This Week in Startups Podcast Por Jason Calacanis arte de portada

This Week in Startups

This Week in Startups

De: Jason Calacanis
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Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world’s greatest founders, operators, investors, and innovators.Jason Calacanis
Episodios
  • 3 AI Agents That Actually Replaced Human Jobs | E2272

    3 AI Agents That Actually Replaced Human Jobs | E2272
    Apr 7 2026
    Anthropic just pulled the plug on Claude subscriptions for OpenClaw and every third party agentic tool. So Jason and Lon welcome back three of our top TWiST OpenClaw experts to break down what it means, how much it’s going to cost now, and whether this is truly the end of the subsidized AI era.And they all brought demos! We’re checking out ClawChief from Ryan Carson, Alex Finn’s agent Henry, and Yazin Alirhayim’s Sidecast protocol, inspired by a special request from JCal!HostsJason Calacanis: http://x.com/jasonLon Harris: https://x.com/lonsGuestsRyan Carson: https://x.com/ryancarsonClawchief: https://github.com/snarktank/clawchiefAlex Finn: https://x.com/AlexFinnCreator Buddy: https://www.creatorbuddy.io/Yazin Alirhayim: https://x.com/yazinsOpenOats / Sidecast: https://github.com/yazinsai/OpenOatsFurther ReadingThe Checklist Manifesto by Atul Gawande: https://www.amazon.com/Checklist-Manifesto-How-Things-Right/dp/0312430000Marc Andreessen on AI job loss: https://x.com/pmarca/status/2040919227641856307OpenAI acquires TBPN: https://openai.com/index/openai-acquires-tbpn/This Week In Startups is made possible by:Gusto - https://Gusto.com/twist Vanta - https://vanta.com/twist Shopify - https://shopify.com/twist Plaud - https://Plaud.ai/twistToday’s show:Timestamps:0:00 Welcome back to TWiST0:32 Jason's thinks Andor is as good as Empire Strikes Back…2:30 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!3:26 Check out the checklist manifesto! https://www.amazon.com/Checklist-Manifesto-How-Things-Right/dp/03124300006:36 Our guests Ryan Carson, Alex Finn, and Yazin Alirhayim, and join the show10:28 Gusto - Check out the online payroll and benefits experts with software built specifically for small businesses and startups. Try Gusto today and get three months FREE at https://Gusto.com/twist.10:46 People are automating their coworkers and getting them fired…18:32 Anthropic Bans OpenClaw20:06 Vanta - Get $1000 off your SOC 2 at https://www.vanta.com/twist24:06 How "caveman talk" makes AI works better27:31 Alex thinks $2000/ month subscription plans are inevitable for AI.29:31 Why is nobody using the leaked Anthropic Model?30:30 Shopify: Turn those What If's into sales with the ecommerce platform powering millions of businesses. Sign up for your $1-per-month trial today at https://shopify.com/twist32:37 Open models have been 6 months behind for the past few years35:53 Why did OpenAI acquire TBPN?42:01 Tactical/ Practical: The product itself is the most important thing44:31 Demo or Die! Yazin is back to show off OpenOats55:05 Ryan's "Claw Chief" https://github.com/snarktank/clawchief/blob/main/skills/executive-assistant/SKILL.md?plain=11:02:14 Alex's big announcement, "Henry intelligent machines"1:12:33 Alex Finn DESTROYS Higgsfield's marketing strategy1:15:35 Throwback to "Pay Per Post"Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason’s suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com
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    1 h y 19 m
  • AI Rebuilt Every YC W26 Startup. Should Founders Be Scared? | E2271

    AI Rebuilt Every YC W26 Startup. Should Founders Be Scared? | E2271
    Apr 3 2026
    This Week In Startups is made possible by:Deel - deel.com/twistGrasshopper Bank - grasshopper.bank/twistRender - render.com/twistPlaud - Plaud.ai/twistAn AI “holding company” rebuilt dozens of YC Winter ‘26 startups in one weekend. Now we’re bringing the founder responsible into Jason’s Courtroom to defend himself.PLUS a live demo of Boardy, the AI that acts like a virtual board member and makes crucial introductions. Find out why he gets to have so much agency, how creator Andrew D’Souza used him to raise his own $17 million round, and how this company ever plans to actually make money.Plus Jason celebrates Apple’s 50th anniversary with a fiery rant about milking the ghost of Steve Jobs… Why OpenAI is acquiring a tech podcast… Jason’s favorite weighted vest for rucking… AND Lon’s Off Duty weekend streaming picks.GuestsMarik Hazan:⁠ https://x.com/MarikHazan⁠Feltsense:⁠ https://feltsense.com/⁠Andrew D’Souza:⁠ https://x.com/andrewdsouza⁠Boardy:⁠ https://www.boardy.ai/⁠Timestamps:0:00 Jason's direction for TWiST and thoughts on legacy media5:14 Marik of Feltsense joins the show6:10 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!7:10 Marik's viral YC replicator stunt9:45 Deel - Founders scale faster on Deel. Set up payroll for any country in minutes, hire anyone anywhere, get visas handled fast, and get back to building. Visit https://deel.com/twist to learn more.20:39 Grasshopper bank - Time is money. Don't waste either. Go to https://grasshopper.bank/twist and get an exclusive $500 cash bonus just for opening an account.21:33 Feltsense founder goes on trial!25:26 Jason dunks on Bank of America's app27:59 TBPN acquired by OpenAI29:28 The All In Podcast is worth $1B!30:13 Render - Find out why 5 million developers are already using the all-in-one cloud platform, Render. Go to https://render.com/twist and apply for the Render Startup Program to get $500-$100,000 in free credits, depending on your stage and backers.33:02 Andrew D'Souza joins the show along with his agent, Boardy!43:17 So how does Boardy make money?48:32 Lon is becoming more and more "AI-pilled."50:41 Tactical/ practical: "If we have data, let's look at data. If all we have are opinions, let's go with mine." -Jim Barskdale, former CEO of Netscape1:01:00 Tactical/ practical: hire a PR firm to report on your competitors' wrongdoings.1:02:58 Jason calls out Apple for being DISGRAZIAD!1:15:09 Lon's TV pick of the week: "Something Very Bad is Going to Happen https://www.youtube.com/watch?v=vMc_pWm7G7o1:19:52 Become an Angel Investor at https://thesyndicate.com/Subscribe to the TWiST500 newsletter:⁠ https://ticker.thisweekinstartups.com⁠Check out the TWIST500:⁠ https://www.twist500.com⁠Subscribe to This Week in Startups on Apple:⁠ https://rb.gy/v19fcp⁠Follow Lon:X:⁠ https://x.com/lons⁠Follow Alex:X:⁠ https://x.com/alex⁠LinkedIn:⁠ ⁠https://www.linkedin.com/in/alexwilhelm⁠Follow Jason:X:⁠ https://twitter.com/Jason⁠LinkedIn:⁠ https://www.linkedin.com/in/jasoncalacanis⁠Check out all our partner offers:⁠ https://partners.launch.co/⁠Great TWIST interviews:⁠ Will Guidara,⁠⁠ Eoghan McCabe⁠,⁠ Steve Huffman⁠,⁠ Brian Chesky⁠,⁠ Bob Moesta,⁠⁠ Aaron Levie⁠,⁠ Sophia Amoruso⁠,⁠ Reid Hoffman⁠,⁠ Frank Slootman⁠,⁠ Billy McFarland⁠Check out Jason’s suite of newsletters:⁠ https://substack.com/@calacanis⁠Follow TWiST:Twitter:⁠ https://twitter.com/TWiStartups⁠YouTube:⁠ https://www.youtube.com/thisweekin⁠Instagram:⁠ https://www.instagram.com/thisweekinstartups⁠TikTok:⁠ https://www.tiktok.com/@thisweekinstartups⁠Substack:⁠ https://twistartups.substack.com⁠
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    1 h y 21 m
  • How 3 CEOs Use AI to Run $10B in Companies | This Week in AI

    How 3 CEOs Use AI to Run $10B in Companies | This Week in AI
    Apr 2 2026

    This Week in AI, JCal sits down with three CEOs building the infrastructure, intelligence, and interfaces for the next era of AI: Jeremy Fraenkel (CEO, Fundamental), Victor Riparbelli (CEO, Synthesia), and Nick Harris (CEO, Lightmatter). We break down what's actually happening beneath the AI hype: the data modality LLMs completely missed, why copper is the real bottleneck in AI data centers, OpenAI shutting down Sora, the build vs. buy debate for AI tools, and how close we really are to AGI.

    • AI's Biggest Blind Spot, Tabular Data: LLMs transformed text, images, and code, but 70-80% of enterprise data lives in rows and columns.
    • Copper Can't Keep Up: Nick explains why AI data centers are hitting a wall. GPUs compute faster than they can communicate. Lightmatter's photonic chips push 1.6 terabits per fiber and can 3x training speed.
    • Why OpenAI Killed Sora & Anthropic's Focus is Winning: Victor breaks down why even OpenAI had to learn the lesson of focus, and why Claude Code has every founder talking.
    • Vibe Coding Your Own CRM vs. Buying Salesforce: Jeremy reveals Fundamental built their own internal CRM using vibe coding. The panel debates when building beats buying and when it's a distraction.
    • The Omnipresent CEO: Jason shares how he's using AI agents for root access to Slack, Gmail, and Notion, resurrecting former employees as AI personas, automating SDR workflows, and summarizing employee inboxes while they're on vacation.
    • Are We Already at AGI?: Nick says the rate of progress is a double exponential. Jeremy argues AGI is a moving goalpost. Victor warns of "Future Shock" and societal disruption.

    🔗 Learn more about Fundamental: https://fundamental.tech🔗 Learn more about Synthesia: https://www.synthesia.io🔗 Learn more about Lightmatter: https://lightmatter.coThis Week In AI is made possible by:PayPal Open - One Platform for all Business: paypalopen.comTimestamps:00:00 Welcome & intro to Jeremy Fraenkel, Victor Riparbelli, and Nick Harris01:47 What is Fundamental? Large tabular models explained07:01 Victor Riparbelli on Synthesia & why OpenAI killed Sora11:09 Claude Code dominance & the Lightspeed founder retreat12:08 Nick Harris on Lightmatter, photonics & the new Moore's Law14:38 Copper vs. fiber: why AI data centers are hitting a wall18:44 Reinventing video: interactive, real-time, personalized21:32 The economics of a custom AI movie23:55 Why Amazon, Google & Meta are building their own chips28:06 Tables have a bandwidth problem too32:27 When will compute be as cheap as storage?36:10 The future of software: every company gets a custom stack38:06 Vibe coding your own CRM vs. buying Salesforce45:57 Jason's quest for root access to Slack50:18 The omnipresent CEO: Doctor Manhattan meets Jesus CEO52:13 Resurrecting former employees as AI personas53:25 Victor's executive changelog for a 650-person company55:07 Whisper Flow & the Plaud Pin1:00:03 AGI: is it already here?1:03:37 Jeremy: we've only solved half the brain1:06:30 70% of Americans fear AI will impact jobs1:08:47 Future Shock & keeping the rope tight*Mentioned in the show:*

    Wisper Flow: https://wisperflow.ai

    • Plaud Pin: https://www.plaud.ai
    • Athena Executive Assistants: https://www.athenawow.com
    • WHOOP: https://www.whoop.com
    • "Future Shock" by Alvin Toffler: https://www.amazon.com/Future-ShockAlvin-Toffler/dp/0394425863
    • Victor on TWiST, E1776: https://youtu.be/jxET4fq_2eA
    • Nick on TWiST, E1787: https://youtu.be/FPW2nnEqfMsSubscribe to This Week in AI on Apple: https://thisweekinai.ai/spotifySubscribe to This Week in AI on Spotify: https://thisweekinai.ai/appleThanks for watching!🤖 If you want to stay ahead of the curve on all things AI, make sure to join our community across all platforms:📩 Get the Weekly Newsletter: https://thisweekinai.ai/📺 Subscribe on YouTube: https://www.youtube.com/@ThisWeekinAIPodcast📸 Instagram: https://www.instagram.com/thisweekinaipodcast
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    30 m
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