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The Family That Couldn't Sleep Audiobook

The Family That Couldn't Sleep: A Medical Mystery

For 200 years, a noble Venetian family has suffered from an inherited disease that strikes their members in middle age, stealing their sleep, eating holes in their brains, and ending their lives in a matter of months. In Papua New Guinea, a primitive tribe is nearly obliterated by a sickness whose chief symptom is uncontrollable laughter. Across Europe, millions of sheep rub their fleeces raw before collapsing. What these strange conditions share is their cause: prions.
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Publisher's Summary

For 200 years, a noble Venetian family has suffered from an inherited disease that strikes their members in middle age, stealing their sleep, eating holes in their brains, and ending their lives in a matter of months. In Papua New Guinea, a primitive tribe is nearly obliterated by a sickness whose chief symptom is uncontrollable laughter. Across Europe, millions of sheep rub their fleeces raw before collapsing. In England, cows attack their owners in the milking parlors, while in the American West, thousands of deer starve to death in fields full of grass.

What these strange conditions, including fatal familial insomnia, kuru, scrapie, and mad cow disease, share is their cause: prions. Prions are ordinary proteins that sometimes "go wrong", resulting in neurological illnesses that are always fatal. Even more mysterious and frightening, prions are almost impossible to destroy because they are not alive and have no DNA. And the diseases they bring are now spreading around the world.

In The Family That Couldn't Sleep, essayist and journalist D. T. Max tells the spellbinding story of the prion's hidden past and deadly future. Through exclusive interviews and original archival research, Max explains this story's connection to human greed and ambition, from the Prussian chemist Justus von Liebig, who made cattle meatier by feeding them the flesh of other cows, to New Guinean natives whose custom of eating the brains of the dead nearly wiped them out.

The biologists who have investigated these afflictions are just as extraordinary. They include Daniel Carleton Gajdusek, a self-described "pedagogic pedophiliac pediatrician" who cracked kuru and won the Nobel Prize, and another Nobel winner, Stanley Prusiner, a driven, feared self-promoter who identified the key protein that revolutionized prion study.

©2006 D.T. Max; (P)2006 Tantor Media, Inc.

What the Critics Say

"Very timely and compellingly written." (Booklist)

What Members Say

Average Customer Rating

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Performance
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  •  
    David Ithaca, NY, USA 11-04-06
    David Ithaca, NY, USA 11-04-06 Member Since 2015
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    "A great scientific mystery"

    This has become one of my favorite non-fiction books on audible. If you enjoyed "Splendid Solution", "The Great Influenza" or "Germs" you will love this one. It may not have the humor or entertainment value of "The Omnivore's Delimma" but the author does a fine job of weaving personal stories with science to create a fascinating story. This is a great introduction to Mad Cow and other prion diseases, and also provides a distrubing account of how governments bumble their way through such outbreaks.

    Grover Gardner also performs another excellent reading. In my opinion, Gardner is by far the top narrator for any material that has any scientific or technical content. His voice moves gracefully over the text - always with the right nuance and pronunciation - allowing the listener to become quite captivated by the story.

    12 of 13 people found this review helpful
  •  
    Bibi Eagle River, AK, United States 03-24-10
    Bibi Eagle River, AK, United States 03-24-10 Member Since 2014
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    "Very entertaining and enlightening"

    Wonderfully written account of prions: the diseases associated with them; the nobel laureates who study them; people affected; and how the problem began, was discovered, and has spread. Like a PBS special and a novel rolled into one, you learn quite a bit while being thoroughly entertained. A page turner.

    4 of 4 people found this review helpful
  •  
    Jennifer Hudson, WI, United States 05-27-09
    Jennifer Hudson, WI, United States 05-27-09 Member Since 2011
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    "Quite informative"

    I know others have put down this book because it isn't just about the life of the family that couldn't sleep. True, it is a book about prions, and tells of all of the research in many fields and into many disorders. But, scientific though it is, it really is facinating and quite easy to follow along with and understand. The reader does have a bit of an annoying habit of ending every sentence the same way with a strange inflection, but you'll get used to it, or at least learn to ignore it.

    2 of 2 people found this review helpful
  •  
    Teri United States 08-31-07
    Teri United States 08-31-07 Member Since 2015

    I'm an obsessive reader of science fiction, psychological thrillers, and anything that might distract me from the misery that is exercise.

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    "A pleasure to hear"

    This book is a wonderful piece for people interested in the medical field. It offers a wonderfully accessible explanation of prion diseases combined with a human touch and a fabulous narrator voice. Highly recommended!

    5 of 6 people found this review helpful
  •  
    julie 11-03-13
    julie 11-03-13

    julie and the kids

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    "a fatal insomnia"
    Where does The Family That Couldn't Sleep rank among all the audiobooks you’ve listened to so far?

    among the top books i have listened to on audible


    What other book might you compare The Family That Couldn't Sleep to and why?

    epigenetics


    What about Grover Gardner’s performance did you like?

    well researched, up to date, and narratives that bring you to understand the lives affected by those afflicted with prion disease.


    If you were to make a film of this book, what would the tag line be?

    a fatal insomnia


    Any additional comments?

    a unique historical perspective on a rare inherited genetic disorder that strikes its victims with symptoms of a lethal insomnia in their most productive years. Also, tied into this narrative of the familial disease, is its link to the prion disease of mad cow, or CJD. The research documented by D.T. Max, brings to light cases of individuals affected by CJD that has occurred in the U.S. and the U.K. which can only be explained prions from contaminated beef. That the threat still exists, and human cases are being suppressed by the USDA, should make anyone concerned about the potential impact of circulating prions in our beef supply.

    1 of 1 people found this review helpful
  •  
    Pam James Lawrence, KS United States 08-24-13
    Pam James Lawrence, KS United States 08-24-13 Member Since 2013
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    "Prion Drama"

    It is surprising how fascinating a medical mystery can be. I was hanging on every word. I was terrified, but still could not stop listening.

    1 of 1 people found this review helpful
  •  
    Mary 06-09-12
    Mary 06-09-12 Member Since 2011
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    "Zombie science"

    I picked this right after starting the short-story anthology Zombies vs. Unicorns (zombie fiction sometimes blames prions) on Kindle. Fun connection. As to this book, it was a great story, interesting science, kept a good pace, and gave me pause (yet again) about eating factory-farm meat...

    1 of 1 people found this review helpful
  •  
    Douglas Auburn, WA, United States 08-29-09
    Douglas Auburn, WA, United States 08-29-09 Member Since 2008

    College English professor who loves classic literature, psychology, neurology and hates pop trash like Twilight and Fifty Shades of Grey.

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    "Fascinating"

    look into the frightening world or prion diseases.

    1 of 1 people found this review helpful
  •  
    Tammy Portsmouth, RI, USA 03-02-07
    Tammy Portsmouth, RI, USA 03-02-07
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    "Great book"

    Any one with a family member with a disability that is neurological in origin will appreciate this book. The author's final chapter says it all. Great narrator.

    4 of 6 people found this review helpful
  •  
    Matthew 10-20-15
    Matthew 10-20-15
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    "Yawn...!"

    I wouldn't say this was a terrible book. I would say it was a mediocre book. It was essentially a medical textbook and it read like one. I usually enjoy books about these subjects, but there was something about this book that I just can’t put my finger on that leaves me with this "it's just average" feeling. Yes, I did learn something, which I always enjoy, but you certainly need to pay attention to every single sentence in this book or you will be totally lost. It was very heavy on the science, but not so much that anyone with a decent public education couldn’t absorb. I usually find myself searching online while listening to books like this to learn even more about the subject, but this book just didn’t evoke that kind of interest for me.

    The only saving grace is the narration. I think that is the only thing that kept me from returning the book at the halfway point. Grover Gardner made it worth holding out to the end; he’s just that good! I'm debating if I'll listen to this book again to see if my opinion changes?

    Ironically, this book has discovered the cure for the Family That Couldn’t Sleep; they just need to listen to this book. Put me to sleep in about 10 minutes every night.

    0 of 0 people found this review helpful

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