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The Philadelphia Chromosome
- A Mutant Gene and the Quest to Cure Cancer at the Genetic Level
- Narrated by: Heather Henderson
- Length: 9 hrs and 43 mins
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For decades after the identification of the structure of DNA, scientists focused only on genes, the regions of the genome that contain codes for the production of proteins. Other regions that make up 98 percent of the human genome were dismissed as "junk," sequences that serve no purpose. But researchers have recently discovered variations and modulations in this junk DNA that are involved with a number of intractable diseases. Junk DNA can play vital and unanticipated roles in the control of gene expression, from fine-tuning individual genes to switching off entire chromosomes.
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1 out of 5 stars
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What’s the point
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Engrossing and captivating, Editing Humanity takes listeners inside the fascinating world of a new gene editing technology called CRISPR, a high-powered genetic toolkit that enables scientists to not only engineer but to edit the DNA of any organism down to the individual building blocks of the genetic code. Davies introduces listeners to arguably the most profound scientific breakthrough of our time. He tracks the scientists on the front lines of its research to the patients whose powerful stories bring the narrative movingly to human scale.
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4 out of 5 stars
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Excellent content, solid execution
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In the fall of 1980, Genentech, Inc., a little-known California genetic engineering company, became the overnight darling of Wall Street, raising over $38 million in its initial public stock offering. Lacking marketed products or substantial profit, the firm nonetheless saw its share price escalate from $35 to $89 in the first few minutes of trading. Coming at a time of economic recession and declining technological competitiveness in the United States, the event ignited a period of speculative frenzy over biotechnology.
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2 out of 5 stars
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Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR - a revolutionary new technology that she helped create - to make heritable changes in human embryos.
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5 out of 5 stars
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In to the abyss we ascend, a scary future
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Tripping Over the Truth
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5 out of 5 stars
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Non-fiction books - please include references
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Publisher's summary
Almost daily, headlines announce newly discovered links between cancers and their genetic causes. Science journalist Jessica Wapner vividly relates the backstory behind those headlines, reconstructing the crucial breakthroughs, explaining the science behind them, and giving due to the dozens of researchers, doctors, and patients whose curiosity and determination restored the promise of a future to the more than 50,000 people diagnosed each year with chronic myeloid leukemia (CML). It is an astonishing tale that will provide victims of other cancers and their loved ones realistic hope that cures may yet be found in their lifetimes.
The Philadelphia Chromosome charts the milestones that led to present-day cancer treatment and tells the inspiring story of the dedicated men and women who, working individually and in concert, have sought to plum the mysteries of the human genome in order to conquer those deadly and most feared diseases called cancer.
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-
The Emperor of All Maladies
- A Biography of Cancer
- By: Siddhartha Mukherjee
- Narrated by: Fred Sanders
- Length: 22 hrs and 18 mins
- Unabridged
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Overall5 out of 5 stars 4,608
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Performance5 out of 5 stars 4,043
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Story5 out of 5 stars 4,021
The Emperor of All Maladies reveals the many faces of an iconic, shape-shifting disease that is the defining plague of our generation. The story of cancer is a story of human ingenuity, resilience, and perseverance but also of hubris, arrogance, paternalism, and misperception, all leveraged against a disease that, just three decades ago, was thought to be easily vanquished in an all-out "war against cancer".
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5 out of 5 stars
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Incredible
- By S.R.E. on 03-02-16
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A Crack in Creation
- Gene Editing and the Unthinkable Power to Control Evolution
- By: Jennifer A. Doudna, Samuel H. Sternberg
- Narrated by: Erin Bennett
- Length: 9 hrs and 22 mins
- Unabridged
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Overall4.5 out of 5 stars 1,342
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Performance4.5 out of 5 stars 1,148
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Story4.5 out of 5 stars 1,147
Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR - a revolutionary new technology that she helped create - to make heritable changes in human embryos.
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5 out of 5 stars
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In to the abyss we ascend, a scary future
- By Philomath on 06-17-17
By: Jennifer A. Doudna, and others
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The Compatibility Gene
- How Our Bodies Fight Disease, Attract Others, and Define Our Selves
- By: Daniel M. Davis
- Narrated by: Christopher Grove
- Length: 7 hrs and 48 mins
- Unabridged
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Overall4.5 out of 5 stars 51
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Performance4.5 out of 5 stars 41
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Story4.5 out of 5 stars 41
Most of the 25,000 genes we possess are the same for all of us. Compatibility genes are those that vary most from person to person and give each of us a unique molecular signature. These genes determine both the extent to which we are susceptible to a vast range of illnesses and the different ways each of us fights disease.
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5 out of 5 stars
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If interested in medicine, got to read
- By Howard Sterling on 06-29-16
By: Daniel M. Davis
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Happy Accidents
- Serendipity in Major Medical Breakthroughs in the Twentieth Century
- By: Morton A. Meyers
- Narrated by: Richard Waterhouse
- Length: 12 hrs and 37 mins
- Unabridged
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Overall4.5 out of 5 stars 50
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Performance4 out of 5 stars 45
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Story4.5 out of 5 stars 44
Happy Accidents is a fascinating, entertaining, and highly accessible look at the surprising role serendipity has played in some of the most important medical discoveries in the 20th century. What do penicillin, chemotherapy drugs, X-rays, Valium, the Pap smear, and Viagra have in common? They were each discovered accidentally, stumbled upon in the search for something else. In discussing medical breakthroughs, Dr. Morton Meyers makes a cogent, highly engaging argument for a more creative, rather than purely linear, approach to science. And it may just save our lives!
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1 out of 5 stars
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Don't waste your money!
- By Amazon Customer on 03-20-16
By: Morton A. Meyers
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The Language of Life
- DNA and the Revolution in Personalized Medicine
- By: Francis S. Collins
- Narrated by: Greg Itzin
- Length: 10 hrs and 45 mins
- Unabridged
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Overall4 out of 5 stars 148
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Performance4.5 out of 5 stars 99
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Story4 out of 5 stars 97
A scientific and medical revolution has crept up on us, based on study after study, from hundreds of laboratories around the world. It is no longer just a theoretical shift: every one of us will be touched by it, and many of us already have been. The meaning of disease, our understanding of the human body, and crucial decisions about what we all need to know and what choices we make about our health are at stake. Welcome to the new world of personalized medicine.
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5 out of 5 stars
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The future of medicine
- By Ronald E on 04-12-10
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The Cancer Chronicles
- Unlocking Medicine's Deepest Mystery
- By: George Johnson
- Narrated by: Arthur Morey
- Length: 8 hrs and 19 mins
- Unabridged
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Overall4.5 out of 5 stars 61
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Performance4.5 out of 5 stars 52
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Story4.5 out of 5 stars 52
When the woman he loved was diagnosed with a metastatic cancer, science writer George Johnson embarked on a journey to learn everything he could about the disease and the people who dedicate their lives to understanding and combating it. What he discovered is a revolution under way - an explosion of new ideas about what cancer really is and where it comes from. In a provocative and intellectually vibrant exploration, he takes us on an adventure through the history and recent advances of cancer research that will challenge everything you thought you knew about the disease.
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5 out of 5 stars
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A quick read - hard to put down
- By Digital Dilema on 09-06-13
By: George Johnson
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Influenza
- The Hundred-Year Hunt to Cure the 1918 Spanish Flu Pandemic
- By: Dr. Jeremy Brown
- Narrated by: Holter Graham
- Length: 6 hrs and 28 mins
- Unabridged
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Overall4.5 out of 5 stars 361
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Performance4.5 out of 5 stars 309
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Story4.5 out of 5 stars 307
On the 100th anniversary of the devastating pandemic of 1918, Jeremy Brown, a veteran ER doctor, explores the troubling, terrifying, and complex history of the flu virus, from the origins of the Great Flu that killed millions, to vexing questions such as: are we prepared for the next epidemic, should you get a flu shot, and how close are we to finding a cure?
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5 out of 5 stars
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Important read
- By Kathryn C. on 12-21-18
By: Dr. Jeremy Brown
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Ten Drugs
- How Plants, Powders, and Pills Have Shaped the History of Medicine
- By: Thomas Hager
- Narrated by: Angelo Di Loreto
- Length: 8 hrs and 39 mins
- Unabridged
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Overall4.5 out of 5 stars 4,848
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Performance4.5 out of 5 stars 4,197
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Story4.5 out of 5 stars 4,179
Beginning with opium, the “joy plant,” which has been used for 10,000 years, Thomas Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.
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4 out of 5 stars
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Engrossing to physicians & lay persons alike
- By C. White on 03-08-19
By: Thomas Hager
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Editing Humanity
- The CRISPR Revolution and the New Era of Genome Editing
- By: Kevin Davies
- Narrated by: Kevin Davies
- Length: 16 hrs and 17 mins
- Unabridged
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Overall4.5 out of 5 stars 76
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Performance4.5 out of 5 stars 65
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Story4.5 out of 5 stars 65
Engrossing and captivating, Editing Humanity takes listeners inside the fascinating world of a new gene editing technology called CRISPR, a high-powered genetic toolkit that enables scientists to not only engineer but to edit the DNA of any organism down to the individual building blocks of the genetic code. Davies introduces listeners to arguably the most profound scientific breakthrough of our time. He tracks the scientists on the front lines of its research to the patients whose powerful stories bring the narrative movingly to human scale.
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4 out of 5 stars
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Excellent content, solid execution
- By Samuel Finlayson on 01-25-21
By: Kevin Davies
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The Secret History of the War on Cancer
- By: Devra Davis Ph.D.
- Narrated by: Pam Ward
- Length: 19 hrs and 11 mins
- Unabridged
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Overall4.5 out of 5 stars 36
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Performance4.5 out of 5 stars 23
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Story4.5 out of 5 stars 24
The War on Cancer was run by leaders of industries that made cancer-causing products and sometimes also profited from drugs and technologies for finding and treating the disease. Filled with compelling personalities and never-before-revealed information, The Secret History of the War on Cancer shows how we began fighting the wrong war, with the wrong weapons, against the wrong enemies, a legacy that persists to this day.
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2 out of 5 stars
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Silly Book
- By Adam Smith on 12-24-14
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The Demon Under The Microscope
- By: Thomas Hager
- Narrated by: Stephen Hoye
- Length: 12 hrs and 14 mins
- Unabridged
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Overall4.5 out of 5 stars 3,480
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Performance4.5 out of 5 stars 2,536
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Story4.5 out of 5 stars 2,534
The Nazis discovered it. The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. This incredible discovery was sulfa, the first antibiotic medication. In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of the drug that shaped modern medicine.
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5 out of 5 stars
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Great Book!!!!!
- By Amazon Customer on 05-21-08
By: Thomas Hager
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The Antidote
- Inside the World of New Pharma
- By: Barry Werth
- Narrated by: Sean Pratt
- Length: 16 hrs and 27 mins
- Unabridged
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Overall4 out of 5 stars 75
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Performance4 out of 5 stars 64
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Story4 out of 5 stars 65
In 1989, the charismatic Joshua Boger left Merck, then America's most admired business, to found a drug company that would challenge industry giants and transform health care. Barry Werth described the company's tumultuous early days during the AIDS crisis in The Billion-Dollar Molecule, a celebrated classic of science and business journalism. Now he returns to tell a riveting story of Vertex's bold endurance and eventual success.
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2 out of 5 stars
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For me this was not interesting
- By Yan on 06-26-17
By: Barry Werth
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Plague of Corruption
- Restoring Faith in the Promise of Science
- By: Dr. Judy Mikovits, Kent Heckenlively, Robert F. Kennedy Jr.
- Narrated by: Mariel Hemingway
- Length: 10 hrs and 10 mins
- Unabridged
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Overall5 out of 5 stars 793
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Performance4.5 out of 5 stars 707
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Story5 out of 5 stars 705
Dr. Judy Mikovits is a modern-day Rosalind Franklin, a brilliant researcher shaking up the old boys' club of science with her groundbreaking discoveries. And like many women who have trespassed into the world of men, she uncovered decades-old secrets that many would prefer to stay buried.
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5 out of 5 stars
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If only most of the public knew these facts
- By David Getoff, CCN on 06-18-20
By: Dr. Judy Mikovits, and others
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Denialism
- How Irrational Thinking Hinders Scientific Progress, Harms the Planet, and Threatens Our Lives
- By: Michael Specter
- Narrated by: Richard Poe
- Length: 8 hrs and 33 mins
- Unabridged
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Overall4 out of 5 stars 150
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Performance4 out of 5 stars 100
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Story4 out of 5 stars 99
New Yorker staff writer Michael Specter has twice won the Global Health Council’s Excellence in Media Award, as well as the Science Journalism Award from the American Association for the Advancement of Science. In Denialism, he fervently argues that people are turning away from new technologies and engaging in a kind of magical thinking that is hindering scientific progress.
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5 out of 5 stars
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A compelling read
- By S on 05-17-11
By: Michael Specter
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A Shot to Save the World
- The Inside Story of the Life-or-Death Race for a COVID-19 Vaccine
- By: Gregory Zuckerman
- Narrated by: Jack Armstrong
- Length: 12 hrs and 6 mins
- Unabridged
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Overall4.5 out of 5 stars 171
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Performance4.5 out of 5 stars 145
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Story4.5 out of 5 stars 144
Few were ready when a mysterious respiratory illness emerged in Wuhan, China, in January 2020. Politicians, government officials, business leaders, and public-health professionals were unprepared for the most devastating pandemic in a century. Many of the world’s biggest drug and vaccine makers were slow to react or couldn’t muster an effective response. It was up to a small group of unlikely and untested scientists and executives to save civilization.
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5 out of 5 stars
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Wow! Do not miss this one.
- By Jacob on 11-18-21
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Missing Microbes
- How the Overuse of Antibiotics Is Fueling Our Modern Plagues
- By: Martin J. Blaser
- Narrated by: Patrick Lawlor
- Length: 8 hrs and 43 mins
- Unabridged
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Overall4.5 out of 5 stars 371
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Performance4.5 out of 5 stars 314
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Story4.5 out of 5 stars 316
In Missing Microbes, Dr. Martin J. Blaser invites us into the wilds of the human microbiome, where for hundreds of thousands of years bacterial and human cells have existed in a peaceful symbiosis that is responsible for the health and equilibrium of our body. Now this invisible eden is being irrevocably damaged by some of our most revered medical advances-antibiotics-threatening the extinction of our irreplaceable microbes with terrible health consequences.
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5 out of 5 stars
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Very enlightening and information well supported
- By James on 05-03-15
By: Martin J. Blaser
What listeners say about The Philadelphia Chromosome
Average customer ratingsReviews - Please select the tabs below to change the source of reviews.
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Overall5 out of 5 stars
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Performance5 out of 5 stars
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Story5 out of 5 stars
- Ronda
- 03-17-16
Great topic for those in medicine
This book details the research and development and treatment for CML patients with the Philadelphia Chromosome defect. I work with cancer patients so I found the book extremely interesting--not overly technical for the lay person, but technical enough to keep me interested and listening with anticipation.
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3 people found this helpful
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Overall4 out of 5 stars
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Performance4 out of 5 stars
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Story5 out of 5 stars
- Michael D. Stone
- 06-27-13
GREAT story.
If you could sum up The Philadelphia Chromosome in three words, what would they be?
Encouraging wonderful story
Who was your favorite character and why?
Dr Brian Druker.... a TRUE modern day HERO!
Have you listened to any of Heather Henderson’s other performances before? How does this one compare?
No
Was there a moment in the book that particularly moved you?
anything that referred to Dr Drukers drive to see this all the way through
Any additional comments?
A REALLY good and important book. Inspirational. Criticism? a tad too repetetive.
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3 people found this helpful