The Human Upgrade: Biohacking for Longevity & Performance Podcast Por Dave Asprey arte de portada

The Human Upgrade: Biohacking for Longevity & Performance

The Human Upgrade: Biohacking for Longevity & Performance

De: Dave Asprey
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For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.

Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.

This isn’t just self-improvement - it’s human enhancement backed by data.

Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.

Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

© Copyright © Bulletproof Media 2023 Ciencia Desarrollo Personal Higiene y Vida Saludable Éxito Personal
Episodios
  • 1 Cup Every Morning Helped Me Lose 100 Pounds (Drink THIS) : 1452

    1 Cup Every Morning Helped Me Lose 100 Pounds (Drink THIS) : 1452
    Apr 19 2026

    I lost 100 pounds, dropped to 4.8% body fat, and my lab tests say I'm biologically in my 30s... at 50 years old. Here's everything I got wrong about weight loss for years, and what actually worked.

    After 18 months of low-calorie dieting and 700+ hours in the gym with zero fat loss, I discovered the truth about saturated fat, intermittent fasting, and why putting butter in my coffee every morning changed everything. This is the foundation of the Bulletproof Diet... and it's helped people around the world lose over a million pounds.


    In this video I break down 9 weight loss myths that are keeping you fat and tired:

    • Why saturated fat is NOT bad for you (and what the real science says)
    • The truth about low-fat diets and why they wreck your hormones
    • Why counting calories is the wrong tool for fat loss
    • How intermittent fasting and butter coffee keep you in fat-burning mode all day
    • The anti-nutrients hiding in "healthy" vegetables, whole grains, and fruit
    • Why 20 minutes of exercise per week beats 6 days in the gym


    Whether you're struggling with stubborn belly fat, constant cravings, brain fog, or low energy... this video is for you. I cover grass-fed butter benefits, MCT oil, biohacking for weight loss, leptin resistance, insulin sensitivity, autophagy, and the real reason the low-fat movement made America sicker.


    0:00 – Introduction

    03:14 – Myth #1: Saturated Fat Is Bad for You

    05:03 – Myth #2: Low-Fat Diets Are Healthy

    07:01 – Myth #3: Cutting Calories Is the Key to Fat Loss

    08:53 – Myth #4: Eating Small Meals Boosts Your Metabolism

    10:24 – Myth #5: All Vegetables Are Good for You

    12:10 – Myth #6: Whole Grains Are Healthy

    13:26 – Myth #7: Fruit Is Always Healthy

    14:42 – Myth #8: You Need to Eat Breakfast Right Away

    15:56 – Myth #9: Exercise Is the Best Way to Lose Weight


    Thank you to our sponsors!

    • Neuronic | Go to www.neuronic.online Code DAVE for $100 off
    • Superstratum Labs | Get Dave's exact home mold detox kit and save 10% at superstratumlabs.com/products/dave
    • iRestore | Grow thicker, healthier hair back naturally. Use code DAVE at irestore.com/DAVE


    Connect with Dave Asprey!


    Website: https://daveasprey.com

    TikTok: https://www.tiktok.com/@daveaspreyofficial

    Instagram: https://www.instagram.com/dave.asprey/

    Facebook: https://www.facebook.com/Daveaspreyofficial/

    X: https://x.com/daveasprey

    YouTube: https://www.youtube.com/c/daveaspreybpr


    The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/


    Danger Coffee: https://dangercoffee.com/DAVE15

    Dave Asprey’s BEYOND Conference: https://beyondconference.com/

    Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

    Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

    Upgrade Labs: https://upgradelabs.com

    40 Years of Zen: https://40yearsofzen.com

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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    18 m
  • Flouride and IQ, Sardinemaxxing, At Home Cancer Cure, Hair Loss Fixes, and more... : 1451

    Flouride and IQ, Sardinemaxxing, At Home Cancer Cure, Hair Loss Fixes, and more... : 1451
    Apr 17 2026
    This week's stories: ***Virologist Self-Injects Oncolytic Virus Therapy, Achieves 4-Year Remission in Triple-Negative Breast Cancer*** A researcher facing terminal triple-negative breast cancer (28% 5-year survival rate) engineered her own measles and vesicular stomatitis viruses and self-administered seven doses directly into her tumor outside formal clinical infrastructure. Four years cancer-free. Dave breaks down the mechanistic basis for oncolytic virotherapy—why cancer cells can't mount antiviral defenses that healthy tissue can—and the regulatory tension between patient autonomy and FDA gatekeeping on experimental immunotherapies. This is either a triumph of DIY biohacking or a cautionary tale about biosafety; either way, oncolytic virotherapy is accelerating toward mainstream clinical use and forcing a reckoning about access to cutting-edge cancer immunology. Sources: -https://www.dana-farber.org/newsroom/news-releases/2026/virus-based-therapy-boosts-anti-cancer-immune-responses-to-brain-cancer -https://www.eurekalert.org/news-releases/1116087 -https://acgtfoundation.org/news/oncolytic-virus-therapy-for-cancer/ ***Spermidine is the Missing Link Between Fasting and Longevity*** A Nature Cell Biology study across yeast, flies, mice, and humans reveals that fasting triggers longevity exclusively through spermidine—blocking spermidine synthesis ablates every lifespan-extending benefit, cardioprotection, and anti-inflammatory outcome, even with identical caloric restriction. Dave explains why your intermittent fasting protocol is metabolically inert without spermidine, the specific foods highest in bioavailable spermidine (wheat germ, aged cheddar, shiitake mushrooms, fermented foods), and how to time supplementation for maximum autophagy activation. This is the most critical missing variable in fasting-focused biohacking that almost no one is tracking. Sources: -https://www.nature.com/articles/s41556-024-01468-x -https://pubmed.ncbi.nlm.nih.gov/39117797/ -https://oxfordhealthspan.com/blogs/aging-well/spermidine-and-healthy-aging-insights-from-a-2026-nature-review -https://www.glp-1.science/blog/spermidine-autophagy-supplement/ ***Hair Regrowth Breakthrough: SHH-Mimetic Peptides Replace Minoxidil*** Topical peptides mimicking sonic hedgehog signaling (the embryonic pathway that initiates hair follicles) activate dermal papilla stem cells and deliver 65% hair regrowth at 24 weeks versus 40% with minoxidil—with zero systemic absorption and zero cardiovascular risk. Dave covers why minoxidil's vasodilation mechanism is crude (and why it triggers tachycardia and hypertrichosis), how SHH-mimetic peptides directly target the actual biological lever (stem cell activation), and why this mechanistic upgrade should reshape hair loss treatment within 12 months. This is precision medicine applied to cosmetic optimization. Sources: -https://finance.yahoo.com/sectors/healthcare/articles/goodbye-minoxidil-clean-bio-hacking-150800494.html ***"Sardinemaxxing": $1.39 Per Can Delivers 370% B12, 982mg Omega-3s, 96% Selenium*** Canned sardines are experiencing a viral surge on TikTok (#sardinemaxxing: 90,000+ videos) because a single 100-gram serving packs 370% daily B12, 982mg omega-3s, 96% selenium, and 24% vitamin D—all for $1.39. Dave breaks down the nutrient density to cost ratio (superior to wild salmon, fish oil supplements, and selenium stacks), the anti-inflammatory mechanisms (B12 methylation support, selenium-dependent glutathione peroxidase, omega-3 IL-6/TNF-α reduction), and why this represents a biohacker's efficiency play: maximum micronutrition per dollar with zero processing overhead. The shift from complexity back to simplicity. Sources: -https://news.northeastern.edu/2026/04/08/what-is-sardinemaxxing/ ***Fluoride in Community Water Has No Effect on IQ or Cognition — Wisconsin Longitudinal Study*** A seven-decade Wisconsin study tracking 10,317 people from age 16 through 80 finds zero evidence that community water fluoridation (0.7 mg/L, the U.S. recommended level) reduces IQ, impairs cognition, or causes neurotoxicity at any life stage. Dave distinguishes between community-level fluoridation and high-endemic-fluoride regions (2–10 mg/L in parts of Asia), clarifies why the anti-fluoridation narrative became culturally dominant without robust U.S. epidemiological data, and examines why 17+ states reversed fluoridation policy based on flawed evidence transfer. This is a case study in how folklore—even with mechanistic rationale—can override data. Individual choice about fluoride exposure remains valid; cognitive toxicity at community water levels is not supported. Sources: -https://www.sciencenews.org/article/fluoride-drinking-water-iq-no-evidence -https://www.nbcnews.com/health/kids-health/fluoride-water-children-iq-brain-cognition-study-rfk-jr-rcna267328 -https://studyfinds.com/...
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    11 m
  • Why I'm Putting 100x Bleach on My Face : 1450

    Why I'm Putting 100x Bleach on My Face : 1450
    Apr 16 2026
    Your body already makes the most powerful wound-healing molecule on the planet, and now you can use it at home. This episode breaks down hypochlorous acid (HOCl), the compound your white blood cells produce naturally, and why it outperforms Neosporin, hydrogen peroxide, and synthetic antibiotics for everything from cuts and burns to eczema, rosacea, and chronic wounds. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Grab a generous discount on your next purchase of Active Skin Repair by using code ‘Dave’ at: https://www.activeskinrepair.com (good until May 21st) Host Dave Asprey sits down with Justin Gardner, a 20-year leader in health, wellness, and regenerative medicine who has founded and sold multiple companies and introduced over 50 innovative products into hospitals and doctors' offices. When Justin discovered hypochlorous acid, he shifted his entire focus to making this medical-grade, non-toxic molecule available to the public, founding Active Skin Repair to give people a cleaner, more effective alternative to the chemical-laden products that dominate the skincare aisle. Dave and Justin cover the full biohacking case for HOCl: how it kills 99.9% of bacteria, viruses, and fungi in 15 seconds, why it does not trigger antibiotic resistance, how it avoids destroying the healthy growth factors that hydrogen peroxide nukes, and how it supports the skin microbiome instead of wrecking it. They also get into AI as a tool for functional medicine research, why the standard of care is the floor not the ceiling, and how smarter not harder approaches to wound care and chronic skin conditions are finally going mainstream. Dave shares the story of treating a mystery acid beetle wound from his Amazon trip using this exact compound, and why it belongs in every medicine cabinet alongside your supplements stack. You'll Learn: Why hypochlorous acid is 100 times more powerful than bleach but has the same safety profile as saline How HOCl mimics your immune system's own wound response instead of overriding it Why hydrogen peroxide and Neosporin can actually stall healing and damage your skin microbiome How HOCl disrupts biofilms in chronic wounds, sinuses, and on the skin during eczema flare-ups Why most HOCl products on the market contain little to no active ingredient How to use AI tools like Claude and Perplexity for functional medicine research that most doctors haven't done Why the US standard of care is the floor, not the ceiling, for anyone serious about longevity and anti-aging How to stack HOCl with red light therapy and other biohacking tools for faster recovery Thank you to our sponsors! - Viome | Check it out at https://www.viome.com/ and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body. - The One Device | Use code DAVE for $10 off at https://www.theonedevice.com/dave - STEMREGEN | Go to https://www.stemregen.co/dave30 Use code DAVE30 for 30% OFF your next order. - Puori | Go to https://www.Puori.com/DAVE or use code DAVE at checkout to get 32% off your Puori Fish Oil subscription. You save more than $18. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Justin Gardner, Active Skin Repair, hypochlorous acid, HOCl, wound healing, skin repair, antimicrobial, biofilm, eczema, rosacea, acne, skin microbiome, regenerative medicine, functional medicine, biohacking, anti-aging, human performance, longevity, supplements, AI healthcare, Dave Asprey, Neosporin alternative, natural healing, chronic wounds, skin inflammation, topical antibiotics, wound care, clean skincare, medical grade skincare, smarter not harder Resources: • Get A Discount On Active Skin Repair By Using Code ‘Dave’ At: https://www.activeskinrepair.com (good until May 21st)• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://...
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    37 m
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Wealth of information from these podcasts. I binge these at work every single day.

Dave is the best

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I am so enlightened by cutting edge research and the years of experience and practice Dave has put in.

Top notch

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Great way to reframe wanting to pack everything in but figuring out what is best for you.

Info everyone needs to know!

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I am so excited to use these ideas and use the equipment and supplements I have already purchased and to tweak and add others. Thank you for this concise and valuable podcast! So excited to share this with loved ones that are stuck and looking for what to focus on next. This is a must listen episode!

Loved this episode! Reminded me and inspired me,!

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I’ve been listening to Dave Aspreys interviews for many years. I recommend his podcasts for anyone actively seeking health education.

Valuable health information!

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