The Human Upgrade: Biohacking for Longevity & Performance Podcast Por Dave Asprey arte de portada

The Human Upgrade: Biohacking for Longevity & Performance

The Human Upgrade: Biohacking for Longevity & Performance

De: Dave Asprey
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For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.

Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.

This isn’t just self-improvement - it’s human enhancement backed by data.

Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.

Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

© Copyright © Bulletproof Media 2023 Ciencia Desarrollo Personal Higiene y Vida Saludable Éxito Personal
Episodios
  • The Secret Peptides and Underground Compounds Doctors Won’t Talk About : 1413

    The Secret Peptides and Underground Compounds Doctors Won’t Talk About : 1413
    Feb 10 2026
    What if the line between “medicine” and “forbidden” has nothing to do with safety and everything to do with permission? This episode gives you a clear framework for understanding peptides, research chemicals, and performance enhancement so you can think for yourself instead of outsourcing your biology Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dylan Gemelli for a candid, unfiltered conversation about the underground world of biohacking, research chemicals, and human performance. Dylan is a long-time biohacker, educator, and researcher who came out of the bodybuilding world and spent more than a decade studying peptides, SARMs, nootropics, and gray-area compounds. He brings first-hand experience, deep research literacy, and a rare ability to explain what these compounds actually do, where the risks are, and why most doctors will never talk about them. Together, they unpack what “research chemicals” really means, why peptides technically fall into that category, and how legality often has little to do with biological reality. They explore compounds like MK-677, S4, and other SARMs, how they interact with growth hormone, muscle, strength, and recovery, and why some of these tools can be more powerful than peptides when used with intention and restraint. Dave also shares his own experiences rebuilding his health using underground tools, why he refuses to ask for permission to take care of his body, and how performance enhancement fits into longevity, metabolism, and real-world function. You’ll Learn: • What research chemicals actually are and why peptides fall into that category • How compounds like MK-677 stimulate growth hormone and affect muscle and recovery • Why SARMs differ from steroids and where the real risks come from • The difference between tobacco and nicotine and why low-dose nicotine can support brain optimization • How performance enhancement fits into longevity, metabolism, and functional medicine thinking • Why strength and neurological drive matter more than size alone • How to think clearly about supplements, nootropics, and biohacking tools without fear or hype • Why taking responsibility for your biology is not cheating Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Thank you to our sponsors! • Antarctica Trip | Join me in Antarctica from March 8–17, 2026. Visit https://www.insiderexpeditions.com/future and use code DAVE for $1,000 off. • AirDoctor | Go to https://airdoctorpro.com/daveasprey and save up to $300 on Air Purifiers. • STEMREGEN | Go to https://stemregen.co/dave30 and use code DAVE30 for 30% off your next order. • Our Place | Visit https://fromourplace.com/DAVE and use code DAVE for 10% off sitewide. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: biohacking research chemicals, peptide biohacking podcast, underground peptides, SARMs explained, MK-677 growth hormone, performance enhancing drugs science, human performance biohacking, longevity biohacking podcast, neuroplasticity optimization, brain optimization nootropics, mitochondrial optimization biohacking, metabolism and hormones, testosterone optimization science, nicotine brain benefits, modafinil cognitive performance, supplements biohacking debate, functional medicine biohacking, muscle vs strength science, anti-aging performance strategies, Dave Asprey biohacking, Dylan Gemelli biohacking, The Human Upgrade podcast, Smarter Not Harder biohacking Resources: • Learn More About Dylan’s Work And Content At: https://dylangemelli.com/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave ...
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    59 m
  • Why Your Muscles Break Down After 40 (Do This To Reverse It) : 1412

    Why Your Muscles Break Down After 40 (Do This To Reverse It) : 1412
    Feb 8 2026

    Your muscles play a far bigger role in aging than most people realize. As you get older, the energy factories inside your muscle cells begin to break down and stop getting replaced, leading to fatigue, weakness, and slower recovery even if you stay active.

    This video explains how that decline happens, why it accelerates after midlife, and what actually restores cellular energy instead of just masking the symptoms.

    By understanding how muscle health, energy production, and recovery are biologically connected, you can rebuild strength, improve endurance, and slow the aging process from the inside out.


    Chapters

    0:00 - Intro: The Youth Switch

    0:53 - Why Muscles Are Your Fountain of Youth

    2:26 - Mitophagy: Your Body's Cleaning System

    4:01 - The Secret Compound: Urolithin A

    6:30 - The Solution: MitoPure

    8:34 - The Complete System

    9:56 - Closing Thoughts


    Thank you to our sponsors!

    • MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order.
    • Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave.


    Resources:

    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

    • Danger Coffee: https://dangercoffee.com/discount/dave15

    • My Daily Supplements: SuppGrade Labs (15% Off)

    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

    • Dave Asprey’s BEYOND Conference: https://beyondconference.com

    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

    • Upgrade Collective: https://www.ourupgradecollective.com

    • Upgrade Labs: https://upgradelabs.com

    • 40 Years of Zen: https://40yearsofzen.com


    Connect with Dave Asprey!

    Website: https://daveasprey.com

    TikTok: https://www.tiktok.com/@daveaspreyofficial

    Instagram: https://www.instagram.com/dave.asprey/

    Facebook: https://www.facebook.com/Daveaspreyofficial/

    X: https://x.com/daveasprey

    YouTube: https://www.youtube.com/c/daveaspreybpr



    The Human Upgrade Podcast:

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    10 m
  • Biohackers in the Epstein Files, Generic GLP-1s, Continuous Ketone Monitors, and more... : 1411

    Biohackers in the Epstein Files, Generic GLP-1s, Continuous Ketone Monitors, and more... : 1411
    Feb 6 2026
    This episode covers: • Longevity Influence In The Epstein Files A new DOJ document release tied to the Epstein investigation pulled physician and longevity influencer Peter Attia into the spotlight, after reports showed he appeared in the files more than 1,800 times and CBS News pulled a planned rebroadcast of its 60 Minutes profile. Dave breaks down why this story matters beyond headlines: longevity relies heavily on trust, authority, and influence, and when those foundations are shaken it exposes how fragile centralized expertise can be. He explains how biohackers can protect themselves by diversifying information sources, understanding mechanisms instead of personalities, and building health strategies that don’t collapse when one voice disappears. • Source: https://variety.com/2026/tv/news/cbs-news-pulls-peter-attia-60-minutes-segment-epstein-1236650930/ • Age-Reversal Gene Therapy Enters Human Trials Life Biosciences received FDA authorization to begin the first U.S. human trial of a partial epigenetic reprogramming gene therapy in the eye, using three Yamanaka factors to restore function in damaged retinal cells. Dave explains why eyes are the ideal first testing ground, what partial reprogramming actually means, and why this marks a shift from longevity theory into real clinical testing. He also clarifies what success would and would not mean for whole-body rejuvenation, and how to separate legitimate gene-therapy advances from consumer products that only claim to affect biological age. • Source: https://fortune.com/2026/01/30/billionaires-longevity-aging-fda-human-clinical-trial-life-biosciences/ • Continuous Ketone Monitoring Moves Toward Reality Wearable continuous ketone monitoring is advancing beyond finger-stick meters, with companies adapting the same model that made continuous glucose monitors mainstream. Dave explains why this is a major upgrade for metabolic flexibility, keto diets, fasting, and diabetes risk management. He breaks down how real-time ketone data can reveal patterns missed by spot checks, and why biohackers should think ahead about data ownership, integration, and how ketone signals interact with glucose, sleep, stress, and training. • Source: https://finance.yahoo.com/news/global-market-blood-ketone-meters-140900796.html • Injectable, Wireless Brain Implants Without Surgery Researchers are developing nano-scale, wireless brain implants capable of crossing the blood-brain barrier without open surgery, opening the door to a new class of neural interfaces. Dave connects this research to other circuit-level interventions like sound and light stimulation, explaining the broader shift from targeting molecules to tuning brain networks. He also addresses the ethical risks, including consent, privacy, and neuro-surveillance, and why biohackers should track this space early rather than after it becomes normalized. • Source: https://longevity.technology/unlocked/longevity-news-roundup-week-5-2026/ • Generic GLP-1 Drugs Could Reshape Global Metabolic Health India’s Sun Pharma is preparing to launch a generic semaglutide-style injectable as patent protections expire, signaling a major price drop and access expansion for GLP-1 drugs. Dave explains why this could transform obesity, diabetes, and cardiovascular disease management worldwide, while also highlighting the risks of muscle loss and metabolic weakness if these drugs are used without proper training and nutrition. He shares how biohackers should think about stacking GLP-1s intelligently, with resistance training, protein intake, and long-term maintenance strategies. • Source: https://longevity.technology/unlocked/longevity-news-roundup-week-5-2026/ All source links are provided for direct access to the original reporting and research. This episode is designed for biohackers, longevity seekers, and high-performance listeners who want clear thinking in a noisy health landscape. Host Dave Asprey connects ethics, emerging science, metabolic data, neurotechnology, and drug access into practical lessons for building a resilient, adaptable health strategy that works even as trends and narratives change. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: longevity influencer ethics, Peter Attia Epstein files, trust in longevity science, epigenetic reprogramming gene therapy, Yamanaka factors OSK, age reversal human trials, Life Biosciences FDA trial, continuous ketone monitoring, CKM metabolic tracking, glucose ketone wearable sensors, Abbott Libre ketone sensor, metabolic flexibility biohacking, wireless brain implants, blood brain barrier neurotech, cognitive longevity technology, GLP-1 generic semaglutide, Sun Pharma GLP-1, GLP-1 muscle loss prevention, resistance training longevity, metabolic health upgrades, biohacking Thank you to our sponsors! - GOT MOLD? | Go to http://gotmold.com/shop and use DAVE10 to save 10% and see what’s in your ...
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    7 m
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Wealth of information from these podcasts. I binge these at work every single day.

Dave is the best

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I am so enlightened by cutting edge research and the years of experience and practice Dave has put in.

Top notch

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Great way to reframe wanting to pack everything in but figuring out what is best for you.

Info everyone needs to know!

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I am so excited to use these ideas and use the equipment and supplements I have already purchased and to tweak and add others. Thank you for this concise and valuable podcast! So excited to share this with loved ones that are stuck and looking for what to focus on next. This is a must listen episode!

Loved this episode! Reminded me and inspired me,!

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I’ve been listening to Dave Aspreys interviews for many years. I recommend his podcasts for anyone actively seeking health education.

Valuable health information!

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