Jonathan Sporn (CEO + Founder of Gilgamesh Pharma) joins for a deep dive into next-gen psychedelic medicines, why duration matters for real-world clinical use, and what it takes to build these therapies the way large pharma would—culminating in a partnership with AbbVie worth up to $1.2B.

In this episode, we discuss:
• Why Gilgamesh is building psychedelic medicines the way large pharma would
• The thesis behind short-acting psychedelics and why long-duration trips are impractical for real-world psychiatry
• How Gilgamesh designs molecules backwards from clinical needs
• Effective approaches to the challenges of trial designs for psychedelics
• What AbbVie’s deal and Spravato’s trajectory mean for psychedelics
• How psychedelic medicines could reshape mental health

Credits:

Created by Greg Kubin and Matias Serebrinsky
Host: Matias and Greg
Produced by Nico V. Rey

Find us at businesstrip.fm and psymed.ventures
Follow us on Instagram and Twitter!
Theme music by Dorian Love
Additional Music: Distant Daze by Zack Frank

Greg speaks with three leaders in mental health philanthropy: Alyson Nieman from Mindful Philanthropy, Sabrina Gracias from Ortus Foundation, and Christena Huntsman Durham from Huntsman Mental Health Foundation, each offering a distinct perspective on how funding decisions get made and where the biggest gaps remain.

In this episode we discuss:

• Trends in mental health philanthropy, and the 10-year challenge: how the field moves from roughly $2B to $35B in annual funding.
• Funding the clinic of the future: a $150M philanthropic gift behind the Huntsman Mental Health Institute’s crisis care center
• Youth mental health: how the Ortus Foundation is addressing regional gaps in the US Intermountain West

Credits:

Created by Greg Kubin and Matias Serebrinsky
Host: Greg Kubin
Produced by Caitlin Ner & Nico V. Rey

Find us at businesstrip.fm and psymed.ventures
Follow us on Instagram and Twitter!
Theme music by Dorian Love
Additional Music: Distant Daze by Zack Frank

Greg interviews Rick Perry, the former Governor of Texas and former U.S. Secretary of Energy and leading advocate for ibogaine, live at the Real Summit.

In this episode, we discuss:

• How a former Texas governor moved from strict opposition to drugs to becoming a leading advocate for ibogaine after firsthand experience and veteran outcomes.
• Ibogaine’s impact on PTSD, opioid addiction, and traumatic brain injury, including Stanford-linked brain imaging data showing functional and structural improvement.
• How veterans are the proving ground that enabled Texas to commit $50M in public funding for ibogaine clinical trials.
• Why ibogaine requires intensive medical supervision and why rigorous trials are essential for legitimacy and scale.
• A vision where ibogaine reshapes addiction treatment, veteran care, and eventually criminal justice and homelessness policy.

Credits:

Created by Greg Kubin and Matias Serebrinsky
Host: Greg Kubin
Produced by Caitlin Ner & Nico V. Rey

Find us at businesstrip.fm and psymed.ventures
Follow us on Instagram and Twitter!
Theme music by Dorian Love
Additional Music: Distant Daze by Zack Frank