Léon Gaultier (Jean-Claude Van Damme) is a soldier in the French Foreign Legion, serving abroad in East Africa. But after his brother is cruelly murdered, Gaultier deserts his assignment and travels to the United States to help his widowed sister-in-law (Lisa Pelikan), who is now struggling to care for her children. But the job market is tough, so Gaultier takes his hand-to-hand combat skills into the brutal world of bare-knuckle fighting, where the paydays are nearly as big as the risks.

In this spoof of "Top Gun," former U.S. Navy pilot Topper Harley (Charlie Sheen) is haunted by an accident in which his father lost control of a fighter jet. When Lt. Cmdr. James Block (Kevin Dunn) asks Topper to come out of retirement and help him complete a classified mission, Topper returns to active duty against the advice of his psychiatrist (Valeria Golino) and soon discovers that he may be a pawn in a devious arms manufacturing conspiracy.

Set across three distinct eras—Viking-era Scandinavia, feudal Japan, and World War II in the skies—the film follows three legendary warriors: Viking Queen Ursa on a brutal vengeance quest alongside her son; samurai brothers Kenji and Kiyoshi torn by honor and betrayal; and U.S. Navy pilot Johnny Torres dogfighting in a Predator-infested Atlantic. Each vignette pits human skill and courage against the alien hunters, culminating in a thrilling convergence on the Predator homeworld, where the trio must unite to survive a gladiatorial showdown. With razor-sharp painterly animation, inventive Predator tech, and a sweeping score, Killer of Killers deepens Predator lore while delivering visceral, globe-spanning sci-fi action.