At any given time, millions of lab mice are being used in research facilities nationwide. And yet nearly all of them can be connected back to a single source: The Jackson Laboratory in Bar Harbor, Maine, where the modern lab mouse was invented.

What started as a research project aimed at understanding heredity is now a global business. Research on lab mice has led to more than two dozen Nobel prizes, helped save countless human lives, and has pushed science and medicine to new heights. But behind it all is a cost that’s rarely discussed outside of the ethics boards that determine how lab mice are used.

In this episode, we hear the story of how a leading eugenicist turned the humble mouse from a household pest into science’s number one guinea pig. Plus, we get a rare peek inside the Jackson Laboratory - where over 10,000 strains of lab mice DNA are kept cryogenically frozen.

Featuring Bethany Brookshire, Kristin Blanchette, Lon Cardon, Rachael Pelletier, Karen Rader, Nadia Rosenthal and Mark Wanner. Produced by Jeongyoon Han. For a transcript and full list of credits, go to outsideinradio.org.

Note: This episode originally aired in April, 2023.

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LINKS

Karen Rader’s book, Making Mice: Standardizing Animals for American Biomedical Research, 1900-1955, is a definitive source on the birth of the lab mouse…

Curious to learn more about pests? Take a look at Bethany Brookshire’s book, Pests: How Humans Create Villains.

This piece from the New Yorker questions the assumptions and ethical choices scientists have made by using lab mice in sterilized lab environments.

In this New York Times essay, Brandon Keim explores how some ethicists want to reduce harm to animals used for research through a new model: repaying them.

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The garment industry has a giant carbon footprint, labor issues, and a massive waste problem. We have the power to change how and where we shop, but there’s another way to shift our consumption: the practice of repairing our clothes. After all, the most sustainable garment is always the one already hanging in your closet.

But mending is more than a household chore: it can also infuse new joy in our habits, skills, perspective, and community.

Outside/In producer Justine Paradis talked to a few repair pros and came up with 8 tips on embracing a repair mindset, lengthening the life of our clothes, and getting the practice of mending into the rhythm of our lives.

Featuring Emilia Petrarca, Dante Zagros Gonzalez, Steve Foss, Arounna Khounnoraj, Sonali Diddi, Vrylena Olney, Ely Spencer, and Ali Mann.

This episode was produced by Justine Paradis. For full credits and transcript, visit outsideinradio.org.

LINKS

A few extraordinary examples of mending: Celia Pym’s Norwegian Sweater, a Japanese fisherman’s jacket constructed with sashiko, wool coats repaired with lavish embroidery, and a plain white t-shirt mended by Maya Skylark.

Look for mending classes at your local library, thrift stores, knitting shops, or other community gathering places. Remote classes are also offered at places like Tatter. You can also find a repair cafe near you, explore starting your own, or try throwing a repair party with friends.

“Why Do Clothes Suck Now” – a great primer on Culture Study

A striking visual demonstrating the decline in sweater quality since the ‘90s.

How to buy a sweater that doesn’t suck (Defector)

“Repair Month” on Emilia Petrarca’s newsletter Shop Rat, including laundry tips and her crowd-sourced Google spreadsheet of repair specialists in NYC and beyond.

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“Operation Night Cat” is a special three-part series from NHPR’s Document team and Outside/In.

Episode 3: A Duck’s a Duck

Two sets of potential crimes, investigated by more than five sets of law enforcement agencies. Why most of them never took a shot at accountability.

News audio clip credit: WMUR. For a full list of credits and transcript, visit outsideinradio.org.

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To hear more of Document's investigative journalism, including their three-part series on New Hampshire's YDC scandal, subscribe wherever you get your podcasts.

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