The Human Upgrade: Biohacking for Longevity & Performance Podcast Por Dave Asprey arte de portada

The Human Upgrade: Biohacking for Longevity & Performance

The Human Upgrade: Biohacking for Longevity & Performance

De: Dave Asprey
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For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.

Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.

This isn’t just self-improvement - it’s human enhancement backed by data.

Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.

Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

© Copyright © Bulletproof Media 2023 Ciencia Desarrollo Personal Higiene y Vida Saludable Éxito Personal
Episodios
  • A-List Celebrities' Anti-Aging Hack to Look 30 At 50 (Drug-free) : 1424

    A-List Celebrities' Anti-Aging Hack to Look 30 At 50 (Drug-free) : 1424
    Mar 1 2026

    What if the secret to living longer wasn't locked in a lab, but hiding in plain sight? And what could lobsters possibly teach us about staying young?


    Scientists have discovered a remarkable connection between an ancient practice and our cellular aging process - one that celebrities and longevity researchers are quietly using to their advantage. It involves an enzyme in your body that most people don't even know exists, yet it plays a crucial role in how fast (or slow) you age.


    The twist? You can activate it in just 10 minutes a day, no prescription required.


    Curious about the biological "switch" that might help you turn back your cellular clock? The answer might surprise you...


    Thank you to our sponsors!

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    • Upgrade Labs: https://upgradelabs.com


    0:00 – Introduction

    0:46 – Lobsters and Human Longevity Connection

    1:14 – Understanding Telomeres and Aging

    2:26 – How Lobsters Defy Aging

    3:32 – Rethinking Aging Biology

    4:53 – The Telomerase Challenge

    6:43 – Natural Ways to Protect Telomeres

    9:33 – Meditation's Role in Anti-Aging

    11:04 – Different Meditation Techniques

    13:19 – Benefits and Long-Term Effects

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    15 m
  • Mexican Cartel Biohacking, Google Anti-Aging Breakthrough, Measles Is Back, Age Reversal In 2026 : 1423

    Mexican Cartel Biohacking, Google Anti-Aging Breakthrough, Measles Is Back, Age Reversal In 2026 : 1423
    Feb 27 2026
    This week’s stories: Sinclair’s This Is the Test: Are we about to see age reversal in humans? At the World Governments Summit 2026 in Dubai, Harvard geneticist David Sinclair told world leaders that ageing could soon be reversible and said the first human clinical trials of epigenetic reprogramming therapies are moving forward. The core idea is that ageing is partly an information problem, how cells read DNA, not just cumulative damage, and that partial reprogramming could restore youthful function without turning tissues into tumors. Dave frames this as a rare binary moment for longevity: either early, localized human trials (starting with tightly controlled tissue targets like the eye) show meaningful functional rejuvenation with acceptable safety, or the field has to recalibrate fast. Either way, the next couple of years will heavily influence where money, regulators, and serious researchers place their bets. • Sources: – World Governments Summit: https://www.worldgovernmentssummit.org/media-hub/news/detail/ageing-could-soon-be-reversible-says-harvard-scientist-at-wgs-2026 – NAD / Life Biosciences coverage: https://www.nad.com/news/fda-greenlights-life-biosciences-human-study-setting-up-pivotal-test-for-aging-theory-from-harvards-david-sinclair AlphaFold 4 in a locked box: DeepMind’s private AI drug design engine Isomorphic Labs, DeepMind’s drug discovery company, unveiled a proprietary drug design engine that outside scientists are comparing to an AlphaFold 4 moment, but for designing drugs, not just predicting structures. The big shift is that this system is closed: no public weights, no open database, and access appears to flow through partnerships with pharma companies. Dave breaks down why that matters for the longevity world: if AI makes early discovery cheaper and faster, we might see more serious shots on ageing targets over the next decade, but a closed model can also mean less transparency, bigger IP moats, and no guarantee that faster discovery leads to cheaper drugs. • Sources: – Nature: https://www.nature.com/articles/d41586-026-00365-7 – Isomorphic Labs: https://www.isomorphiclabs.com/articles/the-isomorphic-labs-drug-design-engine-unlocks-a-new-frontier Peptides in the freezer: El Mencho’s anti aging stash and the dark side of wellness After reports and images from the final hideout linked to Jalisco New Generation Cartel leader Nemesio Oseguera Cervantes (El Mencho), coverage highlighted a detail that feels uncomfortably familiar to anyone in the modern wellness internet: injectable vials stored in a freezer with a schedule attached, including Tationil Plus, a glutathione based injectable marketed in some places for “cellular health,” cosmetic effects, and anti ageing. Dave uses the absurdity as a narrative wedge, not cartel gossip, to talk about how normalized gray market injectables have become, and how marketing (“detox,” “cellular reset”) often outruns evidence and safety. The segment pivots into a practical filter: which compounds are real therapeutics under medical supervision, and which are expensive folklore with sourcing risk and unknown long term downsides. • Sources: – New York Post: https://nypost.com/2026/02/25/world-news/inside-the-luxurious-love-nest-where-mexican-drug-lord-el-mencho-spent-his-final-days/ – Sky News (Reuters photos referenced): https://news.sky.com/story/inside-the-mexican-villa-where-feared-drug-lord-el-mencho-spent-final-hours-13511954 – Reuters photo gallery: https://www.reuters.com/pictures/el-menchos-last-hideout-inside-villa-where-cartel-leader-spent-final-hours-2026-02-25/W7DK5WEXS5IMLLZQO2P3CXGXFM The disease we thought was dead: measles comes roaring back Measles cases have surged in early 2026, with reporting citing at least 588 cases in the U.S. by late January, already more than many full year totals, and additional updates showing continued acceleration into February. Dave reframes this as a healthspan floor issue: you can argue about peptides and mitochondria all day, but measles is so contagious that once community immunity drops, outbreaks move fast and hit the most vulnerable first, especially infants and immunocompromised people. He also flags the systems problem: many clinicians have never seen measles, which increases the odds of delayed recognition and wider exposure in waiting rooms. The actionable move is boring and high ROI: verify MMR status for you and your family and close gaps before outbreaks get closer to home. • Sources: – AMA Morning Rounds (Week of Feb. 2, 2026): https://www.ama-assn.org/about/publications-newsletters/top-news-stories-ama-morning-rounds-week-feb-2-2026 – ABC News (CDC case count coverage): https://abcnews.com/Health/588-us-measles-cases-reported-january-cdc/story?id=129699078 – CIDRAP (case tracking context): https://www.cidrap.umn.edu/measles/...
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    9 m
  • The Secret to Staying DANGEROUS After 50 : 1422

    The Secret to Staying DANGEROUS After 50 : 1422
    Feb 26 2026
    Peptides can change how you heal, lean out, build muscle, and age, but only if you stop taking influencer advice and start thinking like a scientist. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Get a discount from BIOLONGEVITY LABS by using code ‘Dave’ at: https://biolongevitylabs.com/ Host Dave Asprey sits down with Josh Felber and Jay Campbell for a deep, practical conversation on what peptides actually are, how they work in the body, and how to use them without doing something dumb. Josh Felber and Jay Campbell are both cofounders of BioLongevity Labs and longtime leaders in the peptide and performance space. Josh is also the host of the Making Bank podcast and a serial entrepreneur in health. Jay has spent more than a decade researching and teaching advanced peptide protocols and performance strategies. They break peptides down in plain English as chains of amino acids that act like signaling molecules, then get into what matters in the real world: delivery methods, dosing, and why pharmacokinetics and timing decide whether something works. You’ll hear why peptide pens feel like a huge upgrade over vials and syringes, why Dave wants patches and microneedle tech next, and how convenience can make the difference between consistency and quitting. Dave and the guys also go deep on mitochondria and longevity. They talk about SS31, now called elamipretide, and why it focuses on mitochondrial membranes and cardiolipin. They cover MOTS-c as a “turbocharger” peptide that people often feel fast, especially if they feel metabolically sluggish. They get into growth hormone peptides like Tesamorelin, Ipamorelin, and CJC, plus why MK-677 sounds convenient but can come with tradeoffs like appetite and other downstream effects. Then the conversation turns into what’s new. Jay shares what he claims is a new long-acting folistatin-style compound called FLGR 242, designed to stay active for weeks. He frames it as a potential solution for GLP users who worry about losing muscle. They also talk about Klotho, what it does in aging, why it is hard to stabilize, and why Jay believes small dosing matters because of kidney risk at higher levels. Dave ties Klotho back to endothelial function and kidney protection, and they swap stories about what people report noticing. You’ll Learn: • What peptides are, explained without jargon • Why delivery matters and why pens beat mixing vials all day • How PK curves change real results and dosing schedules • What elamipretide means for mitochondria and longevity • Why MOTS-c can feel like a fast energy shift for some people • How Tesamorelin, Ipamorelin, and CJC fit into growth hormone support • Why MK-677 sounds easy but can bring unwanted effects • What Jay claims FLGR 242 does for myostatin, muscle, and fat loss • Why Klotho shows up in longevity research and why dose matters Thank you to our sponsors! • 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Generation Lab | Go to https://www.generationlab.com/ and use code Dave20 for $20 off to see what your body is really doing beneath the surface. • Pique | Establish a powerful foundation for sustained wellness at https://www.piquelife.com/DAVE and unlock 20% off. • Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: peptides, biohacking, Dave Asprey, Jay Campbell, Josh Felber, BioLongevity Labs, mitochondrial peptides, elamipretide SS31, MOTS-c, growth hormone peptides, Tesamorelin, Ipamorelin, CJC-1295, MK-677, folistatin, myostatin inhibitor, FLGR 242, Clotho peptide, longevity science, anti-aging, human performance, muscle growth, fat loss, GLP-1 muscle preservation, pharmacokinetics, peptide dosing, nootropics, functional medicine, metabolism, endothelial function, kidney protection Resources: • Get a discount from BIOLONGEVITY LABS by using code ‘Dave’ at: https://biolongevitylabs.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to ...
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    1 h y 1 m
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Wealth of information from these podcasts. I binge these at work every single day.

Dave is the best

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I am so enlightened by cutting edge research and the years of experience and practice Dave has put in.

Top notch

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Great way to reframe wanting to pack everything in but figuring out what is best for you.

Info everyone needs to know!

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I am so excited to use these ideas and use the equipment and supplements I have already purchased and to tweak and add others. Thank you for this concise and valuable podcast! So excited to share this with loved ones that are stuck and looking for what to focus on next. This is a must listen episode!

Loved this episode! Reminded me and inspired me,!

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I’ve been listening to Dave Aspreys interviews for many years. I recommend his podcasts for anyone actively seeking health education.

Valuable health information!

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