Revisiting Depression — Dopamine-Serotonin Balance Gains Attention for Treatment-Resistant Depression

• A major clinical trial in The Lancet Psychiatry found that boosting dopamine with pramipexole improved symptoms in treatment-resistant depression. This challenges the long-dominant serotonin deficiency theory
• Supporting those findings, another study showed that agomelatine, a serotonin-blocking drug, consistently reduced anxiety and depression in multiple placebo-controlled trials
• Research shows polyunsaturated and monounsaturated fats (PUFs and MUFs) directly trigger platelet aggregation and serotonin release, while saturated fats do not, linking modern diets to serotonin excess
• Studies confirm that combinations of unsaturated fats amplify serotonin release even at sub-threshold levels, making everyday dietary choices especially relevant to serotonin-driven health risks and mood instability
• Increasing GABA helps your body break down serotonin, restoring calm, better sleep, and mood stability without SSRI side effects, making it a safer alternative for addressing depression and anxiety