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The U.S. set to begin blockading Iran's ports this hour after ceasefire talks failed to yield a breakthrough:

Carl Quintanilla, Sara Eisen, and David Faber got the latest out of Washington in addition to new housing data - before diving into the investor implications with Citi Wealth's CIO, and Former Defense Secretary Mark Esper. Plus: a fresh read on how surging energy prices are impacting the consumer - with Sunoco Chairman and luxury mall operator Ray Washburne.

Elsewhere this hour: what's pressuring Goldman Sachs shares in the early trade as they kick off a huge week of quarterly reports... and an impassioned interview with the Executive Chairman of Replimune - whose shares are plunging after FDA denial of a key treatment.

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The opening hour of CNBC’s "Squawk on the Street" with Carl Quintanilla, Jim Cramer and David Faber is broadcast each weekday from the floor of the New York Stock Exchange, on site at the opening bell with the up-to-the-minute news investors need to know and interviews with the most influential CEOs and greatest market minds.

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