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The Human Upgrade: Biohacking for Longevity & Performance

The Human Upgrade: Biohacking for Longevity & Performance

De: Dave Asprey
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For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.

Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.

This isn’t just self-improvement - it’s human enhancement backed by data.

Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.

Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

© Copyright © Bulletproof Media 2023 Ciencia Desarrollo Personal Higiene y Vida Saludable Éxito Personal
Episodios
  • Reversing The American Food Pyramid | Calley Means : 1395

    Reversing The American Food Pyramid | Calley Means : 1395
    Jan 9 2026
    Back in 2024 with Calley Means at South by Southwest, we sat down and talked about his mission to flip the old American food pyramid upside down for the greater good. Well guess what, the pressure is finally working! This rerun is the ultimate receipt that focus, repetition, and smart lobbying for human health can still move the needle! Host Dave Asprey sits down with Calley Means, entrepreneur, policy advocate, and co-author of Good Energy. Together, they break down how the U.S. healthcare system became a sick-care system, why ultra-processed food dominates public policy, and how individuals can reclaim autonomy over their biology. From CGMs and metabolic health to food subsidies, lobbying, and free speech, this episode challenges deeply held assumptions about medicine, nutrition, and personal responsibility.You’ll Learn: • Why chronic disease is the most profitable business model in modern history • How metabolic dysfunction drives obesity, diabetes, depression, and infertility • Why ultra-processed food sits at the root of America’s health collapse • How CGMs and metabolic data threaten entrenched healthcare incentives • What “food is medicine” really means and where it gets weaponized • How HSA and FSA dollars can legally support food, exercise, and prevention • Why fixing incentives matters more than blaming individuals • How reclaiming health autonomy is tied to free speech and human resilience Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: Calley Means Good Energy, Calley Means interview, Good Energy metabolic health, metabolic dysfunction America, ultra processed food policy, food is medicine debate, healthcare incentives crisis, chronic disease economics, insulin resistance epidemic, CGM health data access, metabolic health lobbying, seed oils sugar inflammation, glyphosate food system, HSA food exercise eligibility, health autonomy biohacking, metabolic freedom podcast, american food pyramid, rfk food pyramid, 2026 food pyramid Thank you to our sponsors! Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade. Resources: • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 – Introduction 2:11 – Mom’s Cancer Story 4:24 – Healthcare System Incentives 10:14 – TruMed and Food as Medicine 15:51 – FDA and IRS Pushback 17:25 – Political Solutions and RFK 19:49 – Childhood Obesity Crisis 21:49 – The Chronic Disease Industry 26:54 – State of Emergency Proposal 29:07 – Healthcare Industry Mindset 31:30 – COVID and Metabolic Health 32:28 – Taking Back Health Autonomy 34:16 – Medical System Collusion 35:56 – Research Corruption 37:21 – Pharma Bribes and Conflicts 40:17 – Ozempic and Civil Rights Groups 42:35 – Personal Mission and Mom’s Legacy 50:16 – Media Power and Free Speech 54:00 – Weaponizing Social Justice 55:16 – Systemic Poisoning of the Population 57:37 – Technology as a Health Solution 1:03:20 – Regenerative Farming and Robotics 1:06:34 – Controlling the Food Supply 1:10:18 – Closing Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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    1 h y 11 m
  • The Willpower Drug: How to Supplement Discipline : 1394

    The Willpower Drug: How to Supplement Discipline : 1394
    Jan 8 2026
    Creatine is a hot subject right now, but I’m guessing you might not know as much about it as you could. Well step into a new creatine masterclass with our friends from Qualia. This episode shows you why it is not just for muscle, but one of the most powerful and well studied upgrades for brain energy, metabolism, sleep resilience, and long term human performance. You will learn how creatine supports mitochondria, buffers ATP, reduces cravings, and helps you think, train, and recover with more energy instead of relying on willpower. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Greg Kelly for a deep, practical masterclass on creatine and energy biology. Greg Kelly is a naturopathic physician, functional medicine expert, and longtime researcher in supplements and nootropics. He has spent decades studying creatine, mitochondrial function, cognition, and performance, and has contributed to peer reviewed research while working directly with athletes, clinicians, and high performers. Together, Dave and Greg break down how creatine works at the cellular level, why it matters for cognition, emotional regulation, and metabolism, and how it supports the brain and body during stress, sleep deprivation, dieting, and recovery. They explore neuroplasticity, ATP production, magnesium, methylation, and why energy availability drives discipline, focus, and resilience more effectively than willpower alone. They also explain why creatine matters for women, aging adults, and people dealing with fatigue or obesity, and how creatine supports brain function even when muscle mass is low. This conversation connects bodybuilding research with modern longevity science, nootropics, functional medicine, and sleep optimization. Dave and Greg also expose why creatine quality matters, how contaminants can impair mitochondrial function, why some products fail label claims, and how to choose forms that absorb better and cause less bloating. Practical strategies like dosing, timing, stacking with magnesium, and using creatine with hot coffee are all covered, including why Dave uses it with Danger Coffee as part of his Smarter Not Harder approach. You’ll Learn: • Why creatine acts as an ATP buffer for both muscles and the brain • How mitochondria drive cognition, metabolism, and emotional regulation • The real dosing debate from low daily maintenance to higher cognitive doses • Why women often need more creatine than men • How creatine supports performance during sleep deprivation and sleep debt • The link between magnesium, creatine phosphate, and ATP production • How methylation and TMG relate to creatine synthesis and timing • Why creatine can reduce cravings by improving cellular energy • How low quality creatine and contaminants can damage mitochondrial function • When creatine matters most for longevity, resilience, and human performance Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Thank you to our sponsors! • Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave • ECHO Water | Go to http://echowater.com/dave and use code DAVE10 for 10% off your ECHO Flask • NeuroVeda Health | Go to https://www.neurovedahealth.com/aspery to learn more and book your week • STEMREGEN | Go to http://stemregen.co/dave30 and use code DAVE30 for 30% off your next order Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: creatine brain energy, creatine ATP buffering, creatine mitochondria, creatine cognitive performance, ...
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    1 h y 21 m
  • How Long Can Humans Really Live… (with Dan Buettner) : 1393

    How Long Can Humans Really Live… (with Dan Buettner) : 1393
    Jan 6 2026
    You’re about to hear one of the most honest longevity conversations ever recorded. This co hosted episode brings together two longevity leaders with opposing views on how long humans can live, yet enormous respect for each other and the science. Recorded live at Eudemonia, this discussion gives you clear frameworks for longevity, biohacking, human performance, and anti aging without all the tribal thinking that can plague modern health conversations! Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dan Buettner for a rare co hosted podcast that explores where biohacking and Blue Zones philosophy clash and where they surprisingly align. Dan Buettner is a National Geographic Explorer, Emmy Award winning producer, and five time New York Times bestselling author. He is best known for identifying the Blue Zones, regions of the world where people live the longest and healthiest lives. His research has reshaped cities, healthcare systems, and insurance models across the United States, improving health outcomes for more than 10 million Americans. His Netflix series Live to 100: Secrets of the Blue Zones earned six Emmy nominations and won three. Dan is also an accomplished endurance athlete with three Guinness World Records in distance cycling. Together, Dave and Dan debate the true limits of human lifespan, whether longevity is driven more by environment or intervention, and how modern tools like AI, functional medicine, supplements, fasting, ketosis, and sleep optimization compare to walkable communities, movement, and purpose. They explore mitochondria, neuroplasticity, metabolism, brain optimization, and why Smarter Not Harder applies whether you follow a carnivore leaning diet, a bean based diet, or something in between. This episode gives you both sides of the longevity argument and lets you decide what fits your biology, values, and goals. You’ll Learn: • Why Dan believes average human lifespan likely tops out in the mid 90s and how Blue Zones support longevity without chronic disease • Why Host Dave Asprey believes biohacking, AI, and modern science could push longevity toward 150, 180, or beyond • How environmental design hacks unconscious behavior more effectively than willpower • The overlooked role of light, darkness, and circadian rhythm in sleep optimization and human performance • How fasting and ketosis support longevity when used strategically instead of obsessively • Why mitochondria signaling may matter more than fixing every cell individually • How neuroplasticity and brain optimization influence aging and resilience • Where supplements and nootropics help and where simplicity wins • The real debate around carnivore diets, carbs, beans, metabolism, and longevity • Why community, purpose, and movement remain foundational even in advanced biohacking • How Danger Coffee fits into energy, focus, and Smarter Not Harder performance strategies Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Thank you to our sponsors! - BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off. - MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order. - Puori | Use code DAVE at http://puori.com/DAVE to get 32% off your Puori Fish Oil when you start a subscription. You save more than $18. - BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: longevity debate, biohacking vs blue zones, dave asprey ...
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    54 m
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Wealth of information from these podcasts. I binge these at work every single day.

Dave is the best

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I am so enlightened by cutting edge research and the years of experience and practice Dave has put in.

Top notch

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Great way to reframe wanting to pack everything in but figuring out what is best for you.

Info everyone needs to know!

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I am so excited to use these ideas and use the equipment and supplements I have already purchased and to tweak and add others. Thank you for this concise and valuable podcast! So excited to share this with loved ones that are stuck and looking for what to focus on next. This is a must listen episode!

Loved this episode! Reminded me and inspired me,!

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I’ve been listening to Dave Aspreys interviews for many years. I recommend his podcasts for anyone actively seeking health education.

Valuable health information!

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