Basic Bone Biology
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Basic Bone Biology
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Greetings witches! This episode Emily Curtin conjures us an Introduction to Basic Bone Biology! From the microscopic to the macroscopic levels, we discuss all those nitty gritty details that help us understand how our skeleton functions and changes. We apply all this new information to learn about how drugs to treat rheumatoid arthritis pose a risk to our bones. Get ready for a deep dive!
References:
Burr, D.B. and Akkus, O. (2019) Bone Morphology and Organization. Basic and Applied Bone Biology Academic Press. 3–25.
Jahid, M., Khan, K. U., Rehan-Ul-Haq, & Ahmed, R. S. (2023). Overview of Rheumatoid Arthritis and Scientific Understanding of the Disease. Mediterranean journal of rheumatology, 34(3), 284–291.
Kareem, R., Botleroo, R. A., Bhandari, R., Ogeyingbo, O. D., Ahmed, R., Gyawali, M., Venkatesan, N., & Elshaikh, A. O. (2021). The Impact of Rheumatoid Arthritis on Bone Loss: Links to Osteoporosis and Osteopenia. Cureus, 13(8), e17519.
Kwon OC, Oh JS, Hong S, Lee CK, Yoo B, Kim YG. Conventional synthetic disease-modifying antirheumatic drugs and bone mineral density in rheumatoid arthritis patients with osteoporosis: possible beneficial effect of leflunomide. Clin Exp Rheumatol. 2019 Sep-Oct;37(5):813-819. Epub 2019 Feb 11. PMID: 30767868.
Adami, G., Orsolini, G., Rossini, M. et al. Changes in bone turnover markers and bone modulators during abatacept treatment. Sci Rep 13, 17183 (2023).
Barreira, S.C., Fonseca, J.E. The Impact of Conventional and Biological Disease Modifying Antirheumatic Drugs on Bone Biology. Rheumatoid Arthritis as a Case Study. Clinic Rev Allerg Immunol 51, 100–109 (2016).