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Still staying at the Hill House hotel while her beloved home is being rebuilt, Jessica Fletcher finds herself sharing the space for a weekend with a dozen members of a wedding party who have gathered there for a rehearsal dinner. The families of the bride and groom can't stand each other but have agreed to put aside years of long-simmering tension to celebrate the nuptials. Unfortunately, a historic blizzard that dumps nearly five feet of snow on Cabot Cove, leaving everyone stranded. But the hotel guests have bigger things to worry about, because a murderer has shown up uninvited.

Bestselling author Jessica Fletcher is in Tampa with her good friend, Cabot Cove's own Dr. Seth Hazlitt, who is visiting a renowned Cuban physician. Alvaro Vasquez is developing a potentially groundbreaking cure for Alzheimer's disease. If he's successful, his American backers stand to make millions. But there is a growing fear that the drug may fall into the hands of a powerful pharmaceutical company. Jessica attends a party at Vasquez's lavish home, but the celebration ends abruptly when guests witness Vasquez seemingly struck by lightning.

Jessica Fletcher has had plenty to worry about over her storied career, both as a best-selling novelist and as a part-time sleuth. But she's never had any reason to doubt her longtime publisher and trusted friend, Lane Barfield. When mounting evidence of financial malfeasance leads to an FBI investigation of Lane, Jessica can't believe what she's reading. So when it appears that Barfield has committed suicide, Jessica takes on the task of clearing his name. Sure enough, Jessica turns up several inconsistencies in the case against Barfield, as well as signs he might have been murdered.