154: Physiology-Guided Sepsis Resuscitation: ANDROMEDA-SHOCK 2, Dynamic Fluid Responsiveness, and SEP-1 with Guest Jaclyn Bond

The science is finally catching up to what clinicians have long known: more fluids aren't always the answer to septic shock. In this episode, host Sarah Lorenzini and Jaclyn Bond MSN-LM, MBA-HM explain what the ANDROMEDA-SHOCK 2 trial reveals about physiology-guided sepsis resuscitation and why fixed-volume fluid strategies can lead to avoidable harm.

They break down how dynamic fluid responsiveness testing helps teams stop guessing, and how tools like FloPatch support real-time assessment of carotid flow time and stroke volume. You'll leave with a clearer idea of when to give fluids, when to stop, and how to justify the decision.

Topics discussed in this episode:

1. The purpose and key findings of the ANDROMEDA-SHOCK 2 study
2. Why dynamic measures of fluid responsiveness matter more than static vitals
3. What recent meta-analysis data shows about physiology-guided fluid strategies
4. Carotid flow time: what it is, how it’s measured, and how it guides decisions
5. Hemodynamic assessment and bedside limitations
6. How FloPatch supports real-time assessment so you can make individualized fluid decisions
7. SEP-1 2026 guideline updates and why it’s better for patients
8. How to apply these principles to your workflow

Website: www.flosonicsmedical.com

See FloPatch in action: https://hubs.ly/Q03-68Hg0

Mentioned in this episode:

Rapid Response Academy Winter 2026 Cohort

https://www.rapidresponseandrescue.com/rra