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Artifact is the dazzling, half-century-spanning story of biologist Lottie Kristin. Born in Michigan in the early 1940s to a taciturn mother and embittered father, Lottie is independent from the start, fascinated with the mysteries of nature and the human body. By age 16, she and her sweetheart, cheerful high school sports hero Charlie Hart, have been through a devastatingly traumatic pregnancy. When an injury ends Charlie’s football career four years later, the two move to Texas hoping for a fresh start.

Lottie Kristin is independent from the start. Born in the middle of the century to a middle-class family in the very middle of America, Lottie is set apart by her smarts and sensuality. A girl who'd rather carry out dissections on a snowy back porch than join her family for Christmas dinner is a strange and exotic artifact in the town of Sleeping Bay. But by her early 20s, Lottie finds herself trapped in a marriage gone stale, with a daughter she adores but whose existence jeopardises her place in the lab and her dream of becoming a scientist.