This Week in Cardiology Podcast Por Medscape arte de portada

This Week in Cardiology

This Week in Cardiology

De: Medscape
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This podcast delivers Dr. John Mandrola’s summary and perspective on top news of the week that cardiologists can’t miss. This podcast is intended for US health professionals only.Copyright 2019, Medscape Ciencia Enfermedades Físicas Higiene y Vida Saludable
Episodios
  • Oct 03 2025 This Week in Cardiology

    Oct 03 2025 This Week in Cardiology
    Oct 3 2025

    Two great stories of translation science leading to beneficial drugs in terrible diseases of the heart and the Sisyphean task of predicting the need for pacing after TAVI are the topics John Mandrola, MD, discusses in this week's podcast.

    This podcast is intended for healthcare professionals only.

    To read a partial transcript or to comment, visit:

    https://www.medscape.com/twic

    I Sotatercept

    • HYPERION Trial https://www.nejm.org/doi/10.1056/NEJMoa2508170
    • ZENITH Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2415160
    • Evidence report on treatment for PAH https://icer.org/news-insights/press-releases/icer-publishes-final-evidence-report-on-treatment-for-pulmonary-arterial-hypertension/
    • PAH Sotatercept Editorial https://www.nejm.org/doi/full/10.1056/NEJMe2503944

    II Acoramidis and ATTR Cardiomyopathy

    • ATTRIBUTE-CM Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2305434?logout=true
    • ATTRIBUTE-CM Analysis - Substudy https://www.jacc.org/doi/10.1016/j.jacc.2025.09.013
    • Tafamadis Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1805689

    III Pacing After TAVI

    • Prophylactic pacemaker after TAVI https://www.jacc.org/doi/10.1016/j.jacep.2025.07.028
    • PROMOTE study https://doi.org/10.1016/j.hrthm.2024.12.019
    • Evaluation of ESC criteria on RBBB patients undergoing TAVI https://doi.org/10.1016/j.hrthm.2024.11.030
    • Editorial on Heart Rhythm journal papers https://www.heartrhythmjournal.com/article/S1547-5271(25)00114-6/abstract

    You may also like:

    The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

    Questions or feedback, please contact news@medscape.net
    Más Menos
    27 m
  • Sep 26 2025 This Week in Cardiology

    Sep 26 2025 This Week in Cardiology
    Sep 26 2025

    A bold trial in valvular heart disease, a CV prevention trial whose message is humility, VTE dogma challenged, more news on oral GLP-1 agonists, and a few public service announcements are the topics John Mandrola, MD, discusses in this week’s podcast.

    This podcast is intended for healthcare professionals only.

    To read a partial transcript or to comment, visit:

    https://www.medscape.com/twic

    I DOUBLE-CHOICE: Minimalist Approach to TAVI May Be as Good as Standard of Care https://www.medscape.com/viewarticle/double-choice-minimalist-approach-tavi-may-be-good-standard-2025a1000pp7

    • Patient & Physician Perspectives on CV Risk https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.124.011837

    II KP Vaccinate Trial

    • KP Vaccinate Trial https://evidence.nejm.org/doi/full/10.1056/EVIDoa2500208
    • IAMI trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.057042
    • Increasing Flu Vaccinations in Patients With Chronic Disease https://jamanetwork.com/journals/jama/fullarticle/2824956
    • MI FREEE Trial https://www.nejm.org/doi/full/10.1056/NEJMsa1107913

    III Hi PRO Trial

    • Apixaban for Extended Treatment of VTE https://www.nejm.org/doi/full/10.1056/NEJMoa2509426
    • Recurrent VTE in Patients with Provoked VTE https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/226140

    IV Oral GLP-1 Agonists

    • ATTAIN 1 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2511774

    You may also like:

    The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

    Questions or feedback, please contact news@medscape.net
    Más Menos
    23 m
  • Sep 19 2025 This Week in Cardiology

    Sep 19 2025 This Week in Cardiology
    Sep 19 2025

    More trials at ESC, including PARACHUTE HF, DAPA ACT HF-TIMI 68, AMALFI, and a super-interesting modeling study of when to start oral anticoagulants in AF, are the topics John Mandrola, MD, discusses in this week's podcast.

    This podcast is intended for healthcare professionals only.

    To read a partial transcript or to comment, visit:

    https://www.medscape.com/twic

    I PARACHUTE HF

    First Evidence of Treatment Benefit in Chagas Heart Failure

    https://www.medscape.com/viewarticle/first-evidence-treatment-benefit-chagas-heart-failure-2025a1000oem

    • PARACHUTE-HF https://www.jacc.org/doi/10.1016/j.jchf.2024.05.021

    II SGLT2i Early Initiation — DAPA ACT HF-TIMI 68 Trial

    Trial Data Support In-Hospital Initiation of SGLT2 Inhibitors for Heart Failure https://www.medscape.com/viewarticle/trial-data-support-hospital-initiation-sglt2-inhibitors-2025a1000o5q

    • DAPA ACT HF-TIMI 68

    https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.076575

    III AMALFI Trial of AF Screening

    Remote ECG Screening Ups Atrial Fibrillation Detection ‘Modestly’ https://www.medscape.com/viewarticle/remote-ecg-screening-ups-atrial-fibrillation-detection-2025a1000myx

    • AMALFI Trial https://jamanetwork.com/journals/jama/article-abstract/2838482
    • STROKESTOP Trial https://www.thelancet.com/article/S0140-6736(21)01637-8/fulltext
    • LOOP Trial 10.1016/S0140-6736(21)01698-6 External Link

    IV Finding that Sweet Spot of Stroke Risk Threshold for Starting DOAC therapy

    • Stroke Risk Threshold for non-Vitamin K Antagonist OAC in AF https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.125.012090
    • Variations in Rates of Stroke Across Patients With AF https://www.ahajournals.org/doi/10.1161/circulationaha.116.024057

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    The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

    Questions or feedback, please contact news@medscape.net
    Más Menos
    34 m
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Dr Mandrola delivers excellent updates on recent publications. The podcast is just the thing for a commute: not too superficial, not too detailed, and do a great job placing the new clinical advances in the context of contemporary practice.

recommend to colleagues

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As a former Cardiology PA now working on the academic side of medicine, I’ve been out of practice for several years. Preparing to teach a cardiology course at a new program, I started brushing up on material—and stumbled across Dr. Mandrola’s podcast. Wow. I wish I had known about this resource back when I was still practicing clinically.

In just a short time, I’ve learned what’s new since I left practice, and even picked up on things I probably should have known better back then. More importantly, I’ve gained an entirely new appreciation for how to critically review clinical trials and recognize bias.

What sets this podcast apart is Dr. Mandrola’s humility and honesty: his willingness to point out flaws in studies, to admit when he doesn’t know something, and to change his perspective when the evidence supports it. That kind of intellectual honesty builds trust, and it makes him feel less like a distant expert and more like a fellow learner walking through the field with you.

I’ve flown through the last two years of episodes in just a week, and I’m looking forward to being a dedicated listener moving forward. Thank you, Dr. Mandrola, for approaching cardiology not as a lecture, but as a thoughtful, ongoing conversation.

Honest, Insightful, and Incredibly Valuable

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I absolutely love listening to this podcast and feel I practice medicine very similarly. I love your critical review of studies as it brings these areas to light. I especially loved your comment at the end of this podcast discussing the reasoning to go into EP. I agree with your reasons, and consider them the same for most fields of medicine, especially any in cardiology, which I practice as a PA in and have for 14 years. Going into medicine just for the money should never be the reason as it will only lead to frustration and burnout. Thank you for your honest reviews and feedback each week.

EP is not about the money -love this statement

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Me gusta el escepticismo del Dr Mandrola. Habla de su objetividad y su compromiso con la ciencia bien hecha

Muy informativo

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