The Human Upgrade: Biohacking for Longevity & Performance Podcast Por Dave Asprey arte de portada

The Human Upgrade: Biohacking for Longevity & Performance

The Human Upgrade: Biohacking for Longevity & Performance

De: Dave Asprey
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For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.

Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.

This isn’t just self-improvement - it’s human enhancement backed by data.

Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.

Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

© Copyright © Bulletproof Media 2023 Ciencia Desarrollo Personal Higiene y Vida Saludable Éxito Personal
Episodios
  • CDC Director Jim O'Neill on Fixing America's Broken Food Policy : 1449

    CDC Director Jim O'Neill on Fixing America's Broken Food Policy : 1449
    Apr 14 2026
    The government is finally catching up to what biohackers have known for decades, and the man helping lead that charge just sat down with Host Dave Asprey to talk longevity science, aging biomarkers, dietary overhaul, AI in medicine, and what a real science-first health agenda actually looks like. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Jim O'Neill served as Deputy Secretary of Health and Human Services and Acting Director of the CDC before being nominated to lead the National Science Foundation in March 2026. Before entering government, he was CEO of SENS Research Foundation, where he led cutting-edge regenerative medicine research targeting mitochondrial mutations, senescent cells, and neocortex rejuvenation. He is a 30-year veteran of health care reform and a genuine longevity insider. Dave and Jim cover the complete rewrite of federal dietary guidelines, the government's new randomized controlled trials on saturated fats, and why grains are no longer the core of a "balanced diet." They dig into a 144 million dollar ARPA H program to establish causal aging biomarkers that will unlock real anti-aging drug development and accelerate the kind of longevity research the SENS Foundation pioneered. Jim explains why current aging clocks and DNA methylation markers are not enough, and what comes next for functional medicine, sleep optimization, and metabolism research. They also break down the CDC's return to its infectious disease core, the future of AI in health care, wearable data for disease surveillance, organ bioprinting, GLP-1s, supplements like vitamin D, peptides, and the right to self-experiment. You will learn: Why the new federal dietary guidelines finally reject grain-centric nutrition and validate what the biohacking world has argued for 25 years How a 144 million dollar government program aims to build the causal biomarkers that will make real anti-aging and longevity drug development possible What Jim thinks about DNA methylation clocks and why better tools are needed to measure aging and human performance How AI is reshaping prescription refills, clinical decision support, Medicare reimbursement, and the future of functional medicine Why Jim wears an Oura Ring and uses sleep optimization data to make daily health decisions The government's evolving stance on peptides, supplements, and therapies that are not patent protected How organ bioprinting using a patient's own cells could solve the organ shortage crisis What real science replication looks like and why the government is now funding it What the CDC is doing to refocus on infectious disease while shedding mission creep How GLP-1s, fitness tracking, and updated nutrition strategies could significantly cut national obesity rates within five years Thank you to our sponsors! - Neuronic | Go to www.neuronic.online Code DAVE for $100 off - iRestore | Reverse hair loss with www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE - Go to timeline.com/dave and save 20% with code DAVE20 - Superstratum Labs | Get Dave's exact home mold detox kit and save 10% at superstratumlabs.com/products/dave Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Jim O'Neill, CDC, HHS, dietary guidelines, saturated fat, aging biomarkers, ARPA H, SENS Research Foundation, longevity, anti-aging, senescent cells, mitochondria, DNA methylation, sleep optimization, Oura Ring, AI healthcare, organ bioprinting, GLP-1, peptides, vitamin D, supplements, functional medicine, biohacking, Dave Asprey, human performance, metabolism Resources: • Learn more at: https://www.hhs.gov/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live ...
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    37 m
  • What Doctor's DON'T Tell You About Megadosing Creatine (Over 40) : 1447

    What Doctor's DON'T Tell You About Megadosing Creatine (Over 40) : 1447
    Apr 12 2026

    My favorite creatine (discount code DAVETUBE): https://www.qualialife.com/ASPREYRECOMMENDS


    Creatine isn’t just for bodybuilders. It’s one of the most overlooked, science-backed nootropics for brain optimization, neuroplasticity, mitochondrial energy, and total human performance. This episode reveals why creatine is a non-negotiable supplement for anyone serious about biohacking, longevity, and cognitive upgrades.


    Host Dave Asprey breaks down the myths and truths about creatine, uncovering how it enhances memory, supports your mitochondria, regulates mood, strengthens bones and heart function, and even aids fetal brain development during pregnancy. Drawing from decades of functional medicine, real-world biohacks, and new research featured in the Wall Street Journal, Dave explains how creatine works not only as a muscle booster but as a universal cellular fuel that supports brain benefits, memory improvement, and sleep optimization.

    Timestamps:

    0:00 – Introduction

    1:14 – Why Creatine Matters

    5:01 – History of Creatine

    6:09 – Debunking the Myths

    8:55 – 5 Ways Creatine Fuels Your Mind & Body

    16:25 – How to Maximize Absorption

    18:13 – Dosing: How Much & When to Take It

    19:07 – Forms of Creatine Explained

    19:50 – Special Use Cases

    21:28 – Biohacking Real-World Applications

    23:21 – What to Stack with Creatine

    24:50 – Choosing the Right Creatine

    28:40 – Recap & Key Takeaways


    Thank you to our sponsors!

    • Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.
    • AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers.


    Connect with Dave Asprey!


    Website: https://daveasprey.com

    TikTok: https://www.tiktok.com/@daveaspreyofficial

    Instagram: https://www.instagram.com/dave.asprey/

    Facebook: https://www.facebook.com/Daveaspreyofficial/

    X: https://x.com/daveasprey

    YouTube: https://www.youtube.com/c/daveaspreybpr


    The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/


    Danger Coffee: https://dangercoffee.com/DAVE15

    Dave Asprey’s BEYOND Conference: https://beyondconference.com/

    Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

    Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

    Upgrade Labs: https://upgradelabs.com

    40 Years of Zen: https://40yearsofzen.com

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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    31 m
  • Superhuman Contact Lenses, Motivation Supplement Stack, Cat Scratches Cause Brain Fog, Amino Acid Shortening Lifespan, and more... : 1448

    Superhuman Contact Lenses, Motivation Supplement Stack, Cat Scratches Cause Brain Fog, Amino Acid Shortening Lifespan, and more... : 1448
    Apr 10 2026
    This week's stories: *Bartonella Hides in Cat Scratches — and It Might Be Why You Feel Like Garbage A stealth bacterial infection transmitted by everyday cat scratches and flea dirt has been quietly linked to chronic fatigue, brain fog, and neurological symptoms for decades. Dave breaks down how Bartonella slips past standard testing, why it's almost never on a conventional doctor's radar, and the specific PCR protocol you need to actually find it. Sources: https://pubmed.ncbi.nlm.nih.gov/ *High Tyrosine Levels May Be Cutting Years Off Men's Lives A Mendelian randomization study of 270,000 UK Biobank participants found that elevated tyrosine is causally linked to nearly a full year of lost lifespan in men — with zero effect in women. The culprit appears to be an inflammatory oxidation pathway that men metabolize very differently. Dave examines what this means for every guy stacking L-tyrosine nootropics or eating high-protein keto. Sources: https://pubmed.ncbi.nlm.nih.gov/41045493/ https://www.aging-us.com/news-room/high-tyrosine-levels-linked-to-shorter-lifespan-in-men https://www.usnews.com/news/health-news/articles/2026-02-27/study-suggests-one-common-amino-acid-may-affect-how-long-men-live *Blue Light Blocking Contact Lenses Are a Legitimate Vision Upgrade ALTIUS Vision's tinted contact lenses aren't just blue light filters — they cut chromatic aberration by 53% and improve motion tracking and contrast sensitivity in ways that software filters simply can't replicate. Dave covers the mechanism, who benefits most (screen workers, TBI recovery, gamers), and how to find a provider. Sources: https://altiusvision.com/chromatic-aberration/ https://altiusvision.com/science-of-altius/ https://www.westvalleyvision.com/-altius--performance-tinted-contact-lenses *Taurine Plus B Vitamins Actually Moves the Needle on Motivation A randomized crossover trial found that a daily stack of taurine, B6, folate, and B12 sustained effort-reward motivation and cut cognitive lapses significantly compared to placebo — and the mechanism runs through glutathione production in brain astrocytes. Dave breaks down why this combo works when either ingredient alone doesn't. Sources: https://pubmed.ncbi.nlm.nih.gov/41889717/ https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1711478/full https://www.nutraingredients.com/Article/2026/03/23/taurine-and-b-vitamins-bost-motivation-and-focus/ *30 Seconds of Smelling Flowers Resets Your Nervous System Research out of the Monell Chemical Senses Center confirms what your grandmother knew: a slow, deep floral inhale measurably lowers heart rate and activates the parasympathetic nervous system — and it works because olfaction bypasses the cortex entirely and hits the limbic system directly. Dave makes the case for building a daily scent ritual. Sources: https://time.com/ https://www.southtabor.com/healthy-living-tip-stop-and-smell-the-flowers/ This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on infection-driven cognitive decline, amino acid optimization, sensory performance, and evidence-based supplementation. Host Dave Asprey connects emerging clinical research, Mendelian randomization data, and real-world protocols into actionable frameworks for extending healthspan and sharpening performance. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: Bartonella cat scratch infection, Bartonella brain fog chronic fatigue, stealth bacterial infection biohacking, tyrosine lifespan men, L-tyrosine risk men longevity, Mendelian randomization amino acid aging, blue light blocking contacts, ALTIUS vision chromatic aberration, performance contact lenses TBI, taurine B vitamins motivation RCT, taurine folate brain health, glutathione astrocytes focus, smelling flowers heart rate stress, olfaction parasympathetic nervous system, floral scent limbic system, biohacking news, longevity research 2026 Thank you to our sponsors! - GOT MOLD? | Go to http://gotmold.com/shop and use DAVE10 to save 10% and see what’s in your air. - MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order. - iRestore | Grow thicker, healthier hair back naturally. Use code DAVE at irestore.com. Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave...
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    10 m
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Wealth of information from these podcasts. I binge these at work every single day.

Dave is the best

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I am so enlightened by cutting edge research and the years of experience and practice Dave has put in.

Top notch

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Great way to reframe wanting to pack everything in but figuring out what is best for you.

Info everyone needs to know!

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I am so excited to use these ideas and use the equipment and supplements I have already purchased and to tweak and add others. Thank you for this concise and valuable podcast! So excited to share this with loved ones that are stuck and looking for what to focus on next. This is a must listen episode!

Loved this episode! Reminded me and inspired me,!

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I’ve been listening to Dave Aspreys interviews for many years. I recommend his podcasts for anyone actively seeking health education.

Valuable health information!

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