Nick Sterling, MD, PhD Podcast Por Nick Sterling MD PhD arte de portada

Nick Sterling, MD, PhD

Nick Sterling, MD, PhD

De: Nick Sterling MD PhD
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Physician focused on the science of preventative health, aging, and athletic performance.Nick Sterling, MD, PhD Higiene y Vida Saludable
Episodios
  • 10 Key Tests to Level-Up Your Heart Health - Add Healthy Years & Lower Heart Attack & Stroke Risk

    10 Key Tests to Level-Up Your Heart Health - Add Healthy Years & Lower Heart Attack & Stroke Risk
    Oct 31 2025

    In this episode, we cover why early atherosclerosis is essentially universal by young adulthood and tests that tell us about cardiovascular risk—beyond a standard lipid panel. We walk through ApoB (and why it can outperform LDL-C in some circumstances), Lp(a) and the case for checking it at least once, inflammation markers like hs-CRP and GlycA, the triglyceride–HDL relationship and TG/HDL ratio, omega-3:omega-6 balance (including an important atrial fibrillation caveat), blood pressure and endothelial stress, plus quick thoughts on homocysteine and coronary calcium scoring.Chapters:00:00 — Why almost everyone has early plaque00:01:01 — ApoB explained 00:02:12 — ApoB vs LDL-C: discordance00:02:38 — Lp(a)00:04:34 — Inflammation: hs-CRP & GlycA00:05:44 — Triglycerides & HDL00:07:19 — Omega-3:6 ratio & Atrial Fibrillation caution00:08:14 — Blood pressure & endothelial stress00:10:03 — Homocysteine & CACSpotify Channel:https://podcasters.spotify.com/pod/show/sterlingmdphd/Social & Website:Instagram - https://www.instagram.com/sterlingmdphdX - https://x.com/sterlingmdphdFacebook - / sterlingmdphdNewsletter - http://eepurl.com/hQpdqTApple Podcasts: https://apple.co/3y438C9References & Show Notes:http://www.nicksterling.com/This content is not medical advice, is for general information purposes only and does not constitute the practice of medicine or any other healthcare professional services. No doctor-patient relationship is formed. This content is not a substitute for medical evaluation or treatment and does not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit http://nicksterling.com/terms for full Terms of Use.
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    12 m
  • How to Find Metabolic Dysfunction EARLY - Longevity & Healthspan

    How to Find Metabolic Dysfunction EARLY - Longevity & Healthspan
    Oct 6 2025
    Spotting Metabolic Dysfunction Early: LP-IR, Waist-to-Hip, Uric Acid & More. In this episode, we cover practical ways to spot early metabolic dysfunction. We walk through the LP-IR (lipoprotein insulin resistance) index and what changing lipid particle patterns reveal, then show how to measure waist-to-hip ratio correctly and interpret risk thresholds. We also touch on where magnesium fits (and its small effects on blood pressure), how to read kidney function more accurately by pairing creatinine with cystatin C, what rising uric acid can signal (including ties to fructose intake and blood pressure), and simple lab/imaging clues of hepatic steatosis/NAFLD.HighlightsLP-IR flags insulin resistance before glucose markers shift.Waist-to-hip ratio is a strong visceral fat proxy.Creatinine + cystatin C improves eGFR accuracy.Uric acid links fructose intake to higher blood pressure.Chapter Markers00:00 Intro: avoid health “icebergs”00:00:41 Metabolic dysfunction 10100:01:26 LP-IR (lipoprotein insulin resistance) explained00:02:22 Triglycerides, VLDL & HDL in insulin resistance00:03:28 Small dense LDL & LP-IR00:04:51 Waist-to-hip ratio: measure & cutoffs00:06:14 Magnesium: insulin sensitivity & small BP effects00:06:47 Kidney function: creatinine + cystatin C (combined eGFR)00:09:06 Uric acid, fructose & blood pressure00:11:08 Liver fat (NAFLD): labs & imagingSpotify Channel:https://podcasters.spotify.com/pod/show/sterlingmdphd/Social & Website:Instagram - https://www.instagram.com/sterlingmdphdX - https://x.com/sterlingmdphdFacebook - / sterlingmdphdNewsletter - http://eepurl.com/hQpdqTApple Podcasts: https://apple.co/3y438C9References & Show Notes:http://www.nicksterling.com/This content is not medical advice, is for general information purposes only,and does not constitute the practice of medicine or any other healthcare professional services. No doctor-patient relationship is formed. This content is not a substitute for medical evaluation or treatment and does not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit http://nicksterling.com/terms for full Terms of Use.
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    13 m
  • How to Catch Insulin Resistance Early - High-Yield Tests Part 1

    How to Catch Insulin Resistance Early - High-Yield Tests Part 1
    Sep 19 2025
    In this episode, we cover the highest-yield lab tests to spot insulin resistance early—often years before routine screening would. I walk through how insulin works, why insulin resistance can be silent for a decade, and which metrics actually move the needle for long-term metabolic health.We dig into fasting glucose and A1C, fasting insulin, and combined indices like HOMA-IR and QUICKI. I also explain when an oral glucose tolerance test or a continuous glucose monitor can add value, the limitations of single time-point labs, and why calibration matters for CGMs. Finally, I preview how lipid test — particularly triglyceride-to-HDL ratio—can flag insulin resistance.Chapter Markers00:00 — Intro00:28 — Insulin resistance as a foundation01:11 — Common causes of mortality in U.S.02:07 — What insulin does (and what goes wrong)02:57 — Glucose tests: fasting glucose & A1C basics04:20 — Early signal: fasting insulin (typical ranges)05:16 — Combined indices: HOMA-IR & QUICKI (cutoffs & caveats)06:18 — OGTT & CGM07:31 — Continuous glucose monitor caveats09:10 — TG/HDL ratio for insulin resistanceHOMA-IR Calculatorhttps://www.mdcalc.com/calc/3120/homa-ir-homeostatic-model-assessment-insulin-resistanceQUICKI Calculatorhttps://www.mdapp.co/insulin-sensitivity-quicki-calculator-324/Quick Referencehttps://nicksterling.com/2025/09/18/quick-reference-guide-tests-for-insulin-resistance-part-1/Spotify Channel:https://podcasters.spotify.com/pod/show/sterlingmdphd/Social & Website:Instagram - https://www.instagram.com/sterlingmdphdX - https://x.com/sterlingmdphdNewsletter - http://eepurl.com/hQpdqTApple Podcasts: https://apple.co/3y438C9This content is not medical advice, is for general information purposes only,and does not constitute the practice of medicine or any other healthcare professional services. No doctor-patient relationship is formed. This content is not a substitute for medical evaluation or treatment and does not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit http://nicksterling.com/terms for full Terms of Use.
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    10 m
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