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The Antidote
- Inside the World of New Pharma
- Narrated by: Sean Pratt
- Length: 16 hrs and 27 mins
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The Antidote
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Publisher's summary
In 1989, the charismatic Joshua Boger left Merck, then America's most admired business, to found a drug company that would challenge industry giants and transform health care. Barry Werth described the company's tumultuous early days during the AIDS crisis in The Billion-Dollar Molecule, a celebrated classic of science and business journalism. Now he returns to tell a riveting story of Vertex's bold endurance and eventual success.
The $325-billion-a-year pharmaceutical business is America's toughest and one of its most profitable. It is riskier and more rigorous at just about every stage than any other business, from the towering biological uncertainties inherent in its mission to treat disease; to the 30-to-1 failure rate in bringing out a successful medicine even after a molecule clears all the hurdles to get to human testing; to the multibillion-dollar cost of ramping up a successful product; to operating in the world's most regulated industry, matched only by nuclear power.
Werth captures the full scope of Vertex's 25-year drive to deliver breakthrough medicines. At a time when America struggles to maintain its innovative edge, The Antidote is a powerful inside look at one of the most intriguing and important business stories of recent decades.
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Story4.5 out of 5 stars 126
Finding the right venture capitalist to back your start-up is a challenge. Even if you manage to get backing, you want your VC to be a partner, not some dictator who will undermine your vision and take control of your life's work. Jeffrey Bussgang is one of a very few people who have played on both sides of this high-stakes game. Now he draws on his unique perspective to offer high-level insights, colorful stories, and practical advice. He reveals how to get noticed, perfect a pitch, and negotiate a partnership that works for everyone.
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5 out of 5 stars
-
slow in beginning but gets really good
- By Diana on 04-11-19
By: Jeffrey Bussgang
-
Rigor Mortis
- How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions
- By: Richard Harris
- Narrated by: Joe Delafield
- Length: 5 hrs and 56 mins
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Overall4.5 out of 5 stars 117
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Performance4.5 out of 5 stars 100
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Story4.5 out of 5 stars 99
American taxpayers spend $30 billion annually funding biomedical research, but over half of these studies can't be replicated due to poor experimental design, improper methods, and sloppy statistics. Bad science doesn't just hold back medical progress, it can sign the equivalent of a death sentence for terminal patients. In Rigor Mortis, Richard Harris explores these urgent issues with vivid anecdotes, personal stories, and interviews with the top biomedical researchers. We need to fix our dysfunctional biomedical system - before it's too late.
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5 out of 5 stars
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Eye opening introduction to biomedical R&D
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By: Richard Harris
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A Shot to Save the World
- The Inside Story of the Life-or-Death Race for a COVID-19 Vaccine
- By: Gregory Zuckerman
- Narrated by: Jack Armstrong
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Overall4.5 out of 5 stars 171
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Performance4.5 out of 5 stars 145
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Story4.5 out of 5 stars 144
Few were ready when a mysterious respiratory illness emerged in Wuhan, China, in January 2020. Politicians, government officials, business leaders, and public-health professionals were unprepared for the most devastating pandemic in a century. Many of the world’s biggest drug and vaccine makers were slow to react or couldn’t muster an effective response. It was up to a small group of unlikely and untested scientists and executives to save civilization.
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5 out of 5 stars
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Wow! Do not miss this one.
- By Jacob on 11-18-21
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Where Does It Hurt?
- An Entrepreneur's Guide to Fixing Health Care
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- Narrated by: Patrick Lawlor
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Performance4.5 out of 5 stars 113
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Story4.5 out of 5 stars 115
A bold new remedy for the sprawling and wasteful health care industry. In this provocative book, Jonathan Bush, cofounder and CEO of athenahealth, calls for a revolution in health care to give customers more choices, freedom, power, and information, and at far lower prices.
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2 out of 5 stars
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No critical thinking
- By Steve from MD on 07-31-14
By: Jonathan Bush, and others
-
American Icon
- Alan Mulally and the Fight to Save Ford Motor Company
- By: Bryce G. Hoffman
- Narrated by: Pete Larkin
- Length: 14 hrs and 45 mins
- Unabridged
-
Overall4.5 out of 5 stars 2,239
-
Performance4.5 out of 5 stars 1,951
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Story4.5 out of 5 stars 1,950
At the end of 2008, Ford Motor Company was just months away from running out of cash. With the auto industry careening toward ruin, Congress offered all three Detroit automakers a bailout. General Motors and Chrysler grabbed the taxpayer lifeline, but Ford decided to save itself. Under the leadership of charismatic CEO Alan Mulally, Ford had already put together a bold plan to unify its divided global operations, transform its lackluster product lineup, and overcome a dysfunctional culture of infighting, backstabbing, and excuses.
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5 out of 5 stars
-
The best business book I ever read
- By Michael on 10-07-12
By: Bryce G. Hoffman
-
Open
- How Compaq Ended IBM's PC Domination and Helped Invent Modern Computing
- By: Rod Canion
- Narrated by: Paul Boehmer
- Length: 6 hrs and 19 mins
- Unabridged
-
Overall4.5 out of 5 stars 116
-
Performance4 out of 5 stars 108
-
Story4.5 out of 5 stars 106
Open provides valuable lessons in leadership in times of crisis, management decision-making under the pressure of extraordinary growth, and the power of a unique, pervasive culture. Open tells the incredible story of Compaq’s meteoric rise from humble beginnings to become the PC industry leader in just over a decade. Along the way, Compaq helped change the face of computing while establishing the foundation for today’s world of tablets and smart phones.
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3 out of 5 stars
-
Wrong narrator for this book
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By: Rod Canion
-
The Firm
- The Story of McKinsey and Its Secret Influence on American Business
- By: Duff McDonald
- Narrated by: Tom Weiner
- Length: 11 hrs and 19 mins
- Unabridged
-
Overall4.5 out of 5 stars 716
-
Performance4.5 out of 5 stars 599
-
Story4 out of 5 stars 598
A behind-the-scenes, revelatory history of McKinsey & Company, America's most influential and controversial business consulting firm, told by one of the nation's leading financial journalists. In The Firm, Duff McDonald uncovers how these high-powered, high-priced business savants have ushered in waves of structural, financial, and technological shifts. With unrivaled access to company documents and current and former employees, McDonald reveals the inner workings of what just might be the most influential private organization in America.
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3 out of 5 stars
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Warning: Non consultants should avoid
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By: Duff McDonald
-
Overhaul
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- Narrated by: Joe Barrett
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- Unabridged
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Overall4.5 out of 5 stars 50
-
Performance4.5 out of 5 stars 39
-
Story4.5 out of 5 stars 39
This first real look inside Team Obama mixes political warfare and big-business shakeups in equal proportions, and comes from a uniquely informed source. Steve Rattner is not just the man brought in by the president to save the auto industry, he is a former New York Times financial reporter who also earned a place among the top tier of Wall Street's most informed investment bankers and corporate experts.
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5 out of 5 stars
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Overhaul - A Memoir
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Who Says Elephants Can't Dance?
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- By: Louis V. Gerstner Jr.
- Narrated by: Edward Herrmann
- Length: 8 hrs and 29 mins
- Unabridged
-
Overall4.5 out of 5 stars 892
-
Performance4.5 out of 5 stars 556
-
Story4.5 out of 5 stars 553
In 1990, IBM had its most profitable year ever. By 1993, the company was on a watch list for extinction, victimized by its own lumbering size, an insular corporate culture, and the PC era IBM had itself helped invent.
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5 out of 5 stars
-
Moderate Start, Picks up FAST!
- By Art H on 02-08-05
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Epic Measures
- One Doctor. Seven Billion Patients.
- By: Jeremy N. Smith
- Narrated by: Patrick Lawlor
- Length: 10 hrs and 12 mins
- Unabridged
-
Overall4.5 out of 5 stars 62
-
Performance4.5 out of 5 stars 51
-
Story4.5 out of 5 stars 49
Moneyball meets medicine in this remarkable chronicle of one of the greatest scientific quests of our time - the groundbreaking program to answer the most essential question for humanity: How do we live and die? - and the visionary mastermind behind it.
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5 out of 5 stars
-
Fabulously insightful read!
- By Dr. Jack E. Fincham on 10-08-15
By: Jeremy N. Smith
-
Good for the Money
- My Fight to Pay Back America
- By: Bob Benmosche
- Narrated by: Sean Pratt
- Length: 9 hrs and 33 mins
- Unabridged
-
Overall4.5 out of 5 stars 70
-
Performance5 out of 5 stars 65
-
Story4.5 out of 5 stars 64
In 2009, at the peak of the financial crisis, AIG - the American insurance behemoth - was sinking fast. It was the peg upon which the nation hung its ire and resentment during the financial crisis: the pinnacle of Wall Street arrogance and greed. When Bob Benmosche climbed aboard as CEO, it was widely assumed that he would go down with his ship. In mere months, he turned things around, pulling AIG from the brink of financial collapse and restoring its profitability.
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4 out of 5 stars
-
Worthwhile, informative, and just short of inspiring
- By Preston on 11-17-21
By: Bob Benmosche
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Silent Invasion
- The Untold Story of the Trump Administration, Covid-19, and Preventing the Next Pandemic Before It's Too Late
- By: Deborah Birx
- Narrated by: Kathe Mazur
- Length: 22 hrs and 3 mins
- Unabridged
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Overall4.5 out of 5 stars 127
-
Performance4.5 out of 5 stars 112
-
Story4.5 out of 5 stars 113
In late February 2020, Dr. Deborah Birx—a lifelong federal health official who had worked at the CDC, the State Department, and the US Army across multiple presidential administrations—was asked to join the Trump White House Coronavirus Task Force and assist the already faltering federal response to the Covid-19 pandemic. For weeks, she’d been raising the alarm behind the scenes about what she saw happening in public—from the apparent lack of urgency at the White House to the routine downplaying of the risks to Americans.
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5 out of 5 stars
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Great insight into Public Health
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By: Deborah Birx
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No Better Time
- The Brief, Remarkable Life of Danny Lewin, the Genius Who Transformed the Internet
- By: Molly Knight Raskin
- Narrated by: Christine Marshall
- Length: 6 hrs and 22 mins
- Unabridged
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Overall4.5 out of 5 stars 65
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Performance4.5 out of 5 stars 61
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Story4.5 out of 5 stars 60
No Better Time tells of a young, driven mathematical genius who wrote a set of algorithms that would create a faster, better Internet. It's the story of a beautiful friendship between a loud, irreverent student and his soft-spoken MIT professor, of a husband and father who spent years struggling to make ends meet only to become a billionaire almost overnight with the success of Akamai Technologies, the Internet content delivery network he cofounded with his mentor.
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4 out of 5 stars
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An Overlooked Hero of 9-11
- By Jean on 05-27-16
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A Bigger Prize
- How We Can Do Better Than the Competition
- By: Margaret Heffernan
- Narrated by: Margaret Heffernan
- Length: 15 hrs and 48 mins
- Unabridged
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Overall4.5 out of 5 stars 37
-
Performance4.5 out of 5 stars 29
-
Story4.5 out of 5 stars 29
From the cranberry bogs of Massachusetts to the classrooms of Singapore and Finland, from tiny start-ups to global engineering firms and beloved American organizations like Ocean Spray, Eileen Fisher, Gore, and Boston Scientific, Heffernan discovers ways of living and working that foster creativity, spark innovation, reinforce our social fabric, and feel so much better than winning.
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5 out of 5 stars
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Margaret Heffernan is brilliant!
- By Eric Willingham on 06-09-16
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Good to Great
- Why Some Companies Make the Leap...And Others Don't
- By: Jim Collins
- Narrated by: Jim Collins
- Length: 10 hrs and 1 min
- Unabridged
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Overall4.5 out of 5 stars 17,359
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Performance4.5 out of 5 stars 14,273
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Story4.5 out of 5 stars 14,176
Built To Last, the defining management study of the 90s, showed how great companies triumph over time and how long-term sustained performance can be engineered into the DNA of an enterprise from the very beginning. But what about companies that are not born with great DNA? How can good companies, mediocre companies, even bad companies achieve enduring greatness?
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3 out of 5 stars
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Good info, over-the-top narration
- By Anaxamaxan on 08-31-10
By: Jim Collins
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Finish Big
- How Great Entrepreneurs Exit Their Companies on Top
- By: Bo Burlingham
- Narrated by: Sean Pratt
- Length: 10 hrs and 17 mins
- Unabridged
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Overall4.5 out of 5 stars 157
-
Performance4.5 out of 5 stars 129
-
Story4.5 out of 5 stars 127
When pioneering business journalist and Inc. magazine editor at large Bo Burlingham wrote Small Giants, it became an instant classic for its original take on a common business problem - how to handle the pressure to grow. Now Burlingham is back to tackle an even more common problem - how to exit your company well. Sooner or later, all entrepreneurs leave their businesses and all businesses get sold, given away, or liquidated.
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5 out of 5 stars
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Begin with the end in mind
- By D. Hartzell on 02-05-15
By: Bo Burlingham
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Data-ism
- The Revolution Transforming Decision Making, Consumer Behavior, and Almost Everything Else
- By: Steve Lohr
- Narrated by: Steve Lohr
- Length: 6 hrs and 33 mins
- Unabridged
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Overall4 out of 5 stars 117
-
Performance4 out of 5 stars 100
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Story4 out of 5 stars 97
Coal, iron ore, and oil were the key productive assets that fueled the Industrial Revolution. Today data is the vital raw material of the information economy. The explosive abundance of this digital asset, more than doubling every two years, is creating a new world of opportunity and challenge. Data-ism is about this next phase, in which vast, Internet-scale data sets are used for discovery and prediction in virtually every field. It is a journey across this emerging world with people, illuminating narrative examples, and insights.
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4 out of 5 stars
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More business case than serious analysis
- By Godfried Gubbels on 06-03-15
By: Steve Lohr
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What listeners say about The Antidote
Average customer ratingsReviews - Please select the tabs below to change the source of reviews.
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Overall5 out of 5 stars
-
Performance4 out of 5 stars
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Story5 out of 5 stars
- Michael Bigger
- 10-28-16
Creating Societal Value
Enjoyed listening to the inside stories about the challenges of creating life enhancing products for humanity. A+
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Overall5 out of 5 stars
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Performance5 out of 5 stars
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Story5 out of 5 stars
- Paul Gerard
- 06-27-15
Development of elegant new medicine
The author brings us inside the finance and science of the development of an entirely new concept in medicine. Vertex looks at chronic illness at the mechanism and focuses on fixing the problem rather than the symptoms. This is the 21st century in health care.
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Overall2 out of 5 stars
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Performance4 out of 5 stars
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Story1 out of 5 stars
- Yan
- 06-26-17
For me this was not interesting
Sorry for the harsh commentary.... It's like someone compiled all of their stock market announcements into a book, flavored with some irrelevant details about the employees... I was hoping to hear some insights about the pharma market. The book started well.
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1 person found this helpful