The Human Upgrade: Biohacking for Longevity & Performance Podcast Por Dave Asprey arte de portada

The Human Upgrade: Biohacking for Longevity & Performance

The Human Upgrade: Biohacking for Longevity & Performance

De: Dave Asprey
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For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.

Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.

This isn’t just self-improvement - it’s human enhancement backed by data.

Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.

Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

© Copyright © Bulletproof Media 2023 Ciencia Desarrollo Personal Higiene y Vida Saludable Éxito Personal
Episodios
  • I Injected Stem Cells Into My Penis (Here's What Happened) : 1439

    I Injected Stem Cells Into My Penis (Here's What Happened) : 1439
    Mar 27 2026
    Your brain is hardware, and if the hardware is broken, no supplement stack, nootropic, or biohacking protocol in the world will get you to full capacity. This episode goes inside the most advanced stem cell and brain optimization clinic on the planet, where Host Dave Asprey undergoes a cutting-edge neurocognitive protocol that combines focused ultrasound, transcranial magnetic stimulation, and mesenchymal stem cells to target specific regions of the brain with millimeter precision. - Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR - Learn more about all the treatments at RMI by visiting: https://daveasprey.com/rmi/ Dr. Victor Urzola is a plastic and reconstructive surgeon with training from the University of Milan, microsurgery credentials from University Henri Poincare in France, and fellowship experience in facial aesthetic surgery and body contouring on both sides of the Atlantic. He is the former president of the Costa Rican Society of Plastic Surgery and holds membership in the Italian, European, and American societies of plastic and aesthetic surgery. As co-founder of RMI Clinic in Costa Rica, Dr. Urzola has spent years pushing the frontier of regenerative medicine, applying the rigor of academic surgical training to stem cell therapy, neurocognitive protocols, and longevity treatments that most clinics in the world are not yet attempting. Dave and Dr. Urzola break down how neuroinflammation silently degrades cognitive function the same way joint inflammation destroys athletic performance, and why treating the brain like a biological system you can upgrade changes everything. They cover the full RMI longevity protocol Dave completed in Costa Rica, including the neurocognitive brain upgrade, plasmapheresis for full-body anti-aging, orthopedic stem cell joint repair, and yes, the enhanced protocol Dave has become known for discussing without apology. This is next-level biohacking and regenerative medicine for anyone serious about brain optimization, longevity, and upgrading every system in the body before problems become permanent. You'll Learn: How RMI uses functional MRI, neuronavigation, and focused ultrasound to target hypofunctioning brain regions with millimeter accuracy Why neuroplasticity and cognitive recovery in dementia patients improved after just 15 days of treatment How plasmapheresis removes pro-inflammatory mediators and toxins from your entire vascular system and why Dave does it annually What shockwave therapy combined with stem cell injection accomplishes for both men and women in ways pharmacological treatment cannot Why cell viability and placement matter more than raw cell count, and how RMI measures both 10 minutes before every injection How orthopedic stem cell protocols achieve 82.5 percent improvement in joint function across 8,000 treated joints Why Dave calls RMI the best hardware upgrade available and 40 Years of Zen the best software upgrade, and how the two work together What the difference feels like between going from standard resolution to 4K inside your own brain Thank you to our sponsors! - HeartMath | Go to https://www.heartmath.com/dave to save 15% off. - EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Victor Urzola, RMI Clinic Costa Rica, stem cell therapy, brain optimization, neurocognitive protocol, focused ultrasound, transcranial magnetic stimulation, neuroinflammation, plasmapheresis, orthopedic stem cells, mesenchymal stem cells, blood brain barrier, regenerative medicine, anti-aging, longevity, biohacking, Dave Asprey, erectile dysfunction treatment, stem cell facelift, human performance Resources: • Learn More About All Of The Treatments at RMI by visiting: https://daveasprey.com/rmi/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND ...
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    31 m
  • Arthur Brooks | Why Your Life Has No Meaning : 1438

    Arthur Brooks | Why Your Life Has No Meaning : 1438
    Mar 26 2026
    What if the real reason you feel stuck, anxious, or unfulfilled has nothing to do with your biohacking stack and everything to do with which half of your brain you're actually using? In this episode, Host Dave Asprey sits down with Harvard professor and bestselling author Arthur Brooks to reveal the neuroscience of meaning, consciousness, and why your left brain's obsession with optimization is quietly destroying your happiness and human performance. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR - Buy Arthur’s new book “The Meaning Of Your Life” at: https://www.penguinrandomhouse.com/books/724315/the-meaning-of-your-life-by-arthur-c-brooks/ Arthur Brooks is a professor at both the Harvard Kennedy School and Harvard Business School, where he teaches leadership and happiness. He writes the wildly popular "How to Build a Life" column at The Atlantic, hosts the weekly podcast "Office Hours with Arthur Brooks," and has authored 15 books, including two number one New York Times bestsellers: Build the Life You Want with Oprah Winfrey, and From Strength to Strength. His new book, The Meaning of Your Life: Finding Purpose in an Age of Emptiness, releases March 31, 2026. Brooks is one of the world's foremost experts on the science of human happiness. Dave and Arthur go deep on hemispheric lateralization, the rediscovered neuroscience showing your right brain holds everything that makes life worth living: meaning, mystery, consciousness, and the ineffable experiences that no AI, no nootropic, and no amount of fasting or sleep optimization can manufacture for you. They break down why the depression and anxiety epidemic is really a right-brain deficiency crisis, and why all the supplements, ketosis protocols, and functional medicine hacks in the world won't fix it if you're living entirely in your left hemisphere. This is a rare episode that bridges hard neuroscience with the deepest questions of human existence. Whether you're deep into anti-aging, neuroplasticity training, or Smarter Not Harder living, this conversation will change how you think about what you're actually optimizing for. You'll Learn: Why the mental health crisis is fundamentally a meaning crisis, and what your brain hemispheres have to do with it How technology, AI, and screen culture are suppressing the right hemisphere and wiring you for anxiety The six scientifically backed ways to open your right brain and unlock experiences of real meaning Why self-improvement fails without first understanding the neuroscience of how ideas install in the brain How suffering, handled correctly, is the single most powerful path to consciousness and purpose Why romantic love, beauty, and deep conversation are forms of neurological medicine What Dave's $2.5 million biohacking journey taught him about the limits of optimization The Buddhist physics of suffering: pain times resistance, and how to lower the resistance instead of the pain Thank you to our sponsors! - Danger Coffee | Grab yours at DangerCoffee.com and use code DAVEPOD at checkout for 15% off. - Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. - Join My Low-Oxalate 30-Day Challenge: daveasprey.com/2026-low-ox-reset - Calroy | Go to Calroy.com/DAVE for exclusive discounts on Arterosil HP, Vascanox HP and all Calroy products.Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Arthur Brooks, Harvard happiness research, meaning of life, hemispheric lateralization, right brain left brain, brain optimization, neuroplasticity, consciousness neuroscience, mental health crisis, depression anxiety solutions, human performance, self-improvement science, longevity mindset, biohacking happiness, Dave Asprey, functional medicine, suffering and purpose, AI limits, meaning and purpose, How to Build a Life Resources: • Buy Arthur’s new book “The Meaning Of Your Life” at: https://www.penguinrandomhouse.com/books/724315/the-meaning-of-your-life-by-arthur-c-brooks/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track ...
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    58 m
  • This Popular Fat Loss Shortcut Destroys Your Youth : 1437

    This Popular Fat Loss Shortcut Destroys Your Youth : 1437
    Mar 24 2026
    Your gut microbiome controls your brain chemistry, your stress response, your sleep, your metabolism, and your ability to lose weight, and most people have no idea how broken theirs actually is. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Get 20% off your next purchase of OMNi-BiOTiC with code ‘Dave20’ at: https://omnibioticlife.com/ In this episode, Host Dave Asprey and microbiome expert Hannah Kleinfeld break down the hidden gut science behind GLP-1 drugs, ADHD, HRV, histamine intolerance, SIBO, and why most probiotics you're taking are probably dead before they even reach your intestines. Hannah Kleinfeld is the co-founder and COO of Omni-Biotic US, a Yale and Harvard graduate, and a certified health coach whose personal battle with Lyme disease drove her deep into functional medicine and microbiome science. Omni-Biotic is the number one probiotic brand in Europe, used in hospital systems alongside antibiotic treatment, and is now bringing that clinical-grade research to the US market. Dave and Hannah go deep on the gut-brain axis, the vagus nerve, and how dysbiosis drives everything from brain fog and poor sleep optimization to inflammation, metabolic dysfunction, and compromised mitochondria. They cover how GLP-1 drugs slow gut transit time and trigger secondary dysbiosis, why most capsule probiotics rehydrate in stomach acid and fail, how short-chain fatty acids like butyrate cross the blood-brain barrier to regulate neuroinflammation, and how your gut bacteria directly control your heart rate variability, hormones, libido, and skin. This is biohacking your biology from the inside out, and it goes far deeper than supplements and fasting. You'll Learn: Why GLP-1 drugs like Ozempic create secondary dysbiosis and what to do about it How gut inflammation suppresses HRV, disrupts sleep, and accelerates aging Why most probiotics rehydrate in stomach acid and never make it to your intestines The gut-brain connection behind ADHD, brain fog, anxiety, and mood disorders How dysbiosis sabotages weight loss by skewing Firmicutes to Bacteroidetes ratios What the vagus nerve has to do with stress resilience and mitochondria health How to support your microbiome through antibiotics, travel, and SIBO recovery The histamine problem hiding inside popular probiotic strains Why the first 1,000 days of a baby's life shape lifelong immunity and HPA axis function How targeted probiotic formulations are changing functional medicine Thank you to our sponsors! Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off todayPre-order Arthur Brook's new book today at themeaningofyourlife.com. You can also see Arthur speak live at the 2026 Beyond Biohacking Conference Fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVEBrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power BundleDave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Hannah Kleinfeld, Omni-Biotic, gut microbiome, probiotics that work, GLP-1 gut damage, Ozempic side effects, secondary dysbiosis, gut brain axis, vagusnerve HRV, SIBO treatment, histamine intolerance probiotics, leaky gut inflammation, butyrate blood brain barrier, ADHD gut connection, probiotic capsules vs powder, antibiotic recovery, gut skin axis, microbiome sleep, Firmicutes Bacteroidetes weight loss, functional medicine gut health Resources: • Get 20% off your next purchase of OMNi-BiOTiC with code ‘Dave20’ at: https://omnibioticlife.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • ...
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    56 m
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Wealth of information from these podcasts. I binge these at work every single day.

Dave is the best

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I am so enlightened by cutting edge research and the years of experience and practice Dave has put in.

Top notch

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Great way to reframe wanting to pack everything in but figuring out what is best for you.

Info everyone needs to know!

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I am so excited to use these ideas and use the equipment and supplements I have already purchased and to tweak and add others. Thank you for this concise and valuable podcast! So excited to share this with loved ones that are stuck and looking for what to focus on next. This is a must listen episode!

Loved this episode! Reminded me and inspired me,!

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I’ve been listening to Dave Aspreys interviews for many years. I recommend his podcasts for anyone actively seeking health education.

Valuable health information!

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