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By investigating thousands of descriptions of epidemics reaching back before the fifth-century-BCE Plague of Athens to the distrust and violence that erupted with Ebola in 2014, Epidemics challenges a dominant hypothesis in the study of epidemics, that invariably across time and space, epidemics provoked hatred, blaming of the "other", and victimizing bearers of epidemic diseases, particularly when diseases were mysterious, without known cures or preventive measures.

An internationally recognized authority on epidemiology, Dr. Rodolfo Saracci, provides a wealth of information on this key field, dispelling some of the myths surrounding the study of epidemiology, and explaining what epidemiology is and how vital it is to the discovery, control, and prevention of disease in world populations. Dr. Saracci provides a general explanation of the principles behind clinical trials, and explains the nature of basic statistics concerning disease.