The Human Upgrade: Biohacking for Longevity & Performance Podcast Por Dave Asprey arte de portada

The Human Upgrade: Biohacking for Longevity & Performance

The Human Upgrade: Biohacking for Longevity & Performance

De: Dave Asprey
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For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.

Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.

This isn’t just self-improvement - it’s human enhancement backed by data.

Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.

Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

© Copyright © Bulletproof Media 2023 Ciencia Desarrollo Personal Higiene y Vida Saludable Éxito Personal
Episodios
  • What If You Stop Eating For 72 Hours? : 1375

    What If You Stop Eating For 72 Hours? : 1375
    Dec 7 2025

    Most people think fasting is just about skipping breakfast. But what if 72 hours without food could actually reverse aging?


    In this video, Dave Asprey breaks down what really happens when you fast for 3 days—and why short fasts don’t reach the deep repair zone your body is built for. You’ll learn:


    The 3 critical stages your body passes through during fasting

    How autophagy turns on and begins cellular repair

    What mistakes destroy your progress (like bad refeeding or skipping electrolytes)

    How to properly prepare, fast, and recover safely

    Why fasting can make your mitochondria stronger, your mind sharper, and your cells younger


    *** Dave's Biohacking Holiday Gift Guide | Go to https://daveasprey.com/giftguide/ to explore the full guide. ***


    Timestamps

    0:00 - Why 16-hour fasts don’t reach real fat burning

    0:54 - The myth of aging and what doctors overlook

    1:48 - How modern life damages your mitochondria

    2:48 - How fasting restores your body’s repair mode

    3:39 - Understanding the phases of fasting

    4:58 - Why short fasts cut results short

    5:34 - Day 1 of fasting

    6:45 - Day 2 of fasting

    7:22 - Day 3 of fasting

    8:24 - Common fasting mistakes that harm your body

    9:35 - How to prepare before your fast

    10:31 - The right way to refeed afterward

    11:14 - Listening to your body’s signals and responses


    Thank you to our sponsors!

    -BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle.


    Resources:

    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

    • Danger Coffee: https://dangercoffee.com/discount/dave15

    • My Daily Supplements: SuppGrade Labs (15% Off)

    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

    • Dave Asprey’s BEYOND Conference: https://beyondconference.com

    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

    • Upgrade Collective: https://www.ourupgradecollective.com

    • Upgrade Labs: https://upgradelabs.com

    • 40 Years of Zen: https://40yearsofzen.com


    Connect with Dave Asprey!

    Website: https://daveasprey.com

    TikTok: https://www.tiktok.com/@daveaspreyofficial

    Instagram: https://www.instagram.com/dave.asprey/

    Facebook: https://www.facebook.com/Daveaspreyofficial/

    X: https://x.com/daveasprey

    YouTube: https://www.youtube.com/c/daveaspreybpr



    The Human Upgrade Podcast:

    Instagram: https://www.instagram.com/TheHumanUpgradePodcast/

    Facebook: https://m.facebook.com/Thehumanupgrade/

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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    12 m
  • The Real Reason Your Face Is Aging So Fast : 1376

    The Real Reason Your Face Is Aging So Fast : 1376
    Dec 5 2025
    Vitamin C, copper peptides, and glutathione behave very differently once you understand how skin absorbs nutrients at the cellular level. This episode shows you how to target collagen production, strengthen mitochondria, improve detox capacity, and upgrade skin density with pharmaceutical grade delivery systems that outperform conventional skincare. You learn why most topical antioxidants never reach their intended targets, how intracellular copper changes longevity pathways, why glutathione affects everything from pigmentation to detox, and how to build a streamlined routine that matches the way high level biohackers actually age. These strategies can help you improve collagen, elasticity, hair density, mitochondrial function, and whole body performance with fewer steps and far more impact. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey talks with Dr. Nayan Patel, a pharmacist, wellness expert, and industry leader who has worked with physicians since 1999 to design custom medications and patient specific protocols. He has been the pharmacist of choice for celebrities, CEOs, and medical professionals seeking precision level formulations. Dr. Patel is the author of The Glutathione Revolution, which summarizes more than a decade of clinical research on glutathione. His team created a patented transdermal technology that delivers glutathione systemically through the skin, and he has since expanded this work to include advanced peptides and new delivery systems that improve absorption far beyond standard topical products. He also developed the Auro GSH Antioxidant Delivery System, a skincare line that uses pharmaceutical grade ingredients at potent concentrations to achieve deeper penetration and more reliable biological effects. Together they break down why vitamin C acts as a stimulant that drives collagen rather than a classic antioxidant, how GHK copper peptide thickens aging skin, and why retinoids often speed up cell turnover at the cost of long term resilience. Dr. Patel explains the difference between cosmetic grade and injectable grade peptides, why purity matters when a delivery system pushes molecules deep into the skin, and how zinc overuse has created widespread copper deficiency that affects hair, metabolism, and mitochondrial health. Dave shares his own protocols for using GHK, glutathione, and vitamin C, along with practical dosing strategies that create visible changes in skin density within four to six weeks. You will learn: • How vitamin C stimulates collagen and why glutathione regenerates oxidized antioxidants • How GHK copper peptide improves elasticity, firmness, and structural integrity • Why purity, molecular size, and delivery tech determine whether peptides actually reach target tissues • How topical copper supports intracellular stores and influences hair health and metabolism • Why zinc overload causes silent copper deficiency and what it means for longevity • How targeted glutathione improves detox, pigmentation, and oxidative stress • The fastest protocol for visible skin density improvements and how long results take to show • How to combine these tools with lasers and skin procedures for stronger outcomes Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: GHK copper peptide, topical glutathione delivery, dextrin absorption technology, intracellular copper uptake, vitamin C collagen stimulation, antioxidant regeneration, cosmetic peptide purity, injectable grade peptides, zinc copper imbalance, mitochondrial skin health, hair follicle regeneration, oxidative stress reduction, glutathione detox support, peptide based skincare, collagen crosslinking support, DMAE skin firmness, CoQ10 topical benefits, skincare biohacking, longevity dermatology, pharmaceutical transdermal systems Resources: • Go to https://aurowellness.com/ ‘DAVE10’ for a discount! • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book –...
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    57 m
  • Feel 70 Percent Better… With Grapes? | Biohacking Tools : 1374

    Feel 70 Percent Better… With Grapes? | Biohacking Tools : 1374
    Dec 4 2025
    If you care about longevity, mitochondria, cardiovascular health, or feeling sharper every day, this episode gives you a clear look at the breakthrough technology that could reshape how supplements are made. Host Dave Asprey talks with Ilan Sobel, CEO of BioHarvest Sciences, about a new way to produce plant compounds at industrial scale without ever growing the plant. Their Botanical Synthesis platform creates highly pure, clinically validated molecules that support blood flow, brain function, metabolic health, and cellular energy with remarkable consistency and little to no environmental waste. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Ilan brings more than two decades of experience in global biotech and consumer health, and under his leadership BioHarvest has grown its flagship product VINIA into one of the fastest growing plant-based supplements in North America. He explains how the company uses plant cell biology and AI guided cultivation to deliver resveratrol, polyphenols, and other high value compounds with superior bioavailability, purity, and measurable clinical effects on arterial dilation, driven by increasing nitric oxide and resulting in improving physical energy, mental alertness and reducing oxidative stress You will learn: • Why traditional extraction wastes most of the plant and creates inconsistent supplement quality • How Botanical Synthesis produces highly bioavailable polyphenols without insecticides, herbacides, fungicides, solvents, or worrying about heavy metal levels.• Why VINIA increases arterial dilation, improves blood flow, and supports healthy nitric oxide levels • How reducing ET1 strengthens vascular health in ways typical nitric oxide supplements cannot • Why better blood flow supports brain performance, mental alertness, and daily physical energy • What clinical studies show about resveratrol absorption, bioavailability, and 12 hour activity in the bloodstream • How piceid resveratrol crosses the blood brain barrier to support cognitive function • Why BioHarvest is developing olive cell compounds like verbascoside for liver fat reduction and cognitive aging • How future saffron cell technology may influence mood, stress, and cognitive health • Why this approach offers major advantages for longevity, anti-aging strategies, and high-performance biologyDave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: plant cell biology, Botanical Synthesis, Vinia polyphenols, piceid resveratrol, nitric oxide production, ET1 reduction, arterial dilation, vascular flexibility, blood flow optimization, brain oxygenation, cognitive alertness, oxidative stress reduction, bioavailable polyphenols, grape cell technology, olive cell compounds, verbascoside research, saffron cell cultivation, clinical blood flow studies, endothelial function, longevity supplementation **Visti www.vinia.com/Dave - for a generous discount on your next purchase** Resources: • VINIA Website: www.vinia.com/Dave • BioHarvest Website: https://bioharvest.com/• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer 1:30 - How BioHarvest Works 5:23 - Piceid Resveratrol & Clinical Studies 13:37 - Blood Flow & Cardiovascular Benefits 17:08 - Brain Health & Cognitive Effects 20:07 - VINIA Product Line & Pricing 22:33 - Nitric Oxide Mechanism & ET1 26:39 - Chews & Hydration Mix 36:35 - VINIA Heroes Program 41:19 - Olive Cell Technology & Verbascoside 45:13 - Pharmaceutical Implications 51:30 - Saffron Development See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Wealth of information from these podcasts. I binge these at work every single day.

Dave is the best

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I am so enlightened by cutting edge research and the years of experience and practice Dave has put in.

Top notch

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Great way to reframe wanting to pack everything in but figuring out what is best for you.

Info everyone needs to know!

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I am so excited to use these ideas and use the equipment and supplements I have already purchased and to tweak and add others. Thank you for this concise and valuable podcast! So excited to share this with loved ones that are stuck and looking for what to focus on next. This is a must listen episode!

Loved this episode! Reminded me and inspired me,!

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I’ve been listening to Dave Aspreys interviews for many years. I recommend his podcasts for anyone actively seeking health education.

Valuable health information!

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