Join Rahul and Rohit Gosain, the Oncology Brothers, in this insightful podcast episode where they discuss the latest advancements in hematology and oncology. In this episode, they are joined by Dr. Mazyar Shadman from Fred Hutch Cancer Center to delve into the Sequoia and Alpine trials that led to the approval of Zanubrutinib in CLL.

Key Points Discussed:

· The Sequoia trial focused on Zanubrutinib in first-line CLL treatment, showcasing its superiority over traditional chemotherapy.

· The Alpine study compared Zanubrutinib to Ibrutinib in relapsed/refractory settings, demonstrating Zanubrutinib's efficacy and safety profile.

· Acalabrutinib and Zanubrutinib were indirectly compared in a post-analysis, shedding light on their differences.

· Dr. Shadman provides insights on managing common side effects of Zanubrutinib, highlighting its improved tolerability.

Tune in to this episode for a comprehensive discussion on Zanubrutinib in CLL, including trial outcomes, comparisons, and practical considerations for patient care. Stay informed with the Oncology Brothers as they navigate the evolving landscape of oncology treatments

Join the Oncology Brothers, Rahul and Rohit Gosain, in this informative podcast episode as they discuss the complexities of myelofibrosis, a challenging blood cancer. They are joined by expert Dr. Naveen Pemmaraju from MD Anderson Cancer Center, who provides valuable insights into diagnosing and managing myelofibrosis.

In this episode, they discuss the importance of a thorough diagnostic workup, including bone marrow biopsy, laboratory values, and clinical history. Dr. Pemmaraju highlights the significance of risk stratification using various scoring systems and the role of molecular analysis in determining prognosis.

The conversation also covers the current treatment landscape for myelofibrosis, focusing on JAK inhibitors such as ruxolitinib, fadratinib, pacritinib, and momelotinib. The hosts and guest expert explore the unique side effects of these medications and strategies for managing them effectively.

Listeners will gain valuable insights into supportive care options for anemia, thrombocytopenia, and leukopenia, including the use of erythropoietin-stimulating agents and other therapeutic interventions. The episode emphasizes the importance of considering allogeneic stem cell transplant as a potential curative option for high-risk patients.

Don't miss this comprehensive discussion on myelofibrosis, packed with practical information and expert advice. Tune in to the Oncology Brothers podcast to stay informed about the latest developments in hematology and oncology.

In this podcast episode from the Oncology Brothers delve into the needs of different patient populations in colorectal cancer. Joined by Dr. Tanios Bekaii-Saab, a medical oncologist, and Ms. Deneen Richmond, a patient advocate, nurse, and the President of the Doctors Community Medical Center, the discussion highlights disparities in access to colorectal cancer screening and treatments among various communities. Deneen shares her personal journey as a patient, emphasizing the importance of trust and being heard in healthcare. The episode also explores strategies to raise awareness and educate different patient groups, including leveraging trusted voices and community outreach. Tune in for valuable insights on understanding and addressing the diverse needs of patients in colorectal cancer care.