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BRAIN PONDERINGS

BRAIN PONDERINGS

By: Mark Mattson
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Conversations with scientists at the forefront of brain research. Hosted by neuroscientist Mark Mattson2022 Hygiene & Healthy Living Natural History Nature & Ecology Physical Illness & Disease Science
Episodes
  • Neurobiology of Aging Lecture #3: mTOR, Functional and Structural Alterations, and Biomarkers

    Neurobiology of Aging Lecture #3: mTOR, Functional and Structural Alterations, and Biomarkers
    Dec 10 2025

    NOTE: This lecture with slides presented can be found on the Brain Ponderings YouTube Channel.

    This episode begins by highlighting recent evidence showing adverse effects on the brain of excessive activation of the mTOR pathway as a consequence of dietary branched chain amino acid consumption. Then I describe evidence that Beyond the age of 40 years brain aging results in progressive decrements in function which are associated with reductions in gray matter and synapse numbers particularly in brain regions that play critical roles in memory, executive functions, and task switching. Recent progress has been made in identifying molecular markers of brain aging in samples of blood or cerebrospinal fluid heralding a better understanding of factors that accelerate or retard brain aging. This episode reviews some of the salient research in these areas.
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    1 hr and 19 mins
  • Neurobiology of Aging Lecture 2: Cellular and Molecular Hallmarks of Brain Aging

    Neurobiology of Aging Lecture 2: Cellular and Molecular Hallmarks of Brain Aging
    Dec 10 2025

    NOTE: This lecture with slides presented can be found on the Brain Ponderings YouTube Channel.

    This video describes 12 major changes that occur in brain cells during aging and their involvement in decline in brain function and the development of neurodegenerative disorders including dementia and Parkinson's disease.
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    1 hr and 21 mins
  • Neurobiology of Aging Lecture Series: #1 – Theories, Comparative Biology, and Animal Models of Aging

    Neurobiology of Aging Lecture Series: #1 – Theories, Comparative Biology, and Animal Models of Aging
    Dec 10 2025
    NOTE: This lecture with slides presented can be found on the Brain Ponderings YouTube Channel. This is the first of five lectures on the Neurobiology of Aging. The other four lectures cover cellular hallmarks, structural and functional aspects, biomarkers, how neurodegenerative disorders occur during aging, and how aging can be slowed and brain health span extended by lifestyle and dietary changes.
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    1 hr and 21 mins
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Dr. Mark Mattson PhD, has devoted his life towards a very worthy goal: how to be a cognitively normal human at the age of 100 and beyond? The dedication as well as a strong will to ackomplish this goal is :SELF-EVEIDENT" in every episode we listen. Thank you Dr.Mattson.

This podcast is a legacy of a "PIONEER" in human longevity & cognitive breakthroughs

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