In this episode of Going anti-Viral, host Dr Michael Saag interviews Adam Castillejo, known as the London patient, who is the second person to have been cured of HIV infection. The discussion, recorded on March 3, 2024, at The Conference on Retroviruses and Opportunistic Infections (CROI), touches on Adam's initial HIV diagnosis in London during the early 2000s, the societal stigma and personal impact of the diagnosis, and his dual battle with HIV and cancer. Adam shares the complex journey of his treatment, including the failure of initial interventions and the ultimate success of a bone marrow transplant from a donor with a CCR5 delta 32 mutation, leading to his cure of HIV and cancer. The conversation delves into the technical aspects of bone marrow transplant, the emotional and physical challenges Adam faced during recovery, and the continued stigma he experiences even post-cure. The episode reflects on the broader implications of Adam's story for HIV research and societal perceptions of the disease.

00:00 Introduction

01:10 Adam's Early Struggle with HIV Diagnosis

02:46 Confronting Stigma and Finding Support

05:26 The Battle Against Cancer and Mental Health Challenges

08:35 The Turning Point: Bone Marrow Transplant

15:14 The Journey of Recovery

17:29 Life After the Cure

22:37 Concluding Thoughts

__________________________________________________

Produced by IAS-USA, Going anti–Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections.

Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences.

Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode.

Follow Going anti-Viral on:
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Episode 14 - HIV Treatment with Long-Acting Injectables with Dr Aadia Rana Recorded Live at CROI 2024 on March 4, 2024

In this episode, Dr Michael Saag and Dr Adia Rana discuss a breakthrough study on using a long-acting injectable HIV treatment with conditional economic incentives for individuals who were unable to take oral therapy. Presented at CROI 2024, the study's positive outcomes offer an effective option for certain individuals with no other options for continuing oral antiretroviral therapy.


For further reading, please visit the link below.

Updated Treatment Recommendation on Use of Cabotegravir and Rilpivirine for People With HIV From the IAS-USA Guidelines Panel

00:00 Introduction to the Podcast and Guest

00:50 Exploring Adherence Challenges and Study Insights

03:27 The Evolution of HIV Treatment: From Oral to Injectable Therapies

10:59 Study Results: A New Alternative for Select Individuals with Limited Treatment Options

16:05 Navigating Real-World Applications and Ethical Considerations

21:08 Reflecting on the Journey and Looking Ahead

25:21 Closing Thoughts and Future Directions

__________________________________________________

Produced by IAS-USA, Going anti–Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections.

Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences.

Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode.

Follow Going anti-Viral on:
Apple Podcasts
YouTube
Instagram
TikTok
...

Episode 13 - Advancements in STI Prevention: Insights from Dr Jean-Michel Molina Recorded Live at CROI 2024 on March 3, 2024

In this episode of Going anti-Viral, Dr Michael Saag and Dr Jean-Michel Molina discuss recent developments in STI prevention, focusing on doxycycline as post-exposure prophylaxis (DoxyPEP) and the evaluation of a meningococcal vaccine for gonorrhea prevention in the ANRS Doxyvac trial. Recorded at CROI 2024, Dr Molina shares insights from clinical trials, including challenges with data analysis and implications for future STI prevention and vaccine research.

00:00 Introduction to the Podcast and Guest

00:30 Innovative Approaches in Clinical Care with Dr Jean-Michel Molina

00:54 Exploring the Impact of Doxycycline and Vaccines on STIs

01:50 Challenges and Insights from Clinical Trials

04:29 The Journey from Interim Analysis to Final Results

09:27 Addressing Data Discrepancies

21:05 Future Directions in STI Prevention and Vaccine Research

26:46 Closing Thoughts and the Importance of Trustworthy Research

__________________________________________________

Produced by IAS-USA, Going anti–Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections.

Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences.

Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode.

Follow Going anti-Viral on:
Apple Podcasts
YouTube
Instagram
TikTok
...