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The Emperor of All Maladies reveals the many faces of an iconic, shape-shifting disease that is the defining plague of our generation. The story of cancer is a story of human ingenuity, resilience, and perseverance but also of hubris, arrogance, paternalism, and misperception, all leveraged against a disease that, just three decades ago, was thought to be easily vanquished in an all-out "war against cancer".

From the author of The Emperor of All Maladies, winner of the Pulitzer Prize, and The Gene, a #1 New York Times bestseller, comes his most spectacular book yet, an exploration of medicine and our radical new ability to manipulate cells. Rich with Mukherjee’s revelatory and exhilarating stories of scientists, doctors, and the patients whose lives may be saved by their work, The Song of the Cell is the third book in this extraordinary writer’s exploration of what it means to be human.

The bestselling author of Leonardo da Vinci and Steve Jobs returns with a “compelling” (The Washington Post) account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.

Brimming with fascinating historical details and modern medical wonders, this important audiobook is a fascinating glimpse into the struggles and "eureka!" moments that people outside of the medical profession rarely see. Written with Dr. Mukherjee's signature eloquence and passionate prose, The Laws of Medicine is a critical book not just for those in the medical profession but for everyone who is moved to better understand how their health and well-being are being treated.

Joining the ranks of popular science classics like The Botany of Desire and The Selfish Gene, a groundbreaking, wondrously informative, and vastly entertaining examination of the most significant revolution in biology since Darwin - a "microbe's-eye view" of the world that reveals a marvelous, radically reconceived picture of life on Earth.

Epigenetics can potentially revolutionize our understanding of the structure and behavior of biological life on Earth. It explains why mapping an organism's genetic code is not enough to determine how it develops or acts and shows how nurture combines with nature to engineer biological diversity. Surveying the 20-year history of the field while also highlighting its latest findings and innovations, this volume provides a readily understandable introduction to the foundations of epigenetics.

In the mid-1970s, scientists began using DNA sequences to reexamine the history of all life. Perhaps the most startling discovery to come out of this new field is horizontal gene transfer (HGT), or the movement of genes across species lines. For instance, we now know that roughly eight percent of the human genome arrived not through traditional inheritance from directly ancestral forms, but sideways by viral infection - a type of HGT. In The Tangled Tree David Quammen chronicles these discoveries through the lives of the researchers who made them.

Arguably the most significant scientific discovery of the new century, the mapping of the 23 pairs of chromosomes that make up the human genome raises almost as many questions as it answers - questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest of your life. Matt Ridley here probes the scientific, philosophical, and moral issues arising as a result of the mapping of the genome.

She Has Her Mother's Laugh presents a profoundly original perspective on what we pass along from generation to generation. Charles Darwin played a crucial part in turning heredity into a scientific question, and yet he failed spectacularly to answer it. The birth of genetics in the early 1900s seemed to do precisely that. Gradually, people translated their old notions about heredity into a language of genes. We need a new definition of what heredity is and, through Carl Zimmer's lucid exposition and storytelling, this resounding tour de force delivers it.

The Earth teems with life: in its oceans, forests, skies, and cities. Yet there's a black hole at the heart of biology. We do not know why complex life is the way it is, or, for that matter, how life first began. In The Vital Question, award-winning author and biochemist Nick Lane radically reframes evolutionary history, putting forward a solution to conundrums that have puzzled generations of scientists.

Millions of words of scholarship have been expended on the world's most famous author and his work. And yet a critical part of the puzzle, Shakespeare's library, is a mystery. For four centuries people have searched for it: in mansions, palaces, and libraries; in riverbeds, sheep pens, and partridge coops; and in the corridors of the mind. Yet no trace of the Bard's manuscripts, books, or letters has ever been found.

Growth has been both an unspoken and an explicit aim of our individual and collective striving. It governs the lives of microorganisms and galaxies; it shapes the capabilities of our extraordinarily large brains and the fortunes of our economies. Growth is manifested in annual increments of continental crust, a rising gross domestic product, a child's growth chart, the spread of cancerous cells. In this magisterial book, Vaclav Smil offers systematic investigation of growth in nature and society, from tiny organisms to the trajectories of empires and civilizations.

Leonardo da Vinci created the two most famous paintings in history, The Last Supper and the Mona Lisa. But in his own mind, he was just as much a man of science and engineering. With a passion that sometimes became obsessive, he pursued innovative studies of anatomy, fossils, birds, the heart, flying machines, botany, geology, and weaponry.

Jonathan Weiner, winner of the Pulitzer Prize for The Beak of the Finch, brings his brilliant reporting skills to the story of Seymour Benzer, the Brooklyn-born maverick scientist whose study of genetics and experiments with fruit fly genes has helped revolutionize or knowledge of the connections between DNA and behavior both animal and human.

Should everyone have privacy in their personal lives? Can privacy exist in a public place? Is there a right to be left alone even in the United States? You may be startled to realize that the original framers were sensitive to the importance of privacy interests relating to sexuality and intimate life, but mostly just for powerful and privileged (and usually White) men.

Robert Sapolsky’s Behave, his now classic account of why humans do good and why they do bad, pointed toward an unsettling conclusion: We may not grasp the precise marriage of nature and nurture that creates the physics and chemistry at the base of human behavior, but that doesn’t mean it doesn’t exist. Now, in Determined, Sapolsky takes his argument all the way, mounting a brilliant (and in his inimitable way, delightful) full-frontal assault on the pleasant fantasy that there is some separate self telling our biology what to do.

From the celebrated neurobiologist and primatologist, a landmark, genre-defining examination of human behavior, both good and bad, and an answer to the question: Why do we do the things we do? Sapolsky's storytelling concept is delightful but it also has a powerful intrinsic logic: He starts by looking at the factors that bear on a person's reaction in the precise moment a behavior occurs, and then hops back in time from there, in stages, ultimately ending up at the deep history of our species and its evolutionary legacy.

Dr. Steven R. Gundry, the New York Times bestselling author of the groundbreaking Plant Paradox series, shares compelling evidence that our gut microbiome is driving our thoughts, feelings, behaviors, and our mental, emotional, and neuronal health—and shows us how to heal our microbiomes to take back control of our minds.

You wake up and feel a tickle in your throat. Your head hurts. You’re mildly annoyed as you get the kids ready for school and dress for work yourself. Meanwhile, an epic war is being fought, just below your skin. Millions are fighting and dying for you to be able to complain as you head out the door. So what, exactly, is your immune system? In Immune, Philipp Dettmer, the brains behind the most popular science channel on YouTube, takes listeners on a journey through the fortress of the human body and its defenses.

Combining the best current medical knowledge with a new approach grounded in integrative medicine, Chopra and Tanzi offer a groundbreaking new model of healing and the healing system, one of the main mysteries in the mind-body connection. The Healing Self is a breakthrough audiobook in self-care for a wide audience. Immunity - the body's ability to ward off disease - can no longer be taken for granted.

We are living through the most prosperous age in all of human history, yet we are listless, divided, and miserable. Wealth and comfort are unparalleled, but our political landscape is unmoored, and rates of suicide, lone­liness, and chronic illness continue to skyrocket. How do we explain the gap between these truths? And how should we respond? For evolutionary biologists Heather Heying and Bret Weinstein, the cause of our troubles is clear: The accelerat­ing rate of change in the modern world has outstripped the capacity of our brains and bodies to adapt.

Living at the limits of our ordinary perception, mosses are a common but largely unnoticed element of the natural world. Gathering Moss is a beautifully written mix of science and personal reflection that invites listeners to explore and learn from the elegantly simple lives of mosses.

Sy Montgomery's popular 2011 Orion magazine piece, "Deep Intellect", about her friendship with a sensitive, sweet-natured octopus named Athena and the grief she felt at her death, went viral, indicating the widespread fascination with these mysterious, almost alien-like creatures. Since then Sy has practiced true immersion journalism, from New England aquarium tanks to the reefs of French Polynesia and the Gulf of Mexico, pursuing these wild, solitary shape-shifters.

Why do women live longer than men? Why do women have menopause? Why are women more likely to get Alzheimer’s? Why do girls score better at every academic subject than boys until puberty, when suddenly their scores plummet? And does the female brain really exist? In Eve, Cat Bohannon answers questions scientists should have been addressing for decades. With boundless curiosity and sharp wit, she covers the past 200 million years to explain the specific science behind the development of the female sex.

Joining the ranks of popular science classics like The Botany of Desire and The Selfish Gene, a groundbreaking, wondrously informative, and vastly entertaining examination of the most significant revolution in biology since Darwin - a "microbe's-eye view" of the world that reveals a marvelous, radically reconceived picture of life on Earth.

Dame Sue Black is an internationally renowned forensic anthropologist and human anatomist. She has lived her life eye to eye with the Grim Reaper, and she writes vividly about it in this book, which is part primer on the basics of identifying human remains, part frank memoir of a woman whose first paying job as a schoolgirl was to apprentice in a butcher shop, and part no-nonsense but deeply humane introduction to the reality of death in our lives. It is a treat for CSI junkies, murder mystery and thriller fans, and anyone seeking a clear-eyed guide to a subject that touches us all.

We may believe that we are the masters of our fates, but in reality, we are at the mercy of hundreds of trillions of single-celled organisms that exert control over every aspect of how our minds and bodies function. These are the diverse species of microbes that work together synergistically to communicate with each other and with every system in our bodies. You are your microbiome’s home, and it wants to take care of you, but first you have to protect it. In Gut Check, Dr. Steven Gundry reveals the emerging science proving that Hippocrates was right—all disease begins in the gut.

Aging - not cancer, not heart disease - is the underlying cause of most human death and suffering. The same cascade of biological changes that renders us wrinkled and gray also opens the door to dementia and disease. We work furiously to conquer each individual disease, but we never think to ask: Is aging itself necessary? Nature tells us it is not: There are tortoises and salamanders who are spry into old age and whose risk of dying is the same no matter how old they are.

For decades Richard Dawkins has been the world's most brilliant scientific communicator, consistently illuminating the wonders of nature and attacking faulty logic. Science in the Soul brings together 42 essays, polemics, and paeans - culled from personal papers, newspapers, lectures, and online salons - all written with Dawkins' characteristic erudition, remorseless wit, and unjaded awe of the natural world.

In Mitochondria and the Future of Medicine, naturopathic doctor Lee Know tells the epic story of mitochondria - the widely misunderstood and often-overlooked powerhouses of our cells. The legendary saga began over two billion years ago, when one bacterium entered another without being digested, which would evolve to create the first mitochondrion. Since then, for life to exist beyond single-celled bacteria, it's the mitochondria that have been responsible for this life-giving energy.

The Blind Watchmaker, knowledgably narrated by author Richard Dawkins, is as prescient and timely a book as ever. The watchmaker belongs to the 18th-century theologian William Paley, who argued that just as a watch is too complicated and functional to have sprung into existence by accident, so too must all living things, with their far greater complexity, be purposefully designed. Charles Darwin's brilliant discovery challenged the creationist arguments; but only Richard Dawkins could have written this elegant riposte.

Don and Mimi Galvin seemed to be living the American dream. After World War II, Don's work with the Air Force brought them to Colorado, where their 12 children perfectly spanned the baby boom: the oldest born in 1945, the youngest in 1965. In those years, there was an established script for a family like the Galvins—aspiration, hard work, upward mobility, domestic harmony. But behind the scenes was a different story: psychological breakdown, sudden shocking violence, hidden abuse. By the mid-1970s, six of the 10 Galvin boys, one after another, were diagnosed as schizophrenic.

For over three decades, Ray Kurzweil has been one of the most respected and provocative advocates of the role of technology in our future. In his classic The Age of Spiritual Machines, he argued that computers would soon rival the full range of human intelligence at its best. Now he examines the next step in this inexorable evolutionary process: The union of human and machine, in which the knowledge and skills embedded in our brains will be combined with the vastly greater capacity, speed, and knowledge-sharing ability of our creations.

Coyote America is both an environmental and a deep natural history of the coyote. It traces both the five-million-year-long biological story of an animal that has become the "wolf" in our backyards and its cultural evolution from a preeminent spot in Native American religions to the hapless foil of the Road Runner. A deeply American tale, the story of the coyote in the American West and beyond is a sort of Manifest Destiny in reverse.

Deep is a voyage from the ocean's surface to its darkest trenches, the most mysterious places on Earth. Fascinated by the sport of freediving - in which competitors descend to great depths on a single breath - James Nestor embeds with a gang of oceangoing extreme athletes and renegade researchers. He finds whales that communicate with other whales hundreds of miles away, sharks that swim in unerringly straight lines through pitch-black waters, and other strange phenomena.

Hay fever. Peanut allergies. Eczema. Either you have an allergy or you know someone who does. Billions of people worldwide—an estimated 30 to 40 percent of the global population—have some form of allergy. Even more concerning, over the last decade the number of people diagnosed with an allergy has been steadily increasing, placing an ever-growing medical burden on individuals, families, communities, and healthcare systems. Medical anthropologist Theresa MacPhail, herself an allergy sufferer whose father died of a bee sting, set out to understand why.

In his articles and in best-selling books such as The Botany of Desire, Michael Pollan has established himself as one of our most important and beloved writers on modern man's place in the natural world. A new literary classic, Second Nature has become a manifesto not just for gardeners but for environmentalists everywhere.

We human beings share 98 percent of our genes with chimpanzees. Yet humans are the dominant species on the planet - having founded civilizations and religions, developed intricate and diverse forms of communication, learned science, built cities, and created breathtaking works of art - while chimps remain animals concerned primarily with the basic necessities of survival. What is it about that two percent difference in DNA that has created such a divergence between evolutionary cousins?

Have you ever wondered what your dogs are thinking? What they're feeling? Now you can finally know! The answers will surprise and delight you as scientist and dog owner Alexandra Horowitz explains how our four-legged friends perceive their daily worlds, each other, and that other quirky animal, the human.

Early studies of the human brain used a simple method: Wait for misfortune to strike - strokes, seizures, infectious diseases, horrendous accidents - and see how victims coped. In many cases their survival was miraculous, if puzzling. Observers were amazed by the transformations that took place when different parts of the brain were destroyed, altering victims' personalities. With the lucid, masterful explanations and razor-sharp wit his fans have come to expect, Kean explores the brain's secret passageways.

In her latest groundbreaking book, The Let Them Theory, Mel Robbins—New York Times bestselling author and one of the world's most respected experts on motivation, confidence, and mindset—teaches you how to stop wasting energy on what you can't control and start focusing on what truly matters: YOU. Your happiness. Your goals. Your life.

Blake Porter is riding high, until he's not. Fired abruptly from his job as a VP of marketing and unable to make the mortgage payments on the new brownstone he shares with his fiancée, he's desperate to make ends meet. Enter Whitney. Beautiful, charming, down-to-earth, and looking for a room to rent. She's exactly what Blake's looking for. Or is she? Because something isn't quite right. The neighbors start treating Blake differently. The smell of decay permeates his home, no matter how hard he scrubs. Strange noises jar him awake in the middle of the night.