Weight-loss drugs that target the hormone GLP-1 have rapidly reshaped the conversation around obesity, appetite and personal responsibility. But alongside the rise of powerful synthetic injectables, researchers are also exploring whether the body’s own appetite signals can be harnessed more naturally. At the heart of the debate is a simple question: are we eating too much because of weak willpower, or because of biology?

As new approaches emerge, the challenge is to balance effectiveness, safety and long-term sustainability in tackling one of modern health’s most persistent problems.

In this interview, Sarah Kennedy, founder of Calocurb, a New Zealand company which has developed a plant-based compound designed to naturally stimulate GLP-1, discusses the science of appetite control and how it compares to injectable drugs.

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This podcast is supported by affiliate arrangements with a select number of companies. We have arranged discounts on certain products and receive a small commission on sales. The income helps to cover production costs and ensures that our interviews remain free for all to listen.

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The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Where we live could be the most important factor in how long and well we live. Teri Slavik-Tsuyuki, co-chair of the Global Wellness Institute’s Wellness Communities Initiative, reveals how homes and neighborhoods influence 85% of our health outcomes—more than our genes.

From pandemic-driven lifestyle shifts to multigenerational living, she shares how intentional design, walkable communities, and social spaces can keep us independent, active, and connected at any age.

Discover the secrets behind wellness-focused communities and how your environment shapes your third chapter of life.

Additional video courtesy: Rancho Mission Viejo

This podcast is supported by affiliate arrangements with a select number of companies. We have arranged discounts on certain products and receive a small commission on sales. The income helps to cover production costs and ensures that our interviews remain free for all to listen.

Visit our SHOP for more details:
https://healthspan-media.com/live-long-podcast/shop/

Listen on: Apple Podcasts Spotify

Support the show

The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Artificial intelligence is rapidly changing how we understand our health — not just how we feel today, but how fast we’re actually aging.

On this episode of Live Long, host Peter Bowes continues his personal experiment with Hundred, the AI-powered longevity platform that combines advanced blood testing, wearable data and personalized insights to track biological age and guide smarter health decisions.

After introducing the app in an earlier conversation, Peter reconnects with Hundred’s founder, Tyler Smith, to go deeper into the idea of a “health operating system” — essentially a personal doctor in your pocket. Together they explore how continuous testing and AI analysis could help prevent disease, spot risks earlier, and motivate lasting behavior change — while also addressing the realities of over-testing, false alarms, privacy concerns and health anxiety.

Peter also shares the results of his own first round of testing, what surprised him most, and how he’s using the data to shape his approach to longevity and healthy aging.

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JOIN HUNDRED

Optimize your healthspan and potentially lower your biological age. Tyler and the team at HUNDRED are offering $75 in credit for add-on tests and supplements from the HUNDRED marketplace when you sign up at hundred.com/livelongpodcast

This podcast is supported by affiliate arrangements with a select number of companies. We have arranged discounts on certain products and receive a small commission on sales. The income helps to cover production costs and ensures that our interviews remain free for all to listen.

Visit our SHOP for more details:
https://healthspan-media.com/live-long-podcast/shop/

Listen on: Apple Podcasts Spotify

Support the show

The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.