The Human Upgrade: Biohacking for Longevity & Performance Podcast Por Dave Asprey arte de portada

The Human Upgrade: Biohacking for Longevity & Performance

The Human Upgrade: Biohacking for Longevity & Performance

De: Dave Asprey
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For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.

Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.

This isn’t just self-improvement - it’s human enhancement backed by data.

Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.

Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

© Copyright © Bulletproof Media 2023 Ciencia Desarrollo Personal Higiene y Vida Saludable Éxito Personal
Episodios
  • How To Hack Your Brain's Missing Youth Molecule | Molly Maloof : 1469

    How To Hack Your Brain's Missing Youth Molecule | Molly Maloof : 1469
    May 19 2026
    Your relationships are reshaping your biology in ways that diet and exercise alone cannot fix, and the science behind it will change how you think about longevity, metabolism, and what it actually means to be healthy. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Molly Maloof, a physician and one of the most innovative voices in personalized medicine, functional medicine, and human performance. Since 2012, she has advised or consulted for over 50 companies across digital health, consumer health, and biotechnology. She pioneered a course on healthspan at Stanford University and founded Adamo Bioscience, a company dedicated to unlocking the science of love as a pathway to healing and human connection. Dr. Maloof brings a rare combination of clinical depth, biohacking credibility, and entrepreneurial range to one of the most overlooked conversations in longevity. Together, Dave and Dr. Maloof dig into the neurobiology of love and attachment, the hormonal drivers of the sex drive and pair bonding, and how chronic isolation wrecks your metabolism at the cellular level. They explore the cell danger response and how toxic relationships, mold exposure, and trauma can lock your cells into a self-protection mode that blocks healing. They also cover psychedelics as hormetic tools, oxytocin as nature's medicine, the placebo response, peptide therapy for mitochondrial repair and anti-aging, and why regenerative medicine is about to rewrite the rules of human lifespan. If you are serious about biohacking your body from the inside out, this episode is essential. You'll Learn: Why human connection is a biological necessity, not a lifestyle preference, and what isolation does to your mitochondria and metabolism How the three neurobiological drives of sex, romantic love, and attachment are wired into your hormones and what happens when they go wrong What the cell danger response is, why it gets stuck, and which peptides, supplements, and therapies help break the cycle How oxytocin drives wound healing, immune function, and the placebo response Why psychedelics work as hormetic love drugs and how they reproduce the neurobiology of romantic love The top peptides for mitochondrial repair, brain optimization, and telomere biology Why Dave and Dr. Maloof believe we have already reached longevity escape velocity How AI is accelerating precision medicine, protein folding breakthroughs, and the future of anti-aging therapeutics Why fasting, breathwork, neurofeedback, and somatic therapies all converge on the same biological reset mechanism How to build the adaptive capacity and bioenergetic reserves to bounce back from anything Thank you to our sponsors! - Danger Coffee | Grab yours at DangerCoffee.com and use code DAVEPOD at checkout for 15% off. - Amp | If you're ready to make fitness fit into your life, go to amp.ai to check it out - Puori | Go to Puori.com/DAVE or use code DAVE at checkout to get 32% off your Puori Fish Oil subscription. You save more than $18 - Our Place | Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. Molly Maloof, Adamo Bioscience, Stanford University, personalized medicine, functional medicine, healthspan, longevity, biohacking, human performance, anti-aging, regenerative medicine, longevity escape velocity, cell danger response, mitochondria, mitochondrial health, oxytocin, vasopressin, dopamine, serotonin, neurobiology of love, attachment theory, pair bonding, sex drive, hormone replacement therapy, testosterone, estrogen, menopause, andropause, libido, female sexual dysfunction, relationship biology, social health, isolation, community, co-regulation, trauma healing, psychedelics, MDMA, psilocybin, ibogaine, ayahuasca, hormetic stress, social hormesis, neurofeedback, 40 Years of Zen, breathwork, nervous system regulation, HPA axis, cortisol, mast cell activation, histamine, long COVID, mold exposure, phospholipid therapy, ...
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    51 m
  • The 4,000-Year-Old Asian Focus Drug That Is Not A Drug : 1468

    The 4,000-Year-Old Asian Focus Drug That Is Not A Drug : 1468
    May 17 2026

    Most guys over 40 rely on coffee just to survive the day, completely unaware that they are pushing their brains into a frantic, high-stress state that actually destroys deep focus and accelerates cognitive decline. In this video, I reveal the science behind why caffeine is failing you and introduce you to a 4,000-year-old amino acid used by monks to achieve effortless, sustained attention. I'll walk you through the optimal 2:1 biohacking stack that flips your coffee from a nervous, jittery habit into a highly controlled focus weapon. You'll learn exactly how to dose it, when to take it, and how to stop the hidden lifestyle habits that are secretly sabotaging your nervous system, so you can reclaim the mental edge you had in your twenties and stay competitive.


    Thank you to our sponsors!

    -HeartMath | Go to https://www.heartmath.com/dave to save 15% off

    -The One Device | Use code DAVE for $10 off at theonedevice.com/dave

    -iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE


    Timestamps:

    00:00 – Intro

    00:21 – Background & Credentials

    01:28 – How Caffeine Works

    03:01 – Alpha vs Beta Brainwaves

    04:06 – The Focus Amino Acid

    04:55 – What Is L-Theanine

    05:35 – Quality & Common Mistakes

    06:51 – Building the Stack

    08:37 – Lifestyle Foundations

    10:36 – Rules & Guidelines


    Connect with Dave Asprey!


    Website: https://daveasprey.com

    TikTok: https://www.tiktok.com/@daveaspreyofficial

    Instagram: https://www.instagram.com/dave.asprey/

    Facebook: https://www.facebook.com/Daveaspreyofficial/

    X: https://x.com/daveasprey

    YouTube: https://www.youtube.com/c/daveaspreybpr


    The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/


    Danger Coffee: https://dangercoffee.com/DAVE15

    Dave Asprey’s BEYOND Conference: https://beyondconference.com/

    Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

    Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

    Upgrade Labs: https://upgradelabs.com

    40 Years of Zen: https://40yearsofzen.com

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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    14 m
  • Semen Switch, Chewing Gum, Creatine Cheat, Cancer Plants, and Bedtime Risk : 1467

    Semen Switch, Chewing Gum, Creatine Cheat, Cancer Plants, and Bedtime Risk : 1467
    May 15 2026
    One Creatine Dose Kept Sleep-Deprived Brains 12% Sharper A randomized, double-blind crossover trial kept 29 healthy adults awake for 21 hours straight ... half the time on a single moderate dose of creatine (~14g), half the time on placebo ... and found the creatine group held on to up to 12% more cognitive performance across logic, reaction time, and language processing. Host Dave Asprey breaks down why sleep deprivation is just another form of brain energy stress, how creatine's phosphate-buffering mechanism stabilizes ATP in the prefrontal cortex under pressure, and why this changes how he thinks about red-eye flights and all-nighters. Vegetarians and women showed the largest effects ... your baseline diet sets your ceiling. Sources: https://pubmed.ncbi.nlm.nih.gov/42075005/ https://www.nutraingredients.com/Article/2026/04/21/single-dose-creatine-may-support-cognition-in-sleep-deprivation-study/ https://pmc.ncbi.nlm.nih.gov/articles/PMC10902318/ https://medicalxpress.com/news/2024-04-creatine-cognitive-deprivation.html Your Gum Is Dosing You With Thousands of Microplastics A pilot study tested 10 commercial gums ... five synthetic, five marketed as natural or plastic-free ... and found every single one shed hundreds to roughly 3,000 microplastic fragments per stick into saliva, with no meaningful difference between synthetic and "natural" varieties. Host Dave Asprey connects this to total toxic load management, explains why "natural" label claims mean nothing without polymer-free verification, and makes the case that even innocent daily habits contribute to the cumulative plastic burden most people aren't tracking. The takeaway isn't panic ... it's precision. Sources: https://www.acs.org/pressroom/presspacs/2025/march/chewing-gum-can-shed-microplastics-into-saliva-pilot-study-finds.html https://www.sciencedirect.com/science/article/pii/S2666911025000243 https://samueli.ucla.edu/bursting-your-bubble-chewing-gum-releases-microplastics-into-your-saliva-ucla-research-shows/ https://www.food-safety.com/articles/10285-study-shows-chewing-gum-releases-thousands-of-microplastics-whether-gum-is-synthetic-or-natural Irregular Bedtimes in Your 40s May Double Heart Attack Risk Finnish researchers followed 3,231 people from age 46 using objective accelerometer data and tracked cardiovascular outcomes for a decade ... finding that people with highly irregular bedtimes, especially combined with short sleep, had roughly double the risk of major cardiovascular events compared to those with consistent sleep timing. Host Dave Asprey explains why your vascular biology runs on a precise circadian schedule, why ambitious, otherwise-healthy people are most at risk of ignoring this lever, and why a 90-minute bedtime window ... protected even on weekends ... may be one of the cheapest cardiovascular interventions available. It'snot just how much you sleep. It's when. Sources: https://www.sciencedaily.com/releases/2026/05/260504154026.htm https://hsph.harvard.edu/topic/aging/ Scientists Decode the Plant Molecule That Kills Cancer Cells in the Lab UBC researchers published a chromosome-level genome map of Mitragyna parvifolia ... a kratom relative ... and used it to decode the full biosynthetic pathway for mitraphylline, a rare alkaloid that has shown real anti-tumor activity in cell and animal models but has never been producible at clinical scale. Host Dave Asprey explains why this is the same early chapter that vincristine and paclitaxel were in before becoming mainstream chemotherapy, draws a hard line between this pipeline story and influencer narratives about kratom as a cancer treatment, and breaks down what it actually means when researchers crack a plant's genetic recipe for a bioactive compound. Nature has been solving cancer for millions of years... we're finally learning to read it. Sources: https://academic.oup.com/plcell/article/37/9/koaf207/8237526 https://www.sciencedaily.com/releases/2026/05/260512213836.htm https://news.ok.ubc.ca/2025/10/14/researchers-reveal-how-plants-make-anti-tumour-drugs/ https://pmc.ncbi.nlm.nih.gov/articles/PMC12217235/ Scientists Built an On/Off Switch for Sperm Production — No Hormones Cornell researchers used a small-molecule inhibitor called JQ1 to pharmacologically shut down sperm production in male mice for the duration of treatment, then stopped the drug and watched full fertility restore... with healthy offspring and no detectable genomic damage. Host Dave Asprey breaks down the BRDT mechanism that makes this work without touching testosterone or hormones, explains why this is a proof-of-concept rather than a near-market drug, and outlines the questions that need answering before this moves to humans: long-term testicular health, epigenetic marks in recovered sperm, and mood and testosterone interaction over time. The era of precision male reproductive biology is just beginning. Sources: https://...
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    11 m
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Wealth of information from these podcasts. I binge these at work every single day.

Dave is the best

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I am so enlightened by cutting edge research and the years of experience and practice Dave has put in.

Top notch

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Great way to reframe wanting to pack everything in but figuring out what is best for you.

Info everyone needs to know!

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I am so excited to use these ideas and use the equipment and supplements I have already purchased and to tweak and add others. Thank you for this concise and valuable podcast! So excited to share this with loved ones that are stuck and looking for what to focus on next. This is a must listen episode!

Loved this episode! Reminded me and inspired me,!

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I’ve been listening to Dave Aspreys interviews for many years. I recommend his podcasts for anyone actively seeking health education.

Valuable health information!

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