The MRC Clinical Trials Unit at UCL is committed to actively involving patients and the public in our trials. All our Patient and Public Involvement (PPI) work is overseen by our PPI Group, made up of MRC CTU staff alongside seven patient representatives, with a wide range of experience in different areas. In this episode of the Trial Talk podcast, two members of the Unit’s PPI Group, Richard Stephens and Ian Newsome, discuss what PPI means to them; how they got involved as patient representatives in clinical research; and how the MRC CTU at UCL embeds PPI into our trials.

Resources:
• Our PPI group: www.mrcctu.ucl.ac.uk/patients-publi…our-ppi-group/
• PPI resources: www.mrcctu.ucl.ac.uk/patients-publi…ppi-resources/
• Testing Treatments: Better Research for Better Healthcare (book): www.ncbi.nlm.nih.gov/books/NBK66204/

For more information and to access the transcript: bit.ly/3KlKtak
For questions or feedback on the podcast series, message us at mrcctu.engage@ucl.ac.uk
As a listener, your opinion is very valuable to us.
Please help us to improve the podcast in the future by filling in this short survey: forms.office.com/e/PjfjQ5Mn6g

Other details:

Date of episode recording: 2024-05-29T00:00:00Z
Duration: 00:34:43
Language of episode: English
Presenter:Charlotte Hartley
Guests: Ian Newsome, Richard Stephens
Producer: Charlotte Hartley

An estimand is a description of the research question a trial seeks to answer, which can help researchers better understand how their study should be designed and analysed. Estimands also provide a clear way to communicate treatment effects to different stakeholders. This episode of the Trial Talk podcast features Principal Research Fellow Brennan Kahan, exploring how triallists could benefit from using estimands. Brennan also discusses his recent paper which aims to demystify new guidance on the use of estimands.

Resources:
• The estimands framework: a primer on the ICH E9(R1): www.bmj.com/content/384/bmj-2023-076316
• 'We must let the research question drive study methods' opinion piece: www.ncbi.nlm.nih.gov/pmc/articles/PMC9908044/
• Estimands in cluster-randomized trials: choosing analyses that answer the right question: www.ncbi.nlm.nih.gov/pmc/articles/PMC9908044/

For more information and to access the transcript: bit.ly/4dazsWF

For questions or feedback on the podcast series, message us at mrcctu.engage@ucl.ac.uk

As a listener, your opinion is very valuable to us. Please help us to improve the podcast in the future by filling in this short survey: forms.office.com/e/PjfjQ5Mn6g

Date of episode recording: 2024-04-25T00:00:00Z
Duration: 00:21:29
Language of episode: English
Presenter: Charlotte Hartley
Guests: Brennan Kahan
Producer: Charlotte Hartley

Clinical trial results usually tell us how effective a treatment was on average for the overall group of participants, but a key question for clinicians, patients and policy makers is: which individual patients benefit most from the treatment and which don’t benefit as much? In the latest episode of the Trial Talk podcast, Peter Godolphin and David Fisher discuss a new method for determining how treatment effects differ between subgroups of patients across multiple clinical trials, as well as how other meta-analysis researchers can use it.

Resources:

• Estimating interactions and subgroup-specific treatment effects in meta-analysis without aggregation bias: A within-trial framework onlinelibrary.wiley.com/doi/10.1002/jrsm.1590
• Cochrane webinar recording training.cochrane.org/resource/estim…-meta-analysis
• GitHub page for metafloat package in Stata github.com/UCL/metafloat
• WHO REACT Group: IL6 Prospective meta-analysis jamanetwork.com/journals/jama/fullarticle/2781880
• STOPCAP collaborators: Docetaxel IPD meta-analysis www.thelancet.com/journals/lanonc/…00230-9/fulltext

For questions about the within-trial framework for subgroup analysis, you can email d.fisher@ucl.ac.uk or p.godolphin@ucl.ac.uk.
For more information and to access the transcript: bit.ly/43boETF
For questions or feedback on the podcast series, message us at mrcctu.engage@ucl.ac.uk
As a listener, your opinion is very valuable to us. Please help us to improve the podcast in the future by filling in this short survey: forms.office.com/e/PjfjQ5Mn6g

Date of episode recording: 2024-03-12T00:00:00Z
Duration: 00:28:44
Language of episode: English
Presenter: Charlotte Hartley
Guests: Peter Godolphin, David Fisher
Producer: Charlotte Hartley