementary particles, human experience, and empty space. He begins with a simple mystery of motion. When we drive at highway speeds with the windows down, the wind beats against our faces. Yet our planet hurtles through the cosmos at 150 miles per second, and we feel nothing of it. How can our voyage be so tranquil when, as Einstein discovered, matter warps space, and space deflects matter? The answer, Strassler reveals, is that empty space is a sea, albeit a paradoxically strange one.

What is life? This is among the most difficult open problems in science, right up there with the nature of consciousness and the existence of matter. All the definitions we have fall short. None help us understand how life originates or the full range of possibilities for what life on other planets might look like. In Life as No One Knows It, physicist and astrobiologist Sara Imari Walker argues that solving the origin of life requires radical new thinking and an experimentally testable theory for what life is.

Conflict is increasing everywhere, threatening everything we hold dear—from our families to our democracy, from our workplaces to our world. In nearly every area of society, we are fighting more and collaborating less, especially over crucial problems that demand solutions. With this groundbreaking book, bestselling author and international negotiator William Ury shares a new “path to possible”—time-tested practices that will help listeners unlock their power to constructively engage and transform conflict.

The hunt for the holy grail of healthy aging has been ongoing for hundreds of years, and Dr. Stephanie Venn-Watson may be its most unlikely champion. As a veterinary epidemiologist, she was recruited by the US Navy to lead a clinical research program to improve the health of Navy dolphins. Using advanced biotechnology to study the healthiest aging dolphins, she discovered C15:0, a saturated fat which has the potential to expand both the health-span and lifespan in long-lived mammals.

The Earth teems with life: in its oceans, forests, skies, and cities. Yet there's a black hole at the heart of biology. We do not know why complex life is the way it is, or, for that matter, how life first began. In The Vital Question, award-winning author and biochemist Nick Lane radically reframes evolutionary history, putting forward a solution to conundrums that have puzzled generations of scientists.

Whether it's absent-minded mistakes at work, a weakness for junk food, a smartphone addiction, or a lack of exercise, everyone has some bad habit or behavior that they'd like to change. But wanting to change and actually doing it - and sticking with it - are two very different things. Dr. Sean Young, an authoritative new voice in the field of behavioral science, knows a great deal about our habits - how we make them and how we can break them.

Vince Beiser explores the Achilles’ heel of “green power” and digital technology–that manufacturing computers, cell phones, electric cars, and other technologies demand skyrocketing amounts of lithium, copper, cobalt, and other materials. Around the world, businesses and governments are scrambling for new places and new ways to get those metals, at enormous cost to people and the planet. Beiser crisscrossed the world to talk to the people involved and report on the damage this race is inflicting, the ways it could get worse, and how we can minimize the damage.

Economic sanctions dominate the landscape of world politics today. First developed in the early twentieth century as a way of exploiting the flows of globalization to defend liberal internationalism, their appeal is that they function as an alternative to war. This view, however, ignores the dark paradox at their core: designed to prevent war, economic sanctions are modeled on devastating techniques of warfare.

How does a neural network become a brain? While neurobiologists investigate how nature accomplishes this feat, computer scientists interested in AI strive to achieve this through technology. The Self-Assembling Brain tells the stories of both fields, exploring the historical and modern approaches taken by the scientists pursuing answers to the quandary: What information is necessary to make an intelligent neural network? As Peter Robin Hiesinger argues, "the information problem" underlies both fields.