Second Trimester Loss & Low AMH: Causes, Testing, and Functional Fertility Insights

We’re diving into the top functional and conventional tests to consider after the second trimester or late pregnancy loss, especially if you’ve been diagnosed with low AMH, high FSH, diminished ovarian reserve (DOR), or premature ovarian insufficiency (POI). If you’ve had a second trimester loss or late pregnancy loss after 20 weeks and been told “everything looks normal,”this episode is for you. We dive into what’s often overlooked in conventional care and how a functional fertility approach can help uncover underlying imbalances that impact conception, hormone health, and pregnancy outcomes. In this episode we cover 7 categories of testing to consider after late loss especially if you have low AMH, diminished ovarian reserve, autoimmune issues, recurrent miscarriage, or unexplained infertility. You’ll learn: The top clotting and thrombophilia markers to test (including Factor V Leiden and antiphospholipid antibodies) Which inflammatory and immune markers (hs-CRP, ANA, cytokines, NK cells) are often missed and why they matter How the vaginal microbiome and hidden infections like ureaplasma can cause second-trimester loss The role of chronic stress, adrenal hormones and the HPA axis in pregnancy outcomes Why a comprehensive blood chemistry panel can reveal nutrient deficiencies and hormone imbalances that are missed by conventional labs Key methylation and genetic SNPs (like MTHFR) that impact detoxification, clotting and hormone metabolism The impact of gut health and stool testing on immune tolerance, estrogen balance and inflammation We’ll also explain how this whole body functional lens can guide your next steps in preconception planning, whether you’re trying again naturally or preparing for IVF. This episode is for you if: You’ve experienced a loss after 14 weeks of pregnancy and are seeking deeper understanding and support. You want to explore both conventional and functional medicine approaches to uncover underlying causes. You’re looking for practical lifestyle, testing, and healing strategies to improve future pregnancy outcomes. --- TIMESTAMPS [00:00:00] Introduction: Late term pregnancy loss overview, compassion, and what to expect in this episode [00:02:30] Functional fertility testing for late term loss thrombophilia panel, immune markers, inflammation, and infections [00:06:00] Stress hormones, nervous system support, and comprehensive blood chemistry for improving pregnancy outcomes [00:09:00] Blood sugar, insulin, and comprehensive thyroid testing in pregnancy loss [00:12:00] Genetic testing, including MTHFR mutations and the importance of body healing before conception [00:14:30] Role of gut health, infections, and estrogen metabolism in pregnancy loss --- RESOURCES 📩 Get your free 10-day elimination diet plan! Email [e-mail] with the subject line 10 DAY to receive your guide and take the first step toward reconnecting with your fertility. Causes of Miscarriage Before 12 Weeks: What Most Doctors Miss: https://fabfertile.com/blogs/podcasts/causes-of-miscarriage-before-12-weeks-what-most-doctors-miss The Clotting Connection: Hidden Causes of Implantation Failure and Miscarriage: https://fabfertile.com/blogs/podcasts/the-clotting-connection-hidden-causes-of-implantation-failure-and-miscarriage Autoimmune Roadblocks to IVF: How ANA Affects Fertility: https://fabfertile.com/blogs/podcasts/autoimmune-roadblocks-to-ivf-how-ana-affects-fertility?_pos=1&_sid=4203e92e4&_ss=r How To Prevent and Reverse Autoimmune Disease and Get Pregnant: https://fabfertile.com/blogs/podcasts/how-to-prevent-and-reverse-autoimmune-disease-and-get-pregnant?_pos=5&_sid=a4eef3155&_ss=r Before Your IVF Transfer, Test This First: https://fabfertile.com/blogs/podcasts/before-your-ivf-transfer-test-this-first?_pos=4&_sid=5114b4bda&_ss=r Low AMH? Why 'Normal' Vitamin D Levels May Still Be Hurting Your Egg Quality: https://fabfertile.com/blogs/podcasts/low-amh-why-normal-vitamin-d-levels-may-still-be-hurting-your-egg-quality?_pos=4&_sid=eac9ba23d&_ss=r Why Addressing Homocysteine Levels Can Boost Egg and Sperm Health: https://fabfertile.com/blogs/podcasts/why-addressing-homocysteine-levels-can-boost-egg-and-sperm-health?_pos=1&_sid=2e1b473ff&_ss=r How MTHFR and methylation affect fertility with high FSH and low AMH: https://fabfertile.com/blogs/education/mthfr-methylation-high-fsh-low-amh-fertility?_pos=2&_sid=d553bdf89&_ss=r How Iron Deficiency Impacts Fertility, Egg Quality & Low AMH: https://fabfertile.com/blogs/podcasts/ferritin-iron-deficiency-fertility-low-amh-high-fsh?_pos=3&_sid=022381a8b&_ss=r 1. Factor V Leiden & Prothrombin Mutation in Late Fetal Loss Martinelli I et al. (2000, New England Journal of Medicine) This study found that women who carry Factor V Leiden or the prothrombin G20210A mutation have a 3.2× greater risk of late fetal loss, likely due to impaired placental blood flow. https://www.nejm.org/doi/full/10.1056/NEJM200010053431405 2. Antiphospholipid...